Concern about the biological hazards involved in microbiological research, especially research involving laboratory animals, has increased in recent years. Working in an animal biosafety level 2 facility （ABSL-2）, c...Concern about the biological hazards involved in microbiological research, especially research involving laboratory animals, has increased in recent years. Working in an animal biosafety level 2 facility （ABSL-2）, commonly used for research on infectious diseases, poses various biological hazards. Here, the regulations and standards related to laboratory biosafety in China are introduced, the potential biological hazards present in ABSL-2 facilities are analyzed, and a series of strategies to control the hazards are presented.展开更多
Experimental research with animals can help the prevention,cure,and alleviation of human ailments.Animal research facilities are critical for scientific advancement,but they can also pose a higher risk than other biom...Experimental research with animals can help the prevention,cure,and alleviation of human ailments.Animal research facilities are critical for scientific advancement,but they can also pose a higher risk than other biomedical laboratories.Zoonosis,allergic reactions,bites,cuts,and scratches by animals are all substantial concerns that can occur in animal facilities.Furthermore,human error and unexpected animal behavior pose a risk not just to humans,but also to the environment and the animals themselves.The majority of biosafety and biosecurity training programs focus on clinical and biomedical laboratories dealing with human safety factors,with little emphasis on animal biosafety.The current virtual training was designed to improve biosafety and biosecurity capabilities of animal laboratory personnel,researchers,and veterinarians from different regions of Pakistan.The results revealed that understanding was improved regarding triggers for risk assessment in addition to annual and regular reviews(56%to 69%),biosecurity(21%to 50%),decontamination(17%to 35%),safe handling of sharps(21%to 35%),Dual Use Research of Concern(DURC)(17%to 40%),Personal Protective Equipment(PPE)usage by waste handlers(60.9%to 75%),waste management(56%to 85%),animal biosafety levels(40.57%to 45%),and good microbiological practices and procedures(17%to 35%).To bring human and animal laboratories up to the same level in terms of biosafety and biosecurity,it is critical to focus on areas that have been overlooked in the past.Training programs focusing on animal biosafety should be conducted more frequently to strengthen bio risk management systems in animal research facilities.展开更多
基金supported by the National Science and Technology Major Projects of Infectious Disease(2012ZX10004-404)
文摘Concern about the biological hazards involved in microbiological research, especially research involving laboratory animals, has increased in recent years. Working in an animal biosafety level 2 facility （ABSL-2）, commonly used for research on infectious diseases, poses various biological hazards. Here, the regulations and standards related to laboratory biosafety in China are introduced, the potential biological hazards present in ABSL-2 facilities are analyzed, and a series of strategies to control the hazards are presented.
文摘Experimental research with animals can help the prevention,cure,and alleviation of human ailments.Animal research facilities are critical for scientific advancement,but they can also pose a higher risk than other biomedical laboratories.Zoonosis,allergic reactions,bites,cuts,and scratches by animals are all substantial concerns that can occur in animal facilities.Furthermore,human error and unexpected animal behavior pose a risk not just to humans,but also to the environment and the animals themselves.The majority of biosafety and biosecurity training programs focus on clinical and biomedical laboratories dealing with human safety factors,with little emphasis on animal biosafety.The current virtual training was designed to improve biosafety and biosecurity capabilities of animal laboratory personnel,researchers,and veterinarians from different regions of Pakistan.The results revealed that understanding was improved regarding triggers for risk assessment in addition to annual and regular reviews(56%to 69%),biosecurity(21%to 50%),decontamination(17%to 35%),safe handling of sharps(21%to 35%),Dual Use Research of Concern(DURC)(17%to 40%),Personal Protective Equipment(PPE)usage by waste handlers(60.9%to 75%),waste management(56%to 85%),animal biosafety levels(40.57%to 45%),and good microbiological practices and procedures(17%to 35%).To bring human and animal laboratories up to the same level in terms of biosafety and biosecurity,it is critical to focus on areas that have been overlooked in the past.Training programs focusing on animal biosafety should be conducted more frequently to strengthen bio risk management systems in animal research facilities.
