Objective: The pilot study was intended to test the feasibility of a multiple-component lifestyle intervention targeting African American adults in a weight control and cardiometabolic risk reduction program on diet, ...Objective: The pilot study was intended to test the feasibility of a multiple-component lifestyle intervention targeting African American adults in a weight control and cardiometabolic risk reduction program on diet, activity, and stress, using community-engagement principles. Methods: Applying mixed qualitative and quantitative measures, the intervention had a two-part sequential study design consisting of 12 weekly small group sessions that provided individual and group counseling in nutrition, exercise, and mindfulness, while incorporating focus group and interactive techniques to learn about barriers and acceptable practices for this population. The program was implemented at an African-American church in Nashville, Tennessee. Results: Thirty-four participants (aged 56.1 ± 11 years, body mass index (BMI) 36.7 ± 6.6 kg/m2) completed the intervention. Lifestyle changes after the 12 weekly sessions showed some positive trends including reduced sodium intake (from 2725.3 ± 326.5 to 2132 ± 330, mg/day, P = 0.008), increased walking steps (from 4392.1 ± 497.2 to 4895.3 ± 497.9, steps/day, not significant), and slightly decreased Perceived Stress Scale (PSS) scores (from 13.7 ± 1.4 to 12.4 ± 1.5, not significant). Body fat % among male participants decreased significantly (from 33.8 ± 2.6 to 28 ± 2.6, %, P = 0.043). Among cardiometabolic risk biomarkers, hemoglobin A1c (HbA1c) decreased significantly (from 6.6 ± 0.2 to 6.1 ± 0.2, %, P β = 2.4, P = 0.006). Twenty-one participants took part in focus groups during the program to identify barriers to healthy lifestyle changes. Primary barriers reported were price, time for preparing healthy meals, unfamiliarity with mindfulness activities, their health condition, and daily schedule available for physical activities. Conclusions: This church-based pilot intervention was proven feasible by showing modest progress in reducing adiposity and decreasing HbA1c levels. The focus group and interactive methods facilitated program direction. Future full-scale studies are warranted to identify key strategies that provide more personalized approaches and supportive environments to sustain a healthy lifestyle among these at risk minorities with limited resources.展开更多
Chagas disease remains a serious problem for public health due to the high disease burden together with its global spreading patterns.However,current treatment and vector control are highly challenged by drug and inse...Chagas disease remains a serious problem for public health due to the high disease burden together with its global spreading patterns.However,current treatment and vector control are highly challenged by drug and insecticide resistance.Chemotherapy and vector control have been proved to be effective attempts to minimize the disease burden.Continued efforts are necessary to keep adapting the surveillance-response systems to the dynamic health systems.More attention and investments are needed to improve appropriate strategy and technology in different settings.This may be accomplished by creating effective risk early warning,addressing vulnerability and building resilience systems,implementing a vector surveillance system,as well as innovating research and technology.展开更多
目的汇总我室参加美国病理家学会(College of American Pathologists,CAP)自身抗体项目的能力比对结果,发现问题并进行整改,提高专业组对自身抗体项目的检测能力和结果准确性。方法回顾分析2012年至2019年参加CAP自身抗体项目情况。按...目的汇总我室参加美国病理家学会(College of American Pathologists,CAP)自身抗体项目的能力比对结果,发现问题并进行整改,提高专业组对自身抗体项目的检测能力和结果准确性。方法回顾分析2012年至2019年参加CAP自身抗体项目情况。按照临床常规样本对待收到的PT样本,在规定日期内通过网络将上述结果反馈给CAP。根据CAP反馈结果,专业组对未评分项目开展自我评估,对不合格项目进行原因分析。结果2012年至2019年我室参加的CAP自身抗体能力比对共计17项、402项次,8年总合格率为98%。13项参评项目的8年总符合率为100%,4个参评项目总符合率未达到100%,项目以及总符合率分别是抗平滑肌抗体(ASMA)90%、抗组蛋白抗体(AHT)92%、抗SSA抗体(SSA)94%、抗胃壁细胞抗体(APC)96%。结论实验室对于自身抗体检测能力较好,对于不合格项目进行原因分析并持续改进,保证实验室检测准确性。展开更多
American trypanosomiasis,commonly known as Chagas disease,is caused by the flagellate protozoan parasite Trypanosoma cruzi.An estimated eight million people infected with T.cruzi currently reside in the endemic region...American trypanosomiasis,commonly known as Chagas disease,is caused by the flagellate protozoan parasite Trypanosoma cruzi.An estimated eight million people infected with T.cruzi currently reside in the endemic regions of Latin America.However,as the disease has now been imported into many non-endemic countries outside of Latin America,it has become a global health issue.We reviewed the transmission patterns and current status of disease spread pertaining to American trypanosomiasis at the global level,as well as recent advances in research.Based on an analysis of the gaps in American trypanosomiasis control,we put forward future research priorities that must be implemented to stop the global spread of the disease.展开更多
文摘Objective: The pilot study was intended to test the feasibility of a multiple-component lifestyle intervention targeting African American adults in a weight control and cardiometabolic risk reduction program on diet, activity, and stress, using community-engagement principles. Methods: Applying mixed qualitative and quantitative measures, the intervention had a two-part sequential study design consisting of 12 weekly small group sessions that provided individual and group counseling in nutrition, exercise, and mindfulness, while incorporating focus group and interactive techniques to learn about barriers and acceptable practices for this population. The program was implemented at an African-American church in Nashville, Tennessee. Results: Thirty-four participants (aged 56.1 ± 11 years, body mass index (BMI) 36.7 ± 6.6 kg/m2) completed the intervention. Lifestyle changes after the 12 weekly sessions showed some positive trends including reduced sodium intake (from 2725.3 ± 326.5 to 2132 ± 330, mg/day, P = 0.008), increased walking steps (from 4392.1 ± 497.2 to 4895.3 ± 497.9, steps/day, not significant), and slightly decreased Perceived Stress Scale (PSS) scores (from 13.7 ± 1.4 to 12.4 ± 1.5, not significant). Body fat % among male participants decreased significantly (from 33.8 ± 2.6 to 28 ± 2.6, %, P = 0.043). Among cardiometabolic risk biomarkers, hemoglobin A1c (HbA1c) decreased significantly (from 6.6 ± 0.2 to 6.1 ± 0.2, %, P β = 2.4, P = 0.006). Twenty-one participants took part in focus groups during the program to identify barriers to healthy lifestyle changes. Primary barriers reported were price, time for preparing healthy meals, unfamiliarity with mindfulness activities, their health condition, and daily schedule available for physical activities. Conclusions: This church-based pilot intervention was proven feasible by showing modest progress in reducing adiposity and decreasing HbA1c levels. The focus group and interactive methods facilitated program direction. Future full-scale studies are warranted to identify key strategies that provide more personalized approaches and supportive environments to sustain a healthy lifestyle among these at risk minorities with limited resources.
基金This work was supported by the National Key Research and Development Program of China(Grant No.2016YFC1202000)the National Natural Science Foundation of China(Grant No.81973108).
文摘Chagas disease remains a serious problem for public health due to the high disease burden together with its global spreading patterns.However,current treatment and vector control are highly challenged by drug and insecticide resistance.Chemotherapy and vector control have been proved to be effective attempts to minimize the disease burden.Continued efforts are necessary to keep adapting the surveillance-response systems to the dynamic health systems.More attention and investments are needed to improve appropriate strategy and technology in different settings.This may be accomplished by creating effective risk early warning,addressing vulnerability and building resilience systems,implementing a vector surveillance system,as well as innovating research and technology.
文摘目的汇总我室参加美国病理家学会(College of American Pathologists,CAP)自身抗体项目的能力比对结果,发现问题并进行整改,提高专业组对自身抗体项目的检测能力和结果准确性。方法回顾分析2012年至2019年参加CAP自身抗体项目情况。按照临床常规样本对待收到的PT样本,在规定日期内通过网络将上述结果反馈给CAP。根据CAP反馈结果,专业组对未评分项目开展自我评估,对不合格项目进行原因分析。结果2012年至2019年我室参加的CAP自身抗体能力比对共计17项、402项次,8年总合格率为98%。13项参评项目的8年总符合率为100%,4个参评项目总符合率未达到100%,项目以及总符合率分别是抗平滑肌抗体(ASMA)90%、抗组蛋白抗体(AHT)92%、抗SSA抗体(SSA)94%、抗胃壁细胞抗体(APC)96%。结论实验室对于自身抗体检测能力较好,对于不合格项目进行原因分析并持续改进,保证实验室检测准确性。
基金This work was supported by the National S&T Major Programme(grant no.2012ZX10004220)Many thanks for Dr.Peiling Yap for her constructive comments on the manuscript.Many thanks also to Mr.Xue Jingbo and Mr.Shen Haimo for their help in drawing the figures.
文摘American trypanosomiasis,commonly known as Chagas disease,is caused by the flagellate protozoan parasite Trypanosoma cruzi.An estimated eight million people infected with T.cruzi currently reside in the endemic regions of Latin America.However,as the disease has now been imported into many non-endemic countries outside of Latin America,it has become a global health issue.We reviewed the transmission patterns and current status of disease spread pertaining to American trypanosomiasis at the global level,as well as recent advances in research.Based on an analysis of the gaps in American trypanosomiasis control,we put forward future research priorities that must be implemented to stop the global spread of the disease.
