AIM:To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possi-ble relationship with gastro-esophageal reflux disease.METHODS:Thirteen healthy male volunteers were enrolled. ...AIM:To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possi-ble relationship with gastro-esophageal reflux disease.METHODS:Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine,losartan,and atenolol,as well as without any drug administration.RESULTS:Peristaltic contractions by the esophageal body were separated into three segments by two troughs. The peak peristaltic pressures in the mid and lower segments of the esophageal body under atenolol administration were signifi cantly higher than those without medication in a supine position. On the other hand,peristaltic pressures under nifedipine administration were lower than those observed without drug ad-ministration. Losartan did not change esophageal body peristalsis. Atenolol elevated LES pressure and slowed peristaltic wave transition,while the effects of nifedip-ine were the opposite. CONCLUSION:Among the anti-hypertensive drugs tested,atenolol enhanced esophageal motor activity,which was in contrast to nifedipine.展开更多
Thermal analysis of some antihypertensive drugs, Telmisartan, Cilazapril and Terazosin HCL was achieved. Thermogravimetry, derivative thermogravimetry and differential thermal analysis were used through the work. Ther...Thermal analysis of some antihypertensive drugs, Telmisartan, Cilazapril and Terazosin HCL was achieved. Thermogravimetry, derivative thermogravimetry and differential thermal analysis were used through the work. Thermogravimetric parameters such as activation energy, frequency factor and reaction order were calculated. The results show the stability value decrease in the order Telmisartan > Cilazapril > Terazosin. This method can be used in the quality control of pharmaceutical compounds because it is simple, fast and cheap.展开更多
目的研究抗焦虑抑郁药物氟哌噻吨0.5mg+美利曲辛10mg(商品名为黛力新)对更年期女性的高血压患者协同降压的疗效。方法对更年期女性高血压患者80例随机分为实验组(常规降压+黛力新)和对照组(常规降压+安慰剂)各40例,进行SCL-90评分并随访...目的研究抗焦虑抑郁药物氟哌噻吨0.5mg+美利曲辛10mg(商品名为黛力新)对更年期女性的高血压患者协同降压的疗效。方法对更年期女性高血压患者80例随机分为实验组(常规降压+黛力新)和对照组(常规降压+安慰剂)各40例,进行SCL-90评分并随访8周,比较两组血压的下降幅度、降压显效率、降压药物的数量以及治疗前后SCL-90评分的差异。结果(1)实验组在治疗2周后至结束时,血压的下降幅度[实验组:(130.6±13.5)/(80.7±10.3)mm Hg比对照组:(150.0±14.5)/(94.5±12.6)mm Hg,P<0.01]和降压显效率(86.8% vs 59.4%,P<0.01)较对照组明显提高。(2)治疗第5周后,对照组联合使用的高血压药物的数量明显较实验组明显增多(3.5±0.6vs1.8±0.6,P<0.01)。(3)实验组治疗后的SCL-90的焦虑、抑郁、躯体化症状因子评分较治疗前明显下降,对照组有轻度下降但仍明显高于常模。结论抗焦虑抑郁药物(黛力新)协同治疗更年期女性高血压患者的疗效显著,可以明显提高降压的有效率和提前显效时间、减少降血压药物的数量,同时显著降低高血压患者的焦虑、抑郁和躯体化症状的水平。展开更多
基金Supported by The Grants-in-Aid from Science Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan, No. 19590724
文摘AIM:To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possi-ble relationship with gastro-esophageal reflux disease.METHODS:Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine,losartan,and atenolol,as well as without any drug administration.RESULTS:Peristaltic contractions by the esophageal body were separated into three segments by two troughs. The peak peristaltic pressures in the mid and lower segments of the esophageal body under atenolol administration were signifi cantly higher than those without medication in a supine position. On the other hand,peristaltic pressures under nifedipine administration were lower than those observed without drug ad-ministration. Losartan did not change esophageal body peristalsis. Atenolol elevated LES pressure and slowed peristaltic wave transition,while the effects of nifedip-ine were the opposite. CONCLUSION:Among the anti-hypertensive drugs tested,atenolol enhanced esophageal motor activity,which was in contrast to nifedipine.
文摘Thermal analysis of some antihypertensive drugs, Telmisartan, Cilazapril and Terazosin HCL was achieved. Thermogravimetry, derivative thermogravimetry and differential thermal analysis were used through the work. Thermogravimetric parameters such as activation energy, frequency factor and reaction order were calculated. The results show the stability value decrease in the order Telmisartan > Cilazapril > Terazosin. This method can be used in the quality control of pharmaceutical compounds because it is simple, fast and cheap.
文摘目的研究抗焦虑抑郁药物氟哌噻吨0.5mg+美利曲辛10mg(商品名为黛力新)对更年期女性的高血压患者协同降压的疗效。方法对更年期女性高血压患者80例随机分为实验组(常规降压+黛力新)和对照组(常规降压+安慰剂)各40例,进行SCL-90评分并随访8周,比较两组血压的下降幅度、降压显效率、降压药物的数量以及治疗前后SCL-90评分的差异。结果(1)实验组在治疗2周后至结束时,血压的下降幅度[实验组:(130.6±13.5)/(80.7±10.3)mm Hg比对照组:(150.0±14.5)/(94.5±12.6)mm Hg,P<0.01]和降压显效率(86.8% vs 59.4%,P<0.01)较对照组明显提高。(2)治疗第5周后,对照组联合使用的高血压药物的数量明显较实验组明显增多(3.5±0.6vs1.8±0.6,P<0.01)。(3)实验组治疗后的SCL-90的焦虑、抑郁、躯体化症状因子评分较治疗前明显下降,对照组有轻度下降但仍明显高于常模。结论抗焦虑抑郁药物(黛力新)协同治疗更年期女性高血压患者的疗效显著,可以明显提高降压的有效率和提前显效时间、减少降血压药物的数量,同时显著降低高血压患者的焦虑、抑郁和躯体化症状的水平。
