Spatial heterogeneity or“patchiness”of plankton distributions in the ocean has always been an attractive and challenging scientific issue to oceanographers.We focused on the accumulation and dynamic mechanism of the...Spatial heterogeneity or“patchiness”of plankton distributions in the ocean has always been an attractive and challenging scientific issue to oceanographers.We focused on the accumulation and dynamic mechanism of the Acetes chinensis in the Lianyungang nearshore licensed fishing area.The Lagrangian frame approaches including the Lagrangian coherent structures theory,Lagrangian residual current,and Lagrangian particle-tracking model were applied to find the transport pathways and aggregation characteristics of Acetes chinensis.There exist some material transport pathways for Acetes chinensis passing through the licensed fishing area,and Acetes chinensis is easy to accumulate in the licensed fishing area.The main mechanism forming this distribution pattern is the local circulation induced by the nonlinear interaction of topography and tidal flow.Both the Lagrangian coherent structure analysis and the particle trajectory tracking indicate that Acetes chinensis in the licensed fishing area come from the nearshore estuary.This work contributed to the adjustment of licensed fishing area and the efficient utilization of fishery resources.展开更多
Joint time–frequency analysis is an emerging method for interpreting the underlying physics in fuel cells,batteries,and supercapacitors.To increase the reliability of time–frequency analysis,a theoretical correlatio...Joint time–frequency analysis is an emerging method for interpreting the underlying physics in fuel cells,batteries,and supercapacitors.To increase the reliability of time–frequency analysis,a theoretical correlation between frequency-domain stationary analysis and time-domain transient analysis is urgently required.The present work formularizes a thorough model reduction of fractional impedance spectra for electrochemical energy devices involving not only the model reduction from fractional-order models to integer-order models and from high-to low-order RC circuits but also insight into the evolution of the characteristic time constants during the whole reduction process.The following work has been carried out:(i)the model-reduction theory is addressed for typical Warburg elements and RC circuits based on the continued fraction expansion theory and the response error minimization technique,respectively;(ii)the order effect on the model reduction of typical Warburg elements is quantitatively evaluated by time–frequency analysis;(iii)the results of time–frequency analysis are confirmed to be useful to determine the reduction order in terms of the kinetic information needed to be captured;and(iv)the results of time–frequency analysis are validated for the model reduction of fractional impedance spectra for lithium-ion batteries,supercapacitors,and solid oxide fuel cells.In turn,the numerical validation has demonstrated the powerful function of the joint time–frequency analysis.The thorough model reduction of fractional impedance spectra addressed in the present work not only clarifies the relationship between time-domain transient analysis and frequency-domain stationary analysis but also enhances the reliability of the joint time–frequency analysis for electrochemical energy devices.展开更多
Principal component analysis(PCA)was employed to determine the implications of geochemical and isotopic data from Cenozoic volcanic activities in the Southeast Asian region,including China(South China Sea(SCS),Hainan ...Principal component analysis(PCA)was employed to determine the implications of geochemical and isotopic data from Cenozoic volcanic activities in the Southeast Asian region,including China(South China Sea(SCS),Hainan Island,Fujian-Zhejiang coast,Taiwan Island),and parts of Vietnam and Thailand.We analyzed 15 trace element indicators and 5 isotopic indicators for 623 volcanic rock samples collected from the study region.Two principal components(PCs)were extracted by PCA based on the trace elements and Sr-Nd-Pb isotopic ratios,which probably indicate an enriched oceanic island basalt-type mantle plume and a depleted mid-ocean ridge basalt-type spreading ridge.The results show that the influence of the Hainan mantle plume on younger volcanic activities(<13 Ma)is stronger than that on older ones(>13 Ma)at the same location in the Southeast Asian region.PCA was employed to verify the mantle-plume-ridge interaction model of volcanic activities beneath the expansion center of SCS and refute the hypothesis that the tension of SCS is triggered by the Hainan plume.This study reveals the efficiency and applicability of PCA in discussing mantle sources of volcanic activities;thus,PCA is a suitable research method for analyzing geochemical data.展开更多
Gears are pivotal in mechanical drives,and gear contact analysis is a typically difficult problem to solve.Emerging isogeometric analysis(IGA)methods have developed new ideas to solve this problem.In this paper,a thre...Gears are pivotal in mechanical drives,and gear contact analysis is a typically difficult problem to solve.Emerging isogeometric analysis(IGA)methods have developed new ideas to solve this problem.In this paper,a threedimensional body parametric gear model of IGA is established,and a theoretical formula is derived to realize single-tooth contact analysis.Results were benchmarked against those obtained from commercial software utilizing the finite element analysis(FEA)method to validate the accuracy of our approach.Our findings indicate that the IGA-based contact algorithmsuccessfullymet theHertz contact test.When juxtaposed with the FEA approach,the IGAmethod demonstrated fewer node degrees of freedomand reduced computational units,all whilemaintaining comparable accuracy.Notably,the IGA method appeared to exhibit consistency in analysis accuracy irrespective of computational unit density,and also significantlymitigated non-physical oscillations in contact stress across the tooth width.This underscores the prowess of IGA in contact analysis.In conclusion,IGA emerges as a potent tool for addressing contact analysis challenges and holds significant promise for 3D gear modeling,simulation,and optimization of various mechanical components.展开更多
Formed on top of the Gulf of Cadiz, the Al Idrissi mud volcano is the shallowest and largest mud volcano in the El Arraiche mud volcano field of the northwestern Moroccan margin. The development and morphology of mud ...Formed on top of the Gulf of Cadiz, the Al Idrissi mud volcano is the shallowest and largest mud volcano in the El Arraiche mud volcano field of the northwestern Moroccan margin. The development and morphology of mud volcanoes from the El Arraiche mud volcanoes group have been studied at a large scale. However, the time interval related to their formation period still needs to be better understood. In this regard, we interpreted and analyzed the seismic facies from the 2D reflection data of the GEOMARGEN-1 campaign, which took place in 2011. The aim was to identify the seismic sequences and draw the Al Idrissi mud volcano system to determine the formation period of the Al Idriss mud volcano. And as a result, the Al Idrissi mud volcano system is made of both buried and superficial bicone and was identified along with the Upper Tortonian to Messinian-Upper Pliocene facies. As the initial mud volcano extrusive edifice, the buried bicone was formed in the Late-Messinian to Early-Pliocene period. However, the superficial bicone, as the final extrusive edifice, was included in the Late Pliocene. In this case, the timing interval between the buried and superficial bicone is equivalent to the Late-Messinian to Upper-Pliocene period. Therefore, the latter corresponds to the Al Idrissi mud volcano formation period.展开更多
The supercritical CO_(2)cOoled Lithium-Lead(COOL)blanket has been designed as one advanced blanket candidate for the Chinese Fusion Engineering Test Reactor(CFETR).This work focuses on the electromagnetic(EM)loads(Max...The supercritical CO_(2)cOoled Lithium-Lead(COOL)blanket has been designed as one advanced blanket candidate for the Chinese Fusion Engineering Test Reactor(CFETR).This work focuses on the electromagnetic(EM)loads(Maxwell force and Lorentz force)acting on the COOL blanket,which are important mechanical loads in further structural analysis of the COOL blanket.A 3D electromagnetic analysis is performed using the ANSYS finite element method to obtain EM loads on the COOL blanket in this study.At first,the magnetic scalar potential(MSP)method is used to obtain the magnetic field and the Maxwell force on the COOL blanket.Then,the magnetic vector potential(MVP)method is performed during a plasma disruption event to get the eddy current distribution.At last,a multi-step method is adopted for the calculation of the Lorentz force and the torque.The maximum Lorentz forces of inboard and outboard blanket structural components are 5624 kN and 2360 kN respectively.展开更多
Correlation power analysis(CPA)combined with genetic algorithms(GA)now achieves greater attack efficiency and can recover all subkeys simultaneously.However,two issues in GA-based CPA still need to be addressed:key de...Correlation power analysis(CPA)combined with genetic algorithms(GA)now achieves greater attack efficiency and can recover all subkeys simultaneously.However,two issues in GA-based CPA still need to be addressed:key degeneration and slow evolution within populations.These challenges significantly hinder key recovery efforts.This paper proposes a screening correlation power analysis framework combined with a genetic algorithm,named SFGA-CPA,to address these issues.SFGA-CPA introduces three operations designed to exploit CPA characteris-tics:propagative operation,constrained crossover,and constrained mutation.Firstly,the propagative operation accelerates population evolution by maximizing the number of correct bytes in each individual.Secondly,the constrained crossover and mutation operations effectively address key degeneration by preventing the compromise of correct bytes.Finally,an intelligent search method is proposed to identify optimal parameters,further improving attack efficiency.Experiments were conducted on both simulated environments and real power traces collected from the SAKURA-G platform.In the case of simulation,SFGA-CPA reduces the number of traces by 27.3%and 60%compared to CPA based on multiple screening methods(MS-CPA)and CPA based on simple GA method(SGA-CPA)when the success rate reaches 90%.Moreover,real experimental results on the SAKURA-G platform demonstrate that our approach outperforms other methods.展开更多
Facial beauty analysis is an important topic in human society.It may be used as a guidance for face beautification applications such as cosmetic surgery.Deep neural networks(DNNs)have recently been adopted for facial ...Facial beauty analysis is an important topic in human society.It may be used as a guidance for face beautification applications such as cosmetic surgery.Deep neural networks(DNNs)have recently been adopted for facial beauty analysis and have achieved remarkable performance.However,most existing DNN-based models regard facial beauty analysis as a normal classification task.They ignore important prior knowledge in traditional machine learning models which illustrate the significant contribution of the geometric features in facial beauty analysis.To be specific,landmarks of the whole face and facial organs are introduced to extract geometric features to make the decision.Inspired by this,we introduce a novel dual-branch network for facial beauty analysis:one branch takes the Swin Transformer as the backbone to model the full face and global patterns,and another branch focuses on the masked facial organs with the residual network to model the local patterns of certain facial parts.Additionally,the designed multi-scale feature fusion module can further facilitate our network to learn complementary semantic information between the two branches.In model optimisation,we propose a hybrid loss function,where especially geometric regulation is introduced by regressing the facial landmarks and it can force the extracted features to convey facial geometric features.Experiments performed on the SCUT-FBP5500 dataset and the SCUT-FBP dataset demonstrate that our model outperforms the state-of-the-art convolutional neural networks models,which proves the effectiveness of the proposed geometric regularisation and dual-branch structure with the hybrid network.To the best of our knowledge,this is the first study to introduce a Vision Transformer into the facial beauty analysis task.展开更多
Algal blooms,the spread of algae on the surface of water bodies,have adverse effects not only on aquatic ecosystems but also on human life.The adverse effects of harmful algal blooms(HABs)necessitate a convenient solu...Algal blooms,the spread of algae on the surface of water bodies,have adverse effects not only on aquatic ecosystems but also on human life.The adverse effects of harmful algal blooms(HABs)necessitate a convenient solution for detection and monitoring.Unmanned aerial vehicles(UAVs)have recently emerged as a tool for algal bloom detection,efficiently providing on-demand images at high spatiotemporal resolutions.This study developed an image processing method for algal bloom area estimation from the aerial images(obtained from the internet)captured using UAVs.As a remote sensing method of HAB detection,analysis,and monitoring,a combination of histogram and texture analyses was used to efficiently estimate the area of HABs.Statistical features like entropy(using the Kullback-Leibler method)were emphasized with the aid of a gray-level co-occurrence matrix.The results showed that the orthogonal images demonstrated fewer errors,and the morphological filter best detected algal blooms in real time,with a precision of 80%.This study provided efficient image processing approaches using on-board UAVs for HAB monitoring.展开更多
DNA methylation has been extensively investigated in recent years,not least because of its known relationship with various diseases.Progress in analytical methods can greatly increase the relevance of DNA methylation ...DNA methylation has been extensively investigated in recent years,not least because of its known relationship with various diseases.Progress in analytical methods can greatly increase the relevance of DNA methylation studies to both clinical medicine and scientific research.Microflu-idic chips are excellent carriers for molecular analysis,and their use can provide improvements from multiple aspects.On-chip molecular analysis has received extensive attention owing to its advantages of portability,high throughput,low cost,and high efficiency.In recent years,the use of novel microfluidic chips for DNA methylation analysis has been widely reported and has shown obvious superiority to conventional methods.In this review,wefirst focus on DNA methylation and its applications.Then,we discuss advanced microfluidic-based methods for DNA methylation analysis and describe the great progress that has been made in recent years.Finally,we summarize the advantages that microfluidic technology brings to DNA methylation analysis and describe several challenges and perspectives for on-chip DNA methylation analysis.This review should help researchers improve their understanding and make progress in developing microfluidic-based methods for DNA methylation analysis.展开更多
Tendon adhesion is a common complication after tendon injury with the development of accumulated fibrotic tissues without effective anti-fibrotic therapies,resulting in severe disability.Macrophages are widely recogni...Tendon adhesion is a common complication after tendon injury with the development of accumulated fibrotic tissues without effective anti-fibrotic therapies,resulting in severe disability.Macrophages are widely recognized as a fibrotic trigger during peritendinous adhesion formation.However,different clusters of macrophages have various functions and receive multiple regulation,which are both still unknown.In our current study,multi-omics analysis including single-cell RNA sequencing and proteomics was performed on both human and mouse tendon adhesion tissue at different stages after tendon injury.The transcriptomes of over 74000 human single cells were profiled.As results,we found that SPP1^(+)macrophages,RGCC^(+)endothelial cells,ACKR1^(+)endothelial cells and ADAM12^(+)fibroblasts participated in tendon adhesion formation.Interestingly,despite specific fibrotic clusters in tendon adhesion,FOLR2^(+)macrophages were identified as an antifibrotic cluster by in vitro experiments using human cells.Furthermore,ACKR1 was verified to regulate FOLR2^(+)macrophages migration at the injured peritendinous site by transplantation of bone marrow from Lysm-Cre;R26R^(tdTomato) mice to lethally irradiated Ackr1^(-/-)mice(Ackr1^(-/-)chimeras;deficient in ACKR1)and control mice(WT chimeras).Compared with WT chimeras,the decline of FOLR2^(+)macrophages was also observed,indicating that ACKR1 was specifically involved in FOLR2^(+)macrophages migration.Taken together,our study not only characterized the fibrosis microenvironment landscape of tendon adhesion by multi-omics analysis,but also uncovered a novel antifibrotic cluster of macrophages and their origin.These results provide potential therapeutic targets against human tendon adhesion.展开更多
This paper considers the finite difference(FD)approximations of diffusion operators and the boundary treatments for different boundary conditions.The proposed schemes have the compact form and could achieve arbitrary ...This paper considers the finite difference(FD)approximations of diffusion operators and the boundary treatments for different boundary conditions.The proposed schemes have the compact form and could achieve arbitrary even order of accuracy.The main idea is to make use of the lower order compact schemes recursively,so as to obtain the high order compact schemes formally.Moreover,the schemes can be implemented efficiently by solving a series of tridiagonal systems recursively or the fast Fourier transform(FFT).With mathematical induction,the eigenvalues of the proposed differencing operators are shown to be bounded away from zero,which indicates the positive definiteness of the operators.To obtain numerical boundary conditions for the high order schemes,the simplified inverse Lax-Wendroff(SILW)procedure is adopted and the stability analysis is performed by the Godunov-Ryabenkii method and the eigenvalue spectrum visualization method.Various numerical experiments are provided to demonstrate the effectiveness and robustness of our algorithms.展开更多
基金the National Natural Science Foundation of China(No.31802297)。
文摘Spatial heterogeneity or“patchiness”of plankton distributions in the ocean has always been an attractive and challenging scientific issue to oceanographers.We focused on the accumulation and dynamic mechanism of the Acetes chinensis in the Lianyungang nearshore licensed fishing area.The Lagrangian frame approaches including the Lagrangian coherent structures theory,Lagrangian residual current,and Lagrangian particle-tracking model were applied to find the transport pathways and aggregation characteristics of Acetes chinensis.There exist some material transport pathways for Acetes chinensis passing through the licensed fishing area,and Acetes chinensis is easy to accumulate in the licensed fishing area.The main mechanism forming this distribution pattern is the local circulation induced by the nonlinear interaction of topography and tidal flow.Both the Lagrangian coherent structure analysis and the particle trajectory tracking indicate that Acetes chinensis in the licensed fishing area come from the nearshore estuary.This work contributed to the adjustment of licensed fishing area and the efficient utilization of fishery resources.
基金support from the National Science Foundation of China(22078190)the National Key R&D Plan of China(2020YFB1505802).
文摘Joint time–frequency analysis is an emerging method for interpreting the underlying physics in fuel cells,batteries,and supercapacitors.To increase the reliability of time–frequency analysis,a theoretical correlation between frequency-domain stationary analysis and time-domain transient analysis is urgently required.The present work formularizes a thorough model reduction of fractional impedance spectra for electrochemical energy devices involving not only the model reduction from fractional-order models to integer-order models and from high-to low-order RC circuits but also insight into the evolution of the characteristic time constants during the whole reduction process.The following work has been carried out:(i)the model-reduction theory is addressed for typical Warburg elements and RC circuits based on the continued fraction expansion theory and the response error minimization technique,respectively;(ii)the order effect on the model reduction of typical Warburg elements is quantitatively evaluated by time–frequency analysis;(iii)the results of time–frequency analysis are confirmed to be useful to determine the reduction order in terms of the kinetic information needed to be captured;and(iv)the results of time–frequency analysis are validated for the model reduction of fractional impedance spectra for lithium-ion batteries,supercapacitors,and solid oxide fuel cells.In turn,the numerical validation has demonstrated the powerful function of the joint time–frequency analysis.The thorough model reduction of fractional impedance spectra addressed in the present work not only clarifies the relationship between time-domain transient analysis and frequency-domain stationary analysis but also enhances the reliability of the joint time–frequency analysis for electrochemical energy devices.
基金Supported by the State Key Laboratory of Marine Environmental Science Visiting Fellowship(No.MELRS2233)the State Key Laboratory of Marine Geology,Tongji University(No.MGK202302)+4 种基金the Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(No.311021003)the Zhujiang Talent Project Foundation of Guangdong Province(No.2017ZT07Z066)the Fundamental Research Funds for the Central Universities,Sun Yat-sen University(Nos.22qntd2101,2021qntd23)the Major Projects of the National Natural Science Foundation of China(Nos.41790465,41590863)the National Natural Science Foundation of China(Nos.42102333,41806077,41904045)。
文摘Principal component analysis(PCA)was employed to determine the implications of geochemical and isotopic data from Cenozoic volcanic activities in the Southeast Asian region,including China(South China Sea(SCS),Hainan Island,Fujian-Zhejiang coast,Taiwan Island),and parts of Vietnam and Thailand.We analyzed 15 trace element indicators and 5 isotopic indicators for 623 volcanic rock samples collected from the study region.Two principal components(PCs)were extracted by PCA based on the trace elements and Sr-Nd-Pb isotopic ratios,which probably indicate an enriched oceanic island basalt-type mantle plume and a depleted mid-ocean ridge basalt-type spreading ridge.The results show that the influence of the Hainan mantle plume on younger volcanic activities(<13 Ma)is stronger than that on older ones(>13 Ma)at the same location in the Southeast Asian region.PCA was employed to verify the mantle-plume-ridge interaction model of volcanic activities beneath the expansion center of SCS and refute the hypothesis that the tension of SCS is triggered by the Hainan plume.This study reveals the efficiency and applicability of PCA in discussing mantle sources of volcanic activities;thus,PCA is a suitable research method for analyzing geochemical data.
基金support provided by the National Nature Science Foundation of China (Grant Nos.52075340,51875360)Project of Science and Technology Commission of Shanghai Municipality (No.19060502300).
文摘Gears are pivotal in mechanical drives,and gear contact analysis is a typically difficult problem to solve.Emerging isogeometric analysis(IGA)methods have developed new ideas to solve this problem.In this paper,a threedimensional body parametric gear model of IGA is established,and a theoretical formula is derived to realize single-tooth contact analysis.Results were benchmarked against those obtained from commercial software utilizing the finite element analysis(FEA)method to validate the accuracy of our approach.Our findings indicate that the IGA-based contact algorithmsuccessfullymet theHertz contact test.When juxtaposed with the FEA approach,the IGAmethod demonstrated fewer node degrees of freedomand reduced computational units,all whilemaintaining comparable accuracy.Notably,the IGA method appeared to exhibit consistency in analysis accuracy irrespective of computational unit density,and also significantlymitigated non-physical oscillations in contact stress across the tooth width.This underscores the prowess of IGA in contact analysis.In conclusion,IGA emerges as a potent tool for addressing contact analysis challenges and holds significant promise for 3D gear modeling,simulation,and optimization of various mechanical components.
文摘Formed on top of the Gulf of Cadiz, the Al Idrissi mud volcano is the shallowest and largest mud volcano in the El Arraiche mud volcano field of the northwestern Moroccan margin. The development and morphology of mud volcanoes from the El Arraiche mud volcanoes group have been studied at a large scale. However, the time interval related to their formation period still needs to be better understood. In this regard, we interpreted and analyzed the seismic facies from the 2D reflection data of the GEOMARGEN-1 campaign, which took place in 2011. The aim was to identify the seismic sequences and draw the Al Idrissi mud volcano system to determine the formation period of the Al Idriss mud volcano. And as a result, the Al Idrissi mud volcano system is made of both buried and superficial bicone and was identified along with the Upper Tortonian to Messinian-Upper Pliocene facies. As the initial mud volcano extrusive edifice, the buried bicone was formed in the Late-Messinian to Early-Pliocene period. However, the superficial bicone, as the final extrusive edifice, was included in the Late Pliocene. In this case, the timing interval between the buried and superficial bicone is equivalent to the Late-Messinian to Upper-Pliocene period. Therefore, the latter corresponds to the Al Idrissi mud volcano formation period.
基金supported by the Comprehensive Research Facility for Fusion Technology(CRAFT)Program of China(No.2018-000052-73-01-001228)National Natural Science Foundation of China(No.12205330)。
文摘The supercritical CO_(2)cOoled Lithium-Lead(COOL)blanket has been designed as one advanced blanket candidate for the Chinese Fusion Engineering Test Reactor(CFETR).This work focuses on the electromagnetic(EM)loads(Maxwell force and Lorentz force)acting on the COOL blanket,which are important mechanical loads in further structural analysis of the COOL blanket.A 3D electromagnetic analysis is performed using the ANSYS finite element method to obtain EM loads on the COOL blanket in this study.At first,the magnetic scalar potential(MSP)method is used to obtain the magnetic field and the Maxwell force on the COOL blanket.Then,the magnetic vector potential(MVP)method is performed during a plasma disruption event to get the eddy current distribution.At last,a multi-step method is adopted for the calculation of the Lorentz force and the torque.The maximum Lorentz forces of inboard and outboard blanket structural components are 5624 kN and 2360 kN respectively.
基金supported by the Hunan Provincial Natrual Science Foundation of China(2022JJ30103)“the 14th Five-Year”Key Disciplines and Application Oriented Special Disciplines of Hunan Province(Xiangjiaotong[2022],351)the Science and Technology Innovation Program of Hunan Province(2016TP1020).
文摘Correlation power analysis(CPA)combined with genetic algorithms(GA)now achieves greater attack efficiency and can recover all subkeys simultaneously.However,two issues in GA-based CPA still need to be addressed:key degeneration and slow evolution within populations.These challenges significantly hinder key recovery efforts.This paper proposes a screening correlation power analysis framework combined with a genetic algorithm,named SFGA-CPA,to address these issues.SFGA-CPA introduces three operations designed to exploit CPA characteris-tics:propagative operation,constrained crossover,and constrained mutation.Firstly,the propagative operation accelerates population evolution by maximizing the number of correct bytes in each individual.Secondly,the constrained crossover and mutation operations effectively address key degeneration by preventing the compromise of correct bytes.Finally,an intelligent search method is proposed to identify optimal parameters,further improving attack efficiency.Experiments were conducted on both simulated environments and real power traces collected from the SAKURA-G platform.In the case of simulation,SFGA-CPA reduces the number of traces by 27.3%and 60%compared to CPA based on multiple screening methods(MS-CPA)and CPA based on simple GA method(SGA-CPA)when the success rate reaches 90%.Moreover,real experimental results on the SAKURA-G platform demonstrate that our approach outperforms other methods.
基金Shenzhen Science and Technology Program,Grant/Award Number:ZDSYS20211021111415025Shenzhen Institute of Artificial Intelligence and Robotics for SocietyYouth Science and Technology Talents Development Project of Guizhou Education Department,Grant/Award Number:QianJiaoheKYZi[2018]459。
文摘Facial beauty analysis is an important topic in human society.It may be used as a guidance for face beautification applications such as cosmetic surgery.Deep neural networks(DNNs)have recently been adopted for facial beauty analysis and have achieved remarkable performance.However,most existing DNN-based models regard facial beauty analysis as a normal classification task.They ignore important prior knowledge in traditional machine learning models which illustrate the significant contribution of the geometric features in facial beauty analysis.To be specific,landmarks of the whole face and facial organs are introduced to extract geometric features to make the decision.Inspired by this,we introduce a novel dual-branch network for facial beauty analysis:one branch takes the Swin Transformer as the backbone to model the full face and global patterns,and another branch focuses on the masked facial organs with the residual network to model the local patterns of certain facial parts.Additionally,the designed multi-scale feature fusion module can further facilitate our network to learn complementary semantic information between the two branches.In model optimisation,we propose a hybrid loss function,where especially geometric regulation is introduced by regressing the facial landmarks and it can force the extracted features to convey facial geometric features.Experiments performed on the SCUT-FBP5500 dataset and the SCUT-FBP dataset demonstrate that our model outperforms the state-of-the-art convolutional neural networks models,which proves the effectiveness of the proposed geometric regularisation and dual-branch structure with the hybrid network.To the best of our knowledge,this is the first study to introduce a Vision Transformer into the facial beauty analysis task.
文摘Algal blooms,the spread of algae on the surface of water bodies,have adverse effects not only on aquatic ecosystems but also on human life.The adverse effects of harmful algal blooms(HABs)necessitate a convenient solution for detection and monitoring.Unmanned aerial vehicles(UAVs)have recently emerged as a tool for algal bloom detection,efficiently providing on-demand images at high spatiotemporal resolutions.This study developed an image processing method for algal bloom area estimation from the aerial images(obtained from the internet)captured using UAVs.As a remote sensing method of HAB detection,analysis,and monitoring,a combination of histogram and texture analyses was used to efficiently estimate the area of HABs.Statistical features like entropy(using the Kullback-Leibler method)were emphasized with the aid of a gray-level co-occurrence matrix.The results showed that the orthogonal images demonstrated fewer errors,and the morphological filter best detected algal blooms in real time,with a precision of 80%.This study provided efficient image processing approaches using on-board UAVs for HAB monitoring.
基金support from the National Key R&D Program of China(Grant No.2018YFE0118700)the National Natural Science Foundation of China(NSFC Grant No.62174119)+1 种基金the 111 Project(Grant No.B07014)the Foundation for Talent Scientists of Nanchang Institute for Microtechnology of Tianjin University.
文摘DNA methylation has been extensively investigated in recent years,not least because of its known relationship with various diseases.Progress in analytical methods can greatly increase the relevance of DNA methylation studies to both clinical medicine and scientific research.Microflu-idic chips are excellent carriers for molecular analysis,and their use can provide improvements from multiple aspects.On-chip molecular analysis has received extensive attention owing to its advantages of portability,high throughput,low cost,and high efficiency.In recent years,the use of novel microfluidic chips for DNA methylation analysis has been widely reported and has shown obvious superiority to conventional methods.In this review,wefirst focus on DNA methylation and its applications.Then,we discuss advanced microfluidic-based methods for DNA methylation analysis and describe the great progress that has been made in recent years.Finally,we summarize the advantages that microfluidic technology brings to DNA methylation analysis and describe several challenges and perspectives for on-chip DNA methylation analysis.This review should help researchers improve their understanding and make progress in developing microfluidic-based methods for DNA methylation analysis.
基金supported by the National Natural Science Foundation of China(No.82172408)Shanghai Jiao Tong University Medical College“Two-hundred Talent”Program(No.20191829)+1 种基金The Second Three-Year Action Plan for Promoting Clinical Skills and Clinical Innovation in Municipal Hospitals of Shanghai Shenkang(No.SHDC2020CR4032)Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration(No.20DZ2254100).
文摘Tendon adhesion is a common complication after tendon injury with the development of accumulated fibrotic tissues without effective anti-fibrotic therapies,resulting in severe disability.Macrophages are widely recognized as a fibrotic trigger during peritendinous adhesion formation.However,different clusters of macrophages have various functions and receive multiple regulation,which are both still unknown.In our current study,multi-omics analysis including single-cell RNA sequencing and proteomics was performed on both human and mouse tendon adhesion tissue at different stages after tendon injury.The transcriptomes of over 74000 human single cells were profiled.As results,we found that SPP1^(+)macrophages,RGCC^(+)endothelial cells,ACKR1^(+)endothelial cells and ADAM12^(+)fibroblasts participated in tendon adhesion formation.Interestingly,despite specific fibrotic clusters in tendon adhesion,FOLR2^(+)macrophages were identified as an antifibrotic cluster by in vitro experiments using human cells.Furthermore,ACKR1 was verified to regulate FOLR2^(+)macrophages migration at the injured peritendinous site by transplantation of bone marrow from Lysm-Cre;R26R^(tdTomato) mice to lethally irradiated Ackr1^(-/-)mice(Ackr1^(-/-)chimeras;deficient in ACKR1)and control mice(WT chimeras).Compared with WT chimeras,the decline of FOLR2^(+)macrophages was also observed,indicating that ACKR1 was specifically involved in FOLR2^(+)macrophages migration.Taken together,our study not only characterized the fibrosis microenvironment landscape of tendon adhesion by multi-omics analysis,but also uncovered a novel antifibrotic cluster of macrophages and their origin.These results provide potential therapeutic targets against human tendon adhesion.
基金supported by the NSFC grant 11801143J.Lu’s research is partially supported by the NSFC grant 11901213+3 种基金the National Key Research and Development Program of China grant 2021YFA1002900supported by the NSFC grant 11801140,12171177the Young Elite Scientists Sponsorship Program by Henan Association for Science and Technology of China grant 2022HYTP0009the Program for Young Key Teacher of Henan Province of China grant 2021GGJS067.
文摘This paper considers the finite difference(FD)approximations of diffusion operators and the boundary treatments for different boundary conditions.The proposed schemes have the compact form and could achieve arbitrary even order of accuracy.The main idea is to make use of the lower order compact schemes recursively,so as to obtain the high order compact schemes formally.Moreover,the schemes can be implemented efficiently by solving a series of tridiagonal systems recursively or the fast Fourier transform(FFT).With mathematical induction,the eigenvalues of the proposed differencing operators are shown to be bounded away from zero,which indicates the positive definiteness of the operators.To obtain numerical boundary conditions for the high order schemes,the simplified inverse Lax-Wendroff(SILW)procedure is adopted and the stability analysis is performed by the Godunov-Ryabenkii method and the eigenvalue spectrum visualization method.Various numerical experiments are provided to demonstrate the effectiveness and robustness of our algorithms.