The RuCl2(PPh3)3/γ-Al2O3 catalyst modified by chiral reagent(1S,2S)-(-)-1,2-diphenyl-1,2-ethylenediamine((1S,2S)-DPEN) was investigated for the asymmetric hydrogenation of acetophenone and its derivatives.At the opti...The RuCl2(PPh3)3/γ-Al2O3 catalyst modified by chiral reagent(1S,2S)-(-)-1,2-diphenyl-1,2-ethylenediamine((1S,2S)-DPEN) was investigated for the asymmetric hydrogenation of acetophenone and its derivatives.At the optimized reaction conditions,85% conversion of acetophenone and 82%e.e.of(R)–α-phenyl ethanol were achieved over RuCl2(PPh3)3/γ-Al2O3 catalyst modified by(1S,2S)-DPEN.Furthermore,the results indicated that there was a synergistic effect between(1S,2S)-DPEN and KOH,which significantly accelerated the reaction rate and enantioselectivity.展开更多
Polydentate ligands, N,N’-bis[o-(diphenylphosphino)benzylidene]-1,2-propane-dia-mine [P2N2Me for short] and N,N’-bis[o-(diphenylphosphino)benzy1]-12-propanediamine [P2N2 H4Me for short] have been synthesized. The in...Polydentate ligands, N,N’-bis[o-(diphenylphosphino)benzylidene]-1,2-propane-dia-mine [P2N2Me for short] and N,N’-bis[o-(diphenylphosphino)benzy1]-12-propanediamine [P2N2 H4Me for short] have been synthesized. The interaction of RuCl2(DMSO)4 with one equiv-alent of P2N2Me or P2N2H4Me in refluxing toluene gave trans-RuCl2(P2N2Me) and trans-RuClz(P2N4H4Me) in good yield, respectively. The ligands and the complexes have been fully characterized by elemental analysis and spectroscopic methods. The complexes act as an excellent catalyst precursor in hydrogen transfer hydrogenation of aretophenone in catalyst: aretophenone :iso-PrOK of 1: 100: 15, leading to 2-phenylethanol of 89-96% yield.展开更多
文摘The RuCl2(PPh3)3/γ-Al2O3 catalyst modified by chiral reagent(1S,2S)-(-)-1,2-diphenyl-1,2-ethylenediamine((1S,2S)-DPEN) was investigated for the asymmetric hydrogenation of acetophenone and its derivatives.At the optimized reaction conditions,85% conversion of acetophenone and 82%e.e.of(R)–α-phenyl ethanol were achieved over RuCl2(PPh3)3/γ-Al2O3 catalyst modified by(1S,2S)-DPEN.Furthermore,the results indicated that there was a synergistic effect between(1S,2S)-DPEN and KOH,which significantly accelerated the reaction rate and enantioselectivity.
文摘Polydentate ligands, N,N’-bis[o-(diphenylphosphino)benzylidene]-1,2-propane-dia-mine [P2N2Me for short] and N,N’-bis[o-(diphenylphosphino)benzy1]-12-propanediamine [P2N2 H4Me for short] have been synthesized. The interaction of RuCl2(DMSO)4 with one equiv-alent of P2N2Me or P2N2H4Me in refluxing toluene gave trans-RuCl2(P2N2Me) and trans-RuClz(P2N4H4Me) in good yield, respectively. The ligands and the complexes have been fully characterized by elemental analysis and spectroscopic methods. The complexes act as an excellent catalyst precursor in hydrogen transfer hydrogenation of aretophenone in catalyst: aretophenone :iso-PrOK of 1: 100: 15, leading to 2-phenylethanol of 89-96% yield.
