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The use of localized proteomics to identify the drivers of Alzheimer's disease pathogenesis 被引量:2
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作者 Eleanor Drummond Thomas Wisniewski 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第6期912-913,共2页
Alzheimer’s disease(AD)is broadly defined by dementia and the presence of specific neuropathological features in the brain(amyloid plaques,neurofibrillary tangles(NFTs)and congophilic amyloid angiopathy).Howeve... Alzheimer’s disease(AD)is broadly defined by dementia and the presence of specific neuropathological features in the brain(amyloid plaques,neurofibrillary tangles(NFTs)and congophilic amyloid angiopathy).However,the rate of disease progression,type of cognitive impairment,and extent of neuropathology vary widely in patients with AD(Murray et al.,2011). 展开更多
关键词 amyloid pathogenesis proteomics localized impairment plaques Murray targeted progression brains
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Heparan sulfate proteoglycans and heparanases in Alzheimer's disease:current outlook and potential therapeutic targets 被引量:2
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作者 Laura Lorente-Gea Beatriz García +2 位作者 Carla Martín Luis M.Quirós Iván Fernández-Vega 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第6期914-915,共2页
Relevance of Alzheimer’s disease(AD):AD is one of the greatest health-care challenges of the 21^st century.It is known to be the most common neurodegenerative disease and,in the United States,the sixth most common... Relevance of Alzheimer’s disease(AD):AD is one of the greatest health-care challenges of the 21^st century.It is known to be the most common neurodegenerative disease and,in the United States,the sixth most common cause of death. 展开更多
关键词 outlook amyloid pathogenesis prion greatest sixth gression challenges neuronal brains
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