Clinicopathological analysis of small intestinal metastasis from extra-abdominal/extra-pelvic malignancy

BACKGROUND The metastatic tumors in the small intestine secondary to extra-abdominal/extrapelvic malignancy are extremely rare.However,the small intestine metastases are extremely prone to misdiagnosis and missed diagnosis due to the lack of specific clinical manifestations and examination methods,thus delaying its treatment.Therefore,in order to improve clinical diagnosis and treatment capabilities,it is necessary to summarize its clinical pathological characteristics and prognosis.AIM To summarize the clinicopathological characteristics of patients with small intestinal metastases from extra-abdominal/extra-pelvic malignancy,and to improve the clinical capability of diagnosis and treatment for rare metastatic tumors in the small intestine.METHODS The clinical data of patients with small intestinal metastases from extra-abdominal/extra-pelvic malignancy were retrieved and summarized,who admitted to and treated in the Air Force Medical Center,Chinese People’s Liberation Army.Then descriptive statistics were performed on the general conditions,primary tumors,secondary tumors in the small intestine,diagnosis and treatment processes,and prognosis.RESULTS Totally 11 patients(9 males and 2 females)were enrolled in this study,including 8 cases(72.3%)of primary lung cancer,1 case(9.1%)of malignant lymphoma of the thyroid,1 case(9.1%)of cutaneous malignant melanoma,and 1 case(9.1%)of testicular cancer.The median age at the diagnosis of primary tumors was 57.9 years old,the median age at the diagnosis of metastatic tumors in the small intestine was 58.81 years old,and the average duration from initial diagnosis of primary tumors to definite diagnosis of small intestinal metastases was 9 months(0-36 months).Moreover,small intestinal metastases was identified at the diagnosis of primary tumors in 4 cases.The small intestinal metastases were distributed in the jejunum and ileum,with such clinical manifestations as hematochezia(5,45.4%)and abdominal pain,vomiting and other obstruction(4,36.4%).In addition,2 patients had no obvious symptoms at the diagnosis of small intestinal metastases,and 5 patients underwent radical resection of small intestinal malignancies and recovered well after surgery.A total of 3 patients did not receive subsequent treatment due to advanced conditions.CONCLUSION Small intestinal metastases of extra-abdominal/extra-pelvic malignancy is rare with high malignancy and great difficulty in diagnosis and treatment.Clinically,patients with extra-abdominal/extra-pelvic malignancy should be alert to the occurrence of this disease,and their prognosis may be improved through active surgery combined with standard targeted therapy.

Explainable Neural Network for Sensitivity Analysis of Lithium-ion Battery Smart Production

Battery production is crucial for determining the quality of electrode,which in turn affects the manufactured battery performance.As battery production is complicated with strongly coupled intermediate and control parameters,an efficient solution that can perform a reliable sensitivity analysis of the production terms of interest and forecast key battery properties in the early production phase is urgently required.This paper performs detailed sensitivity analysis of key production terms on determining the properties of manufactured battery electrode via advanced data-driven modelling.To be specific,an explainable neural network named generalized additive model with structured interaction(GAM-SI)is designed to predict two key battery properties,including electrode mass loading and porosity,while the effects of four early production terms on manufactured batteries are explained and analysed.The experimental results reveal that the proposed method is able to accurately predict battery electrode properties in the mixing and coating stages.In addition,the importance ratio ranking,global interpretation and local interpretation of both the main effects and pairwise interactions can be effectively visualized by the designed neural network.Due to the merits of interpretability,the proposed GAM-SI can help engineers gain important insights for understanding complicated production behavior,further benefitting smart battery production.

Comprehensive analysis of gene mutations and mismatch repair in Chinese colorectal cancer patients

BACKGROUND RAS,BRAF,and mismatch repair(MMR)/microsatellite instability(MSI)are crucial biomarkers recommended by clinical practice guidelines for colorectal cancer(CRC).However,their characteristics and influencing factors in Chinese patients have not been thoroughly described.AIM To analyze the clinicopathological features of KRAS,NRAS,BRAF,and PIK3CA mutations and the DNA MMR status in CRC.METHODS We enrolled 2271 Chinese CRC patients at the China-Japan Friendship Hospital.MMR proteins were tested using immunohistochemical analysis,and the KRAS/NRAS/BRAF/PIK3CA mutations were determined using quantitative polymerase chain reaction.Microsatellite status was determined using an MSI detection kit.Statistical analyses were conducted using SPSS software and logistic regression.RESULTS The KRAS,NRAS,BRAF,and PIK3CA mutations were detected in 44.6%,3.4%,3.7%,and 3.9% of CRC patients,respectively.KRAS mutations were more likely to occur in patients with moderate-to-high differentiation.BRAF mutations were more likely to occur in patients with right-sided CRC,poorly differentiated,or no perineural invasion.Deficient MMR(dMMR)was detected in 7.9% of all patients and 16.8% of those with mucinous adenocarcinomas.KRAS,NRAS,BRAF,and PIK3CA mutations were detected in 29.6%,1.1%,8.1%,and 22.3% of patients with dMMR,respectively.The dMMR was more likely to occur in patients with a family history of CRC,aged<50 years,right-sided CRC,poorly differentiated histology,no perineural invasion,and with carcinoma in situ,stage I,or stage II tumors.CONCLUSION This study analyzed the molecular profiles of KRAS,NRAS,BRAF,PIK3CA,and MMR/MSI in CRC,identifying key influencing factors,with implications for clinical management of CRC.

Clinical and molecular significance of homologous recombination deficiency positive non-small cell lung cancer in Chinese population:An integrated genomic and transcriptional analysis

Objective:The clinical significance of homologous recombination deficiency(HRD)in breast cancer,ovarian cancer,and prostate cancer has been established,but the value of HRD in non-small cell lung cancer(NSCLC)has not been fully investigated.This study aimed to systematically analyze the HRD status of untreated NSCLC and its relationship with patient prognosis to further guide clinical care.Methods:A total of 355 treatment-naïve NSCLC patients were retrospectively enrolled.HRD status was assessed using the AmoyDx Genomic Scar Score(GSS),with a score of≥50 considered HRD-positive.Genomic,transcriptomic,tumor microenvironmental characteristics and prognosis between HRD-positive and HRDnegative patients were analyzed.Results:Of the patients,25.1%(89/355)were HRD-positive.Compared to HRD-negative patients,HRDpositive patients had more somatic pathogenic homologous recombination repair(HRR)mutations,higher tumor mutation burden(TMB)(P<0.001),and fewer driver gene mutations(P<0.001).Furthermore,HRD-positive NSCLC had more amplifications in PI3K pathway and cell cycle genes,MET and MYC in epidermal growth factor receptor(EGFR)/anaplastic lymphoma kinase(ALK)mutant NSCLC,and more PIK3CA and AURKA in EGFR/ALK wild-type NSCLC.HRD-positive NSCLC displayed higher tumor proliferation and immunosuppression activity.HRD-negative NSCLC showed activated signatures of major histocompatibility complex(MHC)-II,interferon(IFN)-γand effector memory CD8+T cells.HRD-positive patients had a worse prognosis and shorter progressionfree survival(PFS)to targeted therapy(first-and third-generation EGFR-TKIs)(P=0.042).Additionally,HRDpositive,EGFR/ALK wild-type patients showed a numerically lower response to platinum-free immunotherapy regimens.Conclusions:Unique genomic and transcriptional characteristics were found in HRD-positive NSCLC.Poor prognosis and poor response to EGFR-TKIs and immunotherapy were observed in HRD-positive NSCLC.This study highlights potential actionable alterations in HRD-positive NSCLC,suggesting possible combinational therapeutic strategies for these patients.

Logical Image Acquisition and Analysis of Android Smartphones

Android smartphones largely dominate the smartphone market. For this reason, it is very important to examine these smartphones in terms of digital forensics since they are often used as evidence in trials. It is possible to acquire a physical or logical image of these devices. Acquiring physical and logical images has advantages and disadvantages compared to each other. Creating the logical image is done at the file system level. Analysis can be made on this logical image. Both logical image acquisition and analysis of the image can be done by software tools. In this study, the differences between logical image and physical image acquisition in Android smartphones, their advantages and disadvantages compared to each other, the difficulties that may be encountered in obtaining physical images, which type of image contributes to obtaining more useful and effective data, which one should be preferred for different conditions, and the benefits of having root authority are discussed. The practice of getting the logical image of the Android smartphones and making an analysis on the image is also included. Although root privileges are not required for logical image acquisition, it has been observed that very limited data will be obtained with the logical image created without root privileges. Nevertheless, logical image acquisition has advantages too against physical image acquisition.

A CSMA/CA based MAC protocol for hybrid Power-line/Visible-light communication networks:Design and analysis

Hybrid Power-line/Visible-light Communication(HPVC)network has been one of the most promising Cooperative Communication(CC)technologies for constructing Smart Home due to its superior communication reliability and hardware efficiency.Current research on HPVC networks focuses on the performance analysis and optimization of the Physical(PHY)layer,where the Power Line Communication(PLC)component only serves as the backbone to provide power to light Emitting Diode(LED)devices.So designing a Media Access Control(MAC)protocol remains a great challenge because it allows both PLC and Visible Light Communication(VLC)components to operate data transmission,i.e.,to achieve a true HPVC network CC.To solve this problem,we propose a new HPC network MAC protocol(HPVC MAC)based on Carrier Sense Multiple Access/Collision Avoidance(CSMA/CA)by combining IEEE 802.15.7 and IEEE 1901 standards.Firstly,we add an Additional Assistance(AA)layer to provide the channel selection strategies for sensor stations,so that they can complete data transmission on the selected channel via the specified CSMA/CA mechanism,respectively.Based on this,we give a detailed working principle of the HPVC MAC,followed by the construction of a joint analytical model for mathematicalmathematical validation of the HPVC MAC.In the modeling process,the impacts of PHY layer settings(including channel fading types and additive noise feature),CSMA/CA mechanisms of 802.15.7 and 1901,and practical configurations(such as traffic rate,transit buffer size)are comprehensively taken into consideration.Moreover,we prove the proposed analytical model has the solvability.Finally,through extensive simulations,we characterize the HPVC MAC performance under different system parameters and verify the correctness of the corresponding analytical model with an average error rate of 4.62%between the simulation and analytical results.

Analysis and Innovative Strategies of Tax Preferential Policies to Promote the Sustainable Development of Small-Scale Individual Businesses

This study conducted an in-depth analysis of the current tax preferential policies for small-scale individual businesses and compared them with similar policies both domestically and internationally,aiming to reveal the advantages and disadvantages of the current system.After examining the impact of these tax preferential policies on the economic status of individual business owners and the broader social economy,this article proposes a set of innovative tax preferential strategies based on theoretical foundations.By developing these innovative strategies and clarifying their implementation paths,the aim is to promote the sustainable and healthy development of small-scale individual businesses,thereby fostering comprehensive socio-economic progress.The conclusion of this study not only summarizes policy recommendations with practical significance but also provides theoretical support for the optimization and innovation of future related systems.

SMA碟簧群的循环受压性能及简化模型

该研究提出将多个形状记忆合金(SMA)碟簧片并联排列形成碟簧组,然后在碟簧组间加入垫片分隔、串联排列形成碟簧群,以提供更高的承载力及变形能力。采用有限元软件ABAQUS建立了一系列SMA碟簧群的三维精细化有限元模型,并进行非线性循环受压分析。结果表明:与钢碟簧的“三角形”荷载-位移曲线相比,SMA碟簧群的荷载-位移曲线呈现鲜明的“旗帜形”特性,具有明显的正向及反向转变平台。随着碟簧片数的增加,碟簧组的总可恢复变形量基本不变,极限承载力及割线刚度近似成比例增加,而随着碟簧组数的增加,碟簧群的总可恢复变形量增加,极限承载力不变,割线刚度近似成比例降低。因此,可根据碟簧群总极限承载力及变形能力的需要,灵活调整碟簧片及碟簧组的数量及布置方式。碟簧组的各层碟簧片由于边界条件不同,应力分布存在明显差异,而变形量亦呈现两端大中间小的哑铃形分布模式,其中加载端碟簧片变形量最大,若超过极限变形量可能发生翻转失效,值得注意。提出了SMA碟簧群的简化模型,通过简化及精细模型的非线性循环受压分析,发现该简化模型的循环受压荷载-位移曲线与精细模型吻合良好,而计算效率提高约38倍。将SMA碟簧群应用于自复位NZ梁柱节点中,并对自复位钢框架进行了验证性的滞回分析。结果表明:采用SMA碟簧群的自复位钢框架最大侧移为4%时可完全复位,且二次刚度相比采用预应力钢绞线的传统自复位钢框架提高近100%,极限承载力提高70%。

高速公路改性沥青SMA上面层施工技术及应用效果

为研究高速公路改性沥青SMA上面层施工技术,提高沥青路面行车的舒适性和安全性,依托实际工程,介绍了改性沥青SMA上面层原材料的各项指标要求,研究了改性沥青SMA上面层的施工技术要点,并进行严格的施工质量检测。

SMA限位对铁路自复位桥墩地震反应的影响

为研究形状记忆合金(SMA)对铁路自复位桥墩地震反应的影响,在已验证的两弹簧模型上增加SMA限位单元,以某铁路桥墩为工程背景,基于OpenSees平台建立数值分析模型,通过输入3条强震记录,采用非线性时程分析方法进行SMA限位的桥墩影响分析。讨论SMA限位装置关键参数初始间隙、初始预加力变化对墩顶位移和墩底弯矩的影响规律,并与预应力钢筋限位进行比较。研究结果表明:在普通地震动El-Centro与Taft波下,自复位桥墩的墩顶位移随限位装置初始间隙δ减小而减小,墩底弯矩随初始间隙δ减小而增大;随SMA限位装置初始预加力增大,自复位桥墩的墩顶位移减小,墩底弯矩增大。在近断层地震动Northridge下,SMA限位对自复位桥墩地震反应的影响复杂。在3条强震记录下,与预应力筋限位相比,SMA限位会减小墩底弯矩,增大墩顶水平位移。

SMA绞线预制梁-柱自复位耗能节点数值研究与参数优化

为了提高预制混凝土框架的抗震能力并控制震后残余变形,提出了一种新型的混合自复位预制混凝土梁柱节点(self-centring precast concrete beam-column connection,SC-PCBCC),其中采用了旋转摩擦阻尼器(rotational friction hinge damper,RFHD)和形状记忆合金(shape memory alloy,SMA)并联的结构。重点探讨了使用SMA绞线控制的自复位装置对SC-PCBCC进行改进。首先,介绍了SC-PCBCC的结构和工作原理;其次验证对比了1.0%、1.5%、2%和2.0%预应变下的超弹性1×7 SMA绞线、RFHD和SC-PCBCC的有限元模型,并进行了初步验证。研究结果表明,该节点具有较高的刚度、承载力、耗能能力以及较好的复位性能;最后对SC-PCBCC中SMA绞线的关键参数:SMA绞线预应变、直径和长度进行了参数分析,以优化其抗震性能。建议SC-PCBCC使用的SMA绞线初始预应变、直径和长度范围分别为1.5%~2.0%、15~18 mm和175~205 mm,以实现SC-PCBCC的优异承载性能、能量耗散和自复位性能。此外,节点中的SMA绞线和RFHD可在震后快速更换,实现高效灾后修复。总体而言,所提出的SC-PCBCC表现出了卓越的减震能力、自复位能力和可修复性。

Screening biomarkers for spinal cord injury using weighted gene co-expression network analysis and machine learning

Immune changes and inflammatory responses have been identified as central events in the pathological process of spinal co rd injury.They can greatly affect nerve regeneration and functional recovery.However,there is still limited understanding of the peripheral immune inflammato ry response in spinal cord inju ry.In this study.we obtained microRNA expression profiles from the peripheral blood of patients with spinal co rd injury using high-throughput sequencing.We also obtained the mRNA expression profile of spinal cord injury patients from the Gene Expression Omnibus(GEO)database(GSE151371).We identified 54 differentially expressed microRNAs and 1656 diffe rentially expressed genes using bioinformatics approaches.Functional enrichment analysis revealed that various common immune and inflammation-related signaling pathways,such as neutrophil extracellular trap formation pathway,T cell receptor signaling pathway,and nuclear factor-κB signal pathway,we re abnormally activated or inhibited in spinal cord inju ry patient samples.We applied an integrated strategy that combines weighted gene co-expression network analysis,LASSO logistic regression,and SVM-RFE algorithm and identified three biomarke rs associated with spinal cord injury:ANO10,BST1,and ZFP36L2.We verified the expression levels and diagnostic perfo rmance of these three genes in the original training dataset and clinical samples through the receiver operating characteristic curve.Quantitative polymerase chain reaction results showed that ANO20 and BST1 mRNA levels were increased and ZFP36L2 mRNA was decreased in the peripheral blood of spinal cord injury patients.We also constructed a small RNA-mRNA interaction network using Cytoscape.Additionally,we evaluated the proportion of 22 types of immune cells in the peripheral blood of spinal co rd injury patients using the CIBERSORT tool.The proportions of naive B cells,plasma cells,monocytes,and neutrophils were increased while the proportions of memory B cells,CD8^(+)T cells,resting natural killer cells,resting dendritic cells,and eosinophils were markedly decreased in spinal cord injury patients increased compared with healthy subjects,and ANO10,BST1 and ZFP26L2we re closely related to the proportion of certain immune cell types.The findings from this study provide new directions for the development of treatment strategies related to immune inflammation in spinal co rd inju ry and suggest that ANO10,BST2,and ZFP36L2 are potential biomarkers for spinal cord injury.The study was registe red in the Chinese Clinical Trial Registry(registration No.ChiCTR2200066985,December 12,2022).

Social-ecological perspective on the suicidal behaviour factors of early adolescents in China:a network analysis

Background In early adolescence,youth are highly prone to suicidal behaviours.Identifying modifiable risk factors during this critical phase is a priority to inform effective suicide prevention strategies.Aims To explore the risk and protective factors of suicidal behaviours(ie,suicidal ideation,plans and attempts)in early adolescence in China using a social-ecological perspective.Methods Using data from the cross-sectional project‘Healthy and Risky Behaviours Among Middle School Students in Anhui Province,China',stratified random cluster sampling was used to select 5724 middle school students who had completed self-report questionnaires in November 2020.Network analysis was employed to examine the correlates of suicidal ideation,plans and attempts at four levels,namely individual(sex,academic performance,serious physical llness/disability,history of self-harm,depression,impulsivity,sleep problems,resilience),family(family economic status,relationship with mother,relationship with father,family violence,childhood abuse,parental mental illness),school(relationship with teachers,relationship with classmates,school-bullying victimisation and perpetration)and social(social support,satisfaction with society).Results In total,37.9%,19.0%and 5.5%of the students reported suicidal ideation,plans and attempts in the past 6 months,respectively.The estimated network revealed that suicidal ideation,plans and attempts were collectively associated with a history of self-harm,sleep problems,childhood abuse,school bullying and victimisation.Centrality analysis indicated that the most influential nodes in the network were history of self-harm and childhood abuse.Notably,the network also showed unique correlates of suicidal ideation(sex,weight=0.60;impulsivity,weight=0.24;family violence,weight=0.17;relationship with teachers,weight=-0.03;school-bullying perpetration,weight=0.22),suicidal plans(social support,weight=-0.15)and suicidal attempts(relationship with mother,weight=-0.10;parental mental llness,weight=0.61).Conclusions This study identified the correlates of suicidal ideation,plans and attempts,and provided practical implications for suicide prevention for young adolescents in China.Firstly,this study highlighted the importance of joint interventions across multiple departments.Secondly,the common risk factors of suicidal ideation,plans and attempts were elucidated.Thirdly,this study proposed target interventions to address the unique influencing factors of suicidal ideation,plans and attempts.

沥青玛蹄脂碎石混合料(SMA-10)配合比设计

沥青玛蹄脂碎石混合料因其良好的耐久性、抗疲劳性和高温稳定性,在高等级公路工程中得到了广泛的应用,但其设计繁琐,为更好地发挥骨架密实型结构,本文在三多一少级配设计特点下,添加纤维以提高骨架加筋效果,结果表明:通过对沥青玛蹄脂混合料SMA-10配合比设计的三个阶段,SMA-10沥青混合料最佳沥青用量为6.1%,木质素纤维(沥青混合料质量%)0.3%时,以实际工程为依据,所制备的SMA-10混合料高温稳定性达4 195次/mm、水稳定度在85%以上,冻融劈裂强度大于80%均符合规范,能够满足道路工程的要求。达到了优化配合比的目的,对提高沥青路面的使用性能和使用寿命具有实际意义。

Advances in microfluidic-based DNA methylation analysis

DNA methylation has been extensively investigated in recent years,not least because of its known relationship with various diseases.Progress in analytical methods can greatly increase the relevance of DNA methylation studies to both clinical medicine and scientific research.Microflu-idic chips are excellent carriers for molecular analysis,and their use can provide improvements from multiple aspects.On-chip molecular analysis has received extensive attention owing to its advantages of portability,high throughput,low cost,and high efficiency.In recent years,the use of novel microfluidic chips for DNA methylation analysis has been widely reported and has shown obvious superiority to conventional methods.In this review,wefirst focus on DNA methylation and its applications.Then,we discuss advanced microfluidic-based methods for DNA methylation analysis and describe the great progress that has been made in recent years.Finally,we summarize the advantages that microfluidic technology brings to DNA methylation analysis and describe several challenges and perspectives for on-chip DNA methylation analysis.This review should help researchers improve their understanding and make progress in developing microfluidic-based methods for DNA methylation analysis.

A Review on Sources,Extractions and Analysis Methods of a Sustainable Biomaterial:Tannins

Condensed and hydrolysable tannins are non-toxic natural polyphenols that are a commercial commodity industrialized for tanning hides to obtain leather and for a growing number of other industrial applications mainly to substitute petroleum-based products.They are a definite class of sustainable materials of the forestry industry.They have been in operation for hundreds of years to manufacture leather and now for a growing number of applications in a variety of other industries,such as wood adhesives,metal coating,pharmaceutical/medical applications and several others.This review presents the main sources,either already or potentially commercial of this forestry by-materials,their industrial and laboratory extraction systems,their systems of analysis with their advantages and drawbacks,be these methods so simple to even appear primitive but nonetheless of proven effectiveness,or very modern and instrumental.It constitutes a basic but essential summary of what is necessary to know of these sustainable materials.In doing so,the review highlights some of the main challenges that remain to be addressed to deliver the quality and economics of tannin supply necessary to fulfill the industrial production requirements for some materials-based uses.

建筑SMA/橡胶复合型隔震支座老化性能的研究

研究建筑形状记忆合金(SMA)/橡胶复合型隔震橡胶支座的老化性能。结果表明:丁腈橡胶(NBR)/溴化丁基橡胶(BIIR)并用比为45/55的并用胶的耐热老化性能最佳;采用最佳并用比的NBR/BIIR并用胶的建筑SMA/橡胶复合型隔震支座热老化后的滞回曲线变化较小,即其水平力学性能稳定,而紫外线照射和温度对其性能有影响,但影响有限,可以通过增加遮蔽物来降低紫外线照射和温度的影响,以延长使用寿命。

超声冲击对SMA490BW耐候钢焊接接头腐蚀疲劳的影响

采用USP-300超声表面加工装置对SMA490BW耐候钢表面进行超声冲击处理。研究超声冲击前后试件的显微组织、显微硬度和残余应力,比较超声冲击前后SMA490BW耐候钢焊接接头的腐蚀速率和腐蚀疲劳寿命。通过光学显微镜观察超声冲击后SMA490BW耐候钢的显微组织,采用测试仪器测试焊接接头的表面硬度和残余应力,分析超声冲击提高SMA490BW耐候钢抗腐蚀性及其疲劳寿命的机理。结果表明,超声冲击处理能使材料表层晶粒细化形成致密的塑性变形层,提高显微硬度,并在材料表面引入有效的残余压应力,降低腐蚀速率,减小失重量。同时,超声冲击处理后裂纹扩展路径变得更加复杂,裂纹扩展速率降低,焊接接头腐蚀疲劳寿命得到提高。

Lagrangian coherent structure analysis on transport of Acetes chinensis along coast of Lianyungang,China

Spatial heterogeneity or“patchiness”of plankton distributions in the ocean has always been an attractive and challenging scientific issue to oceanographers.We focused on the accumulation and dynamic mechanism of the Acetes chinensis in the Lianyungang nearshore licensed fishing area.The Lagrangian frame approaches including the Lagrangian coherent structures theory,Lagrangian residual current,and Lagrangian particle-tracking model were applied to find the transport pathways and aggregation characteristics of Acetes chinensis.There exist some material transport pathways for Acetes chinensis passing through the licensed fishing area,and Acetes chinensis is easy to accumulate in the licensed fishing area.The main mechanism forming this distribution pattern is the local circulation induced by the nonlinear interaction of topography and tidal flow.Both the Lagrangian coherent structure analysis and the particle trajectory tracking indicate that Acetes chinensis in the licensed fishing area come from the nearshore estuary.This work contributed to the adjustment of licensed fishing area and the efficient utilization of fishery resources.

Iron and ferritin effects on intensive care unit mortality:A metaanalysis

BACKGROUND The effect of serum iron or ferritin parameters on mortality among critically ill patients is not well characterized.AIM To determine the association between serum iron or ferritin parameters and mortality among critically ill patients.METHODS Web of Science,Embase,PubMed,and Cochrane Library databases were searched for studies on serum iron or ferritin parameters and mortality among critically ill patients.Two reviewers independently assessed,selected,and abstracted data from studies reporting on serum iron or ferritin parameters and mortality among critically ill patients.Data on serum iron or ferritin levels,mortality,and demographics were extracted.RESULTS Nineteen studies comprising 125490 patients were eligible for inclusion.We observed a slight negative effect of serum ferritin on mortality in the United States population[relative risk(RR)1.002;95%CI:1.002-1.004].In patients with sepsis,serum iron had a significant negative effect on mortality(RR=1.567;95%CI:1.208-1.925).CONCLUSION This systematic review presents evidence of a negative correlation between serum iron levels and mortality among patients with sepsis.Furthermore,it reveals a minor yet adverse impact of serum ferritin on mortality among the United States population.