Metal/nucleophilic Lewis base dual catalysis has been recognized as a reliable and promising strategy for finishing ideal organic synthesis over the past decades.The new strategy can usually achieve some chemical reac...Metal/nucleophilic Lewis base dual catalysis has been recognized as a reliable and promising strategy for finishing ideal organic synthesis over the past decades.The new strategy can usually achieve some chemical reactions that cannot be realized by the traditionally mono-catalytic system,dramatically expanding the synthetic utility of chemical transformations by leveraging additional activation modes.Thus considerable progress has been made in the synthesis of a wide range of heterocyclic and biologically active compounds by using the combination of diversely metal/nucleophilic Lewis base dual catalysts,including metal/phosphine,metal/N-heterocyclic carbene(NHC)and metal/tertiary amine dual catalysis systems.In this review,we describe a comprehensive and updated advance of metal/nucleophilic Lewis base dual catalytic annualtion reactions,meanwhile,the related mechanism and the application of these annulation strategies in natural product total synthesis will be highlighted in detail.展开更多
Lewis base-catalyzed annulations of allenoates have been one of the most powerful synthetic strategies for the synthesis of various valuable cycles,especially in the preparation of biologically active natural products...Lewis base-catalyzed annulations of allenoates have been one of the most powerful synthetic strategies for the synthesis of various valuable cycles,especially in the preparation of biologically active natural products and pharmaceuticals.Generally,the effective Lewis bases mainly include tertiary phosphine,NHC and tertiary amine catalysts,among those catalysis,tertiary amine Lewis bases have proven to be effective catalysts for a range of synthetic transformations.In the past decades,tremendous progress in-volving tertiary amines-promoted cycloaddition of allenoates has been made in the chemoselective con-struction of valuable motifs.This review describes a comprehensive and updated summary of tertiary amine Lewis base-promoted annulation reactions of allenoates.Diverse reactivities,chemoselectivties and detailed reaction mechanisms will be highlighted in this review.展开更多
基金the National Natural Science Foundation of China(No.21702189)the Key Scientific and Technological Project of Henan Province(No.202102310004)+1 种基金Science and Technology Research and Development Plan Joint Fund(cultivation of superior disciplines)Project(No.222301420042)Zhengzhou University(No.JC21253007)of China for financial support of this research.
文摘Metal/nucleophilic Lewis base dual catalysis has been recognized as a reliable and promising strategy for finishing ideal organic synthesis over the past decades.The new strategy can usually achieve some chemical reactions that cannot be realized by the traditionally mono-catalytic system,dramatically expanding the synthetic utility of chemical transformations by leveraging additional activation modes.Thus considerable progress has been made in the synthesis of a wide range of heterocyclic and biologically active compounds by using the combination of diversely metal/nucleophilic Lewis base dual catalysts,including metal/phosphine,metal/N-heterocyclic carbene(NHC)and metal/tertiary amine dual catalysis systems.In this review,we describe a comprehensive and updated advance of metal/nucleophilic Lewis base dual catalytic annualtion reactions,meanwhile,the related mechanism and the application of these annulation strategies in natural product total synthesis will be highlighted in detail.
基金the National Natural Science Foundation of China(No.21702189)Key Scientific and Technological Project of Henan Province(No.202102310004)Zhengzhou University(No.JC21253007)of China for financial support.
文摘Lewis base-catalyzed annulations of allenoates have been one of the most powerful synthetic strategies for the synthesis of various valuable cycles,especially in the preparation of biologically active natural products and pharmaceuticals.Generally,the effective Lewis bases mainly include tertiary phosphine,NHC and tertiary amine catalysts,among those catalysis,tertiary amine Lewis bases have proven to be effective catalysts for a range of synthetic transformations.In the past decades,tremendous progress in-volving tertiary amines-promoted cycloaddition of allenoates has been made in the chemoselective con-struction of valuable motifs.This review describes a comprehensive and updated summary of tertiary amine Lewis base-promoted annulation reactions of allenoates.Diverse reactivities,chemoselectivties and detailed reaction mechanisms will be highlighted in this review.
