In order to clarify the possible relationship between the changes of behavior/personality and metabolic changes of 5 hydroxytryptamine (5 HT) in Antarctic expedition members, plasma tryptophan (Trp) and urinary 5 ...In order to clarify the possible relationship between the changes of behavior/personality and metabolic changes of 5 hydroxytryptamine (5 HT) in Antarctic expedition members, plasma tryptophan (Trp) and urinary 5 hydroxy 3 indoleacetic acid (5 HIAA) were studied for 24 winter over and 19 summer over members of the 8th and 11th CHINARE respectively. Results showed that plasma Trp decreased significantly after residing 1￣3 months at Great Wall Station and did not recover on returning back to Beijing from Antarctica by two weeks travelling. Urinary 5 HIAA increased significantly after residing 6 months at Great Wall Station, and recovered on returning back to Beijing from Antarctica in the winter over members. The decrease of plasma Trp may be related to the decline of brain 5 HT which might play a role in the changes of behavior/personality . Increase of urinary 5 HIAA might reflect metabolic changes of 5 HT as a whole, but cold weather involving in the release response of platelet should be considered. Therefore, supplement of related food rich in Trp or intervention of L Trp might be valuable.展开更多
Since Changes of cardiac function, el ectroencephalogram findings, immune responses as well as the personality of the Antarctic expedition members had been reported by our group, the underlying contribution of behavio...Since Changes of cardiac function, el ectroencephalogram findings, immune responses as well as the personality of the Antarctic expedition members had been reported by our group, the underlying contribution of behavior and physiological changeS would be further studied in this time. Samples were taken,under standardized procedures, on the same individual at different time such as (A) before leaving to Antarctica(B) 2 weeks after arrival at Great Wall Saution(C) 12. 5 months after arrival(D) after returning back to Beijing for a break(summer-over memos) (E)after returning back to Dening for a long break(winter-over member).Results showed that a Prominent increase of urinary Noradrenaline(NE) in Antarctica(B) decreased at(C),and retUrned to the normal range in comparison with(A) and(D). The increase Of urinary Adrenaline was even greater than that of NE at Antarctica(B). It indicated that an rather early response in activation of sylnpothetic system,especially the adrenal glands,gradually lowered down as time went on.Plasma and urinary cortisol also inereased significantly at Antarctica(B), but sustained for a long time even after returning back to Beijing. Both parameters are closely related to stress syndrome.Plasma Tryptophan decreased significantly at Antarctica (B). Some even sustained after retUrning to Beijing(E). Whether or not,such changes might correlated to the change of 5-HT metabolism in brain,in turn to show some effeCt on psychoological or mental disturbanceS,which should be carefully evaluated.Serum MDA, the perokidation product, increaSing together with the findings of decreased RBC SOD activity, the scanvengrr for O2, and increased plasma glucuronidase, the lysozyme release from damage of lysosome membrane, strongly indicated the presence of cellular damage by increasing O2 production and membrase perokidation and with damage Of lysosome unduly. Severe cold and extensive ultraviolet expeure should be considered carefully.The sitwficances of the above findings were discuss and the possible preventive or therapeutic measures have ben suggested. Since the destruction of the ozonelayer might increase the extent of ultraviolet radiation,it is worth to further investigate the biological damage effect of ultraviolet in Antarctica.展开更多
The serum thyroid hormone and plasma catecholamine were examined in 18 male and 2 female members of the Chinese Antarctic Expedition (who spent the 2000 or 2001 austral winter at the Great Wall Station) . The changes ...The serum thyroid hormone and plasma catecholamine were examined in 18 male and 2 female members of the Chinese Antarctic Expedition (who spent the 2000 or 2001 austral winter at the Great Wall Station) . The changes of serum thyroid hormone i. e. total thyroxine (TT4) and free T4 (FT4) , total triodothyronine (TT3) and freeT3 ( FT3 ) , thyroid stimulating hormone ( TSH ) and plasma catecholamine, including norepinephrine (NE) , epinephrine ( E) and dopamine ( DA ) , were investigated by Chemoluminescence Immunoassay (CLIA) and High Performance Liquid Chromatography with electrochemical detection (HPLC-ECD) . Samples were taken at different time; (1)1 day before departure to Antarctica (16th expedition 1999/12/ 09; 17th expedition 2000/12/06). (2) 1 day after returned to China after living 54 weeks in Antarctica ( 16th expedition 2000/12/25 ; 17th expedition 2001/12/25 ). Comparing the data of before departure and returned, results showed that there was a significant decrease in the contents of TT4 (P <0. 01) with no significant change in the content of TT3 , FT3 and FT4. It was also found that the content of TSH increased significantly (P <0. 001) ; No significant changes of plasma NE and DA were found but the content of E decreased significantly ( P < 0. 001) . The results indicated that the special Antarctic environment led to a restrain effect on the thyroid function and the level of plasma E in Antarctic expedition members. Both the thyroid and adrenal medulla system were associated in response to the Antarctic systemic stress.展开更多
文摘In order to clarify the possible relationship between the changes of behavior/personality and metabolic changes of 5 hydroxytryptamine (5 HT) in Antarctic expedition members, plasma tryptophan (Trp) and urinary 5 hydroxy 3 indoleacetic acid (5 HIAA) were studied for 24 winter over and 19 summer over members of the 8th and 11th CHINARE respectively. Results showed that plasma Trp decreased significantly after residing 1￣3 months at Great Wall Station and did not recover on returning back to Beijing from Antarctica by two weeks travelling. Urinary 5 HIAA increased significantly after residing 6 months at Great Wall Station, and recovered on returning back to Beijing from Antarctica in the winter over members. The decrease of plasma Trp may be related to the decline of brain 5 HT which might play a role in the changes of behavior/personality . Increase of urinary 5 HIAA might reflect metabolic changes of 5 HT as a whole, but cold weather involving in the release response of platelet should be considered. Therefore, supplement of related food rich in Trp or intervention of L Trp might be valuable.
文摘Since Changes of cardiac function, el ectroencephalogram findings, immune responses as well as the personality of the Antarctic expedition members had been reported by our group, the underlying contribution of behavior and physiological changeS would be further studied in this time. Samples were taken,under standardized procedures, on the same individual at different time such as (A) before leaving to Antarctica(B) 2 weeks after arrival at Great Wall Saution(C) 12. 5 months after arrival(D) after returning back to Beijing for a break(summer-over memos) (E)after returning back to Dening for a long break(winter-over member).Results showed that a Prominent increase of urinary Noradrenaline(NE) in Antarctica(B) decreased at(C),and retUrned to the normal range in comparison with(A) and(D). The increase Of urinary Adrenaline was even greater than that of NE at Antarctica(B). It indicated that an rather early response in activation of sylnpothetic system,especially the adrenal glands,gradually lowered down as time went on.Plasma and urinary cortisol also inereased significantly at Antarctica(B), but sustained for a long time even after returning back to Beijing. Both parameters are closely related to stress syndrome.Plasma Tryptophan decreased significantly at Antarctica (B). Some even sustained after retUrning to Beijing(E). Whether or not,such changes might correlated to the change of 5-HT metabolism in brain,in turn to show some effeCt on psychoological or mental disturbanceS,which should be carefully evaluated.Serum MDA, the perokidation product, increaSing together with the findings of decreased RBC SOD activity, the scanvengrr for O2, and increased plasma glucuronidase, the lysozyme release from damage of lysosome membrane, strongly indicated the presence of cellular damage by increasing O2 production and membrase perokidation and with damage Of lysosome unduly. Severe cold and extensive ultraviolet expeure should be considered carefully.The sitwficances of the above findings were discuss and the possible preventive or therapeutic measures have ben suggested. Since the destruction of the ozonelayer might increase the extent of ultraviolet radiation,it is worth to further investigate the biological damage effect of ultraviolet in Antarctica.
基金support by Chinese National Science Foundation(No.3997801)
文摘The serum thyroid hormone and plasma catecholamine were examined in 18 male and 2 female members of the Chinese Antarctic Expedition (who spent the 2000 or 2001 austral winter at the Great Wall Station) . The changes of serum thyroid hormone i. e. total thyroxine (TT4) and free T4 (FT4) , total triodothyronine (TT3) and freeT3 ( FT3 ) , thyroid stimulating hormone ( TSH ) and plasma catecholamine, including norepinephrine (NE) , epinephrine ( E) and dopamine ( DA ) , were investigated by Chemoluminescence Immunoassay (CLIA) and High Performance Liquid Chromatography with electrochemical detection (HPLC-ECD) . Samples were taken at different time; (1)1 day before departure to Antarctica (16th expedition 1999/12/ 09; 17th expedition 2000/12/06). (2) 1 day after returned to China after living 54 weeks in Antarctica ( 16th expedition 2000/12/25 ; 17th expedition 2001/12/25 ). Comparing the data of before departure and returned, results showed that there was a significant decrease in the contents of TT4 (P <0. 01) with no significant change in the content of TT3 , FT3 and FT4. It was also found that the content of TSH increased significantly (P <0. 001) ; No significant changes of plasma NE and DA were found but the content of E decreased significantly ( P < 0. 001) . The results indicated that the special Antarctic environment led to a restrain effect on the thyroid function and the level of plasma E in Antarctic expedition members. Both the thyroid and adrenal medulla system were associated in response to the Antarctic systemic stress.
