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Design,preparation,application of advanced array structured materials and their action mechanism analyses for high performance lithium-sulfur batteries
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作者 Nanping Deng Xiaofan Feng +7 位作者 Yongbing Jin Zhaozhao Peng Yang Feng Ying Tian Yong Liu Lu Gao Weimin Kang Bowen Cheng 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第2期266-303,I0007,共39页
Lithium-sulfur battery(LSB)has brought much attention and concern because of high theoretical specific capacity and energy density as one of main competitors for next-generation energy storage systems.The widely comme... Lithium-sulfur battery(LSB)has brought much attention and concern because of high theoretical specific capacity and energy density as one of main competitors for next-generation energy storage systems.The widely commercial application and development of LSB is mainly hindered by serious“shuttle effect”of lithium polysulfides(Li PSs),slow reaction kinetics,notorious lithium dendrites,etc.In various structures of LSB materials,array structured materials,possessing the composition of ordered micro units with the same or similar characteristics of each unit,present excellent application potential for various secondary cells due to some merits such as immobilization of active substances,high specific surface area,appropriate pore sizes,easy modification of functional material surface,accommodated huge volume change,enough facilitated transportation for electrons/lithium ions,and special functional groups strongly adsorbing Li PSs.Thus many novel array structured materials are applied to battery for tackling thorny problems mentioned above.In this review,recent progresses and developments on array structured materials applied in LSBs including preparation ways,collaborative structural designs based on array structures,and action mechanism analyses in improving electrochemical performance and safety are summarized.Meanwhile,we also have detailed discussion for array structured materials in LSBs and constructed the structure-function relationships between array structured materials and battery performances.Lastly,some directions and prospects about preparation ways,functional modifications,and practical applications of array structured materials in LSBs are generalized.We hope the review can attract more researchers'attention and bring more studying on array structured materials for other secondary batteries including LSB. 展开更多
关键词 Array structured materials Preparation methods and structural designs Action mechanism analyses Advanced Li-S batteries Excellent electrochemical performances and safety
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The need to develop tailored tools for improving the quality of thematic bibliometric analyses: Evidence from papers published in Sustainability and Scientometrics
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作者 Alvaro Cabezas-Clavijo Yusnelkis Milanés-Guisado +1 位作者 Ruben Alba-Ruiz Ángel MDelgado-Vázquez 《Journal of Data and Information Science》 CSCD 2023年第4期10-35,共26页
Purpose: The aim of this article is to explore up to seven parameters related to the methodological quality and reproducibility of thematic bibliometric research published in the two most productive journals in biblio... Purpose: The aim of this article is to explore up to seven parameters related to the methodological quality and reproducibility of thematic bibliometric research published in the two most productive journals in bibliometrics, Sustainability(a journal outside the discipline) and Scientometrics, the flagship journal in the field.Design/methodology/approach: The study identifies the need for developing tailored tools for improving the quality of thematic bibliometric analyses, and presents a framework that can guide the development of such tools. A total of 508 papers are analysed, 77% of Sustainability, and 23% published in Scientometrics, for the 2019-2021 period.Findings: An average of 2.6 shortcomings per paper was found for the whole sample, with an almost identical number of flaws in both journals. Sustainability has more flaws than Scientometrics in four of the seven parameters studied, while Scientometrics has more shortcomings in the remaining three variables.Research limitations: The first limitation of this work is that it is a study of two scientific journals, so the results cannot be directly extrapolated to the set of thematic bibliometric analyses published in journals from all fields.Practical implications: We propose the adoption of protocols, guidelines, and other similar tools, adapted to bibliometric practice, which could increase the thoroughness, transparency, and reproducibility of this type of research.Originality/value: These results show considerable room for improvement in terms of the adequate use and breakdown of methodological procedures in thematic bibliometric research, both in journals in the Information Science area and journals outside the discipline. 展开更多
关键词 Thematic bibliometric analyses SUSTAINABILITY SCIENTOMETRICS Reproducibility Methodological quality
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Mechanical stress and deformation analyses of pressurized cylindrical shells based on a higher-order modeling
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作者 S.Mannani L.Collini M.Arefi 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第2期24-33,共10页
In this research,mechanical stress,static strain and deformation analyses of a cylindrical pressure vessel subjected to mechanical loads are presented.The kinematic relations are developed based on higherorder sinusoi... In this research,mechanical stress,static strain and deformation analyses of a cylindrical pressure vessel subjected to mechanical loads are presented.The kinematic relations are developed based on higherorder sinusoidal shear deformation theory.Thickness stretching formulation is accounted for more accurate analysis.The total transverse deflection is divided into bending,shear and thickness stretching parts in which the third term is responsible for change of deflection along the thickness direction.The axisymmetric formulations are derived through principle of virtual work.A parametric study is presented to investigate variation of stress and strain components along the thickness and longitudinal directions.To explore effect of thickness stretching model on the static results,a comparison between the present results with the available results of literature is presented.As an important output,effect of micro-scale parameter is studied on the static stress and strain distribution. 展开更多
关键词 Principle of virtual work Thickness-stretched and shear deformable model Stress and strain analyses Cylindrical pressure vessel
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Weathering and accumulation of trace elements in the soils of the Porali Plain, Balochistan: repercussions in agriculture
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作者 Maria Kaleem Erum Bashir +2 位作者 Shahid Naseem Tahir Rafique Bushra Shahab 《Acta Geochimica》 EI CAS CSCD 2024年第2期214-234,共21页
This study is thefirst attempt to assess the nature of the soil,especially on the western side of the Porali Plain in Balochistan;a new emerging agriculture hub,using weathering and pollution indices supplemented by mu... This study is thefirst attempt to assess the nature of the soil,especially on the western side of the Porali Plain in Balochistan;a new emerging agriculture hub,using weathering and pollution indices supplemented by multi-variate analysis based on geochemical data.The outcomes of this study are expected to help farmers in soil manage-ment and selecting suitable crops for the region.Twenty-five soil samples were collected,mainly from the arable land of the Porali Plain.After drying and coning-quarter-ing,soil samples were analyzed for major and trace ele-ments using the XRF technique;sieving and hydrometric methods were employed for granulometric analysis.Esti-mated data were analyzed using Excel,SPSS,and Surfer software to calculate various indices,correlation matrix,and spatial distribution.The granulometric analysis showed that 76%of the samples belonged to loam types of soil,12%to sand type,and 8%to silt type.Weathering indices:CIA,CIW,PIA,PWI,WIP,CIX,and ICV were calculated to infer the level of alteration.These indices reflect mod-erate to intense weathering;supported by K_(2)O/AI_(2)O_(3),Rb/K_(2)O,Rb/Ti,and Rb/Sr ratios.Assessment of the geo-ac-cumulation and Nemerow Pollution indices pinpoint rela-tively high concentrations of Pb,Ni,and Cr concentration in the soils.The correlation matrix and Principal Compo-nent Analysis show that the soil in this study area is mainly derived from the weathering of igneous rocks of Bela Ophiolite(Cretaceous age)and Jurassic sedimentary rocks of Mor Range having SEDEX/MVT type mineralization.Weathering may result in the undesirable accumulation of certain trace elements which adversely affects crops. 展开更多
关键词 Weathering indices Pollution indices ACCUMULATION Repercussions Trace elements Multivariate analyses Porali Plain BALOCHISTAN
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Encroachment drives facilitation at alpine shrublines
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作者 Yafeng Wang Eryuan Liang J.Julio Camarero 《Forest Ecosystems》 SCIE CSCD 2024年第1期62-72,共11页
Ongoing encroachment is driving recent alpine shrubline dynamics globally,but the role of shrub-shrub interactions in shaping shrublines and their relationships with stem density changes remain poorly understood.Here,... Ongoing encroachment is driving recent alpine shrubline dynamics globally,but the role of shrub-shrub interactions in shaping shrublines and their relationships with stem density changes remain poorly understood.Here,the size and age of shrubs from 26 Salix shrubline populations along a 900-km latitudinal gradient(30°-38°N)were measured and mapped across the eastern Tibetan Plateau.Point pattern analyses were used to quantify the spatial distribution patterns of juveniles and adults,and to assess spatial associations between them.Mean intensity of univariate and bivariate spatial patterns was related to biotic and abiotic variables.Bivariate mark correlation functions with a quantitative mark(shrub height,basal stem diameter,crown width)were also employed to investigate the spatial relationships between shrub traits of juveniles and adults.Structural equation models were used to explore the relationships among conspecific interactions,patterns,shrub traits and recruitment dynamics under climate change.Most shrublines showed clustered patterns,suggesting the existence of conspecific facilitation.Clustered patterns of juveniles and conspecific interactions(potentially facilitation)tended to intensify with increasing soil moisture stress.Summer warming before 2010 triggered positive effects on population interactions and spatial patterns via increased shrub recruitment.However,summer warming after2010 triggered negative effects on interactions through reduced shrub recruitment.Therefore,shrub recruitment shifts under rapid climate change could impact spatial patterns,alter conspecific interactions and modify the direction and degree of shrublines responses to climate.These changes would have profound implications for the stability of alpine woody ecosystems. 展开更多
关键词 Alpine shrubline Positive interactions FACILITATION Spatial clustering Point pattern analyses
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Numerical investigation of hydro-morphodynamic characteristics of a cascading failure of landslide dams
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作者 ZHONG Qiming CHEN Lingchun +3 位作者 MEI Shengyao SHAN Yibo WU Hao ZHAO Kunpeng 《Journal of Mountain Science》 SCIE CSCD 2024年第6期1868-1885,共18页
A cascading failure of landslide dams caused by strong earthquakes or torrential rains in mountainous river valleys can pose great threats to people’s lives,properties,and infrastructures.In this study,based on the t... A cascading failure of landslide dams caused by strong earthquakes or torrential rains in mountainous river valleys can pose great threats to people’s lives,properties,and infrastructures.In this study,based on the three-dimensional Reynoldsaveraged Navier-Stokes equations(RANS),the renormalization group(RNG)k-εturbulence model,suspended and bed load transport equations,and the instability discriminant formula of dam breach side slope,and the explicit finite volume method(FVM),a detailed numerical simulation model for calculating the hydro-morphodynamic characteristics of cascading dam breach process has been developed.The developed numerical model can simulate the breach hydrograph and the dam breach morphology evolution during the cascading failure process of landslide dams.A model test of the breaches of two cascading landslide dams has been used as the validation case.The comparison of the calculated and measured results indicates that the breach hydrograph and the breach morphology evolution process of the upstream and downstream dams are generally consistent with each other,and the relative errors of the key breaching parameters,i.e.,the peak breach flow and the time to peak of each dam,are less than±5%.Further,the comparison of the breach hydrographs of the upstream and downstream dams shows that there is an amplification effect of the breach flood on the cascading landslide dam failures.Three key parameters,i.e.,the distance between the upstream and the downstream dams,the river channel slope,and the downstream dam height,have been used to study the flood amplification effect.The parameter sensitivity analyses show that the peak breach flow at the downstream dam decreases with increasing distance between the upstream and the downstream dams,and the downstream dam height.Further,the peak breach flow at the downstream dam first increases and then decreases with steepening of the river channel slope.When the flood caused by the upstream dam failure flows to the downstream dam,it can produce a surge wave that overtops and erodes the dam crest,resulting in a lowering of the dam crest elevation.This has an impact on the failure occurrence time and the peak breach flow of the downstream dam.The influence of the surge wave on the downstream dam failure process is related to the volume of water that overtops the dam crest and the erosion characteristics of dam material.Moreover,the cascading failure case of the Xiaogangjian and Lower Xiaogangjian landslide dams has also been used as the representative case for validating the model.In comparisons of the calculated and measured breach hydrographs and final breach morphologies,the relative errors of the key dam breaching parameters are all within±10%,which verify the rationality of the model is applicable to real-world cases.Overall,the numerical model developed in this study can provide important technical support for the risk assessment and emergency treatment of failures of cascading landslide dams. 展开更多
关键词 Cascading landslide dams Cascading dam failure process Detailed numerical simulation model Flood amplification effect Parameter sensitivity analyses
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Causal roles of gut microbiota in cholangiocarcinoma etiology suggested by genetic study
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作者 Zhi-Tao Chen Chen-Chen Ding +3 位作者 Kai-Lei Chen Yang-Jun Gu Chi-Cheng Lu Qi-Yong Li 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第4期1319-1333,共15页
BACKGROUND Cholangiocarcinoma(CCA)is a highly malignant biliary tract cancer with poor prognosis.Previous studies have implicated the gut microbiota in CCA,but evidence for causal mechanisms is lacking.AIM To investig... BACKGROUND Cholangiocarcinoma(CCA)is a highly malignant biliary tract cancer with poor prognosis.Previous studies have implicated the gut microbiota in CCA,but evidence for causal mechanisms is lacking.AIM To investigate the causal relationship between gut microbiota and CCA risk.METHODS We performed a two-sample mendelian randomization study to evaluate potential causal associations between gut microbiota and CCA risk using genome-wide association study summary statistics for 196 gut microbial taxa and CCA.Genetic variants were used as instrumental variables.Multiple sensitivity analyses assessed result robustness.RESULTS Fifteen gut microbial taxa showed significant causal associations with CCA risk.Higher genetically predicted abundance of genus Eubacteriumnodatum group,genus Ruminococcustorques group,genus Coprococcus,genus Dorea,and phylum Actinobacteria were associated with reduced risk of gallbladder cancer and extrahepatic CCA.Increased intrahepatic CCA risk was associated with higher abundance of family Veillonellaceae,genus Alistipes,order Enterobacteriales,and phylum Firmicutes.Protective effects against CCA were suggested for genus Collinsella,genus Eisenbergiella,genus Anaerostipes,genus Paraprevotella,genus Parasutterella,and phylum Verrucomicrobia.Sensitivity analyses indicated these findings were reliable without pleiotropy.CONCLUSION This pioneering study provides novel evidence that specific gut microbiota may play causal roles in CCA risk.Further experimental validation of these candidate microbes is warranted to consolidate causality and mechanisms. 展开更多
关键词 CHOLANGIOCARCINOMA Mendelian randomization Gut microbiota Instrumental variables Sensitivity analyses
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Self-assembly of differentiated dental pulp stem cells facilitates spheroid human dental organoid formation and prevascularization
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作者 Fei Liu Jing Xiao +4 位作者 Lei-Hui Chen Yu-Yue Pan Jun-Zhang Tian Zhi-Ren Zhang Xiao-Chun Bai 《World Journal of Stem Cells》 SCIE 2024年第3期287-304,共18页
BACKGROUND The self-assembly of solid organs from stem cells has the potential to greatly expand the applicability of regenerative medicine.Stem cells can self-organise into microsized organ units,partially modelling ... BACKGROUND The self-assembly of solid organs from stem cells has the potential to greatly expand the applicability of regenerative medicine.Stem cells can self-organise into microsized organ units,partially modelling tissue function and regeneration.Dental pulp organoids have been used to recapitulate the processes of tooth development and related diseases.However,the lack of vasculature limits the utility of dental pulp organoids.AIM To improve survival and aid in recovery after stem cell transplantation,we demonstrated the three-dimensional(3D)self-assembly of adult stem cell-human dental pulp stem cells(hDPSCs)and endothelial cells(ECs)into a novel type of spheroid-shaped dental pulp organoid in vitro under hypoxia and conditioned medium(CM).METHODS During culture,primary hDPSCs were induced to differentiate into ECs by exposing them to a hypoxic environment and CM.The hypoxic pretreated hDPSCs were then mixed with ECs at specific ratios and conditioned in a 3D environment to produce prevascularized dental pulp organoids.The biological characteristics of the organoids were analysed,and the regulatory pathways associated with angiogenesis were studied.RESULTS The combination of these two agents resulted in prevascularized human dental pulp organoids(Vorganoids)that more closely resembled dental pulp tissue in terms of morphology and function.Single-cell RNA sequencing of dental pulp tissue and RNA sequencing of Vorganoids were integrated to analyse key regulatory pathways associated with angiogenesis.The biomarkers forkhead box protein O1 and fibroblast growth factor 2 were identified to be involved in the regulation of Vorganoids.CONCLUSION In this innovative study,we effectively established an in vitro model of Vorganoids and used it to elucidate new mechanisms of angiogenesis during regeneration,facilitating the development of clinical treatment strategies. 展开更多
关键词 Human dental pulp stem cells Prevascularized organoids Integrated analyses ANGIOGENESIS Forkhead box protein O1
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In silico prospective analysis of the medicinal plants activity on the CagA oncoprotein from Helicobacter pylori
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作者 Rafaela Viana Vieira Gabrielle Caroline Peiter +2 位作者 Fabrício Freire de Melo Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira 《World Journal of Clinical Oncology》 2024年第5期653-663,共11页
BACKGROUND Colonization with Helicobacter pylori(H.pylori)has a strong correlation with gastric cancer,and the virulence factor CagA is implicated in carcinogenesis.Studies have been conducted using medicinal plants w... BACKGROUND Colonization with Helicobacter pylori(H.pylori)has a strong correlation with gastric cancer,and the virulence factor CagA is implicated in carcinogenesis.Studies have been conducted using medicinal plants with the aim of eliminating the pathogen;however,the possibility of blocking H.pylori-induced cell differentiation to prevent the onset and/or progression of tumors has not been addressed.This type of study is expensive and time-consuming,requiring in vitro and/or in vivo tests,which can be solved using bioinformatics.Therefore,prospective computational analyses were conducted to assess the feasibility of interaction between phenolic compounds from medicinal plants and the CagA oncoprotein.AIM To perform a computational prospecting of the interactions between phenolic compounds from medicinal plants and the CagA oncoprotein of H.pylori.METHODS In this in silico study,the structures of the phenolic compounds(ligands)kaempferol,myricetin,quercetin,ponciretin(flavonoids),and chlorogenic acid(phenolic acid)were selected from the PubChem database.These phenolic compounds were chosen based on previous studies that suggested medicinal plants as non-drug treatments to eliminate H.pylori infection.The three-dimensional structure model of the CagA oncoprotein of H.pylori(receptor)was obtained through molecular modeling using computational tools from the I-Tasser platform,employing the threading methodology.The primary sequence of CagA was sourced from GenBank(BAK52797.1).A screening was conducted to identify binding sites in the structure of the CagA oncoprotein that could potentially interact with the ligands,utilizing the GRaSP online platform.Both the ligands and receptor were prepared for molecular docking using AutoDock Tools 4(ADT)software,and the simulations were carried out using a combination of ADT and AutoDock Vina v.1.2.0 software.Two sets of simulations were performed:One involving the central region of CagA with phenolic compounds,and another involving the carboxy-terminus region of CagA with phenolic compounds.The receptor-ligand complexes were then analyzed using PyMol and BIOVIA Discovery Studio software.RESULTS The structure model obtained for the CagA oncoprotein exhibited high quality(C-score=0.09)and was validated using parameters from the MolProbity platform.The GRaSP online platform identified 24 residues(phenylalanine and leucine)as potential binding sites on the CagA oncoprotein.Molecular docking simulations were conducted with the three-dimensional model of the CagA oncoprotein.No complexes were observed in the simulations between the carboxy-terminus region of CagA and the phenolic compounds;however,all phenolic compounds interacted with the central region of the oncoprotein.Phenolic compounds and CagA exhibited significant affinity energy(-7.9 to-9.1 kcal/mol):CagA/kaempferol formed 28 chemical bonds,CagA/myricetin formed 18 chemical bonds,CagA/quercetin formed 16 chemical bonds,CagA/ponciretin formed 13 chemical bonds,and CagA/chlorogenic acid formed 17 chemical bonds.Although none of the phenolic compounds directly bound to the amino acid residues of the K-Xn-R-X-R membrane binding motif,all of them bound to residues,mostly positively or negatively charged,located near this region.CONCLUSION In silico,the tested phenolic compounds formed stable complexes with CagA.Therefore,they could be tested in vitro and/or in vivo to validate the findings,and to assess interference in CagA/cellular target interactions and in the oncogenic differentiation of gastric cells. 展开更多
关键词 CagA oncoprotein Phenolic compounds Helicobacter pylori In silico analyses Medicinal plants Prospective analysis
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3-Dimensional Kinematic Comparison of Arm Movements between an Individual with NGLY1 Deficiency and a Neurotypical Individual
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作者 Charles S. Layne Christopher A. Malaya +6 位作者 Brock Futrell Dacia Martinez Diaz Christian Alfaro Hannah E. Gustafson Subhalakshmi Chandrasekaran Rhea M. Phatak Bernhard Suter 《Case Reports in Clinical Medicine》 2024年第4期122-146,共25页
NGLY1 Deficiency is an ultra-rare autosomal recessively inherited disorder. Characteristic symptoms include among others, developmental delays, movement disorders, liver function abnormalities, seizures, and problems ... NGLY1 Deficiency is an ultra-rare autosomal recessively inherited disorder. Characteristic symptoms include among others, developmental delays, movement disorders, liver function abnormalities, seizures, and problems with tear formation. Movements are hyperkinetic and may include dysmetric, choreo-athetoid, myoclonic and dystonic movement elements. To date, there have been no quantitative reports describing arm movements of individuals with NGLY1 Deficiency. This report provides quantitative information about a series of arm movements performed by an individual with NGLY1 Deficiency and an aged-matched neurotypical participant. Three categories of arm movements were tested: 1) open ended reaches without specific end point targets;2) goal-directed reaches that included grasping an object;3) picking up small objects from a table placed in front of the participants. Arm movement kinematics were obtained with a camera-based motion analysis system and “initiation” and “maintenance” phases were identified for each movement. The combination of the two phases was labeled as a “complete” movement. Three-dimensional analysis techniques were used to quantify the movements and included hand trajectory pathlength, joint motion area, as well as hand trajectory and joint jerk cost. These techniques were required to fully characterize the movements because the NGLY1 individual was unable to perform movements only in the primary plane of progression instead producing motion across all three planes of movement. The individual with NGLY1 Deficiency was unable to pick up objects from a table or effectively complete movements requiring crossing the midline. The successfully completed movements were analyzed using the above techniques and the results of the two participants were compared statistically. Almost all comparisons revealed significant differences between the two participants, with a notable exception of the 3D initiation area as a percentage of the complete movement. The statistical tests of these measures revealed no significant differences between the two participants, possibly suggesting a common underlying motor control strategy. The 3D techniques used in this report effectively characterized arm movements of an individual with NGLY1 deficiency and can be used to provide information to evaluate the effectiveness of genetic, pharmacological, or physical rehabilitation therapies. 展开更多
关键词 NGLY1 Deficiency Developmental Disorders KINEMATICS 3 Dimensional analyses
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Analyses on Marketing Strategies of Penglai's Tourism
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作者 徐宜华 《海外英语》 2013年第7X期285-288,共4页
Although tourism marketing has made great progress in recent years,researches on it are far from enough.Current re searches on tourism marketing at home and abroad lack pertinence and mostly provide theoretical basis ... Although tourism marketing has made great progress in recent years,researches on it are far from enough.Current re searches on tourism marketing at home and abroad lack pertinence and mostly provide theoretical basis for tourism development within a wide range.The researches on tourism marketing of Penglai are few and far between.Based on previous studies and the status quo of tourism marketing strategy,the below statements tries to find out existing problems of Penglai's tourism,put for ward countermeasures and propose feasible marketing patterns suitable for its tourism development.It subsequently concludes that it can make contribution to the sustainable development of Penglai's tourism and provide other county-level tourism cities with reference for marketing tourism marketing strategies. 展开更多
关键词 Penglai TOURISM MARKETING STRATEGY analyseS
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Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses 被引量:10
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作者 Susan Yost Philip Stashenko +6 位作者 Yoonhee Choi Maria Kukuruzinska Caroline A.Genco Andrew Salama Ellen O.Weinberg Carolyn D.Kramer Jorge Frias-Lopez 《International Journal of Oral Science》 SCIE CAS CSCD 2018年第4期263-272,共10页
Oral squamous cell carcinoma(OSCC) is the most prevalent and most commonly studied oral cancer. However, there is a void regarding the role that the oral microbiome may play in OSCC. Although the relationship between ... Oral squamous cell carcinoma(OSCC) is the most prevalent and most commonly studied oral cancer. However, there is a void regarding the role that the oral microbiome may play in OSCC. Although the relationship between microbial community composition and OSCC has been thoroughly investigated, microbial profiles of the human microbiome in cancer are understudied. Here we performed a small pilot study of community-wide metatranscriptome analysis to profile mRNA expression in the entire oral microbiome in OSCC to reveal molecular functions associated with this disease. Fusobacteria showed a statistically significantly higher number of transcripts at tumour sites and tumour-adjacent sites of cancer patients compared to the healthy controls analysed. Regardless of the community composition, specific metabolic signatures were consistently found in disease. Activities such as iron ion transport, tryptophanase activity, peptidase activities and superoxide dismutase were over-represented in tumour and tumour-adjacent samples when compared to the healthy controls. The expression of putative virulence factors in the oral communities associated with OSCC showed that activities related to capsule biosynthesis, flagellum synthesis and assembly, chemotaxis, iron transport, haemolysins and adhesins were upregulated at tumour sites. Moreover, activities associated with protection against reactive nitrogen intermediates, chemotaxis, flagellar and capsule biosynthesis were also upregulated in non-tumour sites of cancer patients. Although they are preliminary, our results further suggest that Fusobacteria may be the leading phylogenetic group responsible for the increase in expression of virulence factors in the oral microbiome of OSCC patients. 展开更多
关键词 profiles analyseS
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Mathematical analyses of the GPS receiver interference tolerance and mean time to loss lock 被引量:4
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作者 Ehab M.Shaheen Sherif A.Elgamel 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2019年第3期440-449,共10页
In this paper, novel mathematical expressions are derived for the Global Positioning System (GPS) receiver interference tolerance in the presence of different types of interference signals such as: continuous wave int... In this paper, novel mathematical expressions are derived for the Global Positioning System (GPS) receiver interference tolerance in the presence of different types of interference signals such as: continuous wave interference, narrowband interference, partial band interference, broadband interference, match spectrum interference and pulse interference. Also, in this paper the mean time to loss lock is determined in order to analyse the mentioned interferences effect on the GPS receiver. These derived analytical expressions are validated with the aid of extensive simulation experiments. 展开更多
关键词 MATHEMATICAL analyseS GPS RECEIVER INTERFERENCE TOLERANCE
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Single-cell omics analyses with single molecular detection:challenges and perspectives 被引量:4
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作者 Gradimir Misevic 《The Journal of Biomedical Research》 CAS CSCD 2021年第4期264-276,共13页
The ultimate goal of single-cell analyses is to obtain the biomolecular content for each cell in unicellular and multicellular organisms at different points of their life cycle under variable environmental conditions.... The ultimate goal of single-cell analyses is to obtain the biomolecular content for each cell in unicellular and multicellular organisms at different points of their life cycle under variable environmental conditions.These require an assessment of:a)the total number of cells,b)the total number of cell types,and c)the complete and quantitative single molecular detection and identification for all classes of biopolymers,and organic and inorganic compounds,in each individual cell.For proteins,glycans,lipids,and metabolites,whose sequences cannot be amplified by copying as in the case of nucleic acids,the detection limit by mass spectrometry is about 105 molecules.Therefore,proteomic,glycomic,lipidomic,and metabolomic analyses do not yet permit the assembly of the complete single-cell omes.The construction of novel nanoelectrophoretic arrays and nano in microarrays on a single 1-cm-diameter chip has shown proof of concept for a high throughput platform for parallel processing of thousands of individual cells.Combined with dynamic secondary ion mass spectrometry,with 3D scanning capability and lateral resolution of 50 nm,the sensitivity of single molecular quantification and identification for all classes of biomolecules could be reached.Further development and routine application of such technological and instrumentation solution would allow assembly of complete omes with a quantitative assessment of structural and functional cellular diversity at the molecular level. 展开更多
关键词 single-cell analyses single molecular detection ome TRANSCRIPTOMICS proteomics GLYCOMICS LIPIDOMICS metabolomics
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Development of x-ray scintillator functioning also as an analyser grating used in grating-based x-ray differential phase contrast imaging 被引量:4
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作者 雷耀虎 刘鑫 +2 位作者 郭金川 赵志刚 牛憨笨 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第4期222-227,共6页
In order to push the grating-based phase contrast imaging system to be used in hospitM and laboratories, this paper designs and develops a novel structure of x-ray scintillator functioning also as an analyser grating,... In order to push the grating-based phase contrast imaging system to be used in hospitM and laboratories, this paper designs and develops a novel structure of x-ray scintillator functioning also as an analyser grating, which has been proposed for grating-based x-ray differential phase contrast imaging. According to this design, the scintillator should have a periodical structure in one dimension with the pitch equaling the period of self-image of the phase grating at the Talbot distance, where one half of the pitch is pixellated and is made of x-ray sensitive fluorescent material, such as CsI(T1), and the remaining part of the pitch is made of x-ray insensitive material, such as silicon. To realize the design, a deep pore array with a high aspect ratio and specially designed grating pattern are successfully manufactured on 5 inch silicon wafer by the photo-assisted electrochemical etching method. The related other problems, such as oxidation-caused geometrical distortion, the filling of CsI(T1) into deep pores and the removal of inside bubbles, have been overcome. Its pixel size, depth and grating pitch are 3 p.m^7.5 ~m, 150 p^m and 3 Ixm, respectively. The microstructure of the scintillator has been examined microscopically and macroscopically by scanning electron microscope and x-ray resolution chart testing, respectively. The preliminary measurements have shown that the proposed scintillator, also functioning as an analyser grating, has been successfully designed and developed. 展开更多
关键词 scintillator screen pore arrays oxidation CsI(T1) analyser grating
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Entropy resistance analyses of a two-stream parallel flow heat exchanger with viscous heating 被引量:3
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作者 程雪涛 梁新刚 《Chinese Physics B》 SCIE EI CAS CSCD 2013年第8期361-364,共4页
Heat exchangers are widely used in industry, and analyses and optimizations of the performance of heat exchangers are important topics. In this paper, we define the concept of entropy resistance based on the entropy g... Heat exchangers are widely used in industry, and analyses and optimizations of the performance of heat exchangers are important topics. In this paper, we define the concept of entropy resistance based on the entropy generation analyses of a one-dimensional heat transfer process. With this concept, a two-stream parallel flow heat exchanger with viscous heating is analyzed and discussed. It is found that the minimization of entropy resistance always leads to the maximum heat transfer rate for the discussed two-stream parallel flow heat exchanger, while the minimizations of entropy generation rate, entropy generation numbers, and revised entropy generation number do not always. 展开更多
关键词 entropy generation minimization heat exchanger entropy resistance analyseS
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Analyses of an air conditioning system with entropy generation minimization and entransy theory 被引量:3
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作者 吴艳秋 蔡黎 吴鸿娟 《Chinese Physics B》 SCIE EI CAS CSCD 2016年第6期130-136,共7页
In this paper,based on the generalized heat transfer law,an air conditioning system is analyzed with the entropy generation minimization and the entransy theory.Taking the coefficient of performance(denoted as COP) ... In this paper,based on the generalized heat transfer law,an air conditioning system is analyzed with the entropy generation minimization and the entransy theory.Taking the coefficient of performance(denoted as COP) and heat flow rate Qout which is released into the room as the optimization objectives,we discuss the applicabilities of the entropy generation minimization and entransy theory to the optimizations.Five numerical cases are presented.Combining the numerical results and theoretical analyses,we can conclude that the optimization applicabilities of the two theories are conditional.If Qout is the optimization objective,larger entransy increase rate always leads to larger Qout,while smaller entropy generation rate does not.If we take COP as the optimization objective,neither the entropy generation minimization nor the concept of entransy increase is always applicable.Furthermore,we find that the concept of entransy dissipation is not applicable for the discussed cases. 展开更多
关键词 entropy generation entransy increase entransy dissipation optimization analyses finite time thermodynamics air conditioning system
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Updated neutronics analyses of a water cooled ceramic breeder blanket for the CFETR 被引量:3
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作者 张小康 刘松林 +2 位作者 李夏 祝庆军 李佳 《Plasma Science and Technology》 SCIE EI CAS CSCD 2017年第11期92-100,共9页
The water cooled ceramic breeder(WCCB) blanket employing pressurized water as a coolant is one of the breeding blanket candidates for the China Fusion Engineering Test Reactor(CFETR).Some updating of neutronics an... The water cooled ceramic breeder(WCCB) blanket employing pressurized water as a coolant is one of the breeding blanket candidates for the China Fusion Engineering Test Reactor(CFETR).Some updating of neutronics analyses was needed, because there were changes in the neutronics performance of the blanket as several significant modifications and improvements have been adopted for the WCCB blanket, including the optimization of radial build-up and customized structure for each blanket module. A 22.5 degree toroidal symmetrical torus sector 3 D neutronics model containing the updated design of the WCCB blanket modules was developed for the neutronics analyses. The tritium breeding capability, nuclear heating power, radiation damage,and decay heat were calculated by the MCNP and FISPACT code. The results show that the packing factor and^6 Li enrichment of the breeder should both be no less than 0.8 to ensure tritium self-sufficiency. The nuclear heating power of the blanket under 200 MW fusion power reaches201.23 MW. The displacement per atom per full power year(FPY) of the plasma-facing component and first wall reach 0.90 and 2.60, respectively. The peak H production rate reaches150.79 appm/FPY and the peak He production reaches 29.09 appm/FPY in blanket module #3.The total decay heat of the blanket modules is 2.64 MW at 1 s after shutdown and the average decay heat density can reach 11.09 kW m^(-3) at that time. The decay heat density of the blanket modules slowly decreases to lower than 10 W m^(-3) in more than ten years. 展开更多
关键词 CFETR WCCB neutronics analyses
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Analyses of active faults, seismic activities and sea floor unstable factors of the Zhujiang River Mouth Basin and its adjacent areas 被引量:2
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作者 Liu Yixuan, Zhang Yixiang, Zhou Jialun , Xie Yixuan, Lu Chengbing, Zhong Jianqiang and Zhan Wenhuan South China Sea Institute of Oceanology, Academia Sinica, Guangzhou, China 《Acta Oceanologica Sinica》 SCIE CAS CSCD 1990年第3期413-428,共16页
-On the basis of the data of geophysics and seismic activities, the analyses of the active faults, seismic activities and the sea floor unstable factors of the Zhujiang River Mouth Basin have been made so as to study ... -On the basis of the data of geophysics and seismic activities, the analyses of the active faults, seismic activities and the sea floor unstable factors of the Zhujiang River Mouth Basin have been made so as to study the characteristics of the compressional subactive continental margin of Cathaysian system, arc littoral strongly active fracture zone, the division of seismic subzone and seismic zone of the continental margin of northern South China Sea, the potential focal area, and to analyze the regional stability. We consider that the Zhujiang River Mouth Basin belongs to a stable or a moderately stable region. 展开更多
关键词 In HIGH NEE analyses of active faults
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An Elevated Perspective: Dyke-Related Fracture Networks Analysed with Uav Photogrammetry 被引量:3
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作者 Gregory DERING Steven MICKLETHWAITE +3 位作者 Stephen J.BARNES Marco FIORENTINI Alexander CRUDEN Eric TOHVER 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2016年第S1期54-55,共2页
An abundance of data from seismic and geodetic monitoring has provided new insight into dyke propagation and emplacement mechanisms.These studies show that faulting and fracturing is part of the magma
关键词 rock An Elevated Perspective Dyke-Related Fracture Networks analysed with Uav Photogrammetry
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