Annona squamosa Linn.fruit is famous for its nutritional value with a long history of medicinal benefits due to the presence of many phytochemicals,including alkaloids,diterpenes,essential oil,phytopeptides,etc.Severa...Annona squamosa Linn.fruit is famous for its nutritional value with a long history of medicinal benefits due to the presence of many phytochemicals,including alkaloids,diterpenes,essential oil,phytopeptides,etc.Several studies envisaged that Annona squamosa possesses cytotoxic,diuretic,antiurolithiatic,antitumor,anti-psoriatic,antioxidant,and hepatoprotective properties.This plant is traditionally used for the treatment of wound infection,dysentery,seizure,tumors,fever,vomiting,parasitic infections,hypertension,thyroid,toothache,acne,heart disease,inflammation,diabetes,hair loss,dandruff,hemorrhage,maggot-infected sores,abortifacient,and cough.However,some chemical constituents isolated from the plant have shown specific toxic effects in human and animal models,such as acute oral toxic effects,genotoxic,neurotoxic,and ocular toxic.The plant has diverse pharmacological actions,the seeds of this plant possess a genotoxic effect but on the contrary,the bark of the plant shows genoprotective activity.A large number of ethnobotanical studies reported the seed of this plant is used to induce abortion in humans,but a scientific study carried out in pregnant rats reported aqueous seed extract of the plant did not interfere with reproductive performance.The presented review summarized the traditional uses,pharmacological,and toxicological activities of the isolated compounds from this plant.Additionally,some patents and commercial products related to Annona squamosa are also brought up in this article to explore its application which would attract the scientific community to search out its hidden side.展开更多
A new Annonaceous acetogenin, squamostolide (1), was isolated from the seeds of Annona squamosa. Its structure was elucidated based on spectroscopic methods and comparison with known compounds. It is the first examp...A new Annonaceous acetogenin, squamostolide (1), was isolated from the seeds of Annona squamosa. Its structure was elucidated based on spectroscopic methods and comparison with known compounds. It is the first example of Annonaceous acetogenin with each of the two ends of the aliphatic chain bearing a g-lactone. The new compound exhibited cytotoxic activity in vitro against bel-7402 and CNE2 human tumor cell lines.展开更多
<i><span style="font-family:"">Annona</span></i><span style="font-family:""> <i>muricata</i> L. and <i>Annona</i> <i>squamosa&l...<i><span style="font-family:"">Annona</span></i><span style="font-family:""> <i>muricata</i> L. and <i>Annona</i> <i>squamosa</i> L. are tropical species whose</span><span style="font-family:""> fleshy fruit is edible. They offer real possibilities for socio-economic use, particularly in the fields of medicine, nutrition, ecosystem conservation and the poverty alleviation. This study was set up to evaluate different methods of micropropagation from juvenile material for the regeneration of these species. Thus, MS medium supplemented with [BAP 2 mg·L<sup>-1</sup>] <i>i.e.</i> M2 produced 2.87 newly <span>formed shoots from the cotyledonary nodes of <i>A.</i> <i>muricata</i>. For the terminal apices of <i>A.</i> <i>squamosa</i>, it was MMS medium supplemented with [BAP 2</span> mg·L<sup>-1</sup>] <i>i.e.</i> MM2 that was most conducive to new shoot formation (3.12). The addition of 0.1 and 0.2 mg·L<sup>-1</sup> of NAA in the M2 medium, made it possi<span>ble to have the best elongations and average number of nodes for the new shoots from cotyledonary nodes of <i>A.</i> <i>muricata</i> (9.11 cm for 5.62 nodes). With <i>A.</i> <i>squamosa</i>, MM7 medium [MMS + BAP 1 mg·L<sup>-1</sup></span></span><span style="font-family:""> </span><span style="font-family:"">+ KIN 1 mg·L<sup>-1</sup>]</span><span style="font-family:""> resulted in an average length of 9.05 cm with 5.62 nodes on average for the apical shoots. A 3-day rhizogenic induction period in the dark with [IBA 50 mg·L<sup>-1</sup>] and 2 g·L<sup>-1</sup> of activated charcoal gave a rooting rate of 66.67% for shoots originating from the cotyledonary nodes of <i>A.</i> <i>squamosa</i>;while with vitroplants from cotyledonary nodes of <i>A.</i> <i>muricata</i>, a better rooting rate (83.33%) was obtained following a 5-day rhizogenic induction. After 30 days of acclimatization, the survival rate reached 83.33% for plants from the tips of <i>A.</i> <i>muricata</i>, whereas for <i>A.</i> <i>squamosa,</i> it was plants grown from cotyledonary nodes that had the same survival rate.展开更多
A novel cyclopeptide, squamin-A has been isolated from the seeds of Annona squamosa Linn.. The structure was elucidated by extensive 2D-NMR, FABMS and amino acid analysis in combination with Marfey's reagents as c...A novel cyclopeptide, squamin-A has been isolated from the seeds of Annona squamosa Linn.. The structure was elucidated by extensive 2D-NMR, FABMS and amino acid analysis in combination with Marfey's reagents as cyclo-[l-prolyl-l-(S-oxo)-methionyl-l-tyrosyl-l-glycyl-tythreonyl-l-valyl-l-alanyl-l-isoleucyl].展开更多
The research progress on pests and insecticide activity of Annona squamosa L. is summarized in the paper, including symptom, occurrence regularity and control methods. Furthermore, the comprehensive technique for cont...The research progress on pests and insecticide activity of Annona squamosa L. is summarized in the paper, including symptom, occurrence regularity and control methods. Furthermore, the comprehensive technique for controlling pests of A. squamosa in the future is preliminarily discussed.展开更多
Eight new annonaceous acetogenins, squamotin A–D(1–4), annosquatin IV–V(5 and 6), muricin O(7) and squamosten B(8), together with four known ones(9–12) were isolated from the seeds of Annona squamosa. Their struct...Eight new annonaceous acetogenins, squamotin A–D(1–4), annosquatin IV–V(5 and 6), muricin O(7) and squamosten B(8), together with four known ones(9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.展开更多
文摘Annona squamosa Linn.fruit is famous for its nutritional value with a long history of medicinal benefits due to the presence of many phytochemicals,including alkaloids,diterpenes,essential oil,phytopeptides,etc.Several studies envisaged that Annona squamosa possesses cytotoxic,diuretic,antiurolithiatic,antitumor,anti-psoriatic,antioxidant,and hepatoprotective properties.This plant is traditionally used for the treatment of wound infection,dysentery,seizure,tumors,fever,vomiting,parasitic infections,hypertension,thyroid,toothache,acne,heart disease,inflammation,diabetes,hair loss,dandruff,hemorrhage,maggot-infected sores,abortifacient,and cough.However,some chemical constituents isolated from the plant have shown specific toxic effects in human and animal models,such as acute oral toxic effects,genotoxic,neurotoxic,and ocular toxic.The plant has diverse pharmacological actions,the seeds of this plant possess a genotoxic effect but on the contrary,the bark of the plant shows genoprotective activity.A large number of ethnobotanical studies reported the seed of this plant is used to induce abortion in humans,but a scientific study carried out in pregnant rats reported aqueous seed extract of the plant did not interfere with reproductive performance.The presented review summarized the traditional uses,pharmacological,and toxicological activities of the isolated compounds from this plant.Additionally,some patents and commercial products related to Annona squamosa are also brought up in this article to explore its application which would attract the scientific community to search out its hidden side.
文摘A new Annonaceous acetogenin, squamostolide (1), was isolated from the seeds of Annona squamosa. Its structure was elucidated based on spectroscopic methods and comparison with known compounds. It is the first example of Annonaceous acetogenin with each of the two ends of the aliphatic chain bearing a g-lactone. The new compound exhibited cytotoxic activity in vitro against bel-7402 and CNE2 human tumor cell lines.
文摘<i><span style="font-family:"">Annona</span></i><span style="font-family:""> <i>muricata</i> L. and <i>Annona</i> <i>squamosa</i> L. are tropical species whose</span><span style="font-family:""> fleshy fruit is edible. They offer real possibilities for socio-economic use, particularly in the fields of medicine, nutrition, ecosystem conservation and the poverty alleviation. This study was set up to evaluate different methods of micropropagation from juvenile material for the regeneration of these species. Thus, MS medium supplemented with [BAP 2 mg·L<sup>-1</sup>] <i>i.e.</i> M2 produced 2.87 newly <span>formed shoots from the cotyledonary nodes of <i>A.</i> <i>muricata</i>. For the terminal apices of <i>A.</i> <i>squamosa</i>, it was MMS medium supplemented with [BAP 2</span> mg·L<sup>-1</sup>] <i>i.e.</i> MM2 that was most conducive to new shoot formation (3.12). The addition of 0.1 and 0.2 mg·L<sup>-1</sup> of NAA in the M2 medium, made it possi<span>ble to have the best elongations and average number of nodes for the new shoots from cotyledonary nodes of <i>A.</i> <i>muricata</i> (9.11 cm for 5.62 nodes). With <i>A.</i> <i>squamosa</i>, MM7 medium [MMS + BAP 1 mg·L<sup>-1</sup></span></span><span style="font-family:""> </span><span style="font-family:"">+ KIN 1 mg·L<sup>-1</sup>]</span><span style="font-family:""> resulted in an average length of 9.05 cm with 5.62 nodes on average for the apical shoots. A 3-day rhizogenic induction period in the dark with [IBA 50 mg·L<sup>-1</sup>] and 2 g·L<sup>-1</sup> of activated charcoal gave a rooting rate of 66.67% for shoots originating from the cotyledonary nodes of <i>A.</i> <i>squamosa</i>;while with vitroplants from cotyledonary nodes of <i>A.</i> <i>muricata</i>, a better rooting rate (83.33%) was obtained following a 5-day rhizogenic induction. After 30 days of acclimatization, the survival rate reached 83.33% for plants from the tips of <i>A.</i> <i>muricata</i>, whereas for <i>A.</i> <i>squamosa,</i> it was plants grown from cotyledonary nodes that had the same survival rate.
文摘A novel cyclopeptide, squamin-A has been isolated from the seeds of Annona squamosa Linn.. The structure was elucidated by extensive 2D-NMR, FABMS and amino acid analysis in combination with Marfey's reagents as cyclo-[l-prolyl-l-(S-oxo)-methionyl-l-tyrosyl-l-glycyl-tythreonyl-l-valyl-l-alanyl-l-isoleucyl].
基金Supported by Basic Research Funds for the National Natural Science Foundation of China ( No. 31201581)Natural Science Foundation of Hainan Province ( No. 312033)Basic Research Funds for Central Public Research Institutes ( No. 1630062012007)
文摘The research progress on pests and insecticide activity of Annona squamosa L. is summarized in the paper, including symptom, occurrence regularity and control methods. Furthermore, the comprehensive technique for controlling pests of A. squamosa in the future is preliminarily discussed.
基金supported by the National Natural Science Foundation of China(Nos.81573577,81274057 and 81403082)
文摘Eight new annonaceous acetogenins, squamotin A–D(1–4), annosquatin IV–V(5 and 6), muricin O(7) and squamosten B(8), together with four known ones(9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.
