目的探讨椎管内硬膜外腔导管介入镇痛与非椎管内途径多药物联合镇痛治疗胰腺癌所致腹部顽固性癌痛的效果及不良反应。方法收集胰腺癌相关腹部顽固性癌痛患者48例,随机分为两组,非全植入式硬膜外腔导管介入镇痛组(试验组):采用硬膜外腔...目的探讨椎管内硬膜外腔导管介入镇痛与非椎管内途径多药物联合镇痛治疗胰腺癌所致腹部顽固性癌痛的效果及不良反应。方法收集胰腺癌相关腹部顽固性癌痛患者48例,随机分为两组,非全植入式硬膜外腔导管介入镇痛组(试验组):采用硬膜外腔导管介入自控镇痛技术,经侧腹壁做皮下隧道,外接自控镇痛泵。药物联合镇痛组(对照组):采用《癌症疼痛诊疗规范(卫生部2011年版)》建议的非介入性治疗,主要为三阶梯镇痛药物的联合,包括口服、静脉、肌注、黏膜、自控镇痛(patient control analgesia,PCA)等用药方式的联合。随访3个月,以视觉模拟评分法(visual analogue scale,VAS)评估镇痛效果,记录VAS降低>20%和降低>50%的病例数,应用美国国立癌症研究院通用毒性标准(National Cancer Institute Common Toxicity Criteria,NCI-CTC)标准(纳入15项观察指标)计算药物毒性评分,记录通用毒性标准(common toxicity criteria,CTC)降低>20%的病例数,计算等效口服吗啡节俭效应,记录两组患者3个月后存活率。结果镇痛治疗4周时试验组与对照组VAS和CTC评分同时降低>20%的病例数分别为79.2%和39.1%,VAS降低>50%和CTC降低>20%的病例数分别为87.5%和34.8%;对照组VAS评分均值由7.8下降到4.8,CTC评分均值由6.8下降到5.8;试验组VAS评分均值由7.9下降到3.2,CTC评分由6.9下降到2.9;试验组和对照组等效口服吗啡节俭率分别94.5%和31.2%(P<0.01);试验组与对照组患者3个月存活率分别为79.2%和33.3%(P<0.01)。结论与非椎管内途径多药物联合镇痛比较,经椎管内硬膜外腔导管介入镇痛治疗胰腺癌所致腹部顽固性癌痛的镇痛效果更好,镇痛药相关药物不良反应降低,患者生活质量显著改善,存活时间明显延长。展开更多
In this paper, a novel image encryption scheme based on Keplers third law and random Hadamard transform is proposed to ensure the security of a digital image. First, a set of Kepler periodic sequences is generated to ...In this paper, a novel image encryption scheme based on Keplers third law and random Hadamard transform is proposed to ensure the security of a digital image. First, a set of Kepler periodic sequences is generated to permutate image data, which is characteristic of the plain-image and the Keplers third law. Then, a random Hadamard matrix is constructed by combining the standard Hadamard matrix with the hyper-Chen chaotic system, which is used to further scramble the image coefficients when the image is transformed through random Hadamard transform. In the end, the permuted image presents interweaving diffusion based on two special matrices, which are constructed by Kepler periodic sequence and chaos system. The experimental results and performance analysis show that the proposed encrypted scheme is highly sensitive to the plain-image and external keys, and has a high security and speed, which are very suitable for secure real-time communication of image data.展开更多
In this study, the thermoelectric properties of pyrene molecule doped with boron and nitrogen atom at different sites of molecule are investigated using density functional theory and none-equilibrium Greens function f...In this study, the thermoelectric properties of pyrene molecule doped with boron and nitrogen atom at different sites of molecule are investigated using density functional theory and none-equilibrium Greens function formalism in the linear response regime. Our calculations show that when the impurities are added to the edge of the molecule, the anti-resonant peaks will appear in the transmission diagram in the vicinity of the Fermi energy level. So it increases the thermoelectric figure of merit of the system in comparison with the one that the impurity is located in the center of molecule. Additionally, the seebeck coefficient signs are not the same among the B, N, and N ＆ B doped devices, indicating that the types of the carriers can be changed with different types of doping.展开更多
文摘目的探讨椎管内硬膜外腔导管介入镇痛与非椎管内途径多药物联合镇痛治疗胰腺癌所致腹部顽固性癌痛的效果及不良反应。方法收集胰腺癌相关腹部顽固性癌痛患者48例,随机分为两组,非全植入式硬膜外腔导管介入镇痛组(试验组):采用硬膜外腔导管介入自控镇痛技术,经侧腹壁做皮下隧道,外接自控镇痛泵。药物联合镇痛组(对照组):采用《癌症疼痛诊疗规范(卫生部2011年版)》建议的非介入性治疗,主要为三阶梯镇痛药物的联合,包括口服、静脉、肌注、黏膜、自控镇痛(patient control analgesia,PCA)等用药方式的联合。随访3个月,以视觉模拟评分法(visual analogue scale,VAS)评估镇痛效果,记录VAS降低>20%和降低>50%的病例数,应用美国国立癌症研究院通用毒性标准(National Cancer Institute Common Toxicity Criteria,NCI-CTC)标准(纳入15项观察指标)计算药物毒性评分,记录通用毒性标准(common toxicity criteria,CTC)降低>20%的病例数,计算等效口服吗啡节俭效应,记录两组患者3个月后存活率。结果镇痛治疗4周时试验组与对照组VAS和CTC评分同时降低>20%的病例数分别为79.2%和39.1%,VAS降低>50%和CTC降低>20%的病例数分别为87.5%和34.8%;对照组VAS评分均值由7.8下降到4.8,CTC评分均值由6.8下降到5.8;试验组VAS评分均值由7.9下降到3.2,CTC评分由6.9下降到2.9;试验组和对照组等效口服吗啡节俭率分别94.5%和31.2%(P<0.01);试验组与对照组患者3个月存活率分别为79.2%和33.3%(P<0.01)。结论与非椎管内途径多药物联合镇痛比较,经椎管内硬膜外腔导管介入镇痛治疗胰腺癌所致腹部顽固性癌痛的镇痛效果更好,镇痛药相关药物不良反应降低,患者生活质量显著改善,存活时间明显延长。
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61661008 and 61603104)the Natural Science Foundation of Guangxi Zhuang Autonomous Region,China(Grant Nos.2015GXNSFBA139256 and 2016GXNSFCA380017)+3 种基金the Funding of Overseas 100 Talents Program of Guangxi Provincial Higher Education,China,the Research Project of Guangxi University of China(Grant No.KY2016YB059)the Guangxi Key Laboratory of Multi-source Information Mining&Security,China(Grant No.MIMS15-07)the Doctoral Research Foundation of Guangxi Normal University,the Guangxi Provincial Experiment Center of Information Sciencethe Innovation Project of Guangxi Graduate Education(Grant No.YCSZ2017055)
文摘In this paper, a novel image encryption scheme based on Keplers third law and random Hadamard transform is proposed to ensure the security of a digital image. First, a set of Kepler periodic sequences is generated to permutate image data, which is characteristic of the plain-image and the Keplers third law. Then, a random Hadamard matrix is constructed by combining the standard Hadamard matrix with the hyper-Chen chaotic system, which is used to further scramble the image coefficients when the image is transformed through random Hadamard transform. In the end, the permuted image presents interweaving diffusion based on two special matrices, which are constructed by Kepler periodic sequence and chaos system. The experimental results and performance analysis show that the proposed encrypted scheme is highly sensitive to the plain-image and external keys, and has a high security and speed, which are very suitable for secure real-time communication of image data.
文摘In this study, the thermoelectric properties of pyrene molecule doped with boron and nitrogen atom at different sites of molecule are investigated using density functional theory and none-equilibrium Greens function formalism in the linear response regime. Our calculations show that when the impurities are added to the edge of the molecule, the anti-resonant peaks will appear in the transmission diagram in the vicinity of the Fermi energy level. So it increases the thermoelectric figure of merit of the system in comparison with the one that the impurity is located in the center of molecule. Additionally, the seebeck coefficient signs are not the same among the B, N, and N ＆ B doped devices, indicating that the types of the carriers can be changed with different types of doping.
