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Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury Electrophysiological changes and long-term efficacy 被引量:14
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作者 Liqing Yao Chuan He +6 位作者 Ying Zhao Jirong Wang Mei Tang Jun Li Ying Wu Lijuan Ao Xiang Hu 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第5期397-403,共7页
Stem cell transplantation can promote functional restoration following acute spinal cord injury (injury time 〈 3 months), but the safety and long-term efficacy of this treatment need further exploration. In this st... Stem cell transplantation can promote functional restoration following acute spinal cord injury (injury time 〈 3 months), but the safety and long-term efficacy of this treatment need further exploration. In this study, 25 patients with traumatic spinal cord injury (injury time 〉 6 months) were treated with human umbilical cord blood stem cells via intravenous and intrathecal injection. The follow-up period was 12 months after transplantation. Results found that autonomic nerve functions were restored and the latent period of somatosensory evoked potentials was reduced. There were no severe adverse reactions in patients following stem cell transplantation. These experimental findings suggest that the transplantation of human umbilical cord blood stem cells is a safe and effective treatment for patients with traumatic spinal cord injury 展开更多
关键词 neural regeneration spinal cord injury human umbilical cord blood stem cells transplantation PARAPLEGIA american spinal Cord injury association score neurological function SECRETION somatosensory evoked potentials SPASM safety photographs-containing paper neurogeneration
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