Determination of Coordination Configuration of Rare Earth Ions with Aminoacids in Solutions with Cooperative Vibronic Spectroscopy

The use of cooperative vibronic spectroscopy to measure coordination numbers of the ligands surrounding rare earth ions in solutions was proposed and demonstrated. It is shown that the time-resolved cooperative vibronic spectroscopy is a very useful technique for the determination of the ligand type and ligand number for different coordination groups. Coordination configuration of arginine with Tb3+ in solutions with different pH values was studied. It demonstrates that the carboxy1 of arginine can replace H2O to coordinate with Tb3+ and the coordination number of carboxyl increases with the increase of pH value of the solutions.

Design and synthesis of some new C_2-symmetric chiral disulfonamides from aminoacids and the application in diethyl zinc addition to benzaldehyde

Nine C2-symmetric chiral disulfonamldes were designed and synthesized from L-valine, L-phenylalanine and L-leucine respectively via one-pot ring opening of aziridines. The application of these disulfonamides as catalyst in the addition of diethyl zinc to benzaldehyde in three reagent systems: Ligand-Ti(OiPr)4-Et2Zn; Ligand-Ti(OiPr)4-H2O-Et2Zn; Ligand-Et2Zn was also described.

Quantification of Solid Residues by Raman Spectroscopy

We suggest a mathematical route which has the capability to obtain quantitative information of solid residues on a substrate of aluminum, in which the evaporation of the deposited micro-drops has the form of coffee rings. In this job, the glycine aminoacid was used as probe molecule. We suppose that the number of moles present on the study sample is proportional to the Raman signal and to the experimental parameters of the used Raman system. Then, the mass and the number of molecules can be determined with these data. We showed that the mathematical expression is simple and elegant for its implementation. On the other hand, we have applied and demonstrated that the technique of principal component analysis (PCA) can be used to obtain quantitative information of the sample. Our results show quantitative analysis of glycine residues between 10-11 to 10-15 g.

Synthesis and Crystal Structure of Ytterbium Trichloride Complex with Proline

The title complex of [(Yb(Pro)2(H2O)5Cl3]n has been synthesized. Its IR spectrum from 4000 to 400 cm-1 has been measured and the possible structure of the complex was proposed. The molecular and crystal structure has been determined by four-circle X-ray diffractometer. The crystal is monoclinic with space group P21. The unit cell parameters are as follows: a=0.8268(l) nm, b=1.0980(3) nm, c =1.1965(4) nm, β=106.97(2)°, V=1.04120(5) nm3, z=2. Positicnal and anisotropic thermal parameters have been corrected by least sqare method and the final deviation R is 0.0812. The prolines exist in two forms in the complex. One form of proline serves as bridging group connecting neighboring Yb atoms, so that the complex form a one-dimensional chain of infinitive length. Another form of proline coordinates with Yb atom through one oxygen atom of the carboxyl group. In addition there are five water moleculers coordinating to each Yb atoms. The coordination number of Yb is eight, forming a distorted trigonal-dodecahedral arrangement. The three Cl-anions are in the neighbourhood of NH+2 cations.

Binary and Ternary Complexes of Cd（ll） Involving Pyrazine 2,3-Dicarboxylic Acid and Various Biologically Relevant Ligands

Binary and ternary complexes of Cd（II） involving pyrazine 2,3-dicarboxylic acid （pzdca） and various biologically relevant ligands containing different functional groups are investigated at 25 ℃, I = 0.10 M （NaNO3） and in 20% （v/v） ethanol-water media. The ligands （L） used are amino acids, dicarboxylic acids and peptides. The results showed the formation of Cd （pzdca） （L） complexes with amino acids and dicarboxylic acids. Peptides form both Cd （pzdca） （L） complexes and the corresponding deprotonated amide species Cd （pzdca） （LH-1）. The relative stabilities of ternary complexes are compared with those of the corresponding binary complexes in terms of AlogK values. The concentration distribution of the complexes in solution was evaluated.

Effects of electro-acupuncture on 5-HT,NOS and gastric mucosa in stress rats

AIM To study the effects of electro acupuncture (EA) on 5 HT, NOS, NO and gastric mucosa in stress rats. METHODS By biochemical methods, the changes of 5 HT and NOS in gastric mucosa, NO and 5 HT in serum were ana_ lysed and the gastric mucosa was examined pathohistologically in stress rats with gastric mucosa damage after EA. The changes before and after stress by EA were compared. RESULTS EA decreased gastric mucosa damage index in the stress rats (2 71±0 40 to 1 86±0 69, P <0 01). EA normalized NOS level in gastric mucosa to the control group. The changes before stress by EA was more obvious than the EA after stress; EA lowered the 5 HT contents of gastric mucosa (μg/g wet weight, 6 91±3 08 to 4 51±1 62, P <0 01). EA recovered the NO level in serum of the stress rats (μmol/L, 5 78±1 49 to 7 91±1 11, P <0 05), and increased the contents of 5 HT and 5 HIAA in serum continuously. CONCLUSION EA stimulation normalizes the NOS and NO levels in gastric mucosa in stress rats, lowers the high 5 HT contents and induces NO releases.

SYNTHESIS AND STRUCTURE OF A NEW TYPE OF COORDINA-TION COMPOUND OF Gd(Ⅲ) WITH H_2 CCH_2CH_2C(^+NH_2)C-HCOO-

The crystal structure of gadolinium L-proline (Pro) complex [Gd2-(C5H9NO2)6 (H2O)6] (ClO4)6 has been determined. The complex crystallizes in the triclinic space group PI with following crystal data: a = 9. 906(3), b=13. 052(5), c = 13.703(5) A. α=109. 63(3), β=110.31(2), γ=100. 73(3)°, V=1470.3(9) A3.Mr=1710. 1, F(000) = 854,μ=26. 30 cm-1, Dc = 1. 931 g/cm3, Z=1.The structure was refined to the final R of 0. 048 for 3804 reflections. The structure is of one-dimensional chain, in which each gadolinium ion lies at the center of a distorted square antiprism of the eight oxygen atoms provided by four bridging carboxylate groups from four Pro ligands, a terminal carboxylate group from one terminal Pro ligand and three water molecules and the two neighbouring gadolinium ions are linked to each other through the two bridging carboxylate groups from the two Pro ligands. The prolines exist in the form of H2 CCH2CH2(+NH2)CHCOO-, and the complexions in the crystal are linked together by the net of hydrogen bonds between theClO4- , NH2+ and the coordinated water molecules.

Diagnostic value of amino acid consumption test on exocrine pancreatic insufficiency

INTRODUCTIONAmino acid consumption test (AACT) has a highsensitivity and specificity in evaluating exocrinepancreatic insufficiency,but its diagnostic valueto exocrine pancreatic insufficiency in Chinese hasnot been well understood.In this study,the oralreagent stimulating pancreatic secretion (O-AACT)was used instead of cerulein(I-AACT) for amidoacid consumption test and the dignostic efficiency ofO-AACT was evaluated and compared with I-AACTon the exocrine pancreatic insufficiency in Chinese.

COMPOSITION ANALYSIS AND RESEARCH DEVELOPMENT OF NORTHERN FOREST ANTS

The compositions of two kinds of ants (Formica cunicu Laria and Polyrhachis vicina Roger) were determined with modern apparatuses. The result was that content of crude protein, fat, vitamin E, formic acid were 43.95%, 22.90%, 15.61 mg / Kg, 4.2% respectively forFormica cunicu Laria, and 42.56%, 21 .90%, 131 .2 mg / Kg, 3.8% respectively for Polyrhachlk vicina Roger.

Low-frequency vibrational modes of glutamine

High-resolution terahertz absorption and Raman spectra of glutamine in the frequency region 0.2 THz-2.8 THz are obtained by using THz time domain spectroscopy and low-frequency Raman spectroscopy. Based on the experimental and the computational results, the vibration modes corresponding to the terahertz absorption and Raman scatting peaks are assigned and further verified by the theoretical calculations. Spectral investigation of the periodic structure of glutamine based on the sophisticated hybrid density functional B3LYP indicates that the vibrational modes come mainly from the inter-molecular hydrogen bond in this frequency region.

Stereoselective Self-Assembly of Chiral Metalla[2]Catenanes and Lemniscular Macrocycles

Designing and stereoselectively constructing chiral mechanically interlocked molecules(MIMs)is a goal that many chemists are pursuing due to their potential in the development of functional molecular machines involved in catalysis,sensing,and chiroptical switching.However,the synthesis of enantiopure supramolecular entities with crystallographic structures remains challenging.Herein,the stereoselective self-assembly of chiral metalla[2]catenanes interlocked by two D-shaped macrocycles was realized by combining long binuclear half-sandwich organometallic Cp*Rh^(III)(Cp*=η^(5)-pentamethylcyclopentadienyl)clip and ditopic monodentate ligand incorporating L-leucine residues.The resulting metalla[2]catenane displayed unique co-conformational mechanical helical chirality characteristics arising from the chirality transfer of the chiral ligand.Furthermore,decreasing the length of the binuclear Cp*Rh^(III)clip and adjusting the steric hindrance of the amino-acid side chains(L-alanine and L-phenylalanine)in the ligands resulted in two lemniscular macrocycles with left-handed(M)-twisted conformational chirality.To the best of our knowledge,the synthesized macrocycles are the first family of homochiral abnormal lemniscate-shaped organometallic macrocycles featuring figure-eight geometries.Metalla[2]catenanes and macrocycles with opposite chirality were also generated by employing corresponding D-amino acid ligands,as evidenced by single-crystal X-ray diffraction,nuclear magnetic resonance,mass,and circular dichroism spectroscopies.Our present study demonstrates that homochiral MIMs can be accessed readily using amino acid–containing ligands through rational molecular design.

Design and Synthesis of Potential Macrocyclic Zinc Metalloprotease Inhibitors

A series of succinate-derived macrocyclic amides 1 were synthezized using ring-closing metathesis in the key step. The substrate scope includes rings of 11 to 14 members. The cyclic dicarboxylic acids 1 represent a family of new model compounds for potential zinc metalloprotease inhibitors. The metathesis precursors were provided by amide coupling of tert-butyl 3-carboxyhex-5-enoate 2 with numerous side chain alkenylated amino acid esters of general type 3 derived from L-tyrosine and L-cysteine.

A novel arg616Cys mutation in the DNA-binding domain of complete androgen insensitivity syndrome in a Chinese family

Awide spectrum of Androgen insensitivity syndrome （AIS） occur due to mutations in the androgen receptor（AR）. The clinical presentation of AIS ranges from a typically male phenotype with decreased body hair and/ or oligospermia to a typically female phenotype with primary amenorrhea and without pubic and axillary hair;