People living on the high plateaus of the world have long fascinated biological anthropologists and geneticists because they live in ＂thin air＂ and epitomize an extreme of human biological adaptation.
The external environment plays a decisive role in the changes of the intestinal microecology.The low oxygen environment of the plateau disturbs the barrier function of the intestinal mucosa,altered flora structure exa...The external environment plays a decisive role in the changes of the intestinal microecology.The low oxygen environment of the plateau disturbs the barrier function of the intestinal mucosa,altered flora structure exacerbates intestinal mucosal barrier damage.It is possible that the mechanism of intestinal mucosal injury is the upregulation of the expression of hypoxia-inducible factor HIF-1αin the intestine under hypoxic environment,along with the sustained expression of inducible nitric oxide synthase(iNOS),which triggers intestinal mucosal injury.展开更多
文摘People living on the high plateaus of the world have long fascinated biological anthropologists and geneticists because they live in ＂thin air＂ and epitomize an extreme of human biological adaptation.
基金Tibet University Student Innovation Training Program(2020XCX023)。
文摘The external environment plays a decisive role in the changes of the intestinal microecology.The low oxygen environment of the plateau disturbs the barrier function of the intestinal mucosa,altered flora structure exacerbates intestinal mucosal barrier damage.It is possible that the mechanism of intestinal mucosal injury is the upregulation of the expression of hypoxia-inducible factor HIF-1αin the intestine under hypoxic environment,along with the sustained expression of inducible nitric oxide synthase(iNOS),which triggers intestinal mucosal injury.
