The Application of 3+1 Holistic Rehabilitation Nursing in Patients with Alzheimer’s Disease

.Thereafter,the full text of all 28 studies were reviewed.Finally,24 studies were included after excluding duplicates,non-3+1 holistic rehabilitation nursing studies,non-experimental studies,studies with inconsistent sample size,wrong data analysis,and unclear outcomes,etc.Results:Upon reviewing the 24 literatures,all the included studies were clinical studies that made comparisons between 3+1 holistic rehabilitation nursing groups and traditional nursing groups.The age of the participants were between 60 and 80 years,and the total number of participates were 2,790.However,there were some studies that did not report the average age(5/24),average duration(14/24),and the ratio of male to female patients(3/24).Only a few studies reported the intervention time(7/24)and classified the disease by severity(4/24).The outcomes included activities of daily living(ADL),Mini-Mental State Examination(MMSE),and Chinese Rehabilitation Research Center Aphasia Examination(CRRCAE).A total of 19 studies showed that 3+1 holistic rehabilitation nursing is effective in improving patients’self-care ability;14 studies showed that this rehabilitation nursing has a significant curative effect for the cognitive function of patients;7 studies showed that this nursing model can promote the recovery of language function in AD patients;5 studies showed the model can significantly reduce the incidence of adverse events and complications upon receiving treatment;2 studies showed that the nursing model is helpful for depression and emotional indifference.Conclusion:Compared with the traditional nursing mode,3+1 holistic rehabilitation nursing is more effective in improving self-care ability,cognitive function,language function,emotional state,and so on.In addition,this nursing model can significantly reduce the incidence of adverse events,falls,pressure sores,and other complications during hospitalization.However,the inclusion criteria and duration of intervention for the included studies need to be further standardized,and more experimental studies on the efficacy of 3+1 holistic rehabilitation nursing on severe AD patients as well as the complications caused by AD are required.The cost of 3+1 holistic rehabilitation nursing,which is specialized and personalized,is high.Therefore,the value of this nursing model still requires much research.

Cognitive training for elderly patients with early Alzheimer’s disease in the Qinghai-Tibet Plateau: A pilot study

BACKGROUND Alzheimer’s disease(AD)influences the social and economic quality of life of older adult patients and their families.AIM To explore the efficacy of cognitive training in clinical nursing for patients with early AD residing in the plateau area.METHODS This pilot study was conducted in patients with early AD treated in the Geriatric Department of the Qinghai Provincial People’s Hospital between August 2019 and March 2021.The patients were divided into a cognitive training group and a conventional nursing group using the random number table method.Patients in the conventional nursing group received conventional nursing,whereas the patients in the cognitive training group received the new nursing intervention.The mini-mental state examination(MMSE)and activities of daily living(ADL)scales were used to compare the cognitive ability and daily activities,respectively,between the two groups before and after the intervention.RESULTS Sixty patients were enrolled in this study,with 30 patients in the cognitive training group and conventional nursing group,respectively.The MMSE and ADL scores were significantly higher in the cognitive training group than in the conventional nursing group after the intervention(MMSE:25.11±2.02 vs 22.26±1.23,P=0.032;ADL:68.72±4.86 vs 60.16±2.27,P=0.018).CONCLUSION The application of cognitive training in clinical nursing for patients with early AD could improve both their cognitive ability and ADL.This method could be applied in clinical practice to manage cognitive dysfunction in patients with early AD.

Analysis of Alzheimer’s Disease:From Pathological Mechanism to Therapeutic Approach in Autophagy

As a“non-curable”disease,Alzheimer’s disease(AD)is the most common neurodegenerative disease in the aged population.Physical and mental pain exerts on every AD patient and their families.Even though there is no worldwide approved treatment against AD now,researchers have never given up on investigating and exploring potential approaches for curing AD.Gene therapy and drug treatment arise for alleviating AD symptoms.This paper illustrates the pathological mechanism of AD and focuses on the role of autophagy in AD pathology.Autophagy is a self-degrading mechanism to clear out dysfunctional cells;abnormal autophagy can directly trigger AD.This paper summarizes the effective and novel therapeutic approaches to treating AD by promoting autophagy activity,as well as AD diagnosis and assessment from early to severe stage,which provides promising approaches for researchers who are interested in AD treatments and feasible directions for science translational medicine.

Clinicians’prescription preferences for treating patients with Alzheimer’s disease in Shanghai

Background:China has more cases of Alzheimer’s disease(AD)than any other country in the world.As training to recognize and manage dementia is in its early stage,it is important to study clinicians’current prescription preferences for treating patients with AD.Methods:This study surveyed neurologists,psychiatrists,and general physicians(GPs)in Shanghai who had outpatients with AD,using a questionnaire asking about their prescription preferences for these patients.Results:Among the 148 clinicians in the study,26.4%were psychiatrists,44.6%were neurologists,and 29.1%were GPs.The groups did not differ significantly in age,gender,or their monthly cases of new patients with mild or moderate AD(P>0.05).Most clinicians prescribed Cholinesterase inhibitors(ChEIs),including Huperzine A,but there were significant group-differences in prescribing specific ChEIs(P<0.05).The daily dosages of ChEI and Memantine prescribed by all three groups were small(P>0.05),and all three groups prescribed piracetam,ergot,and ginkgo biloba drugs.All three groups also tended to treat AD patients with a combination of antidepressants and anxiolytics,although psychiatrists were significantly more likely than neurologists to combine antipsychotics with other drugs(P<0.05).Conclusion:Clinicians in Shanghai prescribed low doses of ChEIs and Memantine for patients with AD.A relatively high proportion also prescribed cognitive enhancers,which lack evidence-based support of their use,and antipsychotics.There is a need for more training about treating patients with AD and for clinicians to standardize their clinical practice.

梓醇-川芎嗪方对SAMP8小鼠认知功能的改善作用及机制

目的:探讨梓醇-川芎嗪方(CT)对快速老化(SAMP8)小鼠认知功能的改善作用及其机制。方法:将50只14周龄SAMP8小鼠随机分为模型(Model)组、梓醇-川芎嗪方低剂量(CT-L)组、中剂量(CT-M)组、高剂量(CT-H)组、盐酸多奈哌齐组(DH组),10只14周龄快速衰老模型对照(SAMR1)小鼠作为对照(Control)组。Control组及Model组均以生理盐水灌胃,各用药组以相应药物灌胃,每日1次,连续8周。采用自主活动实验、筑巢行为实验、新物体辨别实验、Morris水迷宫实验等行为学观察。行为学观察后,检测各组小鼠海马组织超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、β-淀粉样蛋白(Aβ)1-42、p-Tau、核因子-κB(NF-κB)p65、核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)及活性氧(ROS)水平,检测各组小鼠血清NF-κB p65、NLRP3、TNF-α、IL-1β及ROS含量。结果:与Model组比较,DH、CT-M、CT-H组小鼠自主活动次数、筑巢行为评分升高、对新物体辨别时间增加、新旧物体辨别时间比值升高、逃避潜伏期明显缩短、跨平台次数和目标象限停留时间增加(P<0.05)。与CT-L组比较,CT-M组、CT-H组、DH组小鼠的自由活动次数、筑巢行为评分升高、探索新物体辨别时间明显增加、新旧物体辨别时间比值升高、逃避潜伏期明显缩短、跨平台次数和目标象限停留时间增加(P<0.05)。与CT-M组比较,CT-H组小鼠的自由活动次数、筑巢行为评分升高、探索新物体辨别时间增加、新旧物体辨别时间比值升高、逃避潜伏期明显缩短、跨平台次数和目标象限停留时间增加(P<0.05)。与DH组比较,CT-H组小鼠的自由活动次数、筑巢行为评分升高、探索新物体辨别时间增加、新旧物体辨别时间比值升高、逃避潜伏期明显缩短、跨平台次数和目标象限停留时间增加(P<0.05)。与Model组比较,DH组和CT-M、CT-H组小鼠海马组织中SOD及GSH水平升高,Aβ_(1-42)、p-Tau、NF-κB p65、NLRP3、TNF-α、IL-1β及ROS水平下降,小鼠血清NF-κB p65、NLRP3、TNF-α、IL-1β及ROS水平下降(P<0.05)。与CT-L组比较,CT-M组、CT-H组、DH组小鼠海马组织中SOD及GSH水平升高,Aβ_(1-42)、p-Tau、NF-κB p65、NLRP3、TNF-α、IL-1β及ROS水平下降,小鼠血清NF-κB p65、NLRP3、TNF-α、IL-1β及ROS水平下降(P<0.05)。与CT-M组比较,CT-H组小鼠海马组织中SOD及GSH水平升高、Aβ_(1-42)、p-Tau、NF-κB p65、NLRP3、TNF-α、IL-1β及ROS水平下降,小鼠血清NF-κB p65、NLRP3、TNF-α、IL-1β及ROS水平下降(P<0.05)。与DH组比较,CT-H组小鼠海马组织中SOD及GSH水平升高、Aβ_(1-42)、p-Tau、NF-κB p65、NLRP3、TNF-α、IL-1β及ROS水平下降,小鼠血清NF-κB p65、NLRP3、TNF-α、IL-1β及ROS水平下降(P<0.05)。结论:梓醇-川芎嗪方可能通过改善氧化/还原失衡状态,抑制脑内炎症反应从而改善SAMP8小鼠的认知功能障碍,且其量效关系呈正相关。

梓醇-川芎嗪方调控STAT3改善阿尔茨海默病神经可塑性的机制研究

目的:探讨梓醇-川芎嗪(CT)方对阿尔茨海默病(AD)的作用及转录激活蛋白3(STAT3)的影响。方法:将野生型C57BL/6J小鼠作为对照组(Control),同时将粉样前体蛋白/早老素1双转染小鼠按照随机数字表法随机分为模型组(Model)、低剂量梓醇-川芎嗪方组(CT-L)、高剂量梓醇-川芎嗪方组(CT-H),每组6只。CT-L组和CT-H组分别给予梓醇-川芎嗪方药50、100 mg/kg灌胃处理。Control组和Model组均给予等体积的生理盐水灌胃。每日1次,连续灌胃8周。水迷宫实验探索梓醇-川芎嗪对AD小鼠学习记忆能力的影响,免疫组化检测海马组织中生长相关蛋白43(GAP-43)的表达。海马神经元HT-22细胞分为空白对照组(Control组)、模型组(Model组)、低剂量梓醇-川芎嗪方组(CT-L组)、高剂量梓醇-川芎嗪方组(CT-H组)、STAT3敲除+梓醇-川芎嗪方组(CT+siSTAT3组)。通过Aβ_(1-42)构建体外AD模型,通过转染siSTAT3构建STAT3沉默的神经元模型,并加入高、低剂量的梓醇-川芎嗪方培养24 h,细胞活性检测(CCK-8)检测细胞活力,蛋白免疫印迹法(Western Blot)检测Cyclin D1、Ki-67、B细胞淋巴瘤/白血病-2(Bcl-2)、Bcl-2相关X蛋白(Bax)、NF200、GAP-43、STAT3和磷酸化的STAT3(p-STAT3)蛋白表达水平,Brdu检测细胞增殖,流式细胞术和末端脱氧核苷酸转移酶介导的dUTP缺口末端标记测定法(TUNEL)染色检测细胞凋亡。结果:梓醇-川芎嗪方可以明显缩短APP/PS1双转染小鼠的逃避潜伏期,提高目标象限停留时间和目标象限停留次数,上调海马组织GAP-43的表达,其中高剂量的梓醇-川芎嗪方作用更显著(P<0.05或P<0.01)。梓醇-川芎嗪方可以恢复AD模型细胞的活力和增殖能力,上调Cyclin D1、Ki-67、NF200、GAP-43和STAT3蛋白的表达,下调凋亡相关蛋白Bax的表达并恢复了抗凋亡Bcl-2蛋白的水平,其中高剂量梓醇-川芎嗪方的作用更显著(P<0.05或P<0.01)。而沉默STAT3逆转了梓醇-川芎嗪方对AD神经元增殖和对NF200、GAP-43蛋白表达的促进作用,阻断了梓醇-川芎嗪方对AD神经元的抗凋亡作用(P<0.05或P<0.01)。结论:梓醇-川芎嗪方可以显著改善AD模型小鼠的认知和记忆能力,且其效应具有剂量依赖性。其作用机制可能与促进神经元细胞的增殖,降低凋亡,调控STAT3的表达从而促进神经元的可塑性有关。

中药Ⅰ号方对APP/PS1双转基因模型小鼠APP代谢的影响

目的研究中药I号方对APP/PS1双转基因模型小鼠APP代谢的影响。方法将5月龄APP/PS1双转基因模型小鼠随机分为模型组(vehicle)、中药Ⅰ号方低剂量组(0.6 g/kg)、中剂量组(1.2 g/kg)和高剂量组(2.4 g/kg),并以同窝阴性小鼠作为正常对照组(wild-type,WT),每组16只,雌雄各半。给药小鼠每天灌胃一次,模型组和正常对照组分别给予等体积的双蒸水灌胃。给药四个月后,用免疫组化和Western blot检测淀粉样前体蛋白(APP)及其代谢产物和分解酶的变化。结果 Western blot结果显示,与模型组相比,治疗组低剂量、中剂量和高剂量给药组能显著降低APP分解酶(ADAM10和BACE1)(P<0.01)及APP的分解产物的量,如:β-CTF(C99)、α-CTF(C83)、s APPα、s APPβ(P<0.01)。结论中药I号方通过影响APP的分解过程减少淀粉样蛋白(β-amyloid peptide,Aβ)的生成,减少脑内老年斑的沉积。

责任制护理干预对老年痴呆症患者认知功能、MMSE与CDT的影响

目的:探讨责任制护理干预对老年痴呆症患者认知功能、精神状态检查(MMSE)与画钟试验(CDT)的影响。方法:将200例老年痴呆症患者随机分为观察组和对照组各100例,观察组采用责任制护理干预,对照组给予常规护理,比较护理前后两组患者神经功能缺损程度及MMSE与CDT的变化。结果:干预后观察组蒙特利尔认知评估量表(MOCA)认知功能评分较干预前显著提高(P<0.05),MMSE、CDT分值与干预前比较有差异有统计学意义(P<0.05);干预后对照组MMSE、CDT分值与干预前比较差异无统计学意义(P>0.05)。结论:责任制护理干预可改善老年痴呆症患者的神经功能缺损程度,提高生活质量,临床效果满意。

Evidence for accuracy of pain assessment and painkillers utilization in neuropsychiatric symptoms of dementia in Calabria region,Italy

During the clinical course of dementia,beside cognitive impairment and memory loss,a very complex challenge is posed by the neuropsychiatric symptoms（NPSs）.Accurate evaluation and treatment of pain impacts positively the agitation of demented patients aged ≥ 65 years.To gather information on the utilization of pain killers in demented patients a preliminary survey has been conducted in collaboration with the Calabrian Pharmacovigilance Territorial Service of the health district of Catanzaro（Italy）.The study has taken into consideration the prescriptions of acetylcholinesterase inhibitors and memantine during the period ranging from July 2015 to June 2016 and the percentage of patients treated against pain with non steroidal antinflammatory drugs,opioids,and anticonvulsants have been monitored.The latter have been evaluated statistically for difference between the treatment before（pre） and after（post） the settlement of acetylcholinesterase inhibitors（ACh EI） or memantine therapy.The results do support accuracy in painkillers utilization in the course of dementia in the regional population of Calabria（Italy）.

国内阿尔茨海默病患者护理文献的可视化分析

目的:通过对国内阿尔茨海默病护理文献的可视化分析,了解近10年国内阿尔茨海默病护理研究的发文情况及研究热点,为临床的护理研究提供参考。方法:检索中国知网(CNKI)有关阿尔茨海默病患者护理的相关文献,检索时间为2013年1月1日至2022年12月31日,运用CiteSpace软件对所检索文献的年发文量、作者合作、机构合作、关键词共现等进行可视化分析。结果:共纳入文献1 132篇,2019年发文量最多,发文量最多的机构是广州市第一人民医院,但尚未形成稳定的核心作者群,机构间的合作较少。排在前3位的关键词为“生活质量”“护理干预”“认知功能”。结论:2019年后阿尔茨海默病护理研究的发文量有所下降,同时研究热点有所转移。后续应加强核心作者、机构之间的合作,提高发文质量,以促进国内阿尔茨海默病在护理领域的研究。

多途径延续护理联合同理心干预对阿尔茨海默病患者认知功能的影响

目的探究多途径延续护理联合同理心干预对阿尔茨海默病(AD)患者认知功能的影响。方法选择2022年12月-2023年8月上海市浦东新区老年医院收治的老年AD患者88例,按随机数字表法分成观察组(n=44)和对照组(n=44)。对照组予以常规康复护理干预,观察组予以多途径延续护理联合同理心干预,时长为12个月。比较2组心理韧性量表(CD-RISC)评分、应对方式量表(MCMQ)评分、血清炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)]水平、认知功能[采用简易精神状态评估量表(MMSE)、画钟测验(CDT)、洛文斯顿认知功能评定量表(LOTCA)评估]评分、日常生活能力评定量表(ADL)评分、老年痴呆症生活质量量表(QOL-AD)评分和护理满意度的差异。结果干预后,2组CD-RISC、MMSE、CDT、LOTCA、ADL、QOL-AD、MCMQ量表积极应对评分均高于同组干预前,且观察组高于对照组(P<0.05);2组MCMQ量表消极应对评分低于同组干预前,且观察组低于对照组(P<0.05);2组TNF-α、IL-1β、IL-6水平均低于同组干预前,且观察组低于对照组(P<0.05);观察组护理满意率高于对照组(93.18%vs 77.27%,P<0.05)。结论多途径延续护理联合同理心干预可改善老年AD患者的认知功能,有效提高患者心理韧性,改变疾病应对方式,降低炎症因子水平,进而改善认知功能,提高自理能力、生活质量和患者满意度,促进康复,护理效果显著,具有一定的临床应用价值。

以八段锦为主的有氧运动对轻中度阿尔茨海默病病人认知功能和生活质量的影响

目的:探讨以八段锦为主的有氧运动对轻中度阿尔茨海默病病人认知功能和生活质量的影响。方法:选取2022年1月1日—12月30日广州医科大学附属脑科医院老年精神科收治的101例轻中度阿尔茨海默病病人作为研究对象,按照随机数字表法将病人分为对照组(51例)和观察组(50例),对照组给予常规护理,观察组在对照组基础上给予以八段锦为主的有氧运动。比较两组病人干预前后的认知功能、日常生活活动能力和生活质量。结果:观察组干预后的认知功能、日常生活活动能力、生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论:以八段锦为主的有氧运动能改善轻中度阿尔茨海默病病人的认知功能,提高日常生活活动能力,从而提高病人的生活质量。

阿尔茨海默病病人认知储备研究进展

综述认知储备的概念起源和发展、工作机制、评估工具、影响因素以及对阿尔茨海默病病人认知储备的干预策略,以期为本土化认知储备评估工具的发展和制定符合我国国情的阿尔茨海默病病人认知储备护理方案提供依据和借鉴意义。

幽默疗法在阿尔茨海默病病人中的应用研究进展

对阿尔茨海默病的概念、幽默疗法在阿尔茨海默病病人中的应用、效果及局限性进行综述,旨在为阿尔茨海默病病人的非药物治疗提供参考。

Effect of Huannao Yicong Prescription (还脑益聪方) Extract onβ-Amyloid Precursor Protein Metabolic Signal Transduction-Related Protein in Brain Tissue of Dementia Model Transgenic Mouse

Objective： To observe the effect of Huannao Yicong Prescription （还脑益聪方, HNYC, a Chinese medical compound） extract on β-amyloid precursor protein （APP） metabolic signal transductionrelated protein kinase C （PKC）, tyrosine amyloid protein kinase （TrKA）, and glycogen synthase kinase-3 （GSK-3） in brain tissue of transgenic mouse dementia model induced by APP. Methods： Sixty dementia model transgenic 3-month-old mice induced by APP695V7171 were randomly allocated in four groups： the model group （A）, the Donepezil （0.65×10^-3 g.kg-1.d-1）-treated group （B）, and the two HNYC-treated groups （C and D） with high dosage （2.8 g.kg^-1.d^-1） and low dosage （1.4 g.kg^-1.d^-1） of HNYC extract, respectively, 15 mice in each group. Besides, a normal control group was set up with 15 C57BL/6J mice with the same age and genetic background as the model mice. The drugs for treatment were administered once a day by dissolving in equal-volume distilled water through gastric infusion, continued for 6 months, to mice in group A and to normal control group equal-volume distilled water was administered instead. Spatial learning and memory capacity of mice were observed by Morris water maze; their one-time escape response memory capacity was tested by diving platform; and changes of PKC, TrkA, and GSK-3 levels in hippocampus and cortex of brain were detected by Western blotting. Results： HNYC extract showed significant effects on increasing the time of model mice for swimming through the flat roof and the swimming time and path in the fourth quadrant （P〈0.05 or P〈0.01）. Diving platform test showed that the latent times in Groups B and C were longer than that in Group A significantly （P〈0.05 and P〈0.01）. Compared with the normal control group, PKC and TrkA protein expression levels in hippocampus and cortex of model mice＇s brain lowered significantly （P〈0.01）, while GSK-3 protein expression increased significantly （P〈0.01）; compared with Group A （the model group）, hippocampal and cortical levels of PKC protein expression in the intervened groups （B-D） as well as those of TrkA in Group C were higher （P〈0.01 or P〈0.05）, while hippocampal levels of GSK-3 in intervened groups were lower （P〈0.01）. Conclusion： HNYC extract could obviously increase the protein expressions of PKC and TrkA and decrease the expression of GSK-3 protein in brain tissue of transgenetic mice model of dementia, and regulate APP metabolic signal transduction path, and thus to suppress the production of A β, which is one of the dominant mechanisms for improving learning/memory capacity of dementia model animals.

提升认知症照顾者居家照护能力的证据总结

目的:系统评价可提高认知症照顾者居家照护能力的最佳证据,为提升认知症居家照顾者照护能力提供循证依据。方法:计算机检索BMJ最佳临床实践、UpToDate、Joanna Briggs Institute(JBI)、英国国家临床医学研究所指南库(NICE)、苏格兰校际指南网(SIGN)、国际指南协作组(GIN)、美国国立指南库(NGC)、国际指南联盟指南图书馆、医脉通、the Cochrane Library、PubMed、EMbase、Web of Science、CINAHL、中国生物医学文献数据库、中国知网、万方数据库、维普数据库、阿尔茨海默病协会网站等数据库及网站资源。纳入近5年关于提高认知症照顾者照护能力的临床实践指南、系统评价、证据总结、专家共识和推荐意见,并进行筛选和质量评价,结合专业判断提取证据并归纳总结。结果:最终纳入19篇文献,其中指南2篇、专家共识5篇、系统评价10篇、临床决策1篇和推荐实践1篇。最终形成四大类(9个主题)共31条关于提高认知症照顾者照护能力的证据。结论:本研究整合形成的认知症居家照顾者提升照护能力的最佳证据,为具体实践提供循证依据,助力提升认知症照顾者居家照护能力,改善病人及照顾者的生活质量。

护理干预对老年痴呆患者家属社会支持的影响

目的:探讨护理干预对老年痴呆患者家属社会支持的影响。方法:选择老年痴呆患者家属60名随机分为研究组和对照组各30名,对照组不进行干预,研究组进行持续、有效的护理干预。采用社会支持量表对老年痴呆患者家属进行测评分析,了解老年痴呆患者家属的社会支持情况。结果:干预后研究组社会支持评分显著高于对照组(P<0.05)。结论:老年痴呆患者家属的社会支持较低,加强对老年痴呆患者家属的心理指导,并提供足够的社会支持,有利于提高老年痴呆患者家属的心理健康水平,从而提高生活质量。

梓醇-川芎嗪方对阿尔茨海默病模型小鼠认知功能的影响

目的探讨梓醇-川芎嗪(CL)方对阿尔茨海默病(AD)模型小鼠认知功能的影响。方法选用APPswe/PS1dE9双转基因模型小鼠,随机分为模型组、梓醇组、川芎嗪组、CL方组、盐酸多奈哌齐(安理申)组,每组10只。6月龄C57BL/6J小鼠10只作为对照组。梓醇组、川芎嗪组、CL方组及安理申组小鼠每天给予相对应剂量的梓醇、川芎嗪、CL方及安理申灌胃。对照组和模型组小鼠每天给予等体积的生理盐水灌胃,各组均为每天1次,连续灌胃8周,进行行为学测试即Morris水迷宫检测和新物体识别(NOR)检测。结果CL方可以明显缩短APPswe/PS1dE9双转基因小鼠的逃避潜伏期、增加目标象限出现次数、延长目标象限游程、提高目标象限游程比、延长目标象限时间、提高目标象限时间比、增加穿台次数、缩短首次穿越平台时间、提高NOR测试中相对识别指数(P<0.05),以上作用不仅优于梓醇组、川芎嗪组,而且也优于安理申组。结论CL方可以有效改善AD模型小鼠的认知障碍,其效果既优于其单一成分,也优于安理申。

护理干预对老年痴呆患者生存质量的影响分析

目的探析护理干预措施对老年痴呆患者生存质量的影响。方法选取该院2010年3月到2012年9月收治的老年痴呆患者60例为研究对象,将其随机分为两组,对照组30例患者采用常规护理措施,干预组30例患者在对照组基础上进行护理干预,护理实践6个月,评价护理干预对老年痴呆症患者的生存质量的影响。结果干预组患者经过为期6个月的护理干预,简易智能精神状态评分明显高于对照组常规护理(P<0.05),患者生活质量明显提高(P<0.05)。结论有效的护理干预措施能有效的改善老年痴呆患者记忆力、定向力、注意力、回忆力、语言能力,效果显著,值得在临床优先广泛推广和应用。

老年性痴呆患者护理模式的国内外比较及其启示

就国内外老年性痴呆患者的护理理念、护理状况、护理方式、护理方法及内容等方面进行比较,强调大力发展、完善我国老年性痴呆患者的服务体系,培养高素质的专门护理人才,以推动我国老年性痴呆患者护理的发展。