Pemphigus is an autoimmune bullous disease observed with lesions in the skin and mucosa. Pemphigus is classified by antibodies against desmogleins, which is cadherin type intercellular adhesion factors involved in adh...Pemphigus is an autoimmune bullous disease observed with lesions in the skin and mucosa. Pemphigus is classified by antibodies against desmogleins, which is cadherin type intercellular adhesion factors involved in adhesion between epidermal cells. In this case, because erosion of the oral mucosa was the primary symptom, a relationship with membrane-dominant pemphigus vulgaris was strongly suspected. And in terms of histopathology, findings not conflicted with pemphigus vulgaris were observed, but given all these different findings, the results did not correspond with bullous pemphigoid in clinical findings, and with pemphigus foliaceus and pemphigus vulgaris in various testing results, leading us to believe this represented a very rare case. We started oral health care, and when application of steroid ointment to the entire surface of the mucosa was continued, symptoms disappeared within approximately 2 months. In this case, relapse has not yet occurred and periodic follow-up was continued.展开更多
天疱疮疾病面积评分(Pemphigus disease area index,PDAI)是评估天疱疮病情活动度众多评分体系中的可靠指标;而抗桥粒芯糖蛋白(Desmoglein,Dsg)抗体,大多学者认为与病情活动度呈正相关,但目前对此尚未达成共识。因此或许可以通过验证PDA...天疱疮疾病面积评分(Pemphigus disease area index,PDAI)是评估天疱疮病情活动度众多评分体系中的可靠指标;而抗桥粒芯糖蛋白(Desmoglein,Dsg)抗体,大多学者认为与病情活动度呈正相关,但目前对此尚未达成共识。因此或许可以通过验证PDAI值与抗Dsg抗体滴度的相关性来证实抗体滴度与病情活动度的关系,并进一步界定出病情轻中重度所对应的抗Dsg抗体滴度区间,指导治疗。国内尚无类似文献报道,还需要进一步的临床研究来证实。展开更多
文摘Pemphigus is an autoimmune bullous disease observed with lesions in the skin and mucosa. Pemphigus is classified by antibodies against desmogleins, which is cadherin type intercellular adhesion factors involved in adhesion between epidermal cells. In this case, because erosion of the oral mucosa was the primary symptom, a relationship with membrane-dominant pemphigus vulgaris was strongly suspected. And in terms of histopathology, findings not conflicted with pemphigus vulgaris were observed, but given all these different findings, the results did not correspond with bullous pemphigoid in clinical findings, and with pemphigus foliaceus and pemphigus vulgaris in various testing results, leading us to believe this represented a very rare case. We started oral health care, and when application of steroid ointment to the entire surface of the mucosa was continued, symptoms disappeared within approximately 2 months. In this case, relapse has not yet occurred and periodic follow-up was continued.
文摘天疱疮疾病面积评分(Pemphigus disease area index,PDAI)是评估天疱疮病情活动度众多评分体系中的可靠指标;而抗桥粒芯糖蛋白(Desmoglein,Dsg)抗体,大多学者认为与病情活动度呈正相关,但目前对此尚未达成共识。因此或许可以通过验证PDAI值与抗Dsg抗体滴度的相关性来证实抗体滴度与病情活动度的关系,并进一步界定出病情轻中重度所对应的抗Dsg抗体滴度区间,指导治疗。国内尚无类似文献报道,还需要进一步的临床研究来证实。
