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Effect of bright-light therapy on depression and anxiety of a patient with Alzheimer’s disease combined with sleep disorder:A case report
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作者 Xi Mei Chen-Jun Zou +2 位作者 Cheng-Ying Zheng Jun Hu Dong-Sheng Zhou 《World Journal of Psychiatry》 SCIE 2024年第12期1982-1987,共6页
BACKGROUND Alzheimer’s disease(AD)is a common type of dementia due to neuronal impairment.In addition,psychobehavioral symptoms including severe sleep disorders,depression and anxiety can occur in most patients with ... BACKGROUND Alzheimer’s disease(AD)is a common type of dementia due to neuronal impairment.In addition,psychobehavioral symptoms including severe sleep disorders,depression and anxiety can occur in most patients with AD.CASE SUMMARY We report a case of a 68-year-old woman with a 2-year history of AD.She initially presented with memory loss,progressively more severe,leading to a depressive and anxious status.The clinical symptoms also included severe sleep disturbances.Considering the age and health state of the patient,a non-pharmacological treatment of bright light therapy was used to improve her sleep quality.The treatment was provided for 30 minutes twice a day,during 8:30 am to 9:00 am and 16:30 pm to 17:00 pm.After 4 weeks of therapy,the sleep quality notably improved,with a marked decrease in daytime sleep,increase in nighttime sleep,and disappearance of nocturnal activity.The depression and anxiety were also suppressed significantly.CONCLUSION This case report suggested that bright light therapy can have a positive effect on sleep quality in elderly patients with AD and can be used as an effective and safe non-pharmacological treatment. 展开更多
关键词 Bright-light therapy sleep disturbance alzheimers disease DEMENTIA Nonpharmacological treatment Case report
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松果体素的节律与阿尔茨海默病 被引量:7
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作者 周江宁 刘雅静 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2012年第8期796-803,共8页
阿尔茨海默病(Alzheimer's disease,AD)患者常伴有生物节律的紊乱,且紊乱的昼夜节律与患者的认知功能损伤显著相关.松果体素水平降低及昼夜节律紊乱发生在AD早期,并与早期病理改变相关.基于松果体素的神经保护作用,给AD患者补充松... 阿尔茨海默病(Alzheimer's disease,AD)患者常伴有生物节律的紊乱,且紊乱的昼夜节律与患者的认知功能损伤显著相关.松果体素水平降低及昼夜节律紊乱发生在AD早期,并与早期病理改变相关.基于松果体素的神经保护作用,给AD患者补充松果体素结合光治疗可以延缓AD认知功能的损伤,至少与已知的抗痴呆药物具有类似的效应.本文系统综述松果体素的节律失调与阿尔茨海默病的关系. 展开更多
关键词 阿尔茨海默病 松果体素 节律紊乱 治疗
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阿尔茨海默病褪黑素与游离钙离子浓度昼夜节律的实验和临床研究 被引量:2
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作者 粱一波 刘衍宇 +5 位作者 关俊文 邓玉丽 张衍 叶志东 黄光壮 罗虹 《国际老年医学杂志》 2013年第2期49-52,共4页
目的:通过动物实验结合临床研究阿尔茨海默病褪黑素与游离钙离子浓度昼夜变化,探讨褪黑素抵抗神经细胞对钙离子吸收的调控机制,为临床防治阿尔茨海默病提供新的思路。方法:采用ELISA法定量测定昼夜不同时间点正常小鼠与阿尔茨海默... 目的:通过动物实验结合临床研究阿尔茨海默病褪黑素与游离钙离子浓度昼夜变化,探讨褪黑素抵抗神经细胞对钙离子吸收的调控机制,为临床防治阿尔茨海默病提供新的思路。方法:采用ELISA法定量测定昼夜不同时间点正常小鼠与阿尔茨海默病模型小鼠血清及脑浆的褪黑素电极法测定游离钙离子浓度;并同步测定正常老人与阿尔茨海默病老人血清褪黑素、游离钙离子浓度,用余弦函数分析昼夜节律。结果:正常小鼠和正常老人褪黑素分泌存在昼夜节律,阿尔茨海默病的小鼠和老人夜晚褪黑素分泌减少昼夜节律消失。结论:褪黑素的降低与神经组织噬钙离子增大可能是阿尔茨海默病的危险因素。 展开更多
关键词 阿尔茨海默病 褪黑素 钙离子 昼夜节律
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