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颅内动脉瘤支架辅助栓塞术中急性血栓形成的治疗 被引量:14
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作者 刘伟 王卓然 +4 位作者 郭庆东 张鑫伟 张磊 付洛安 费舟 《中华神经外科疾病研究杂志》 CAS 2018年第2期130-134,共5页
目的探讨支架辅助栓塞颅内动脉瘤术中支架内血栓形成的治疗方案。方法回顾性分析2012年1月至2015年1月因颅内动脉瘤在西京医院接受支架辅助栓塞治疗共276例,术中支架内血栓形成16例,其中未破裂动脉瘤7例,破裂动脉瘤9例,囊性动脉瘤14例,... 目的探讨支架辅助栓塞颅内动脉瘤术中支架内血栓形成的治疗方案。方法回顾性分析2012年1月至2015年1月因颅内动脉瘤在西京医院接受支架辅助栓塞治疗共276例,术中支架内血栓形成16例,其中未破裂动脉瘤7例,破裂动脉瘤9例,囊性动脉瘤14例,夹层动脉瘤2例,总结患者临床资料。使用替罗非班溶栓7例,使用支架取栓2例,使用微导管微导丝通过4例,未处理6例。结果溶栓取栓血管再通8例,术后出血1例,血栓栓塞相关症状4例。结论未破裂动脉瘤术中血栓形成使用替罗非班动脉接触性溶栓联合静脉给药是安全有效的。已破裂动脉瘤术中血栓形成后使用替罗非班动脉接触性溶栓联合静脉给药溶栓治疗方法的安全有效性仍需进一步观察,可使用微导管微导丝通过的办法达到血管再通。 展开更多
关键词 颅内动脉瘤 支架 血栓 替罗非班
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Rho激酶抑制剂联合甘露醇对颅内动脉瘤术后脑水肿患者NIHSS评分及脑水肿缩小程度的影响 被引量:3
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作者 柯学庭 杨炳湖 《哈尔滨医药》 2018年第5期401-403,共3页
目的研究Rho激酶抑制剂联合甘露醇治疗颅内动脉瘤术后脑水肿患者的临床效果。方法选取我院2014年10月至2017年7月我院联合惠州市中心人民医院收治的颅内动脉瘤术后脑水肿患者86例,按治疗方案不同分组,各43例。对照组给予甘露醇治疗,观... 目的研究Rho激酶抑制剂联合甘露醇治疗颅内动脉瘤术后脑水肿患者的临床效果。方法选取我院2014年10月至2017年7月我院联合惠州市中心人民医院收治的颅内动脉瘤术后脑水肿患者86例,按治疗方案不同分组,各43例。对照组给予甘露醇治疗,观察组给予Rho激酶抑制剂(盐酸法舒地尔)+甘露醇治疗。比较两组疗效、治疗前后神经功能缺损(NIHSS)评分、脑水肿范围、脑动脉血流速度及不良反应。结果观察组治疗总有效率97.67%,高于对照组81.40%,差异有统计学意义(P<0.05);治疗前,两组NIHSS评分、脑水肿范围无明显差异(P>0.05);治疗3 d后、治疗7 d后两组NIHSS评分、脑水肿范围呈下降趋势,且观察组NIHSS评分、脑水肿范围下降幅度较大,两组NIHSS评分、脑水肿范围组间、时间点、组间·时间点交互作用相比,差异有统计学意义(P<0.05);治疗前,两组脑动脉血流速度无明显差异(P>0.05);治疗7 d后大脑前动脉、后动脉、中动脉血流速度高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率9.30%与对照组6.98%相比无明显差异(P>0.05)。结论Rho激酶抑制剂联合甘露醇治疗颅内动脉瘤术后脑水肿患者疗效显著,可促进脑水肿缩小,加快神经功能恢复,提高脑动脉血流速度,且不增加药物不良反应。 展开更多
关键词 颅内动脉瘤术后脑水肿 甘露醇 Rho激酶抑制
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Contrast-enhanced Ultrasound in Detecting Endoleaks with Failed Computed Tomography Angiography Diagnosis after Endovascular Abdominal Aortic Aneurysm Repair 被引量:8
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作者 Xiao Yang Yue-Xin Chen +5 位作者 Bo Zhang Yu-Xin Jiang Chang-Wei Liu Rui-Na Zhao Qiong Wu Da-Ming Zhang 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第18期2491-2497,共7页
Background: Endovascular aneurysnl repair (EVAR) is one of the first-line therapies of abdominal aortic aneurysms. Postoperative endoleak is the most common complication of EVAR. Computed tomography angiography (... Background: Endovascular aneurysnl repair (EVAR) is one of the first-line therapies of abdominal aortic aneurysms. Postoperative endoleak is the most common complication of EVAR. Computed tomography angiography (CTA), which is routine for follow-up, has side effects (e.g., radiation) and also has a certain percentage of missed diagnosis. Preliminary studies on contrast-enhanced ultrasound (CEUS) have shown that the sensitivity of CEUS for detecting endoleak is no lower than that of CTA. To investigate the advantages of CEUS, we conducted CEUS examinations of post-EVAR cases in which CTA failed to detect endoleak or could not verify the type of endoleak. Methods: Post-EVAR patients, who were clinically considered to have endoleak and met the inclusion criteria were enrolled between March 2013 and November 2014. All of the patients underwent color Doppler flow imaging (CDFI) and a CEUS examination. Size, location, microbubble dispersion, and hemodynamic characteristics of leaks were recorded. Comparison between the diagnosis of CEUS and CDF1 was conducted using Fisher's exact test and clinical outcomes of all patients were followed up. Results: Sixteen patients were enrolled, and 12 (75%) had endoleaks with verified types by CEUS. Among 12 cases of endoleaks were positive by CEUS, 10 were CDFl-positive, and the four CEUS-negative cases were all negative by CDFI. The diagnostic values of CEUS and CDFI were statistically difl'erent (P = 0,008). Six patients with high-pressure endoleaks received endovascular re-intervention guided by CEUS results. One patient with type Ⅲ endoleak had open surgery when endovascular repair failed. Conclusions: C EUS is a new, safe, and effective means for detection ofendoleaks post-EVAR. This technique can be used as a supplement for routine CTA follow-up to provide more detailed information on endoleak and its category. 展开更多
关键词 Abdominal Aortic aneurysnl: Color Doppler Flow Imaging Contrast-enhanced Ultrasound: Endoleak EndovascularAneurysm Repair
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