Objective:To assess the feasibility of coronary angiography by transradial approach with 4F catheter.Methods:The procedural details,picture quality,local complication were recorded for coronary by transradial approach...Objective:To assess the feasibility of coronary angiography by transradial approach with 4F catheter.Methods:The procedural details,picture quality,local complication were recorded for coronary by transradial approach with 4F catheter in 138 patients.Results:The success rate of angiography was 97.7%;fluoroscopy time was(5.05±3.23)minutes,total procedural time was(20.51±3.37)minutes;the incidence of dislodgement,excessive engagement of either coronary artery was 7.8%,9.4%,repectively;the angiographic scores for left anterior descending,circumflex and right coronary arteries were(2.87±0.40),(2.88±0.39),(2.90±0.35),respectively.The spasm complication occurred 4.3% in radial artery and 1.5% in coronary artery.There were no occlusion of radial artery during follow up.Conclusion:4F catheter could be the first chosen in some selecting patients for its nice maneuverability,fine images and fewer vascular complications.展开更多
Feasibility analysis of soft constraints for input and output variables is critical for model predictive control(MPC).When encountering the infeasible situation, some way should be found to adjust the constraints to g...Feasibility analysis of soft constraints for input and output variables is critical for model predictive control(MPC).When encountering the infeasible situation, some way should be found to adjust the constraints to guarantee that the optimal control law exists. For MPC integrated with soft sensor, considering the soft constraints for critical variables additionally makes it more complicated and difficult for feasibility analysis and constraint adjustment. Therefore, the main contributions are that a linear programming approach is proposed for feasibility analysis, and the corresponding constraint adjustment method and procedure are given as well. The feasibility analysis gives considerations to the manipulated, secondary and critical variables, and the increment of manipulated variables as well. The feasibility analysis and the constraint adjustment are conducted in the entire control process and guarantee the existence of optimal control. In final, a simulation case confirms the contributions in this paper.展开更多
The energy efficient product can be operated with longer duration.They offer wonderful solutions compared to other conventional water pumping system as it needs less maintenance,simple in installation,zero fuel cost,l...The energy efficient product can be operated with longer duration.They offer wonderful solutions compared to other conventional water pumping system as it needs less maintenance,simple in installation,zero fuel cost,longer operating life,highly reliable and free from production of greenhouse gases.In this paper we analyzed the different topologies of DC–DC converter in terms of their operating region of MPPT,quality of input and output currents.We discussed the MPPT algorithms to address partial shading effects in SPV array,present state of the technology,factors affecting the performance of the system,efficiency improvements and identified the research gaps.Also,the economic feasibility analysis has been done for the real time scenario using the Homer Pro software.The estimation of total dynamic head and horse power calculation has been done to decide the total load capacity.The economic analysis results such as cumulative cash flow over project lifetime of 25 years are presented.It is observed that the capital investment requirement is$7,425 for installing Fronius PV system that has a nominal capacity of 2.47 kW and annualized savings will be$134.93.In the long-term perspective,the return on investment is−2.18%as per the present tariff plan.展开更多
In this paper,the anti-tumor effects of Aconiti Radix were reviewed and summarized,and the clinical feasibility of Aconiti Radix as a potential anti-tumor drug was analyzed,in order to provide a useful reference for t...In this paper,the anti-tumor effects of Aconiti Radix were reviewed and summarized,and the clinical feasibility of Aconiti Radix as a potential anti-tumor drug was analyzed,in order to provide a useful reference for the future research and development of new anti-cancer drugs of Aconiti Radix.展开更多
Projects for energy supply based on the exploitation of renewable energy have a very predictable cash flow. The initial costs are usually high, with the acquisition of technologically evolving equipment. However, main...Projects for energy supply based on the exploitation of renewable energy have a very predictable cash flow. The initial costs are usually high, with the acquisition of technologically evolving equipment. However, maintenance costs are relatively low and easily predictable. Likewise, operating costs are often very low as there is no need to buy inputs. Power storage devices are often short-lived and contribute to a relative cost increase. At the same time, these projects are often not approved because they are directly compared to projects based on non-renewable resources, with cash flows that may not be so easily predictable and with much lower start-up costs. Fossil fuels have hardly predictable costs, established by non-technical criteria and related to geopolitical issues. In addition, their operating costs are usually very high, precisely because of the need to purchase fossil fuels. This paper proposes the calculation of terminal value in cash flows of power generation projects and its application for feasibility analysis of projects based on renewable resources. The proposed method suggests the calculation of terminal value as the moving average calculated for five-year intervals with constant growth rate of 5%. This method also encourages the inclusion in the cash flow of annual values that add up to the end of the analysis period the sufficient value to renew the system components at the end of the usual analysis period of 20 - 25 years. The application of the proposed method to a diesel wind system simulated with the well-known Homer software indicates the modification of the results of the Homer with the preference for systems with greater wind penetration instead of the systems with greater consumption of fossil fuels.展开更多
Though numerous English learning researches have been done for English majors,there is not fairly enough analysis ofEnglish mobile micro learning especially in vocabulary.Based on the condition,the author tries to ana...Though numerous English learning researches have been done for English majors,there is not fairly enough analysis ofEnglish mobile micro learning especially in vocabulary.Based on the condition,the author tries to analyze the feasibility of Englishmajors’vocabulary learning via mobile devices based on mobile micro learning mode in the way of questionnaire survey.In theend,the result of the research proves that it could be feasible to adopt mobile micro learning mode in English majors’vocabularylearning.展开更多
Relative navigation is crucial for spacecraft noncooperative rendezvous,and angles-only navigation using visible and infrared cameras provides a feasible solution.Herein,an angles-only navigation algorithm with multis...Relative navigation is crucial for spacecraft noncooperative rendezvous,and angles-only navigation using visible and infrared cameras provides a feasible solution.Herein,an angles-only navigation algorithm with multisensor data fusion is proposed to derive the relative motion states between two noncooperative spacecraft.First,the design model of the proposed algorithm is introduced,including the derivation of the state propagation and measurement equations.Subsequently,models for the sensor and actuator are introduced,and the effects of various factors on the sensors and actuators are considered.The square-root unscented Kalman filter is used to design the angles-only navigation filtering scherne.Additionally,the Clohessy-Wiltshire terminal guidance algorithm is introducedto obtain the theoretical relative motion trajectories during the rendezvous operations of two noncooperative spacecraft.Finally,the effectiveness of the proposed angles-only navigation algorithm is verified using a semi-physical simulation platform.The results prove that an optical navigation camera combined with average accelerometers and occasional orbital maneuvers is feasible for spacecraft noncooperative rendezvous using angles-only navigation.展开更多
With the extending scale of agricultural production,the treatment and utilization of waste have become increasingly serious environmental problem.Taking city garden and Zhongnan pasture in Pujiang Town of Minhang Dist...With the extending scale of agricultural production,the treatment and utilization of waste have become increasingly serious environmental problem.Taking city garden and Zhongnan pasture in Pujiang Town of Minhang District in Shanghai for example,according to the analysis on discharge characteristic of waste and balance of resources and energy utilization,mixed anaerobic digestion was chosen to dispose waste based on government guidance and feasibility analysis of project,and the combining disposal and resource utilization of waste were realized in two enterprises,providing reference for close cases.展开更多
In this paper, the discussion is concentrated on the properties of the polluted sediments and the combination of clean-up and disposal process for the upper layer heavily polluted sediments with good flowability. Base...In this paper, the discussion is concentrated on the properties of the polluted sediments and the combination of clean-up and disposal process for the upper layer heavily polluted sediments with good flowability. Based on the systematic analyses of various clean-up processes, a suitable engineering process has been evaluated and recommended. The process has been applied to the river reclamation in Yangpu District of Shanghai City, China. An improved centrifuge is used for dewatering the dredged sludge, which plays an important role in the combination of clean-up and disposal process. The assessment of the engineering process shows its environmental and technical economy feasibility, which is much better than that of traditional dredging-disposal processes.展开更多
With the development of anti-radiation weapons,the effectiveness evaluation of anti-radiation weapons has been turned from the simple accuracy index to the integrated countermeasure capability.The research priority is...With the development of anti-radiation weapons,the effectiveness evaluation of anti-radiation weapons has been turned from the simple accuracy index to the integrated countermeasure capability.The research priority is how to access the combat effectiveness of anti-radiation weapons in a complex countermeasure environment.For the present situation of range test of anti-radiation weapons,a combat effectiveness assessment model based on non-linear index aggregation is proposed for anti-radiation weapons.And the corresponding index system model,index aggregation methods,index marking method and index weight determination are given.Finally,the simulation results verify the efficiency and feasibility of the proposed method.展开更多
The organization of coordinated attack and the selection of aiming point which affect hit probability were analyzed for the countermeasures taken by the hostile submarines at two helicopters' coordinated attack.A ...The organization of coordinated attack and the selection of aiming point which affect hit probability were analyzed for the countermeasures taken by the hostile submarines at two helicopters' coordinated attack.A computational model of coordinated attack parameters,a model of submarine maneuver,and a model of noise jammer were established.Compared to single helicopter' torpedo attack,the coordinated attack of two helicopters can effectively increase the hit probability of torpedo and achieve the higher target detecting probability under counterwork condition.展开更多
Utilizing anaerobic metabolisms for the production of biotechnologically relevant products presents potential advantages,such as increased yields and reduced energy dissipation.However,lower energy dissipation may ind...Utilizing anaerobic metabolisms for the production of biotechnologically relevant products presents potential advantages,such as increased yields and reduced energy dissipation.However,lower energy dissipation may indicate that certain reactions are operating closer to their thermodynamic equilibrium.While stoichiometric analyses and genetic modifications are frequently employed in metabolic engineering,the use of thermodynamic tools to evaluate the feasibility of planned interventions is less documented.In this study,we propose a novel metabolic engineering strategy to achieve an efficient anaerobic production of poly-(R)-3-hydroxybutyrate(PHB)in the model organism Escherichia coli.Our approach involves re-routing of two-thirds of the glycolytic flux through non-oxidative glycolysis and coupling PHB synthesis with NADH re-oxidation.We complemented our stoichiometric analysis with various thermodynamic approaches to assess the feasibility and the bottlenecks in the proposed engineered pathway.According to our calculations,the main thermodynamic bottleneck are the reactions catalyzed by the acetoacetyl-CoAβ-ketothiolase(EC 2.3.1.9)and the acetoacetyl-CoA reductase(EC 1.1.1.36).Furthermore,we calculated thermodynamically consistent sets of kinetic parameters to determine the enzyme amounts required for sustaining the conversion fluxes.In the case of the engineered conversion route,the protein pool necessary to sustain the desired fluxes could account for 20%of the whole cell dry weight.展开更多
Cropping systems worldwide have been affected by the current trend in global warming and the optimization of cropping systems is an important area of research in the transition of agricultural land. The Loess Plateau ...Cropping systems worldwide have been affected by the current trend in global warming and the optimization of cropping systems is an important area of research in the transition of agricultural land. The Loess Plateau is a typical ecologically fragile region with the most serious soil erosion in China. We carried out a field experiment in Yan’an city on the Loess Plateau to explore the effect of sowing date on crop growth and yield. We then analyzed the feasibility of a double-cropping system by considering climatic adaptability, ecological suitability and economic viability. Our results showed that different sowing dates resulted in significant differences in crop growth and that appropriate early sowing can result in higher crop yields for early maturing varieties. We showed that double-cropping systems of sweet maize(Zea mays)–forage rape and feed maize–forage rape are feasible on the Loess Plateau. We discuss the implications for the efficient use of farmland, which is important in guiding agricultural supply-side reform and the development of modern agricultural management.展开更多
In the traditional extractive distillation process,organic solvents are often used as entrainers.However,environmental influence and high energy-consumption are significant problems in industrial application.In this s...In the traditional extractive distillation process,organic solvents are often used as entrainers.However,environmental influence and high energy-consumption are significant problems in industrial application.In this study,a systematic screening strategy and innovative energy-saving design for ionic liquid-based extractive distillation process was proposed.The innovative energy-saving design focused on the binary minimum azeotrope mixtures isopropanol and water.Miscibility,environmental impact and physical properties(e.g.,melting point and viscosity)of 30 ionic liquids were investigated.1-Ethyl-3-methyl-imidazolium dicyanamide and 1-butyl-3-methyl-imidazolium dicyanamide were selected as candidate entrainers.Feasibility analysis of these two ionic liquids was further performed via residue curve maps,isovolatility line and temperature profiles.An innovative ionic liquid-based extractive distillation process combining distillation column and stripping column was designed and optimized with the objective function of minimizing the total annualized cost.The results demonstrate that the total annualized cost was reduced by 19.9%with 1-ethyl-3-methyl-imidazolium dicyanamide as the entrainer and by 24.3%with 1-butyl-3-methyl-imidazolium dicyanamide,compared with that of dimethyl sulfoxide.The method proposed in this study is conducive to the green and sustainable development of extractive distillation process.展开更多
文摘Objective:To assess the feasibility of coronary angiography by transradial approach with 4F catheter.Methods:The procedural details,picture quality,local complication were recorded for coronary by transradial approach with 4F catheter in 138 patients.Results:The success rate of angiography was 97.7%;fluoroscopy time was(5.05±3.23)minutes,total procedural time was(20.51±3.37)minutes;the incidence of dislodgement,excessive engagement of either coronary artery was 7.8%,9.4%,repectively;the angiographic scores for left anterior descending,circumflex and right coronary arteries were(2.87±0.40),(2.88±0.39),(2.90±0.35),respectively.The spasm complication occurred 4.3% in radial artery and 1.5% in coronary artery.There were no occlusion of radial artery during follow up.Conclusion:4F catheter could be the first chosen in some selecting patients for its nice maneuverability,fine images and fewer vascular complications.
文摘Feasibility analysis of soft constraints for input and output variables is critical for model predictive control(MPC).When encountering the infeasible situation, some way should be found to adjust the constraints to guarantee that the optimal control law exists. For MPC integrated with soft sensor, considering the soft constraints for critical variables additionally makes it more complicated and difficult for feasibility analysis and constraint adjustment. Therefore, the main contributions are that a linear programming approach is proposed for feasibility analysis, and the corresponding constraint adjustment method and procedure are given as well. The feasibility analysis gives considerations to the manipulated, secondary and critical variables, and the increment of manipulated variables as well. The feasibility analysis and the constraint adjustment are conducted in the entire control process and guarantee the existence of optimal control. In final, a simulation case confirms the contributions in this paper.
文摘The energy efficient product can be operated with longer duration.They offer wonderful solutions compared to other conventional water pumping system as it needs less maintenance,simple in installation,zero fuel cost,longer operating life,highly reliable and free from production of greenhouse gases.In this paper we analyzed the different topologies of DC–DC converter in terms of their operating region of MPPT,quality of input and output currents.We discussed the MPPT algorithms to address partial shading effects in SPV array,present state of the technology,factors affecting the performance of the system,efficiency improvements and identified the research gaps.Also,the economic feasibility analysis has been done for the real time scenario using the Homer Pro software.The estimation of total dynamic head and horse power calculation has been done to decide the total load capacity.The economic analysis results such as cumulative cash flow over project lifetime of 25 years are presented.It is observed that the capital investment requirement is$7,425 for installing Fronius PV system that has a nominal capacity of 2.47 kW and annualized savings will be$134.93.In the long-term perspective,the return on investment is−2.18%as per the present tariff plan.
基金Supported by Science and Technology Innovation Plan for Medical Workers in Shandong Province(SDYWZGKCJH2023095)Clinical Pharmacy Research Project of Shandong Provincial Medical Association(YXH2022ZX010)+1 种基金Traditional Chinese Medicine Science and Technology Development Project of Shandong Province(2019-0400&2021Q097)Traditional Chinese Medicine Research Program of Qingdao City(2020-zyy031)Medical Research Guidance Plan of Qingdao City(2020-WJZD087).
文摘In this paper,the anti-tumor effects of Aconiti Radix were reviewed and summarized,and the clinical feasibility of Aconiti Radix as a potential anti-tumor drug was analyzed,in order to provide a useful reference for the future research and development of new anti-cancer drugs of Aconiti Radix.
基金This work was developed as a part of research activities on renewable energy developed at the Instituto de Pesquisas Hidráulicas,Universidade Federal do Rio Grande do SulThe authors acknowledge the support received by the institutionThe second author acknowledges the financial support received from CNPq(proc.n.309021/2014-6)for his research work.
文摘Projects for energy supply based on the exploitation of renewable energy have a very predictable cash flow. The initial costs are usually high, with the acquisition of technologically evolving equipment. However, maintenance costs are relatively low and easily predictable. Likewise, operating costs are often very low as there is no need to buy inputs. Power storage devices are often short-lived and contribute to a relative cost increase. At the same time, these projects are often not approved because they are directly compared to projects based on non-renewable resources, with cash flows that may not be so easily predictable and with much lower start-up costs. Fossil fuels have hardly predictable costs, established by non-technical criteria and related to geopolitical issues. In addition, their operating costs are usually very high, precisely because of the need to purchase fossil fuels. This paper proposes the calculation of terminal value in cash flows of power generation projects and its application for feasibility analysis of projects based on renewable resources. The proposed method suggests the calculation of terminal value as the moving average calculated for five-year intervals with constant growth rate of 5%. This method also encourages the inclusion in the cash flow of annual values that add up to the end of the analysis period the sufficient value to renew the system components at the end of the usual analysis period of 20 - 25 years. The application of the proposed method to a diesel wind system simulated with the well-known Homer software indicates the modification of the results of the Homer with the preference for systems with greater wind penetration instead of the systems with greater consumption of fossil fuels.
文摘Though numerous English learning researches have been done for English majors,there is not fairly enough analysis ofEnglish mobile micro learning especially in vocabulary.Based on the condition,the author tries to analyze the feasibility of Englishmajors’vocabulary learning via mobile devices based on mobile micro learning mode in the way of questionnaire survey.In theend,the result of the research proves that it could be feasible to adopt mobile micro learning mode in English majors’vocabularylearning.
基金supported by the China Aerospace Science and Technology Corporation Eighth Research Institute Industry-University-Research Cooperation Fund(SAST 2020-019).
文摘Relative navigation is crucial for spacecraft noncooperative rendezvous,and angles-only navigation using visible and infrared cameras provides a feasible solution.Herein,an angles-only navigation algorithm with multisensor data fusion is proposed to derive the relative motion states between two noncooperative spacecraft.First,the design model of the proposed algorithm is introduced,including the derivation of the state propagation and measurement equations.Subsequently,models for the sensor and actuator are introduced,and the effects of various factors on the sensors and actuators are considered.The square-root unscented Kalman filter is used to design the angles-only navigation filtering scherne.Additionally,the Clohessy-Wiltshire terminal guidance algorithm is introducedto obtain the theoretical relative motion trajectories during the rendezvous operations of two noncooperative spacecraft.Finally,the effectiveness of the proposed angles-only navigation algorithm is verified using a semi-physical simulation platform.The results prove that an optical navigation camera combined with average accelerometers and occasional orbital maneuvers is feasible for spacecraft noncooperative rendezvous using angles-only navigation.
基金Supported by Science and Technology Planning Project of Science Committee Science Committee(08DZ1980902)~~
文摘With the extending scale of agricultural production,the treatment and utilization of waste have become increasingly serious environmental problem.Taking city garden and Zhongnan pasture in Pujiang Town of Minhang District in Shanghai for example,according to the analysis on discharge characteristic of waste and balance of resources and energy utilization,mixed anaerobic digestion was chosen to dispose waste based on government guidance and feasibility analysis of project,and the combining disposal and resource utilization of waste were realized in two enterprises,providing reference for close cases.
文摘In this paper, the discussion is concentrated on the properties of the polluted sediments and the combination of clean-up and disposal process for the upper layer heavily polluted sediments with good flowability. Based on the systematic analyses of various clean-up processes, a suitable engineering process has been evaluated and recommended. The process has been applied to the river reclamation in Yangpu District of Shanghai City, China. An improved centrifuge is used for dewatering the dredged sludge, which plays an important role in the combination of clean-up and disposal process. The assessment of the engineering process shows its environmental and technical economy feasibility, which is much better than that of traditional dredging-disposal processes.
文摘With the development of anti-radiation weapons,the effectiveness evaluation of anti-radiation weapons has been turned from the simple accuracy index to the integrated countermeasure capability.The research priority is how to access the combat effectiveness of anti-radiation weapons in a complex countermeasure environment.For the present situation of range test of anti-radiation weapons,a combat effectiveness assessment model based on non-linear index aggregation is proposed for anti-radiation weapons.And the corresponding index system model,index aggregation methods,index marking method and index weight determination are given.Finally,the simulation results verify the efficiency and feasibility of the proposed method.
文摘The organization of coordinated attack and the selection of aiming point which affect hit probability were analyzed for the countermeasures taken by the hostile submarines at two helicopters' coordinated attack.A computational model of coordinated attack parameters,a model of submarine maneuver,and a model of noise jammer were established.Compared to single helicopter' torpedo attack,the coordinated attack of two helicopters can effectively increase the hit probability of torpedo and achieve the higher target detecting probability under counterwork condition.
基金supported by the joint research program NWO-FAPESP of the Dutch Organization for Scientific Research(NWO)and the Sao Paulo Research Foundation(FAPESP)(code NWO:BBE.2017.013code FAPESP:2017/50249-6)+1 种基金The contributions of Karel Olavarria and Diana Z.Sousa were also supported by a SIAM Gravitation Grant(024.002.002)from the Dutch Ministry of Education,Culture and Science(OCW)and by the Centre for Living Technologies,a part of the Alliance TU/e,WUR,UU,UMC Utrecht(www.ewuu.nl)The contribution of Mark C.M.van Loosdrecht was supported by the SIAM Gravitation Grant(024.002.002).
文摘Utilizing anaerobic metabolisms for the production of biotechnologically relevant products presents potential advantages,such as increased yields and reduced energy dissipation.However,lower energy dissipation may indicate that certain reactions are operating closer to their thermodynamic equilibrium.While stoichiometric analyses and genetic modifications are frequently employed in metabolic engineering,the use of thermodynamic tools to evaluate the feasibility of planned interventions is less documented.In this study,we propose a novel metabolic engineering strategy to achieve an efficient anaerobic production of poly-(R)-3-hydroxybutyrate(PHB)in the model organism Escherichia coli.Our approach involves re-routing of two-thirds of the glycolytic flux through non-oxidative glycolysis and coupling PHB synthesis with NADH re-oxidation.We complemented our stoichiometric analysis with various thermodynamic approaches to assess the feasibility and the bottlenecks in the proposed engineered pathway.According to our calculations,the main thermodynamic bottleneck are the reactions catalyzed by the acetoacetyl-CoAβ-ketothiolase(EC 2.3.1.9)and the acetoacetyl-CoA reductase(EC 1.1.1.36).Furthermore,we calculated thermodynamically consistent sets of kinetic parameters to determine the enzyme amounts required for sustaining the conversion fluxes.In the case of the engineered conversion route,the protein pool necessary to sustain the desired fluxes could account for 20%of the whole cell dry weight.
基金National Natural Science Foundation of China,No.41931293, No.41801175, No.42201287Postdoctoral Science Foundation of China,No.2020M680658。
文摘Cropping systems worldwide have been affected by the current trend in global warming and the optimization of cropping systems is an important area of research in the transition of agricultural land. The Loess Plateau is a typical ecologically fragile region with the most serious soil erosion in China. We carried out a field experiment in Yan’an city on the Loess Plateau to explore the effect of sowing date on crop growth and yield. We then analyzed the feasibility of a double-cropping system by considering climatic adaptability, ecological suitability and economic viability. Our results showed that different sowing dates resulted in significant differences in crop growth and that appropriate early sowing can result in higher crop yields for early maturing varieties. We showed that double-cropping systems of sweet maize(Zea mays)–forage rape and feed maize–forage rape are feasible on the Loess Plateau. We discuss the implications for the efficient use of farmland, which is important in guiding agricultural supply-side reform and the development of modern agricultural management.
基金supported by the National Natural Science Foundation of China(Grant No.21878028)the Chongqing Joint Chinese Medicine Scientific Research Project(Grant No.2020ZY023984)the Fundamental Research Funds for the Central Universities(Grant No.2022CDJXY-003).
文摘In the traditional extractive distillation process,organic solvents are often used as entrainers.However,environmental influence and high energy-consumption are significant problems in industrial application.In this study,a systematic screening strategy and innovative energy-saving design for ionic liquid-based extractive distillation process was proposed.The innovative energy-saving design focused on the binary minimum azeotrope mixtures isopropanol and water.Miscibility,environmental impact and physical properties(e.g.,melting point and viscosity)of 30 ionic liquids were investigated.1-Ethyl-3-methyl-imidazolium dicyanamide and 1-butyl-3-methyl-imidazolium dicyanamide were selected as candidate entrainers.Feasibility analysis of these two ionic liquids was further performed via residue curve maps,isovolatility line and temperature profiles.An innovative ionic liquid-based extractive distillation process combining distillation column and stripping column was designed and optimized with the objective function of minimizing the total annualized cost.The results demonstrate that the total annualized cost was reduced by 19.9%with 1-ethyl-3-methyl-imidazolium dicyanamide as the entrainer and by 24.3%with 1-butyl-3-methyl-imidazolium dicyanamide,compared with that of dimethyl sulfoxide.The method proposed in this study is conducive to the green and sustainable development of extractive distillation process.