Fetal liver tissues obtained from 28 human fetuses with gestation age from 3 to 6 months and fetal bone marrow from 35 human fetuses from 3 to 7 months were observed by immunochemical staining with anti-platelet GPⅡ ...Fetal liver tissues obtained from 28 human fetuses with gestation age from 3 to 6 months and fetal bone marrow from 35 human fetuses from 3 to 7 months were observed by immunochemical staining with anti-platelet GPⅡ b / Ⅲa monoclonal antibody and ABC technique. In the fetal liver, megakaryocytes were wholly located among growing fetal liver cells and near foci of hemopoiesis. Some megakaryocytes in the fetal liver were small7890- lymphoid-like megakaryocytes. The size of megakaryocytes both in the fetal liver (14.79 ± 4.52μm) and in the fetal bone marrow (16.08±7.39 μm) was small, which did not vary significantly over the gestation age ranging from 3 to 6 or 7 months. However, the maturation stage of megakaryocytes in the fetal liver shifted to more mature stage with the advancement of gestation, although the maturation stage of megakaryocytes in the fetal bone marrow did not change with the advancement of gestation from 4 to 7 months, the megakaryocyte in the fetal bone marrow was less mature展开更多
Forty four consecutive subjects aged 29-58 years (21 males and 23 females) with a clinical diagnosis of heterozygous familial hypercholesterolemia periodically treated every 30 days with LDL-apheresis for statin resis...Forty four consecutive subjects aged 29-58 years (21 males and 23 females) with a clinical diagnosis of heterozygous familial hypercholesterolemia periodically treated every 30 days with LDL-apheresis for statin resistance, were enrolled in this study. A lipid profile was obtained immediately before starting LDL-apheresis, a second profile was obtained within four hours after LDL-apheresis. Chit activity and anti-oxLDL levels were determined with appropriate methods in all patients before and after LDL- apheresis. Total cholesterol, LDL-cholesterol, HDL- cholesterol and triglycerides decreased significantly after LDL-apheresis, while the variations of Chit activity and anti-oxLDL were not significant after LDL-apheresis. The correlation between Chit and total cholesterol was negative (r= –0.44 and –0.50 res- pectively) before and after LDL-apheresis as between Chit and LDL-cholesterol (r= –0.45 and –0.55 respectively). Anti-oxLDL concentration before and after LDL-apheresis positively correlated with Chit activity (r= 0.52 and r = 0.63 respectively), negatively with total cholesterol (r= –0.33 and r = –0.35 res- pectively) and with LDL (r = –0.32 and r = –0.21 respectively). We think that removing LDL with LDL-apheresis the anti-oxLDL/oxLDL ratio could increase and the excess of anti-oxLDL could induce macrophage activation through the surface Fc receptors. Alternatively with high levels of LDL- cholesterol, the deposition of foam cells represent the characteristic evolution of atherosclerosis process. Macrophage activation in the heterozygous familial hypercholesterolemia could represent an attempt for re-modeling the vessel wall, reducing the growth of lipid plaques.展开更多
This paper presents a human body communication(HBC)transceiver for wireless body network applications.The transceiver employs on frequency shift keying(FSK)modulation and op-erates in 40 MHz-60 MHz which is the resona...This paper presents a human body communication(HBC)transceiver for wireless body network applications.The transceiver employs on frequency shift keying(FSK)modulation and op-erates in 40 MHz-60 MHz which is the resonant frequency of the human body as an antenna.It achieves high performance and stability through establish passive microstrip line and via models and active device-models.The proposed transceiver is designed and fabricated by FR4 printed cir-cuit board(PCB)process,the transceiver has the ability of configurable data rate up to 2 Mbps and it achieves-86 dBm receiving sensitivity at 2 Mbps data rate.Meanwhile,the transceiver out-put power dynamics range is 34 dB.Furthermore,with a visual interaction interface,the transceiv-er can be agility use in a variety of scenarios.Its measurements are verified on human body.The result shows that the transceiver has ability to send data from person to person by relying on hu-man body antenna radiation.The transceiver shows great prospect in wireless body area networks(WBAN)for telemedicine and emergency communication.展开更多
This paper proposes a novel flexible antenna design operating at very high frequency(VHF)band for on-body applications such as human body communication(HBC).The antenna consists of back-to-back E-shaped fractal and co...This paper proposes a novel flexible antenna design operating at very high frequency(VHF)band for on-body applications such as human body communication(HBC).The antenna consists of back-to-back E-shaped fractal and complimentary structures designed over a thin flex-ible substrate.The overall design working on the principle of fractal geometries and capacitive coupling is highly beneficial to achieve better antenna characteristics even at low frequencies around 35 MHz-45 MHz that are being used for HBC application.The proposed antenna obtained a large bandwidth of around 10.0 MHz in air and a bandwidth of around 8.0 MHz during on-body opera-tion.The antenna has been tested in three different scenarios viz.air,on-body single antenna and on-body communication using two antennas.The insertion loss is reduced to a minimum in all three scenarios,which is quite beneficial for better signal transmission.The size miniaturization with high flexibility in such low frequencies has also been achieved in the paper that makes the proposed design suitable for human body communication applications.展开更多
针对目前生物识别技术在穿戴式设备上应用的缺陷,提出一种可应用于可穿戴设备上的生物识别方法。利用300 k Hz^1.5 GHz的电磁波在人体通信信道传输中产生的幅度衰减特性曲线作为生物特征。为了验证此方法的可行性,首先,利用矢量网络分...针对目前生物识别技术在穿戴式设备上应用的缺陷,提出一种可应用于可穿戴设备上的生物识别方法。利用300 k Hz^1.5 GHz的电磁波在人体通信信道传输中产生的幅度衰减特性曲线作为生物特征。为了验证此方法的可行性,首先,利用矢量网络分析仪测量生物特征;其次,提取数据的梯度,使用支持向量机进行分类器模型训练和测试。验证结果与直接对采集的生物特征进行分析的方法对比,引入梯度的分析方法使得正确识别率从90.45%提高到94.54%,等错误率从0.95%降低到0.14%,接收者操作特征曲线下面积从0.997 1增加到0.999 9。因此,基于人体通信的身份识别方法可为穿戴式设备的身份认证系统研究提供一种方法。展开更多
文摘Fetal liver tissues obtained from 28 human fetuses with gestation age from 3 to 6 months and fetal bone marrow from 35 human fetuses from 3 to 7 months were observed by immunochemical staining with anti-platelet GPⅡ b / Ⅲa monoclonal antibody and ABC technique. In the fetal liver, megakaryocytes were wholly located among growing fetal liver cells and near foci of hemopoiesis. Some megakaryocytes in the fetal liver were small7890- lymphoid-like megakaryocytes. The size of megakaryocytes both in the fetal liver (14.79 ± 4.52μm) and in the fetal bone marrow (16.08±7.39 μm) was small, which did not vary significantly over the gestation age ranging from 3 to 6 or 7 months. However, the maturation stage of megakaryocytes in the fetal liver shifted to more mature stage with the advancement of gestation, although the maturation stage of megakaryocytes in the fetal bone marrow did not change with the advancement of gestation from 4 to 7 months, the megakaryocyte in the fetal bone marrow was less mature
文摘Forty four consecutive subjects aged 29-58 years (21 males and 23 females) with a clinical diagnosis of heterozygous familial hypercholesterolemia periodically treated every 30 days with LDL-apheresis for statin resistance, were enrolled in this study. A lipid profile was obtained immediately before starting LDL-apheresis, a second profile was obtained within four hours after LDL-apheresis. Chit activity and anti-oxLDL levels were determined with appropriate methods in all patients before and after LDL- apheresis. Total cholesterol, LDL-cholesterol, HDL- cholesterol and triglycerides decreased significantly after LDL-apheresis, while the variations of Chit activity and anti-oxLDL were not significant after LDL-apheresis. The correlation between Chit and total cholesterol was negative (r= –0.44 and –0.50 res- pectively) before and after LDL-apheresis as between Chit and LDL-cholesterol (r= –0.45 and –0.55 respectively). Anti-oxLDL concentration before and after LDL-apheresis positively correlated with Chit activity (r= 0.52 and r = 0.63 respectively), negatively with total cholesterol (r= –0.33 and r = –0.35 res- pectively) and with LDL (r = –0.32 and r = –0.21 respectively). We think that removing LDL with LDL-apheresis the anti-oxLDL/oxLDL ratio could increase and the excess of anti-oxLDL could induce macrophage activation through the surface Fc receptors. Alternatively with high levels of LDL- cholesterol, the deposition of foam cells represent the characteristic evolution of atherosclerosis process. Macrophage activation in the heterozygous familial hypercholesterolemia could represent an attempt for re-modeling the vessel wall, reducing the growth of lipid plaques.
基金the National Key R&D Program of China(No.2018YFC2001002)the National Natural Sci-ence Foundation of China(No.62173318)+1 种基金Shenzhen Basic Research Project(No.JCYJ20180507182231907,PIFI 2020 FYB0001)CAS Key Lab of Health Informatics.
文摘This paper presents a human body communication(HBC)transceiver for wireless body network applications.The transceiver employs on frequency shift keying(FSK)modulation and op-erates in 40 MHz-60 MHz which is the resonant frequency of the human body as an antenna.It achieves high performance and stability through establish passive microstrip line and via models and active device-models.The proposed transceiver is designed and fabricated by FR4 printed cir-cuit board(PCB)process,the transceiver has the ability of configurable data rate up to 2 Mbps and it achieves-86 dBm receiving sensitivity at 2 Mbps data rate.Meanwhile,the transceiver out-put power dynamics range is 34 dB.Furthermore,with a visual interaction interface,the transceiv-er can be agility use in a variety of scenarios.Its measurements are verified on human body.The result shows that the transceiver has ability to send data from person to person by relying on hu-man body antenna radiation.The transceiver shows great prospect in wireless body area networks(WBAN)for telemedicine and emergency communication.
基金National Key Research and Development Pro-gram of China(No.2018YFC2001002)Shenzhen Basic Re-search Project(Nos.JCYJ20180507182231907,PIFI 2020FYB0001)CAS Key Lab of Health Informatics.
文摘This paper proposes a novel flexible antenna design operating at very high frequency(VHF)band for on-body applications such as human body communication(HBC).The antenna consists of back-to-back E-shaped fractal and complimentary structures designed over a thin flex-ible substrate.The overall design working on the principle of fractal geometries and capacitive coupling is highly beneficial to achieve better antenna characteristics even at low frequencies around 35 MHz-45 MHz that are being used for HBC application.The proposed antenna obtained a large bandwidth of around 10.0 MHz in air and a bandwidth of around 8.0 MHz during on-body opera-tion.The antenna has been tested in three different scenarios viz.air,on-body single antenna and on-body communication using two antennas.The insertion loss is reduced to a minimum in all three scenarios,which is quite beneficial for better signal transmission.The size miniaturization with high flexibility in such low frequencies has also been achieved in the paper that makes the proposed design suitable for human body communication applications.
