A [ReO（Amino）2OH] complex was successfully synthesized by the ligand exchange method using oxorhenuim gluconate and an aminothiazole ligand. The complex was characterized elemental analysis and IR, UV-Vis, NMR and m...A [ReO（Amino）2OH] complex was successfully synthesized by the ligand exchange method using oxorhenuim gluconate and an aminothiazole ligand. The complex was characterized elemental analysis and IR, UV-Vis, NMR and mass spectroscopes. The technetium tracer 99mTcO-complex has also been synthesized by two methods using Ligand exchange method and direct reduction method. The radiochemical purity of the complex was over 95% as measured by thin layer chromatography. In vitro studies showed that the complex possessed good stability under physiological conditions. The partition coefficient indicated that the complex hydrophilic and the electrophoresis results showed that the complex neutral. Normal biodistributions of the 99mTC complex exhibit high lung, liver and spleen uptake of 27%, I 1%, and 12%, respectively. Blood and lungs clearance was quite, while liver activity remained high for a longer period with 12% injection dose present at 1 h post-inj ection. The radioactivity from the novel technetium complex was excreted mainly through the hepatobiliary system, which passed 35% of the complex at 1 h post-injection, and partially through the kidneys.展开更多
文摘A [ReO（Amino）2OH] complex was successfully synthesized by the ligand exchange method using oxorhenuim gluconate and an aminothiazole ligand. The complex was characterized elemental analysis and IR, UV-Vis, NMR and mass spectroscopes. The technetium tracer 99mTcO-complex has also been synthesized by two methods using Ligand exchange method and direct reduction method. The radiochemical purity of the complex was over 95% as measured by thin layer chromatography. In vitro studies showed that the complex possessed good stability under physiological conditions. The partition coefficient indicated that the complex hydrophilic and the electrophoresis results showed that the complex neutral. Normal biodistributions of the 99mTC complex exhibit high lung, liver and spleen uptake of 27%, I 1%, and 12%, respectively. Blood and lungs clearance was quite, while liver activity remained high for a longer period with 12% injection dose present at 1 h post-inj ection. The radioactivity from the novel technetium complex was excreted mainly through the hepatobiliary system, which passed 35% of the complex at 1 h post-injection, and partially through the kidneys.
