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Clinical Efficacy and Therapeutic Mechanisms of Traditional Chinese Medicine for Neuroprotection and Neurogenesis in Stroke Treatment 被引量:1
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作者 Jian-Gang SHEN 《Digital Chinese Medicine》 2018年第3期191-197,共7页
Stroke is the leading cause of human disability with limited effective drugs availability. The disruption of multiple signaling pathways in stroke makes developing new drugs be difficult. Traditional Chinese medicine(... Stroke is the leading cause of human disability with limited effective drugs availability. The disruption of multiple signaling pathways in stroke makes developing new drugs be difficult. Traditional Chinese medicine(TCM) has its unique advantage in targeting multiple signaling pathways with multiple components. Many TCM formulas have the potential for neuroprotection and neurogenesis, but well-designed clinical trials are insufficient and underlying mechanisms unclear. Herein, we introduce the commonly used TCM formulas for stroke treatment and selectively introduce two classic formulas, An Gong Niu Huang(AGNH) pill and Bu Yang Huan Wu Decoction(BYHWD) for neuroprotection and neurogenesis, respectively. Current scientific evidence and clinical trials indicate AGNH pill could be an effective neuroprotective formula as adjunct therapy with relative safety. On the other hand, as a representative TCM formula for post stroke disability, BYHWD could improve the neurological outcome with its neuroprotective and neurogenic effects. The underlying mechanisms could be attributed to the modulation of multiple molecular targets with its multiple components. In conclusion, TCM formulas could be potential adjunct therapies for stroke treatment. The clinical efficacies and molecular mechanisms of promoting neuroprotection and neurogenesis remain to be further studies. 展开更多
关键词 Stroke NEUROPROTECTION NEUROGENESIS traditional chinese medicine Bu Yang Huan Wu Decoction An gong niu huang pill
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疏血通注射液联合安宫牛黄丸治疗中风疗效及对患者凝血功能、Cytc和Caspase-3表达的影响 被引量:4
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作者 王诗会 郭伟 +1 位作者 姜曾凯 赵晓玲 《陕西中医》 2018年第11期1527-1529,共3页
目的:探讨疏血通注射液联合安宫牛黄丸对缺血性中风患者凝血功能、细胞色素C(Cytc)、Caspase-3指标的变化。方法:选择102例缺血性中风患者,按照患者入院先后顺序进行标记,偶数号作为对照组,奇数号作为观察组,每组51例。对照组患者采用... 目的:探讨疏血通注射液联合安宫牛黄丸对缺血性中风患者凝血功能、细胞色素C(Cytc)、Caspase-3指标的变化。方法:选择102例缺血性中风患者,按照患者入院先后顺序进行标记,偶数号作为对照组,奇数号作为观察组,每组51例。对照组患者采用疏血通注射液治疗,观察组患者采用安宫牛黄丸与疏血通注射液联合治疗,7d为1个疗程,6个周期后观察两组患者临床疗效、治疗前神经功能缺损状况、凝血功能(PT、TT、APTT、FIB)和Cytc、Caspase-3指标水平的变化。结果:观察组与对照组的临床总有效率分别为92.16%、78.43%,差异有统计学意义(P<0.05);治疗后观察组神经功能缺损(NIHSS)评分高于对照组患者(P<0.05);治疗后观察组患者凝血功能各项指标比对照组患者均降低(P<0.05);治疗后观察组患者Cytc、Caspase-3指标均降低,与对照组比较差异有统计学意义(P<0.05)。结论:疏血通注射液联合安宫牛黄丸治疗出血性中风患者,明显提高患者的临床疗效,神经功能得到恢复,改善患者凝血功能,降低出血情况,同时抑制了患者的Cytc、Caspase-3水平。 展开更多
关键词 中风(中医)/中医药疗法 安宫牛黄丸/中医药疗法 @疏血通注射液
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