Objective: To explore the possible factors influencing lumbar spinal bone mineral contents and bone mineral densities in Chinese adolescents with early ankylosing spondylitis(AS). Methods: Thirty-one male Chinese adol...Objective: To explore the possible factors influencing lumbar spinal bone mineral contents and bone mineral densities in Chinese adolescents with early ankylosing spondylitis(AS). Methods: Thirty-one male Chinese adolescent outpatients with early AS were included and compared with 31 age-matched male controls. Age (year), height (cm), total body weight (kg) together with body mass index (BMI, kg/m 2) of all subjects and disease duration (month), BASMI, BASFI, BASDAI, SASSS as well as ESR (mm/h) of AS patients were obtained. Lumbar 2-4 bone mineral content (L 2-4BMC, g) and lumbar 2-4 areal bone mineral density (L 2-4 BMD, g/cm 2) were evaluated using dual-energy X-ray absorptiometry (DEXA) with Lunar DPX-IQ device and lumbar 2-4 volumetric bone mineral apparent density (L 2-4 BMAD, g/cm 3) was subsequently calculated. Correlation and multiple regression analyses were performed. Results: Compared with 31 age-matched male controls, AS patients had significantly lower L 2-4BMD [(0.984±0.142) g/cm 2 vs (1.055±0.137) g/cm 2, P=0.049] and L 2-4BMAD [(0.1527±0.0173) g/cm 3 vs (0.1630±0.0195) g/cm 3, P=0.032]. In AS patients, multiple regression analysis identified that only the factor of height was significantly correlated with L 2-4BMC (R=0.673, P=0.000) and the factor of weight had predominant influences on L 2-4BMD (R=0.620, P=0.000) as well as L 2-4BMAD (R=0.510, P=0.003). Conclusion: The young patients with early AS had marked reduction in lumbar spine bone mineral densities, which indicated an important primary event leading to osteoporosis. Positive effects of height and weight on lumbar spine bone mass and densities could expectantly make favorable contributions to early prevention of AS associated bone loss and subsequent osteoporosis.展开更多
目的：探讨男性和女性强直性脊柱炎（ Ankylosing Spondylitis，AS）患者骨密度（ Bone mineral density，BMD）及BMD与其他临床指标的相关性。方法回顾性调查2006年3月至2014年12月中日友好医院中医风湿病科确诊为AS的患者，其中女性16...目的：探讨男性和女性强直性脊柱炎（ Ankylosing Spondylitis，AS）患者骨密度（ Bone mineral density，BMD）及BMD与其他临床指标的相关性。方法回顾性调查2006年3月至2014年12月中日友好医院中医风湿病科确诊为AS的患者，其中女性168例，男性587例，年龄在20岁～45岁，双光能X线法检测腰椎、股骨颈、股骨粗隆的BMD，并与年龄、病程、疾病活动性指标、影像学指标进行相关分析。结果①男性AS患者腰椎BMD较女性腰椎BMD显著减低（ P＜0.01）；男性AS患者骨质疏松（Osteoporosis，OP）及骨量减少（Osteopenia，OT）总发生率为71.04％，显著高于女性AS患者的42.86％（P＜0.05），且在腰椎、股骨颈、股骨粗隆部位的OP、OT发生率均显著高于女性AS患者（P＜0.01）；②中年龄组（30～39岁）及高年龄组（40～45岁）的AS患者中男性腰椎BMD较女性显著降低（ P＜0.01）；高年龄组AS患者中男性股骨颈BMD较女性显著降低（ P＜0.01）；病程5～10年及大于10年的AS患者中男性腰椎、股骨颈BMD较女性显著降低（ P＜0.01、P＜0.01、P＜0.01、P＜0.05）③相关性分析显示男性与女性AS患者BMD与疾病活动指标ESR、CRP，体征、骶髂关节炎分级等有相关性，而男性AS患者BMD与年龄、病程尚呈显著负相关（ P＜0.05）。结论男女AS患者均有较高的OT、OP的发生率，且男性OT及OP的较之女性更为显著，特别是腰椎BMD男性AS患者减低更为突出。此外年龄越大、病程越长的男性AS患者BMD减低程度越明显。男性与女性AS患者BMD的下降均与疾病程度、病情的活动性、肢体活动功能、HLA-B27相关联。对于男性AS患者更需要重视OT及OP的诊断与防治。展开更多
目的研究不同类型高冲击运动对于骨密度（bone mineral density,BMD）和骨矿含量（bone mineral content,BMC）的影响。方法招募39名志愿者,其中伞兵、篮球运动员和作为对照组的普通大学生各13名,将其分成两组（第1组：20～22岁;第2组...目的研究不同类型高冲击运动对于骨密度（bone mineral density,BMD）和骨矿含量（bone mineral content,BMC）的影响。方法招募39名志愿者,其中伞兵、篮球运动员和作为对照组的普通大学生各13名,将其分成两组（第1组：20～22岁;第2组：23～25岁）,分别测量跟骨、第1～5跖骨、髋关节和腰椎（L1～4）BMD和BMC。结果篮球运动员跟骨、第1、2跖骨、总腰椎和髋部BMC显著大于伞兵和对照组;篮球运动员在腰椎、髋关节和股骨颈处BMD也显著大于其他组;伞兵和对照组在测量部位的BMD和BMC无显著性差异。结论 BMC与BMD并非总是正比于平时运动时的垂直地面反作用力。相比跳伞训练,篮球运动能更好提高BMC和BMD,这种变载荷运动作为训练方法,更有利于降低骨质疏松性骨折的风险。展开更多
探讨非骨质疏松男性体重指数(Body mass index,BMI)与腰椎骨密度(Bone mineral density,BMD)、骨矿含量(Bone mineral content,BMC)之间的相关性,明确体重指数对人体腰椎BMD、BMC的影响。对2003.8～2005.12因骨关节疼痛在四川大学华西...探讨非骨质疏松男性体重指数(Body mass index,BMI)与腰椎骨密度(Bone mineral density,BMD)、骨矿含量(Bone mineral content,BMC)之间的相关性,明确体重指数对人体腰椎BMD、BMC的影响。对2003.8～2005.12因骨关节疼痛在四川大学华西医院就诊并经双能X线骨密度仪检测,骨密度<-2.5SD的838例男性患者,计算BMI(Kg/m2)并分组:BMI≥23为第1组(该组按BMI≥29为A组46人、25≤BMI<28.9为B组201人、23≤BMI<24.9为C组193人);18.5<BMI<22.9为第2组311人;BMI≤18.5为第3组68人,应用SPSS13.0统计软件进行统计分析。(1)1、2、3组间比较,L2-L4BMD、平均BMD、aBMC比较均为3组>2组>1组,差异显著有统计学意义(P<0.05或P<0.01);L3和L4BMC、aBMC及L2aBMC均为3组>2组>1组,差异显著(P<0.01),而L2BMC为1组>3组>2组,无统计学意义(P>0.05);T值组间比较无统计学意义(P>0.05)。(2)1组中,A、B、C三组内比较,L2-L4BMD、平均BMD均为C组>B组>A组,差异显著,有统计学意义(P<0.05或P<0.01);L3和L4BMC、aBMC及L2aBMC均为C组>B组>A组,差异显著(P<0.01),而L2BMC为A组>C组>B组,差异无统计学意义(P>0.05);T值各组内比较无统计学意义(P>0.05)。(3)BMI与平均BMD呈负相关性(P<0.01,r=-0.189)。非骨质疏松男性其体重指数升高可降低腰椎平均骨密度,且肥胖越明显者,其腰椎平均骨密度下降越明显,L3和L4骨密度、骨矿含量、总骨矿含量下降幅度可能大于L2。展开更多
文摘Objective: To explore the possible factors influencing lumbar spinal bone mineral contents and bone mineral densities in Chinese adolescents with early ankylosing spondylitis(AS). Methods: Thirty-one male Chinese adolescent outpatients with early AS were included and compared with 31 age-matched male controls. Age (year), height (cm), total body weight (kg) together with body mass index (BMI, kg/m 2) of all subjects and disease duration (month), BASMI, BASFI, BASDAI, SASSS as well as ESR (mm/h) of AS patients were obtained. Lumbar 2-4 bone mineral content (L 2-4BMC, g) and lumbar 2-4 areal bone mineral density (L 2-4 BMD, g/cm 2) were evaluated using dual-energy X-ray absorptiometry (DEXA) with Lunar DPX-IQ device and lumbar 2-4 volumetric bone mineral apparent density (L 2-4 BMAD, g/cm 3) was subsequently calculated. Correlation and multiple regression analyses were performed. Results: Compared with 31 age-matched male controls, AS patients had significantly lower L 2-4BMD [(0.984±0.142) g/cm 2 vs (1.055±0.137) g/cm 2, P=0.049] and L 2-4BMAD [(0.1527±0.0173) g/cm 3 vs (0.1630±0.0195) g/cm 3, P=0.032]. In AS patients, multiple regression analysis identified that only the factor of height was significantly correlated with L 2-4BMC (R=0.673, P=0.000) and the factor of weight had predominant influences on L 2-4BMD (R=0.620, P=0.000) as well as L 2-4BMAD (R=0.510, P=0.003). Conclusion: The young patients with early AS had marked reduction in lumbar spine bone mineral densities, which indicated an important primary event leading to osteoporosis. Positive effects of height and weight on lumbar spine bone mass and densities could expectantly make favorable contributions to early prevention of AS associated bone loss and subsequent osteoporosis.
文摘目的研究不同类型高冲击运动对于骨密度（bone mineral density,BMD）和骨矿含量（bone mineral content,BMC）的影响。方法招募39名志愿者,其中伞兵、篮球运动员和作为对照组的普通大学生各13名,将其分成两组（第1组：20～22岁;第2组：23～25岁）,分别测量跟骨、第1～5跖骨、髋关节和腰椎（L1～4）BMD和BMC。结果篮球运动员跟骨、第1、2跖骨、总腰椎和髋部BMC显著大于伞兵和对照组;篮球运动员在腰椎、髋关节和股骨颈处BMD也显著大于其他组;伞兵和对照组在测量部位的BMD和BMC无显著性差异。结论 BMC与BMD并非总是正比于平时运动时的垂直地面反作用力。相比跳伞训练,篮球运动能更好提高BMC和BMD,这种变载荷运动作为训练方法,更有利于降低骨质疏松性骨折的风险。
文摘探讨非骨质疏松男性体重指数(Body mass index,BMI)与腰椎骨密度(Bone mineral density,BMD)、骨矿含量(Bone mineral content,BMC)之间的相关性,明确体重指数对人体腰椎BMD、BMC的影响。对2003.8～2005.12因骨关节疼痛在四川大学华西医院就诊并经双能X线骨密度仪检测,骨密度<-2.5SD的838例男性患者,计算BMI(Kg/m2)并分组:BMI≥23为第1组(该组按BMI≥29为A组46人、25≤BMI<28.9为B组201人、23≤BMI<24.9为C组193人);18.5<BMI<22.9为第2组311人;BMI≤18.5为第3组68人,应用SPSS13.0统计软件进行统计分析。(1)1、2、3组间比较,L2-L4BMD、平均BMD、aBMC比较均为3组>2组>1组,差异显著有统计学意义(P<0.05或P<0.01);L3和L4BMC、aBMC及L2aBMC均为3组>2组>1组,差异显著(P<0.01),而L2BMC为1组>3组>2组,无统计学意义(P>0.05);T值组间比较无统计学意义(P>0.05)。(2)1组中,A、B、C三组内比较,L2-L4BMD、平均BMD均为C组>B组>A组,差异显著,有统计学意义(P<0.05或P<0.01);L3和L4BMC、aBMC及L2aBMC均为C组>B组>A组,差异显著(P<0.01),而L2BMC为A组>C组>B组,差异无统计学意义(P>0.05);T值各组内比较无统计学意义(P>0.05)。(3)BMI与平均BMD呈负相关性(P<0.01,r=-0.189)。非骨质疏松男性其体重指数升高可降低腰椎平均骨密度,且肥胖越明显者,其腰椎平均骨密度下降越明显,L3和L4骨密度、骨矿含量、总骨矿含量下降幅度可能大于L2。
