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Liu-Jun-Zi decoction alleviates chemotherapy-induced anorexia by regulating gut microbiota and TLR4/MyD88/NF-κB p65 signaling pathway
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作者 Yu-Jie Gao Xi-Pei Wu +4 位作者 Bin-Bin Ye Yong-Zhao Dai Yao-Zhong Zhao Xiu-Xiu Liao Ke Nie 《Traditional Medicine Research》 2024年第8期47-58,共12页
Background:Liu-Jun-Zi decoction(LJZD),a classical nourishing formula in China,has been proven to be effective in treating chemotherapy-induced anorexia.In this study,the mechanism of LJZD in alleviating chemotherapy-i... Background:Liu-Jun-Zi decoction(LJZD),a classical nourishing formula in China,has been proven to be effective in treating chemotherapy-induced anorexia.In this study,the mechanism of LJZD in alleviating chemotherapy-induced anorexia was discussed from the aspects of regulating gut microbiota,repairing intestinal barrier injury and inhibiting inflammatory pathways.Methods:A rat model of chemotherapy-induced anorexia was established using cisplatin.The study evaluated the therapeutic effects of LJZD by observing the weight,food intake,and intestinal pathology of rats.The impact of LJZD on gut microbiota and metabolites,specifically short-chain fatty acids,was investigated through gut microbiota analysis and targeted metabolomics.The anti-inflammatory and intestinal protective effects of LJZD were assessed by examining the expression of intestinal tight junction proteins associated with the inflammatory pathway.Results:LJZD alleviated cisplatin-induced inflammation and intestinal barrier disruption,as evidenced by upregulated expression of tight junction protein 1(TJ-1)and occludin,along with reduced serum levels of interleukin 6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and lipopolysaccharide.Additionally,LJZD alleviated microbiota imbalance and regulated the levels of short-chain fatty acids,especially increased the relative abundance of Coriobacteriales Incertae Sedis,Lactabacillus johnsonii F19785,Parasutterella,and reduced the Tyzzerella.In the hypothalamus,LJZD exerts suppressive effects on the toll-like receptor 4(TLR4)/myeloid differentiation factor 88(MyD88)/nuclear factor-κB(NF-κB)p65 signaling pathway,leading to a downregulation in the transcriptional activity of IL-6 and IL-1β,as well as Interleukin 6 receptors(IL-6R)and Interleukin-1βreceptors(IL-1R1)mRNA expression levels.Conclusion:In summary,LJZD alleviate chemotherapy-induced anorexia by modulating the gut microbiota,repairing the intestinal mechanical barriers,and suppressing the TLR4/MyD88/NF-κB p65 signaling pathway. 展开更多
关键词 Liu-Jun-Zi decoction chemotherapy-induced anorexia cisplatin TLR4/MyD818/NF-κB p65 gut microbiota rat
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Eating Disorders and Pregnancy: The Case of Anorexia
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作者 Anne-Sophie Gautier 《Open Journal of Psychiatry》 2024年第4期353-373,共21页
The question of the link between pregnancy and eating disorders is an important question. At the moment, there are few concrete answers for these patients. Despite common fertility challenges, patients who suffer from... The question of the link between pregnancy and eating disorders is an important question. At the moment, there are few concrete answers for these patients. Despite common fertility challenges, patients who suffer from ED are able to access maternity. ED and pregnancy can either have an easy evolution or experience a lot of trouble. Many studies describe obstetrical and foetal complications (low birthweight, inadequate intra-uterine growth, small head circumference, miscarriage, caesarean section). Those patients are frequently reluctant to address their disease with their specialist, who also often doesn’t know how to screen the signs. The lack of official data to train the specialists further increases these difficulties. However, ED are frequent in the general population and young patients are likely to eventually want to become mothers. It is thus essential to know how to screen those patients early and accurately to improve their treatment and care. Eating disorders impact the pregnancy, the delivery and the postpartum as well as the growth of the baby. It is an important public health problem. The evolution from being a woman to becoming a mother is a difficult one, and even more so when the women is suffering from ED. Those patients must handle their nutritional fears, the anxiety about their body changing with pregnancy and the daily challenges. The early interactions with their baby have consequences on their development. It seems necessary to evaluate how to improve the screening and the patient care in ED patients. Screening should begin from the pregnancy desire to the postpartum. This patient care should be based on a multidisciplinary care team. 展开更多
关键词 Eating Disorders anorexia PREGNANCY CHILD POSTPARTUM
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The Outcome of Adolescent-Onset Anorexia Nervosa: A Study of 144 Cases 被引量:1
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作者 Solenn Kermarrec Bernard Kabuth +2 位作者 Anne-Christine Rat Michel Vidailhet Colette Vidailhet 《Health》 2014年第14期1883-1893,共11页
Objectives: To evaluate the long-term outcome of adolescents with anorexia nervosa and attempt to define prognostic factors for outcome. Methods: Transversal, descriptive epidemiological study with a strict methodolog... Objectives: To evaluate the long-term outcome of adolescents with anorexia nervosa and attempt to define prognostic factors for outcome. Methods: Transversal, descriptive epidemiological study with a strict methodology: minimum interval of 4 years since first admission, evaluation using clearly defined diagnostic criteria (EAT-40 self-evaluation, HSCL, global patient-driven self-evaluation and hetero evaluation: clinical interview and LECE). The 198 subjects are former adolescent anorexics treated at the H&ocirc;pital d’Enfants (Children’s Hospital) in Nancy (France). Results: Clinical evaluation of the 144 subjects traced showed positive outcome for 68.1%, intermediate outcome for 23.2% and poor outcome for 8.7%. 5 factors for a good prognosis were found (middle socioeconomic class of parents, no prior treatment, hospitalization > 1 month, 展开更多
关键词 anorexia Nervosa ADOLESCENT EPIDEMIOLOGY PROGNOSIS OUTCOME
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Self-reported and behavioural impulsivity in anorexia nervosa
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作者 Andrea Phillipou Larry Allen Abel +3 位作者 David Jonathan Castle Caroline Gurvich Matthew Edward Hughes Susan Lee Rossell 《World Journal of Psychiatry》 SCIE 2016年第3期345-350,共6页
AIM To examine how self-reported and behavioural impulsivity are related in anorexia nervosa(AN).METHODS Twenty-four females with AN and 25 healthy controls(HC) participant in the study.Self-reported impulsivity was a... AIM To examine how self-reported and behavioural impulsivity are related in anorexia nervosa(AN).METHODS Twenty-four females with AN and 25 healthy controls(HC) participant in the study.Self-reported impulsivity was assessed with the Barratt Impulsiveness Scale(BIS-11).The scale yields three second-order factors:Attentional,motor and non-planning.Behavioural impulsivity was investigated with the continuous performance test(CPT),a computer-based task of sustained attention in which numbers are flashed briefly on screen and participants are required to click the mouse when the same number appears consecutively.The rate of commission and omission errors can be used a measure of behavioural imulsivity.RESULTS AN participants self-reported increased attentional [AN:20.67(3.64),HC:13.88(2.91),P = 0.001] and reduced motor impulsivity [AN:11.55(2.28),HC:14.08(2.78),P = 0.002].The rate of omission or commission errors on the CPT did not differ between groups(P > 0.05).BIS-11 and CPT measures did not significantly correlate,but attentional impulsivity was related to negative mood states in AN(depression:r = 0.52,P = 0.010,anxiety:r = 0.55,P = 0.006,stress:r = 0.57,P = 0.004).CONCLUSION The discrepancy between self-reported and behavioural impulsivity are discussed in terms of perfectionism in AN.Furthermore,it is suggested that improving negative mood states may resolve this inconsistency in AN. 展开更多
关键词 EATING DISORDER Continuous performance anorexia nervosa Attention Inhibition
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Systematic review of evidence for different treatment settings in anorexia nervosa
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作者 Sloane Madden Phillipa Hay Stephen Touyz 《World Journal of Psychiatry》 SCIE 2015年第1期147-153,共7页
AIM: To compare outcomes in anorexia nervosa(AN) in different treatment settings: inpatient, partial hospitalization and outpatient. METHODS: Completed and published in the English language, randomized controlled tria... AIM: To compare outcomes in anorexia nervosa(AN) in different treatment settings: inpatient, partial hospitalization and outpatient. METHODS: Completed and published in the English language, randomized controlled trials comparing treatment in two or more settings or comparing different lengths of inpatient stay, were identified by database searches using terms "anorexia nervosa" and "treatment" dated to July 2014. Trials were assessed for risk of bias and quality according to the Cochrane handbook by two authors(Madden S and Hay P) Data were extracted on trial quality, participant features and setting, main outcomes and attrition. RESULTS: Five studies were identified, two comparing inpatient treatment to outpatient treatment, one study comparing different lengths of inpatient treatment, one comparing inpatient treatment to day patient treatment and one comparing day patient treatment with outpatient treatment. There was no difference in treatment outcomes between the different treatment settings and different lengths of inpatient treatment. Both outpatient treatment and day patient treatment were significantly cheaper than inpatient treatment. Brief inpatient treatment followed by evidence based outpatient care was also cheaper than prolonged inpatient care for weight normalization also followed by evidence based outpatient care. CONCLUSION: There is preliminary support for AN treatment in less restrictive settings but more research is needed to identify the optimum treatment setting for anorexia nervosa. 展开更多
关键词 anorexia nervosa Treatment INPATIENT OUTPATIENT DAY PATIENT
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Liujunzi decoction ameliorats cisplatin-induced anorexia via adjusting metabolic disorders in rats
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作者 DAI Yong-zhao CHEN Si-qi NIE Ke 《中国药理学与毒理学杂志》 CAS 北大核心 2021年第10期728-729,共2页
OBJECTIVE Cisplatin is a formidable chemotherapy agent widely applying in antineoplastic treatments,but its side effects often limit the clinical usage.Metabolic disorders are one of the side effects induced by cispla... OBJECTIVE Cisplatin is a formidable chemotherapy agent widely applying in antineoplastic treatments,but its side effects often limit the clinical usage.Metabolic disorders are one of the side effects induced by cisplatin,which closely relate to the onset of chemotherapy-induced anorexia(CIA)in cancer patients but lacks effective controls.Liujunzi decoction(LJZD)is a traditional Chinese formula that has a promising effect in treating CIA.However,whether LJZD ameliorates CIA through adjusting cisplatin-induced metabolic disorders remain unknow.The present study evaluated the mechanism of cisplatin-induced metabolic disorders,and the effect of LJZD in ameliorating these disturbances.METHODS 42 male Sprague-Dawley(SD)rats(180-220 g)were randomly divided into 3 groups:normal control group(distilled water+saline),model group(distilled water+cisplatin),LJZD group(4.8 g·kg^(-1)Liujunzi decoction ingredients+cisplatin).Intragastrical administered each drug twice a day(7∶00-19∶00)since day 0 for 4 d,animals were intraperitoneal injected with cisplatin 6 mg·kg^(-1)1 h after administration while normal control groups were injected with same volume of saline.On day 3,each group was anesthetized with pentobarbital sodium 45 mg·kg^(-1)(ip),and blood samples were collected from aorta abdominalis.Then the samples were analyzed using an LC-ESI-MS/MS system.Significantly regulated metabolites between groups were determined by VIP≥1 and absolute Log2FC(fold change)≥1.Identified metabolites were mapped to Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway database using Metaboanalyst 5.0(https://www.metaboanalyst.ca/).RESULTS A total of 133,77 and 32 differential metabolites were filtrated in control vs model,control vs LJZD and model vs LJZD groups respectively.Comparing to control,the levels of hexadecanoic acid(Log2FC=6.3153),linoleic acid(Log2FC=5.3478),and 8,11-icosadienoic acid(Log2FC=5.2342)significantly increased,and the levels of N-acetyl-L-tyrosine(Log2FC=-2.6283),cinnamic acid(Log2FC=-2.3381),N-acetylphenylalanine(Log2FC=-2.2501)significantly decreased in model group.The KEGG pathway enrichments of these metabolites indicated that,cisplatin-induced metabolic disorders by disturbing metabolism pathways such as linoleic acid metabolism,biosynthesis of unsaturated fatty acids,and phenylalanine metabolism,which suggested that the onset of CIA was partly associated with the metabolic disorders of linoleic acid,unsaturated fatty acids,and phenylalanine.Compared to control,treatment of LJZD significantly increased the levels of 4-hydroxytryptamine(Log2FC=12.0186),hexadecanoic acid(Log2FC=5.7412),linoleic acid(Log2FC=5.1877)and significantly decreased the levels of N-acetylmethionine(Log2FC=-1.7317),2-aminoethanesulfinic acid(Log2FC=-1.6578),N-acetyl-L-tyrosine(Log2FC=-1.5355).And comparing to the model group,4-hydroxytryptamine(Log2FC=12.0186),7,12-diketocholic acid(Log2FC=2.0998),N-acetylneuraminic acid(Log2FC=2.0560)markedly increased,and 3-hydroxy-3-methylpentane-1(Log2FC=-1.9202),5-dioic acid(Log2FC=-1.7166),N-isovaleroylglycine,hexanoyl glycine(Log2FC=-1.4958)markedly decreased in LJZD group.It was worth noting that,there were 23 differential metabolites filtrated both in control vs model and model vs LJZD groups,which were the key metabolites of LJZD in treating CIA.Among these 23 common metabolites,there were 16 metabolites excluding the control vs LJZD group,that was,LJZD had no effect in normal rats while being able to ameliorated cisplatin-induced metabolic disorders by regulating these 16 metabolites.Cisplatin-induced downregulation of 11 metabolites such as hydrocinnamic acid,(±)12(13)epoxy-9Z-octadecenoic acid,cinnamic acid were upregulated after LJZD treatment,and cisplatin-induced upregulation of imidazoleacetic acid,2′-deoxycytidine-5′-monophosphate and other 5 metabolites were downregulated by LJZD.The KEGG pathway analysis indicated that the linoleic acid metabolism,histidine metabolism,and pyrimidine metabolism were the most enriched metabolic pathway.Thus,cisplatin-induced metabolic disturbances mainly by disturbing linoleic acid metabolism,histidine metabolism,and pyrimidine metabolism,and LJZD interacted with these metabolic pathways to reduce metabolic disorders and thus ameliorated CIA.CONCLUSION Cisplatin-induced anorexia was closely related to the metabolic disorders of linoleic acid metabolism,biosynthesis of unsaturated fatty acids,and phenylalanine metabolism.The mechanism of LJZD in ameliorating CIA was in concerned with the metabolic adjustments,relating to the regulation of linoleic acid metabolism,histidine metabolism,and pyrimidine metabolism. 展开更多
关键词 Liujunzi decoction chemotherapy-induced anorexia CISPLATIN METABOLOMIC metabolic disorders
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Clinical Factors Influencing Quality of Life in Anorexia Nervosa Patients
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作者 Chikako Kane Masahito Tomotake +2 位作者 Sayo Hamatani Shinichi Chiba Tetsuro Ohmori 《Open Journal of Psychiatry》 2018年第1期50-60,共11页
Objective: The purpose of this study was to elucidate clinical factors influencing quality of life (QOL) in anorexia nervosa (AN) patients. Methods: Twenty female patients with AN (median age = 30.0 years, quartile de... Objective: The purpose of this study was to elucidate clinical factors influencing quality of life (QOL) in anorexia nervosa (AN) patients. Methods: Twenty female patients with AN (median age = 30.0 years, quartile deviation = 6.8) and forty female healthy controls (HC) (median age = 30.0 years, quartile deviation = 8.6) participated in the study. QOL was assessed with the 36-Item Short Form Health Survey (SF-36) and social support was evaluated using the Multidimensional Scale of Perceived Social Support (MSPSS). Clinical symptoms were evaluated with the Structured Interview Guide for the Hamilton Depression Rating Scale (SIGH-D) and the Eating Disorder Inventory-2 (EDI-2). Results: Scores of the SF-36 Mental Component Summary (MCS) (U = 124.0, P U = 223.0, P = 0.006) and scores of total (U = 108.0, P < 0.0001) and subscales of the MSPSS were lower in AN group than HC group, and the SIGH-D score was higher (U = 46.0, P ρ = &minus;0.565, P < 0.05) and subscales of the EDI-2 Interoceptive Confusion (ρ = &minus;0.556, P ρ = &minus;0.581, P ρ = &minus;0.617, P < 0.05) were negatively correlated to MCS, and score of Interoceptive Confusion subscale showed a negative correlation to RCS (ρ = &minus;0.672, P < 0.05). Moreover, stepwise regression analysis showed that the SIGH-D score was an independent predictor of MCS and Interoceptive Confusion score predicted RCS. Conclusion: These results suggest that among a variety of clinical symptoms and psychopathologies, depressive symptoms, poor emotional awareness and impaired sense of control are the most important influencing factors on AN patients’ QOL. 展开更多
关键词 anorexia Nervosa Quality of LIFE Influencing FACTOR DEPRESSION Interoceptive CONFUSION
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Psychotherapy in anorexia nervosa: What does the absence of evidence mean?
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作者 Emilio Gutiérrez Olaia Carrera 《World Journal of Translational Medicine》 2014年第3期150-157,共8页
Psychological treatment in anorexia nervosa(AN) is disheartening. Psychotherapy is the "treatment of choice" for adults though this recommendation is grounded on the absence of good quality clinical studies.... Psychological treatment in anorexia nervosa(AN) is disheartening. Psychotherapy is the "treatment of choice" for adults though this recommendation is grounded on the absence of good quality clinical studies. This paper seeks to address the question of why improvements in the psychological treatment of AN have been thwarted, and why one of the best treatments available for adult patients is specialist supportive clinical management that has entered the stage through the backdoor of nonspecific supportive treatments originally serving as a placebo treatment assigned in randomized clinical trials to control for non-specific aspects of true psychosocial treatments. The possibility that most of the psychopathological features that characterise the AN symptoms profile could be best understood as the direct consequences of emaciation would enhance the utility of research with animal models for generating new hypothesis to improve AN treatment. 展开更多
关键词 PSYCHOTHERAPY anorexia nervosa SPECIALIST supportive clinical management Non-specific PLACEBO Efficacy
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Epidemiology of anorexia nervosa in a French community-based sample of 39,542 adolescents
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作者 Nathalie T. Godart Stéphane Legleye +4 位作者 Caroline Huas Sylvana M. Coté Marie Choquet Bruno Falissard Evelyne Touchette 《Open Journal of Epidemiology》 2013年第2期53-61,共9页
Purpose: To assess the prevalence of DSM-IV anorexia nervosa criteria, anorexia nervosa and subthreshold subgroups, and their incidence between the ages of 12 and 17 years using Cole’s international thinness cut-offs... Purpose: To assess the prevalence of DSM-IV anorexia nervosa criteria, anorexia nervosa and subthreshold subgroups, and their incidence between the ages of 12 and 17 years using Cole’s international thinness cut-offs, and to characterize these anorexic adolescents by parental socioeconomic status and whether or not they reported receiving treatment. Method: In all, a representative sample of 39,542 French adolescents (19,658 girls and 19,884 boys) was recruited in a cross-sectional study in 2008. Anorexia nervosa DSM-IV diagnosis was determined by a self-administered questionnaire. Results: Among females, 0.5% (n = 105) met criteria for anorexia nervosa between the ages of 12 and 17 years, whereas among males, the prevalence was 0.03% (n = 6). In females, the prevalence of sub-threshold anorexia nervosa was found to be between 1.2% (n = 216) and 3.3% (n = 618);more than 75% were of the restrictive subtype. The highest incidence of anorexia nervosa was at 16 years. There was also a greater prevalence of sub-threshold anorexia nervosa subgroups among subjects with high parental socioeconomic status. More than half of the female adolescents who met the anorexia nervosa criteria reported receiving treatment for their disorder, versus 23% to 40% of the adolescents in the sub-threshold subgroups (P sample of adolescents. Using Cole’s international thinness cut-off could improve international comparability among studies. Adolescents from the higher socioeconomic categories were more likely to be anorexic. 展开更多
关键词 anorexia Nervosa Prevalence INCIDENCE ADOLESCENCE Community Survey
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Anorexia nervosa:Outpatient treatment and medical management
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作者 Stein Frostad Mette Bentz 《World Journal of Psychiatry》 SCIE 2022年第4期558-579,共22页
Anorexia nervosa(AN)is a disabling,costly and potentially deadly illness.Treatment failure and relapse are common after completing treatment,and a substantial proportion of patients develop severe and enduring AN.The ... Anorexia nervosa(AN)is a disabling,costly and potentially deadly illness.Treatment failure and relapse are common after completing treatment,and a substantial proportion of patients develop severe and enduring AN.The time from AN debut to the treatment initiation is normally unreasonably long.Over the past 20 years there has been empirical support for the efficacy of several treatments for AN.Moreover,outpatient treatment with family-based therapy or individual psychotherapy is associated with good outcomes for a substantial proportion of patients.Early intervention improves outcomes and should be a priority for all patients.Outpatient treatment is usually the best format for early intervention,and it has been demonstrated that even patients with severe or extreme AN can be treated as outpatients if they are medically stable.Inpatient care is more disruptive,more costly,and usually has a longer waiting list than does outpatient care.The decision as to whether to proceed with outpatient treatment or to transfer the patient for inpatient therapy may be difficult.The core aim of this opinion review is to provide the knowledge base needed for performing safe outpatient treatment of AN.The scientific essentials for outpatient treatment are described,including how to assess and manage the medical risks of AN and how to decide when transition to inpatient care is indicated.The following aspects are discussed:early intervention,outpatient treatment of AN,including outpatient psychotherapy for severe and extreme AN,how to determine when outpatient treatment is safe,and when transfer to inpatient healthcare is indicated.Emerging treatments,ethical issues and outstanding research questions are also addressed. 展开更多
关键词 anorexia nervosa Outpatient treatment Medical management Outpatient psychotherapy Inpatient healthcare
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Experience of Management of Anorexia Nervosa Patients with Extremely Severe Malnutrition in a Transdisciplinary Clinical Nutrition-Eating Disorders Inpatient Unit
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作者 M. Guinhut J. C. Melchior +1 位作者 N. Godart M. Hanachi 《International Journal of Clinical Medicine》 2020年第12期750-768,共19页
<strong>Background:</strong> The question of where to hospitalize extremely malnourished patients with anorexia nervosa (AN) is a real dilemma. On one hand, psychiatrists have to deal with severe medical c... <strong>Background:</strong> The question of where to hospitalize extremely malnourished patients with anorexia nervosa (AN) is a real dilemma. On one hand, psychiatrists have to deal with severe medical complications that are not within their competences and that justify hospitalization in an internal medicine ward. On the other hand, medical doctors have to face psychic decompensations that would justify admission to a psychiatric ward. In this context, we share our experience of management of severely malnourished AN adult patients in a transdisciplinary specialized eating disorders (ED) unit, referral center for AN associated with somatic severity. <strong>Method:</strong> First, we described the modalities of care proposed to patients with AN hospitalized in the medical unit. Intensive medical care, both somatic and psychiatric, are provided thanks to a transdisciplinary therapeutic program, where objectives are to: medically stabilize the patient, initiate progressive refeeding and start supportive psychotherapy before being transferred to a psychiatric ED unit. Secondly, we conducted a retrospective descriptive study that included all adult patients with AN admitted for the first time to the unit, between November 1997 and January 2014, for severe malnutrition and/or complications of the ED. Objective was to specify patients’ characteristics: demographic, nutritional status, history of ED, care pathway. <strong>Results: </strong>Among a cohort of 386 adult patients with AN (21 males and 365 females) admitted for the first time in the unit, mean age was 29.4 (±11.5) years, mean BMI was 12.7 (±2.2) kg/m<sup>2</sup>. Before being supported in the unit, 78.2% of patients had already been hospitalized in other hospitals. Mean length of stay was 35.2 days. Patients were clinically serious and unstable because of life-threatening somatic complications due to a low BMI. During hospital stay, a temporary transfer to medical intensive care unit was necessary for 25.6% of patients. Average patient weight gain was 0.777 kg per week and 81.9% of patients benefited from enteral nutrition.<strong> Conclusion: </strong>This specialized transdisciplinary unit where physician nutritionists and psychiatrists coordinate medical care together, allow a better understanding and management of extreme malnutrition associated with AN. Thanks to their expertise, care teams are less critical and less rejecting towards patients. Thus, therapeutic alliance could be optimized. 展开更多
关键词 anorexia Nervosa Severe Malnutrition Referral Center Transdisciplinarity
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Balancing the Inpatient-Nurse Relationship in Anorexia Care
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作者 Kristine Rø rtveit +1 位作者 Anna-Maria Sikveland Britt Saetre Hansen 《Open Journal of Nursing》 2020年第9期858-872,共15页
<strong>Background:</strong> Nurses play a central role in the treatment of inpatients with anorexia, where bonding is a key factor. The inpatient-nurse relationship is based on a confident alliance charac... <strong>Background:</strong> Nurses play a central role in the treatment of inpatients with anorexia, where bonding is a key factor. The inpatient-nurse relationship is based on a confident alliance characterized by important factors such as trust, confidentiality, responsiveness, genuineness, and consistency. <strong>Aim and Research Question:</strong> The aim of this study was to describe patients’ in-depth experiences of their relationship with nurses when hospitalized for anorexia. The research question was: How do women hospitalized due to anorexia nervosa experience the nurse-patient relationship? <strong>Method:</strong> A hermeneutic approach with in-depth interviews was employed. Five women with previous experience of inpatient care for anorexia were interviewed. <strong>Findings:</strong> The findings summarized how the women experienced the relationship with professional nurses in a ward characterized by a high degree of structure. The main theme Balancing feelings of emotional contradictions in the patient-nurse relationship was described by two sub-themes;Opening up for a care relationship in a rigid and structured ward atmosphere and Fluctuating in a paradox of conflicting feelings. <strong>Discussion:</strong> From the patients’ perspective, balancing the patient-nurse relationship when an inpatient involves conflicting emotional challenges. Structured interventions are perceived as effective by the patients, although they may be ambivalent about them. Therefore, a good relationship depends on the establishment of emotional and stable interaction with the nurses. <strong>Implications for Nursing Practice:</strong> Patients need interventions based on safe and competent quality care. A hermeneutic approach may improve the nurses’ ability to meet these patients in their lifeworld and establish a confident relationship. Special education related to anorexia care should be a priority in nursing. 展开更多
关键词 anorexia Nervosa Eating Disorders HERMENEUTICS Nurse-Patient Relationship
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Metaphors of Anorexia Analysis of Peony's Starved-for-loveSelf in Lisa See's Peony in Love
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作者 ZHANG Na 《Journal of Literature and Art Studies》 2017年第6期663-669,共7页
In Asian American writer Lisa See's novel Peony in Love (2007), the love-sick maiden Peony commits anorexiawhich finally leads to her annihilation. Anorexia, as well as foot bonding, both of which are distortions o... In Asian American writer Lisa See's novel Peony in Love (2007), the love-sick maiden Peony commits anorexiawhich finally leads to her annihilation. Anorexia, as well as foot bonding, both of which are distortions of femalebody, convey various metaphors. The novel repeatedly presents the inability to eat or eating monotonous meals assymptoms of the nervous breakdown. Through a series of feminist psychological analysis, this paper is designed tofigure out these metaphors of anorexia within the text in the following three dimensions: anorexia as imitation of art,anorexia as failure in mother-daughter relationship and the anorexic female body as a language. After explanationsof the metaphorical meaning of anorexia, this paper aims to analyze Peony's starved-for-love self, and draw aconclusion about lovesickness during the whole process of Peony's maturation. 展开更多
关键词 anorexia foot bonding female body FEMINIST psychology lovesick
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Is osteoporosis risk in anorexia nervosa underestimated? A case report series
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作者 Bruno Pacciardi Claudio Cargioli +4 位作者 Simone Belli Biagio Cotugno Samanta Augusto Luca Di Paolo Mauro Mauri 《Open Journal of Internal Medicine》 2013年第4期115-118,共4页
Introduction: Anorexia nervosa (AN) is a mental disorder whose features are deliberate weight loss, disordered body image, and intrusive overvalued fears of gaining weight. Long-term consequences of AN include endocri... Introduction: Anorexia nervosa (AN) is a mental disorder whose features are deliberate weight loss, disordered body image, and intrusive overvalued fears of gaining weight. Long-term consequences of AN include endocrine dysfunctions leading to secondary amenorrhea, bone loss and/or osteoporosis with an increased risk of bone fracture. Therefore young women with AN may develop a risk for bone fractures comparable to that of postmenopausal women. Methods: In this case report series Bone Mineral Density (BMD) was examined by Dual energy X-ray Absorptiometry (DXA) in 19 hospitalized patients with diagnosis of AN and prolonged amenorrhea. Results: All patients showed a lumbar/femoral bone loss or osteoporosis, with an increased fracture risk comparable to that of postmenopausal women. Conclusions: Our observation suggests that DXA evaluation of anorexic patients with prolonged amenorrhea would be helpful to prevent fracture risk in this population of patients. However, although DXA is almost routinely recommended in women over 65, it is not in young AN patients with prolonged amenorrhea. 展开更多
关键词 anorexia Nervosa AMENORRHEA OSTEOPOROSIS Fracturerisk DXA BMD
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Study of the effect of Jian-Pi-Xiao-Shi formula on infantile rats with anorexia
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作者 Yu-Jing Shi Jia Liang +1 位作者 Wen-Yi Zhu Hong Meng 《Drug Combination Therapy》 2021年第2期1-8,共8页
Background:The objective of this study was to study the effect of Chinese patent drug Jian-Pi-Xiao-Shi formula on rats with infantile anorexia.Methods:The Sprague Dawley rats with 4 weeks old were divided into 5 group... Background:The objective of this study was to study the effect of Chinese patent drug Jian-Pi-Xiao-Shi formula on rats with infantile anorexia.Methods:The Sprague Dawley rats with 4 weeks old were divided into 5 groups:normal group,model group,large,medium,and small doses of sample group.Twelve rats were included in each group with half males and half females.In addition to the normal group,the rats in each group were free to take the special feed during 28 consecutive days,which results in the pretended anorexia model,being the rats in the normal group free to take the ordinary feed.Except for the normal group and the model group,the other groups were given Chinese patent drug Jian-Pi-Xiao-Shi formula by a gavage of 1 mL/100g once a day for 28 days.The distilled water was given to the normal group and the model group under the same conditions.After 28 days,the contents of theβ-endorphin,cholecystokinin octapeptide,gastrin,motilin and pepsin were measured.Results:The results demonstrated that the Chinese patent drug Jian-Pi-Xiao-Shi formula could significantly increase the body weight and the food intake of the infantile rats with anorexia,increase the pepsin activity,the content of motilin and the expression ofβ-endorphin,and in the other hand decrease the expression of the cholecystokinin.Conclusion:The Chinese patent drug Jian-Pi-Xiao-Shi formula can promote the appetite and the digestive function of infantile rats with anorexia.This study suggested that the Chinese patent drug Jian-Pi-Xiao-Shi formula can enhance the appetite of the children and to improve the overall digestive function. 展开更多
关键词 Jian-Pi-Xiao-Shi formula Infantile anorexia Orexigenic hormone Digestive function
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Severe Sinus Bradycardia in Anorexia Nervosa-A Case Report
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作者 Yuichieo Yhchi Msasyuki Kato +4 位作者 Shouzou Ishise Ryozo Tatami Ryoyu Takeda Yoshikatu Nakai Isamu Miyamori 《South China Journal of Cardiology》 CAS 2007年第3期171-172,共2页
A case of anorexia nervosa complicated with severe sinus bradycardia and low T3 syndrome was reported.
关键词 anorexia nervosa BRADYCARDIA low T3 syndrome
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Clinical Analysis of 60 Cases of Children's Anorexia Treated with Massage
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作者 Yu Ping(Fushun TCM Hospital,Liaoning Province 113008,China ) 《中国针灸》 CAS CSCD 北大核心 1995年第S2期327-327,共1页
ClinicalAnalysisof60CasesofChildren'sAnorexiaTreatedwithMassage¥YuPing(FushunTCMHospital,LiaoningProvince113... ClinicalAnalysisof60CasesofChildren'sAnorexiaTreatedwithMassage¥YuPing(FushunTCMHospital,LiaoningProvince113008,China)Childre... 展开更多
关键词 Clinical Analysis of 60 Cases of Children’s anorexia Treated with Massage
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基于“脑-肠轴”理论探讨运脾消食颗粒对厌食模型大鼠CCK、Ghrelin的影响 被引量:1
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作者 杨志华 沈玉鹏 +1 位作者 李怡霏 石玉蛟 《辽宁中医药大学学报》 CAS 2024年第5期1-6,共6页
目的基于“脑-肠轴”理论,通过观察运脾消食颗粒对厌食模型大鼠血清、下丘脑、胃窦和小肠组织中胆囊收缩素(CCK)、促生长素(Ghrelin)的影响,探讨其分子机制。方法建立厌食大鼠模型,选取72只Wistar日龄30 d大鼠,SPF级,雌雄各半,体质量(60... 目的基于“脑-肠轴”理论,通过观察运脾消食颗粒对厌食模型大鼠血清、下丘脑、胃窦和小肠组织中胆囊收缩素(CCK)、促生长素(Ghrelin)的影响,探讨其分子机制。方法建立厌食大鼠模型,选取72只Wistar日龄30 d大鼠,SPF级,雌雄各半,体质量(60±10)g,随机分为空白组、模型组、阳性组(儿宝颗粒,1.75 g/kg)、运脾消食颗粒高剂量组(4.20 g/kg)、运脾消食颗粒中剂量组(2.10 g/kg)、运脾消食颗粒低剂量组(1.05 g/kg),每组12只;模型建立后灌胃给药,容量10 mL/kg,空白组和模型组灌胃等量0.9%氯化钠溶液,连续14 d,最后1次给药结束禁食禁水24 h,采集标本,ELISA法检测大鼠血清、下丘脑、胃窦和小肠组织中CCK、Ghrelin含量,Western Blot法检测大鼠下丘脑、胃窦和小肠组织中CCK、Ghrelin蛋白水平。结果对比空白组,模型组血清中CCK含量增加,Ghrelin含量下降,下丘脑、胃窦和小肠组织中CCK含量及蛋白水平增加,Ghrelin含量及蛋白水平下降(P<0.05);对比模型组,运脾消食颗粒高、中、低剂量组和阳性组血清中CCK含量明显下降,Ghrelin含量明显增加,下丘脑、胃窦和小肠组织中CCK含量及蛋白水平明显下降,Ghrelin含量及蛋白水平明显增加(P<0.05);对比阳性组,运脾消食颗粒高剂量组血清中CCK含量明显下降,Ghrelin含量明显增加,下丘脑、胃窦和小肠组织中CCK含量及蛋白水平明显下降,Ghrelin含量及蛋白水平明显增加(P<0.05)。结论运脾消食颗粒高剂量组可显著降低厌食模型大鼠血清、下丘脑、胃窦和小肠组织中CCK含量及蛋白表达,增加Ghrelin含量及蛋白表达,进而调节“脑-肠轴”的分泌异常,改善大鼠的胃肠功能。 展开更多
关键词 运脾消食颗粒 “脑-肠轴”理论 厌食模型 CCK GHRELIN
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慢性心力衰竭患者厌食症现状及其影响因素
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作者 李高叶 杨丽 +2 位作者 廖婷婷 刘玲芳 甘露 《广西医学》 CAS 2024年第6期839-846,共8页
目的调查慢性心力衰竭患者厌食症现状及其影响因素。方法采用便利抽样法,选取160例慢性心力衰竭患者,使用临床资料调查问卷、中文版厌食症恶病质治疗功能性评估‑厌食恶病质分量表、匹兹堡睡眠质量指数(PSQI)量表、医院焦虑抑郁量表对其... 目的调查慢性心力衰竭患者厌食症现状及其影响因素。方法采用便利抽样法,选取160例慢性心力衰竭患者,使用临床资料调查问卷、中文版厌食症恶病质治疗功能性评估‑厌食恶病质分量表、匹兹堡睡眠质量指数(PSQI)量表、医院焦虑抑郁量表对其进行调查,采用多因素Logistic回归模型分析影响慢性心力衰竭患者厌食症发生的因素。结果160例慢性心力衰竭患者中,厌食症发生率为50.63%(81/160)。多因素Logistic回归分析结果显示,家庭人均月收入、美国纽约心脏病学会(NYHA)心功能分级、合并消化系统疾病情况、红细胞计数、血钾水平、PSQI量表总分是慢性心力衰竭患者发生厌食症的影响因素(P<0.05)。结论慢性心力衰竭患者厌食症发生率较高,家庭人均月收入、NYHA心功能分级、合并消化系统疾病情况、红细胞计数、血钾水平、睡眠质量是慢性心力衰竭患者发生厌食症的影响因素。 展开更多
关键词 慢性心力衰竭 厌食症 影响因素
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补肾健脾膏方治疗脾虚厌食症及其对中医证候和生长发育的影响
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作者 陈斐斐 徐辉甫 鲁芳 《长春中医药大学学报》 2024年第11期1220-1223,共4页
目的 探究补肾健脾膏方治疗脾虚厌食症及其对中医证候和生长发育的影响。方法 选取2021年10月-2023年10月我院收治的106例脾虚厌食症患儿为研究对象,使用信封法将患儿分为研究组和常规组,各53例。常规组接受厌食症常规药物治疗,研究组... 目的 探究补肾健脾膏方治疗脾虚厌食症及其对中医证候和生长发育的影响。方法 选取2021年10月-2023年10月我院收治的106例脾虚厌食症患儿为研究对象,使用信封法将患儿分为研究组和常规组,各53例。常规组接受厌食症常规药物治疗,研究组在常规药物基础上联用补肾健脾膏方治疗,治疗周期均为4周。比较2组患儿的治疗有效率、中医证候积分、日摄食量、体质量指数(BMI)、胃肠道功能[胃泌素(GA)、胃动素(MLT)、血管活性肠肽(VIP)]、血清微量元素[血清铁(SF)、血清锌(Zn)、血清钙(Ca)]、药物不良反应、随访预后6个月内患儿的身高变化及预后复发率。结果 研究组的治疗有效率为96.23%,常规组为84.91%,研究组高于常规组(P<0.05);研究组主症、次症的中医证候积分均低于常规组(P<0.05);研究组治疗后的日摄食量和BMI均高于常规组(P<0.05);研究组GA、MLT水平高于常规组,VIP水平低于常规组(P<0.05);研究组SF、Zn、Ca均高于常规组(P<0.05);2组的不良反应发生率比较无统计学意义(P>0.05);研究组预后6个月的身高高于常规组(P<0.05);研究组患儿的复发率为7.55%,常规组患儿的复发率为22.64%,研究组低于常规组(P<0.05)。结论 补肾健脾膏方可有效改善脾虚厌食症患儿的厌食症状,增加每日摄食量,改善胃肠道功能,促进微量元素吸收,保障患儿正常生长发育。 展开更多
关键词 补肾健脾膏方 厌食症 中医证候 生长发育
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