Study of the hippocampus and the anterior cingulate gyrus by proton MR spectroscopy in patients with post-traumatic stress disorder

Objective:To explore the characteristics of metabolic changes in patients with post-traumatic stress disorder through 1H-MRS in neuroanatomical circuit comparing with age-matches controls.Methods:Fifty patients with post-traumatic stress disorder and SO gender-and agematched normal controls were involved.The neurochemical abnormalities including the levels of choline(Cho)/ creatine(Cr) and N-acetylaspartate(NAA)/Cr were measured respectively in hippocampus and the anterior cingulate gyrus with three-dimension 1H-proton specrroscopy(3D 1H-MRS).Results:The values of NAA/Cr ratios in hippocampus and the anterior cingulate gyrus were significant lower in patients with post-traumatic stress disorder(1.71±0.32,left l.58±0.29, right 1.55±0.31) than that in controls(2.24±0.41,left 1.98±0.27,right 2.02±0.36)(P【0.05).but the values of Cho/Cr in hippocampus(left 1.64±0.23,right 1.66±0.34) were no significant with that of controls(left 1.48±0.29,right 1.54±0.38).Values of Cho/Cr in cingulate gyrus were significant higher in post-traumatic stress disorder patients(I.88±0.44) than that in controls(1.37.±0.32) (P【0.05).Conclusions:The results indicate some special neurochemical and histological structure changes in post-traumatic stress disorder patients,which might occurre earlier in anterior cingulate gyrusthe than in hippocampus.

原发性失眠患者奖赏网络关键核团在静息态fMRI功能连接的改变

目的:利用功能性磁共振成像(fMRI)技术观察原发性患者奖赏网络区域中脑腹侧被盖(Ventral ttegmental area,VTA)以及伏隔核(Nucleus accumbens,NAcc)脑功能连接的改变。方法:28例原发性失眠比较26例健康对照组脑功能成像的改变,并分析中脑腹侧被盖以及伏隔核功能连接的改变与失眠的情绪障碍障碍之间的关系。结果:比较原发性失眠患者对比健康对照组,VTA与NAcc全脑的功能连接均降低,与VTA-l功能连接增降低的脑区为双侧前扣带回、左侧眶额回,与VTA-r功能连接增降低的脑区为双侧前扣带回、左侧眶额回、右侧中央前回,与NAcc-l功能连接降低的脑区为双侧丘脑、辅助运动区,与NAcc-r功能连接降低的脑区为双侧丘脑、小脑。结论:睡眠障碍会显著降低奖赏网络中VTA与NAcc的功能连接,说明长期睡眠障碍可能影响在原发性失眠患者奖赏处理能力,导致失眠患者情感功能发生障碍。