Objective:To explore the relationships among ambient temperature,ischemic stroke severity,and blood pressure.Methods:Meteorological data(2005–2015)were collected from the Guangzhou Meteorological Data Service.Ischemi...Objective:To explore the relationships among ambient temperature,ischemic stroke severity,and blood pressure.Methods:Meteorological data(2005–2015)were collected from the Guangzhou Meteorological Data Service.Ischemic stroke patients from the Department of Neurology of the First Affiliated Hospital,Sun Yat-sen University were retrospectively evaluated,each winter from 2005 to 2015.Patient demographics,baseline measurements,and National Institute of Health Stroke Scale(NIHSS)score were evaluated.Results:Three hundred sixty-two patients were included.The median latency from symptom onset to admission was 2 d(IQR:1–3 d).During recruitment,the highest and lowest temperatures were 39℃and 1.3℃,respectively.Hypertension was the most common comorbidity(75.1%).NIHSS scores at admission and discharge were higher in the cold-exposed group than in the controls regardless of the average temperature at admission.In addition,systolic and diastolic blood pressure values at admission were higher in the cold-exposed group than in the controls.When stratified by hypertensive status,the average and minimum temperatures at admission were negatively associated with systolic and diastolic blood pressure values in hypertensive patients.Reductions in the average and minimum temperatures at symptom onset were associated with more severe stroke.Conclusion:Ischemic stroke patients with symptom onset in winter had higher systolic blood pressure values and more serious neurologic deficits upon admission.展开更多
ObjectiveThis study was designed to evaluate the effects of imidapril on blood gas parameters in broiler chickens. MethodTwenty-four chickens were randomly divided into three groups (n=8), control group, low temperatu...ObjectiveThis study was designed to evaluate the effects of imidapril on blood gas parameters in broiler chickens. MethodTwenty-four chickens were randomly divided into three groups (n=8), control group, low temperature group and imidapril group. Chickens in low temperature group and imidapril group were exposed to low ambient temperature (12-18 ℃) from age at 14 d to 45 d, whereas the control group was exposed to 24-30 ℃; chickens in imidapril group were gavaged with imidapril (3 mg/kg) once daily for 30 d. At age of 45 d, blood was taken from wing vein and blood gas parameters were evaluated by blood gas analyzer in Luoyang Central Hospital Affiliated to Zhengzhou University. ResultImidapril significantly increased hematocrit (HCT) and total hemoglobin content (T HBC ) and blood Na concentration in broiler chickens exposed to low ambient temperature. No significant differences were observed in pH, P CO 2 , P O 2 , K + , Ca 2+ , HCO 3-, HCO 3std , T CO 2 , BE and SO 2c . ConclusionImidapril increases hematocrit, total hemoglobin content and blood Na + concentration in chickens exposed to low ambient temperature.展开更多
目的观察浮针联合Mulligan手法治疗瘀血阻络型椎动脉型颈椎病的临床疗效及对血清血栓素B2(B2 of thromboxane,TXB2)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、神经元特异性烯醇酶(neuron specific enolase,NSE)水平及血流...目的观察浮针联合Mulligan手法治疗瘀血阻络型椎动脉型颈椎病的临床疗效及对血清血栓素B2(B2 of thromboxane,TXB2)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、神经元特异性烯醇酶(neuron specific enolase,NSE)水平及血流动力学的影响。方法将124例瘀血阻络型椎动脉型颈椎病患者随机分为观察组和对照组,每组62例。对照组患者采用Mulligan手法治疗,观察组采用浮针联合Mulligan手法治疗。观察两组治疗前后血清TXB2、TNF-α、前列腺素E2(prostaglandin E2,PGE2)、NSE、一氧化氮(nitric oxide,NO)和白介素-6(interleukin-6,IL-6)水平,观察两组治疗前后椎动脉阻力指数(resistance index,RI)、椎动脉和椎基底动脉平均峰流速、椎动脉型颈椎病功能评定量表(vertebral artery type cervical spondylosis functional assessment scale,FS-CSA)、改良颈性眩晕症状与功能评估量表(modified evaluation scale for cervical vertigo,ESCV)评分、中医证候积分、颈椎椎体水平位移、椎体角度位移和椎体屈伸活动范围情况,并比较两组临床疗效。结果两组治疗后血清TNF-α、TXB2和PGE2水平降低(P<0.05),且观察组低于对照组(P<0.05)。两组治疗后血清NSE和IL-6水平降低,NO水平升高(P<0.05);且观察组血清NSE、IL-6低于对照组(P<0.05),NO高于对照组(P<0.05)。两组治疗后椎动脉和椎基底动脉平均峰流速提高(P<0.05),椎动脉RI降低(P<0.05);且观察组椎动脉和椎基底动脉平均峰流速高于对照组(P<0.05),椎动脉RI低于对照组(P<0.05)。两组治疗后ESCV评分、FS-CSA和中医证候积分降低(P<0.05);且观察组低于对照组(P<0.05)。两组治疗后椎体角度位移和椎体水平位移降低(P<0.05),椎体屈伸活动范围增大(P<0.05);观察组椎体角度位移、椎体水平位移低于对照组(P<0.05),椎体屈伸活动范围大于对照组(P<0.05)。对照组总有效率为85.5%,观察组为96.8%,两组比较差异有统计学意义(P<0.05)。结论浮针联合Mulligan手法治疗瘀血阻络型椎动脉型颈椎病,可减轻炎症反应,调节血管内皮功能,改善颈部血流,有助于改善颈椎功能,提高临床疗效。展开更多
文摘Objective:To explore the relationships among ambient temperature,ischemic stroke severity,and blood pressure.Methods:Meteorological data(2005–2015)were collected from the Guangzhou Meteorological Data Service.Ischemic stroke patients from the Department of Neurology of the First Affiliated Hospital,Sun Yat-sen University were retrospectively evaluated,each winter from 2005 to 2015.Patient demographics,baseline measurements,and National Institute of Health Stroke Scale(NIHSS)score were evaluated.Results:Three hundred sixty-two patients were included.The median latency from symptom onset to admission was 2 d(IQR:1–3 d).During recruitment,the highest and lowest temperatures were 39℃and 1.3℃,respectively.Hypertension was the most common comorbidity(75.1%).NIHSS scores at admission and discharge were higher in the cold-exposed group than in the controls regardless of the average temperature at admission.In addition,systolic and diastolic blood pressure values at admission were higher in the cold-exposed group than in the controls.When stratified by hypertensive status,the average and minimum temperatures at admission were negatively associated with systolic and diastolic blood pressure values in hypertensive patients.Reductions in the average and minimum temperatures at symptom onset were associated with more severe stroke.Conclusion:Ischemic stroke patients with symptom onset in winter had higher systolic blood pressure values and more serious neurologic deficits upon admission.
基金Supported by Doctoral Scientific Research Fund of Henan University of Science and Technology(09001575)Project of Henan Science and Technology(122300410234)Science and Technology Research Projects of Education Department of Henan Province(13A320429)
文摘ObjectiveThis study was designed to evaluate the effects of imidapril on blood gas parameters in broiler chickens. MethodTwenty-four chickens were randomly divided into three groups (n=8), control group, low temperature group and imidapril group. Chickens in low temperature group and imidapril group were exposed to low ambient temperature (12-18 ℃) from age at 14 d to 45 d, whereas the control group was exposed to 24-30 ℃; chickens in imidapril group were gavaged with imidapril (3 mg/kg) once daily for 30 d. At age of 45 d, blood was taken from wing vein and blood gas parameters were evaluated by blood gas analyzer in Luoyang Central Hospital Affiliated to Zhengzhou University. ResultImidapril significantly increased hematocrit (HCT) and total hemoglobin content (T HBC ) and blood Na concentration in broiler chickens exposed to low ambient temperature. No significant differences were observed in pH, P CO 2 , P O 2 , K + , Ca 2+ , HCO 3-, HCO 3std , T CO 2 , BE and SO 2c . ConclusionImidapril increases hematocrit, total hemoglobin content and blood Na + concentration in chickens exposed to low ambient temperature.
