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SERUM LEVELS OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH ANGINA PECTORIS AND ACUTE MYOCARDIAL INFARCTION 被引量:5
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作者 尹瑞兴 冯建章 +1 位作者 陈旦红 乌汉东 《Chinese Medical Sciences Journal》 CAS CSCD 2000年第4期205-209,共5页
Objective. To determine whether serum vascular endothelial growth factor(VEGF)concentrations are altered in several kinds of coronary heart disease patients. Materials and methods. Using a VEGF enzyme-linked immunosor... Objective. To determine whether serum vascular endothelial growth factor(VEGF)concentrations are altered in several kinds of coronary heart disease patients. Materials and methods. Using a VEGF enzyme-linked immunosorbent assay(ELISA), serum VEGF concentrations were determined in antecubital venous blood of 16 patients with stable angina pectoris(SAP), 16 with unstable angina pectoris(UAP) and 16 with acute myocardial infarction(AMI) before and after thrombolytic therapy, and of 16 age- and sex-matched healthy volunteers who used as controls. Results. The concentrations of serum VEGF in patients with SAP(9860±2699pg/ml) and UAP (10361±2489pg/ml) tended to be higher than those in control subjects(8044±2457pg/ml), but the differences did not reach statistical significance (P>005 for each). Before thrombolytic therapy, the concentrations of serum VEGF in patients with AMI (28592±12515pg/ml) were significantly higher than those in patients with SAP, UAP or control subjects (P<001,respectively), and correlated with synchronous serum creatine kinase (CK) and its MB isoenzyme (CK-MB) contents(r=0866,P<0001 and r=0948,P<0001;respectively). Three hours after thrombolysis, the concentrations of VEGF had fallen to 11157±3129pg/ml (P<001 vs. before thrombolytic therapy and P<005 vs.control subjects). Conclusion. The present study shows that serum concentrations of VEGF in patients with AMI are markedly elevated and that increased serum VEGF levels may be one of the most sensitive indexes in diagnosing AMI and judging reperfusion. 展开更多
关键词 angina pectoris myocardial infarction vascular endothelial growth factor
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Infuences of Previous Angina Pectoris on Coronary Collateral Circulation and Left Ventricular Function in Patients with Acute Myocardial Infarction
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作者 罗初凡 杜志民 +6 位作者 胡承恒 梅卫义 伍贵富 《South China Journal of Cardiology》 CAS 2001年第2期62-64,68,共4页
Objective To investigate the influences of previous angina pectoris on coronary collateral circulation and left ventricular function in patients with acute myocardial infarction. Methods 307 patients with a first epis... Objective To investigate the influences of previous angina pectoris on coronary collateral circulation and left ventricular function in patients with acute myocardial infarction. Methods 307 patients with a first episode acute myocardial infarction underwent selective coronary angiography and left ventriculography. The relation of previous angina pectoris to coronary collateral circulation, peak creatine kinase and left ventricular function were analyzed. Results ①In the 307 patients, there were 192 (62. 5 % ) with previous angina [PA ( + ) group] and 115 (37. 5 % ) without [PA (-) group]. ②The peak creatine kinase (CK) and CK -MB were significantly higher in PA (-) group than in PA (+) group ( P < 0. 05 for both comparisons) . ③ Collateral circulation to infarct - related artery was more likely to be present in PA ( + ) group than in PA (-) group ( P < 0. 05) . (4) The left ventricular ejection fraction was significantly increased, and the left ventricular wall motion Cortina score decreased, in PA (+) group than in PA (-) group ( P < 0. 01 for both comparisons) . Conclusion In patients with acute myocardial infarction, previous angina pectoris may have beneficial effects on coronary collateral circulation and left ventricular function. 展开更多
关键词 myocardial infarction acute angina pectoris Collateral circulation Ventric-ular function LEFT
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Rapid decrease of necrotic core after acute myocardial infarction
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作者 Jun Ho Lee Eun-Seok Shin +4 位作者 Shin-Jae Kim Jong Min Kim Jung Won Hwang Hector M. Garcia-Garcia Patrick W. Serruys 《World Journal of Cardiovascular Diseases》 2012年第2期95-98,共4页
It is well known that the increase of necrotic core in previous atherosclerotic coronary artery disease is one of the conditions of vulnerable plaque. However, it is not known how fast necrotic core could decrease in ... It is well known that the increase of necrotic core in previous atherosclerotic coronary artery disease is one of the conditions of vulnerable plaque. However, it is not known how fast necrotic core could decrease in a vulnerable plaque. We had 2 patients who had suffered from acute myocardial infarction and had large amount of necrotic core in their culprit lesions at baseline, which decreased markedly within 7 days. Also, they were clinically stable and asymptomatic over 1 year follow-up. It is first report to show mar-kedly decrease of necrotic core amount within only 7 days in culprit lesions of 2 cases of acute myocardial infarction with angiographically minimal lesions. 展开更多
关键词 VULNERABLE PLAQUE IVUS acute myocardial infarction Variant angina
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Armarium facilitating angina management post myocardial infarction concomitant with coronavirus disease 2019 被引量:1
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作者 Xiao-Qing CAI Pi-Qi JIAO +12 位作者 Tao WU Fu-Ming CHEN Bao-Shi HAN Jiu-Cong ZHANG Yong-Jiu XIAO Zhi-Feng CHEN Jun LI Yu-Ying ZHAO Ling MA Yan LIU Ya-Jun SHI Pei-Jun DAI Yun-Dai CHEN 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2020年第4期217-220,共4页
The outbreak and spread of coronavirus disease 2019(COVID-19)are not only a disaster of people’s life and health over the world,[1–3]but also the challenge for medical practitioner in clinical management.Owing to ma... The outbreak and spread of coronavirus disease 2019(COVID-19)are not only a disaster of people’s life and health over the world,[1–3]but also the challenge for medical practitioner in clinical management.Owing to many diagnostic instruments are not suitable or convenient to use any more in contagious ward considering the risk of cross infections,such as traditional stethoscope or electrocardiogram(ECG).In this scenarios,wireless and digital equipment are optimal choices for epidemic management in order to exert rapid diagnosis and disease evaluation.Herein,we reported a case of the patient suffering both COVID-19 and myocardial infarction,for which the tele-ECG and wireless stethoscope facilitated the accurate diagnosis and instant management. 展开更多
关键词 acute myocardial infarction angina CORONAVIRUS disease 2019 ELECTROCARDIOGRAM STETHOSCOPE
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Coronary Artery Vasospasm with Acute Myocardial Infarction in a Male Patient: Case Report 被引量:1
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作者 Angelo Alencar Mello Savoldi Alexandre Mello Savoldi +2 位作者 Gustavo Alexandre Dutra Shirley Katherine Tinajero Enriquez Gregue Marques Leite Costa 《Journal of Pharmacy and Pharmacology》 2018年第5期495-501,共7页
We present a 48-year-old male patient with a history of classic precordialgia, ST-segment elevation in inferior leads (II, III and aVF), with t:oponin m:d CK-MB (creatine kinase-MB) elevated on the day of admiss... We present a 48-year-old male patient with a history of classic precordialgia, ST-segment elevation in inferior leads (II, III and aVF), with t:oponin m:d CK-MB (creatine kinase-MB) elevated on the day of admission that received conventional anti-ischemic treatment. Hemodynamically stable, symptom-free, is referred to cardiac catheterization. In the selective catheterization of the left coronary artery, a moderate lesion was observed in the middle third of the anterior descending coronary artery; in the right coronary artery, a subocclusive proximal lesion with TIMI (thrombolysis in myocardial infarction) II. We performed a single projection m:d opted for angioplasty. Before, it was decided to re-evaluate the left coronary artery, m:d it was observed in the contrast test that anterior descending artery was occluded. Intra-coronary nitroglycerin and new contrast injection were performed, which showed totally open descending artery with TIMI III, without obstructive lesions as initially suggested, and improvement of pain. It was a severe coronary vasospasm. When a new contrast injection was performed in the right coronary, with a therapeutic catheter, the disappeaxance of the subocclusive lesion and the presence of a normal coronary flow were observed, although there was a moderate plaque in its proximal third, which motivated the maintenance of angioplasty with stent placement in a proxhnal third of right coronary artery. During the passage of the intracoronary guidewire it was once again evident that diffuse coronary artery vasoreactivity was present; the procedure was successfully completed. 展开更多
关键词 angina pectoris VARIANT acute myocardial infarction.
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Impact of angina prior to acute ST-elevation myocardial infarction on short-term outcomes after primary percutaneous coronary intervention: results from the Shanghai Registry of Acute Coronary Syndrome (SRACE) 被引量:7
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作者 ZHANG Qi ZHANG Rui-yan +6 位作者 ZHU Tian-qi HU Jian YANG Zhen-kun DING Feng-hua DU Run ZHU Zheng-bin SHEN Wei-feng 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第6期977-982,共6页
Background The clinical significance of ischemic chest pain before acute ST-elevation myocardial infarction (STEMI) remains an interesting issue of investigation particularly in the era of percutaneous coronary inte... Background The clinical significance of ischemic chest pain before acute ST-elevation myocardial infarction (STEMI) remains an interesting issue of investigation particularly in the era of percutaneous coronary intervention (PCI). This study aimed to assess the impact of angina prior to STEMI on short-term clinical outcomes in patients with acute STEMI undergoing primary PCI. Methods Among a total of 875 consecutive patients with STEMI undergoing primary PCI, 292 had episodes of angina within 24 hours of STEMI (PA group) and the remaining 583 were free of anginal symptoms (non-PA group). Clinical characteristics, angiographic and procedural features, and in-hospital and 30-day outcomes were compared between the two groups. Results Diabetes was less common (17.5% vs. 23.3%, P=-0.04) and symptom-to-door time was shortened ((191.6_+96.8) minutes vs. (357.2_+341.9) minutes, P 〈0.001) in the PA group than in the non-PA group. Patients with angina prior to STEMI had fewer totally or nearly totally occluded infarct-related artery (TIMI flow grade 0-1) at initial angiography (75.0% vs. 90.7%, P 〈0.001), and achieved more TIMI flow grade 3 after primary PCI (84.2% vs. 78.2%, P=0.04). These were associated with higher rates of overall procedural success (95.9% vs. 91.8%, P=0.02) and of complete ST-segment resolution at 90 minutes after the procedure (51.7% vs. 40.3%, P=0.001). During a 30-day clinical follow-up, the left ventricular ejection fraction was significantly improved ((53.0±8.6)% vs. (51.1±9.7)%, P=-0.002) and the primary endpoint of major adverse cardiac events was reduced in the PA group (7.2% vs. 12.7%, P=0.01). Conclusion Presence of angina prior to acute STEMI is associated with better outcome at a 30-day clinical follow-up in patients undergoing primary PCI. 展开更多
关键词 acute myocardial infarction preinfarction angina primary angioplasty STENT OUTCOMES
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基于脉络学说探讨急性ST段抬高型心肌梗死辨证论治
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作者 常成成 袁国强 +4 位作者 常丽萍 魏聪 王磊 孙永辉 贾振华 《世界中医药》 CAS 北大核心 2024年第3期362-367,共6页
急性ST段抬高型心肌梗死(STEMI)具有发病急骤、病情凶险的临床表现,属脉络血管系统病研究疾病之一。脉络学说作为指导脉络-血管系统病防治的系统理论,根据STEMI的临床特点,认为应当在分阶段治疗的同时注重整体全程论治,进而在结合辨证... 急性ST段抬高型心肌梗死(STEMI)具有发病急骤、病情凶险的临床表现,属脉络血管系统病研究疾病之一。脉络学说作为指导脉络-血管系统病防治的系统理论,根据STEMI的临床特点,认为应当在分阶段治疗的同时注重整体全程论治,进而在结合辨证论治原则及循证医学研究基础上,提出以脉络学说为指导的再灌注术前及术后治疗的新干预策略及辨证论治思路,形成对本病的系统防治理念,为本病的中西医结合治疗提供了新的治疗参考。 展开更多
关键词 脉络学说 急性心肌梗死 营卫理论 再灌注治疗 心绞痛 心律失常 心力衰竭
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血清ESM-1、sICAM-1与不稳定型心绞痛患者冠心病严重程度的关系及对急性心肌梗死发病的预测价值
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作者 黄瑛 余朝萍 刘天虎 《中国现代医学杂志》 CAS 2024年第18期71-76,共6页
目的分析不稳定型心绞痛(UAP)患者血清内皮细胞特异分子-1(ESM-1)、可溶性细胞间黏附分子-1(sICAM-1)与冠状动脉粥样硬化性心脏病(以下简称冠心病)严重程度的关系及对急性心肌梗死(AMI)发病的预测价值。方法选取2021年1月—2023年6月成... 目的分析不稳定型心绞痛(UAP)患者血清内皮细胞特异分子-1(ESM-1)、可溶性细胞间黏附分子-1(sICAM-1)与冠状动脉粥样硬化性心脏病(以下简称冠心病)严重程度的关系及对急性心肌梗死(AMI)发病的预测价值。方法选取2021年1月—2023年6月成都医学院第三附属医院收治的78例UAP患者。采用酶联免疫吸附试验检测ESM-1、sICAM-1水平。采用Gensini评估冠脉狭窄积分,依据患者狭窄积分将其分为轻中度组和重度组,分析不同病情严重程度患者ESM-1、sICAM-1水平。给予吸氧、抗血小板、抗凝、抗心肌缺血等治疗后,随访统计治疗6个月内AMI发生情况,将发生AMI患者纳入发生组,反之为未发生组。分析影响UAP患者发生AMI的因素及其对AMI发病的预测价值。结果重度组ESM-1、sICAM-1水平均高于轻中度组(P<0.05)。发生组Gensini评分、ESM-1、sICAM-1、NYHA分级均高于未发生组(P<0.05),SAQ评分低于未发生组(P<0.05)。多因素逐步Logistic回归分析结果表明,Gensini评分[OR=4.674(95%CI:1.598,13.675)]、SAQ评分[OR=4.802(95%CI:1.641,14.049)]、ESM-1[OR=5.573(95%CI:1.905,16.306)]和sICAM-1[OR=4.411(95%CI:1.508,12.904)]是UAP患者发生AMI的危险因素(P<0.05)。受试者工作特征曲线结果表明,Gensini评分、ESM-1、sICAM-1、SAQ评分及联合预测UAP患者发生AMI的敏感性分别为70.0%(95%CI:0.570,0.830)、75.0%(95%CI:0.621,0.882)、75.0%(95%CI:0.614,0.872)、70.0%(95%CI:0.562,0.841)、90.0%(95%CI:0.862,0.904);特异性分别为72.4%(95%CI:0.584,0.863)、75.7%(95%CI:0.618,0.898)、77.6%(95%CI:0.635,0.910)、67.0%(95%CI:0.548,0.823)、91.4%(95%CI:0.773,0.944)。Gensini评分、ESM-1、sICAM-1、SAQ评分联合预测UAP患者发生AMI的价值较高,曲线下面积>0.9。结论ESM-1、sICAM-1与冠心病严重程度有关,Gensini评分、ESM-1、sICAM-1、SAQ评分联合预测UAP患者发生AMI的效能较好。 展开更多
关键词 不稳定型心绞痛 冠心病 急性心肌梗死 内皮细胞特异分子-1 可溶性细胞间黏附分子-1
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培元活血汤治疗稳定性心绞痛疗效及对心肌梗死的预防作用
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作者 孙晓媛 姜燕 崔萍 《山东中医杂志》 2024年第6期585-589,597,共6页
目的:观察培元活血汤治疗稳定性心绞痛(SAP)的疗效及对心肌梗死的预防作用。方法:将98例SAP患者按随机数字表法分为对照组和观察组各49例。对照组给予常规西药治疗,观察组在此基础上给予培元活血汤治疗,两组均以4周为1个疗程,共治疗2个... 目的:观察培元活血汤治疗稳定性心绞痛(SAP)的疗效及对心肌梗死的预防作用。方法:将98例SAP患者按随机数字表法分为对照组和观察组各49例。对照组给予常规西药治疗,观察组在此基础上给予培元活血汤治疗,两组均以4周为1个疗程,共治疗2个疗程。比较两组中医证候积分、心绞痛发生情况(每次发作持续时间、发作频率、疼痛程度)、每周硝酸甘油用量、血清炎症因子[超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、心肌梗死发生率,并评价临床疗效。结果:治疗后,两组中医证候积分均低于治疗前,且观察组低于对照组(P<0.05);两组各项心绞痛发生情况较治疗前均改善(P<0.05),且观察组各项心绞痛发生情况均优于对照组(P<0.05);两组每周硝酸甘油用量均较治疗前减少(P<0.05),且观察组少于对照组(P<0.05);两组各项血清炎症因子水平均较治疗前降低(P<0.05),且观察组低于对照组(P<0.05);观察组心肌梗死发生率低于对照组(P<0.05)、临床总有效率高于对照组(P<0.05)。结论:培元活血汤联合常规西药治疗SAP疗效确切,可改善患者中医证候和心绞痛症状,减少硝酸甘油用量,减轻机体炎症反应,降低心肌梗死发生率。 展开更多
关键词 稳定性心绞痛 气虚血瘀 培元活血汤 心肌梗死 中医证候 炎症因子
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急性冠脉综合征患者动态心电图缺血性J波发生状况及诊断意义分析
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作者 杜梦依 《临床医学研究与实践》 2024年第21期103-106,共4页
目的分析急性冠脉综合征(ACS)患者动态心电图缺血性J波发生状况及诊断意义。方法回顾性分析我院2020年1月至2021年12月收治的72例ACS患者动态心电图资料,包括不稳定心绞痛(UAP)患者(UAP组)与急性心肌梗死(AMI)患者(AMI组),各36例。采集... 目的分析急性冠脉综合征(ACS)患者动态心电图缺血性J波发生状况及诊断意义。方法回顾性分析我院2020年1月至2021年12月收治的72例ACS患者动态心电图资料,包括不稳定心绞痛(UAP)患者(UAP组)与急性心肌梗死(AMI)患者(AMI组),各36例。采集患者有、无心肌缺血发作时的24 h动态心电图检查结果各1次,统计分析UAP组、AMI组患者的动态心电图缺血性J波发生率以及两组有心肌缺血发作时24 h动态心电图出现缺血性J波患者的心律失常发生率。结果UAP组患者有心肌缺血发作时的24 h动态心电图缺血性J波发生率显著高于无心肌缺血发作时,差异具有统计学意义(P<0.05)。AMI组患者有心肌缺血发作时的24 h动态心电图缺血性J波发生率显著高于无心肌缺血发作时,差异具有统计学意义(P<0.05)。UAP组与AMI组有心肌缺血发作时24 h动态心电图出现缺血性J波患者的心律失常发生率无显著差异(P>0.05)。结论动态心电图缺血性J波发生状况对ACS患者具有较高的诊断价值,还可帮助指导医师对ACS患者的室性心律失常提供预防和治疗依据,从而保障患者预后。 展开更多
关键词 急性冠脉综合征 不稳定心绞痛 急性心肌梗死 动态心电图 缺血性J波
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血府逐瘀汤加减治疗急性心肌梗死后心绞痛患者的临床疗效分析
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作者 崔喜荣 《中外医药研究》 2024年第8期84-86,共3页
目的:探讨急性心肌梗死后心绞痛患者采用血府逐瘀汤加减治疗的有效性。方法:选取2022年6月—2023年6月烟台市蓬莱中医医院收治的急性心肌梗死后心绞痛患者80例,随机分为对照组与研究组,各40例。对照组采用阿司匹林肠溶片联合单硝酸异山... 目的:探讨急性心肌梗死后心绞痛患者采用血府逐瘀汤加减治疗的有效性。方法:选取2022年6月—2023年6月烟台市蓬莱中医医院收治的急性心肌梗死后心绞痛患者80例,随机分为对照组与研究组,各40例。对照组采用阿司匹林肠溶片联合单硝酸异山梨酯片治疗,研究组在对照组治疗基础上服用血府逐瘀汤。比较两组患者临床疗效、心绞痛发作情况、心功能相关指标以及血脂情况。结果:研究组患者治疗总有效率高于对照组,差异有统计学意义(P<0.05)。研究组治疗后心绞痛发作次数少于对照组,发作持续时间短于对照组,差异有统计学意义(P<0.05)。研究组左室收缩末期内径、左室舒张末期内径低于对照组,左室射血分数高于对照组,差异有统计学意义(P<0.05)。研究组总胆固醇、甘油三酯、低密度脂蛋白胆固醇较对照组明显降低,高密度脂蛋白胆固醇较对照组明显升高,差异有统计学意义(P<0.05)。结论:血府逐瘀汤加减治疗急性心肌梗死后心绞痛患者可改善其预后,对血脂水平有调节作用,能改善患者心功能,有利于心绞痛症状缓解,促使病情好转。 展开更多
关键词 急性心肌梗死 心绞痛 血府逐瘀汤 心功能 血脂水平
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连续性护理对心肌梗死患者出院后心绞痛发作及生活质量的影响
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作者 万春玲 《智慧健康》 2024年第7期207-210,共4页
目的 探究连续性护理对心肌梗死患者出院后心绞痛发作及生活质量的影响。方法 选取在本院就诊的心肌梗死患者80例,随机分为对照组和观察组,每组40例。对照组进行常规护理,观察组应用连续性护理。统计两组患者的心绞痛发生情况以及生活... 目的 探究连续性护理对心肌梗死患者出院后心绞痛发作及生活质量的影响。方法 选取在本院就诊的心肌梗死患者80例,随机分为对照组和观察组,每组40例。对照组进行常规护理,观察组应用连续性护理。统计两组患者的心绞痛发生情况以及生活质量。结果 观察组患者的心绞痛发生情况以及生活质量等临床指标均优于对照组(P<0.05)。结论 对于心肌梗死患者实施连续性护理,可以显著改善患者心绞痛,提升生活质量。 展开更多
关键词 连续性护理 心肌梗死 心绞痛 生活质量
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Impact of gout on in-hospital outcomes of acute coronary syndrome-related hospitalizations and revascularizations: Insights from the national inpatient sample 被引量:4
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作者 Rupak Desai Tarang Parekh +7 位作者 Hemant Goyal Hee Kong Fong Dipen Zalavadia Nanush Damarlapally Rajkumar Doshi Sejal Savani Gautam Kumar Rajesh Sachdeva 《World Journal of Cardiology》 CAS 2019年第5期137-148,共12页
BACKGROUND Previous studies have established a role of gout in predicting risk and prognosis of cardiovascular diseases. However, large-scale data on the impact of gout on inpatient outcomes of acute coronary syndrome... BACKGROUND Previous studies have established a role of gout in predicting risk and prognosis of cardiovascular diseases. However, large-scale data on the impact of gout on inpatient outcomes of acute coronary syndrome (ACS)-related hospitalizations and post-revascularization is inadequate. AIM To evaluate the impact of gout on in-hospital outcomes of ACS hospitalizations, subsequent healthcare burden and predictors of post-revascularization inpatient mortality. METHODS We used the national inpatient sample (2010-2014) to identify the ACS and goutrelated hospitalizations, relevant comorbidities, revascularization and postrevascularization outcomes using the ICD-9 CM codes. A multivariable analysis was performed to evaluate the predictors of post-revascularization in-hospital mortality. RESULTS We identified 3144744 ACS-related hospitalizations, of which 105198 (3.35%) also had gout. The ACS-gout cohort were more often older white males with a higher prevalence of comorbidities. Coronary artery bypass grafting was required more often in the ACS-gout cohort. Post-revascularization complications including cardiac (3.2% vs 2.9%), respiratory (3.5% vs 2.9%), and hemorrhage (3.1% vs 2.7%) were higher whereas all-cause mortality was lower (2.2% vs 3.0%) in the ACSgout cohort (P < 0.001). An older age (OR 15.63, CI: 5.51-44.39), non-elective admissions (OR 2.00, CI: 1.44-2.79), lower household income (OR 1.44, CI: 1.17- 1.78), and comorbid conditions predicted higher mortality in ACS-gout cohort undergoing revascularization (P < 0.001). Odds of post-revascularization inhospital mortality were lower in Hispanics (OR 0.45, CI: 0.31-0.67) and Asians (OR 0.65, CI: 0.45-0.94) as compared to white (P < 0.001). However, postoperative complications significantly raised mortality odds. Mean length of stay, transfer to other facilities, and hospital charges were higher in the ACS-gout cohort. CONCLUSION Although gout was not independently associated with an increased risk of postrevascularization in-hospital mortality in ACS, it did increase postrevascularization complications. 展开更多
关键词 GOUT Serum uric acid acute CORONARY syndrome Unstable angina myocardial infarction Revascularization Percutaneous CORONARY intervention CORONARY artery bypass grafting IN-HOSPITAL OUTCOMES
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Significantly reduced function of T cells in patients with acute arterial thrombosis 被引量:4
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作者 Wen-Wen YAN Kun-Shan ZHANG Qiang-Lin DUAN Le-Min WANG 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2015年第3期287-293,共7页
Objectives To explore the intrinsic factors related to the pathogenesis of acute arterial thrombosis (AAT) and to elucidate the patho- genesis of AAT on the basis of differentially expressed genes. Methods Patients ... Objectives To explore the intrinsic factors related to the pathogenesis of acute arterial thrombosis (AAT) and to elucidate the patho- genesis of AAT on the basis of differentially expressed genes. Methods Patients with acute myocardial infarction (AMI), stable angina (SA) and healthy controls (n = 20 per group) were recruited, and the whole human genome microarray analysis was performed to detect the differentially expressed genes among these subjects. Results Patients with AMI had disease-specific gene expression pattern. Biological functional analysis showed the function of T cells was significantly reduced, the mitochondrial metabolism significantly decreased, the ion metabolism was abnormal, the cell apoptosis and inflammatory reaction increased, the phagocytosis elevated, the neutrophil-mediated immunity increased and the post-traumatic repair of cells and tissues increased in AMI patients. The biological function in SA group and healthy controis remained stable and was comparable. Conclusions The reduced function ofT cell gene models in AAT showed the dysfunction of the immune system. The pathogenesis of AAT may be related to the inflammatory reaction after arterial intima infection caused by potential pathogenic microorganisms. 展开更多
关键词 acute arterial thrombosis Gene expression pattern myocardial infarction Stable angina
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Study on metabonomics in patients with acute coronary syndrome based on LC-MS technology
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作者 YU Peng YANG Zhe-jun +3 位作者 SHI Rui-jie SUN Wei-xin CHEN Xiao-hu SHEN Le 《Journal of Hainan Medical University》 2022年第22期15-23,共9页
Objective:To investigate the plasma metabolic components of patients with unstable angina(UA)and acute myocardial infarction(AMI),and to screen potential biomarkers and explore possible biological mechanisms in order ... Objective:To investigate the plasma metabolic components of patients with unstable angina(UA)and acute myocardial infarction(AMI),and to screen potential biomarkers and explore possible biological mechanisms in order to provide reference for early evaluation of acute coronary syndrome.Methods:Plasma samples from patients with UA and AMI were collected to obtain their general information,and the metabolites were detected by LCMS technology.Combined with univariate statistical analysis,the significantly different metabolites and their pathways were further determined by partial least squares discriminant analysis and orthogonalized partial least squares discriminant analysis models.Results:A total of 33 samples from UA group and 47 samples from AMI group were included for testing.Then 54 metabolites and 20 pathways were found to be significantly different between them.Metabolites such as pantoprazole,acetylcarnitine,palmitoyl ethanolamide,betaine,caprylic acid,bilirubin,histidine,oleic acid,citrate,vanillin can be used as potential biomarkers to distinguish them.The pathways include ABC transporters,aminoacyl-tRNA biosynthesis,central carbon metabolism in cancer and so on.Conclusion:There are significant differences in the plasma metabolic components of UA and AMI.Studies related to metabolomics may guide significance for exploring the biological nature of ACS. 展开更多
关键词 acute coronary syndrome Unstable angina acute myocardial infarction Metabolomics Differential metabolites
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Prognosis of Patients with Acute Coronary Syndromes and Bleeding—The Importance of Routine Use of a Bleeding Risk Score
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作者 Alexandre de Matos Soeiro Ricardo Cesar Campos Devezae Silva +5 位作者 Aline Siqueira Bossa Cindel Nogueira Zullino Tatiana de Carvalho Andreucci Torres Leal Maria Carolina Feres de Almeida Soeiro Carlos V. Serrano Jr. Múcio Tavares Oliveira Jr. 《World Journal of Cardiovascular Diseases》 2015年第12期327-334,共8页
Introduction: Recent studies showed relation between mortality and bleeding in acute coronary syndromes. Objective: The objective is to analyze the prognosis of patients with acute coronary syndromes with or without i... Introduction: Recent studies showed relation between mortality and bleeding in acute coronary syndromes. Objective: The objective is to analyze the prognosis of patients with acute coronary syndromes with or without in-hospital major and/or minor bleedings. Methods: This was a pro-spective data bank analysis study with 546 patients (39 with bleeding (group I) and 507 without bleeding (group II)) with acute coronary syndromes included between May 2010 and May 2013. Besides, Mehran bleeding risk score was calculated to all patients. The primary endpoint was all causes of in-hospital death and combined events. Comparison between groups was made by Anova and Q-square. Multivariate analysis was determined by logistic regression and was considered significant when p p = 0.005) and combined events (35.9% vs 11.4%, p < 0.001). The same results were observed in multivariate and long-term analysis. Con-clusions: Almost half of patients with acute coronary syndromes had higher risk of bleeding, and that with major or minor bleedings had greater deaths and combined events. 展开更多
关键词 UNSTABLE angina BLEEDING acute myocardial infarction
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血清ApoB/ApoA1、LTBP-2、VASP对不稳定型心绞痛进展至急性心肌梗死的预测效能 被引量:6
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作者 曹学民 张颖 《河北医药》 CAS 2023年第11期1637-1640,1645,共5页
目的探讨血清载脂蛋白B(ApoB)/载脂蛋白A1(ApoA1)、潜在转化生长因子结合蛋白-2(LTBP-2)、血管扩张刺激磷蛋白(VASP)对不稳定型心绞痛(UA)进展至急性心肌梗死(AMI)的预测效能。方法选取2020年1月至2021年12月收治的80例UA患者,根据住院... 目的探讨血清载脂蛋白B(ApoB)/载脂蛋白A1(ApoA1)、潜在转化生长因子结合蛋白-2(LTBP-2)、血管扩张刺激磷蛋白(VASP)对不稳定型心绞痛(UA)进展至急性心肌梗死(AMI)的预测效能。方法选取2020年1月至2021年12月收治的80例UA患者,根据住院期间是否进展为AMI分为AMI组(26例)和UA组(54例)。比较2组临床资料、血清ApoB/ApoA1、LTBP-2、VASP水平,分析各血清指标与冠脉狭窄程度、心功能分级及UA进展至AMI风险的关系,评价其对UA进展至AMI的预测效能。结果2组UA病程、冠脉狭窄程度、心功能分级差异有统计学意义(P<0.05);AMI组血清ApoB/ApoA1、LTBP-2水平高于UA组,VASP水平低于UA组(P<0.05);血清ApoB/ApoA1、LTBP-2与冠脉狭窄程度、心功能分级呈正相关,VASP与冠脉狭窄程度、心功能分级呈负相关(P<0.05);校正UA病程、冠脉狭窄程度、心功能分级等其他因素前后,血清ApoB/ApoA1、LTBP-2、VASP均与UA进展至AMI风险独立相关(P<0.05);血清ApoB/ApoA1、LTBP-2、VASP联合预测UA进展至AMI的AUC为0.951(95%CI:0.878~0.987),大于各指标单独预测。结论血清ApoB/ApoA1、LTBP-2、VASP可作为UA进展至AMI的预测因子,联合预测价值较为可靠,为临床及早防治提供帮助。 展开更多
关键词 不稳定型心绞痛 急性心肌梗死 载脂蛋白B/载脂蛋白A1 潜在转化生长因子结合蛋白-2 血管扩张刺激磷蛋白
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血清NT-proBNP、UA/Cr联合检测对UAP患者发生AMI的预测价值
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作者 吴晶晶 陈润祥 +2 位作者 廖占玲 安国印 郭洁 《医学临床研究》 CAS 2023年第2期241-244,共4页
【目的】探讨不稳定型心绞痛(UAP)患者血清氨基末端B型脑钠肽前体(NT-proBNP)、尿酸(UA)/肌酐(Cr)与冠心病严重程度的关系及对急性心肌梗死(AMI)发病的预测价值。【方法】本院收治的127例UAP患者为研究对象,对比不同严重程度UAP患者血清... 【目的】探讨不稳定型心绞痛(UAP)患者血清氨基末端B型脑钠肽前体(NT-proBNP)、尿酸(UA)/肌酐(Cr)与冠心病严重程度的关系及对急性心肌梗死(AMI)发病的预测价值。【方法】本院收治的127例UAP患者为研究对象,对比不同严重程度UAP患者血清NT-proBNP、UA/Cr水平。随访1个月,统计UAP患者AMI发生情况,并依据是否发生AMI分为发生组(23例)和未发生组(104例)。比较两组患者的临床资料,采用Logistic多因素回归分析影响UAP患者发生AMI的危险因素,绘制受试者工作特征(ROC)曲线,以曲线下面积(AUC)评价血清NT-proBNP、UA/Cr对UAP患者发生AMI的预测效能。【结果】重度组UAP患者血清NT-proBNP、UA/Cr均高于轻度组和中度组(P<0.05);中度组UAP患者血清NT-proBNP、UA/Cr高于轻度组(P<0.05)。发生组冠心病重度占比、心脏肌钙蛋白I(cTnI)、同型半胱氨酸、UA、NT-proBNP及UA/Cr高于未发生组(P<0.05),左室射血分数(LVEF)则低于未发生组(P<0.05)。多因素分析结果显示,病情为重度、LVEF、cTnI、NT-proBNP及UA/Cr均为影响发生UAP患者AMI的危险因素(均P<0.05)。ROC分析显示,血清NT-proBNP、UA/Cr及两者联合检测对UAP患者发生AMI预测的灵敏度分别为69.57%、73.91%、79.52%,特异度分别为79.81%、74.04%、98.08%,AUC分别为0.721、0.770、0.901。【结论】UAP患者血清NT-proBNP、UA/Cr与冠心病严重程度及AMI发病有关,且两者联合检测对UAP患者发生AMI的预测效能较高。 展开更多
关键词 心绞痛 不稳定型 心肌梗死 急性病 利钠肽 脑/血液 尿酸/血液
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不同评分对不稳定型心绞痛患者冠状动脉病变严重程度的预测价值 被引量:1
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作者 秦巍 薛文平 +7 位作者 祝丽丽 冯超群 吕新琳 刘佳梅 于海燕 卜海伟 刘静怡 单伟超 《长春中医药大学学报》 2023年第4期435-439,共5页
目的探究不同评分对不稳定型心绞痛(UA)患者冠状动脉病变严重程度的预测价值。方法回顾性分析2018年1月-12月于我院行冠脉造影的681例UA患者的临床资料,分别计算患者的全球急性冠状动脉事件注册(GRACE)、心肌梗死溶栓疗法(TIMI)、韩国... 目的探究不同评分对不稳定型心绞痛(UA)患者冠状动脉病变严重程度的预测价值。方法回顾性分析2018年1月-12月于我院行冠脉造影的681例UA患者的临床资料,分别计算患者的全球急性冠状动脉事件注册(GRACE)、心肌梗死溶栓疗法(TIMI)、韩国急性心肌梗死注册(KAMIR)评分和量化冠状动脉病病变严重程度的Gensini评分,并依据Gensini评分将患者分为轻度狭窄组(575例)、中度狭窄组(44例)和重度狭窄组(62例),分析不同组别间3种评分与Gensini评分的相关性,使用受试者工作特征(ROC)曲线评价3种评分对UA患者冠状动脉病变严重程度的预测价值。结果不稳定型心绞痛患者3种评分与Gensini评分均呈正相关关系,UA患者轻度狭窄组的GRACE评分、TIMI评分、KAMIR评分明显低于中度和重度狭窄组,3种评分与Gensini评分之间均呈正相关,且均能预测UA患者发生中度及重度病变事件,差异均有统计学意义(P<0.05)。结论KAMIR评分的预测效能优于GRACE评分和TIMI评分,说明患者血糖也是评价不稳定型心绞痛患者病变严重程度的重要指标。 展开更多
关键词 不稳定型心绞痛 心肌梗死溶栓疗法评分 韩国急性心肌梗死注册评分 全球急性冠状动脉事件注册评分
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冠心宁片对经皮冠状动脉介入治疗心血瘀阻型急性ST段抬高型心肌梗死的影响 被引量:2
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作者 胡艳艳 何明 +5 位作者 刘金涛 王丽慧 曾奋飞 朱泳金 潘琪宏 李秋菊 《新中医》 CAS 2023年第16期81-85,共5页
目的:观察冠心宁片对心血瘀阻型急性ST段抬高型心肌梗死(STEMI)患者行经皮冠状动脉介入治疗(PCI)后临床疗效的影响。方法:选取心血瘀阻型STEMI患者共60例,采用随机数字表法分为2组各30例。2组在PCI前后均给予西药常规治疗,治疗组在行PC... 目的:观察冠心宁片对心血瘀阻型急性ST段抬高型心肌梗死(STEMI)患者行经皮冠状动脉介入治疗(PCI)后临床疗效的影响。方法:选取心血瘀阻型STEMI患者共60例,采用随机数字表法分为2组各30例。2组在PCI前后均给予西药常规治疗,治疗组在行PCI后加用冠心宁片常规剂量进行治疗,疗程4周。比较2组治疗4周后的临床疗效、心肌损伤标志物水平、心功能指标、西雅图心绞痛量表(SAQ),以及不良反应发生率。结果:治疗4周后,治疗组总有效率100%,对照组93.33%,差异无统计学意义(P>0.05)。治疗4周后,2组肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、高敏肌钙蛋白-T (cTn-T)水平均下降,且治疗组cTn-T水平低于对照组,差异均有统计学意义(P<0.05),但2组间CK、CK-MB比较,差异均无统计学意义(P>0.05)。治疗4周后,治疗组心功能指标左室射血分数(LVEF)高于对照组,差异有统计学意义(P<0.05);左室舒张末内径(LVEDD)小于对照组,差异有统计学意义(P<0.05)。治疗4周后,治疗组西雅图心绞痛量表(SAQ)各项评分躯体活动受限程度、心绞痛稳定状态、心绞痛发作情况、治疗满意程度、疾病认知程度均高于对照组,差异均有统计学意义(P<0.05)。2组不良反应发生率均为13.33%,差异无统计学意义(P>0.05)。结论:冠心宁片可提高心血瘀阻型STEMI患者PCI后生活质量,心功能恢复更好,且安全可靠。 展开更多
关键词 急性ST段抬高型心肌梗死 经皮冠状动脉介入治疗 心血瘀阻型 冠心宁片 心肌损伤标志物 心功能 西雅图心绞痛量表
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