Correlation of serum Hp-specific antibody and anti-HP-CagA antibody with coronary artery lesions in patients with coronary heart disease

Objective: To investigate the correlation of serum Hp-specific antibody and anti-HP-CagA antibody with coronary artery lesions in patients with coronary heart disease. Methods: A total of 119 patients with coronary heart disease were enrolled in coronary heart disease group and 100 healthy subjects were enrolled in normal control group. The differences in serum HP-IgG and anti-HP-CagA-IgG contents as well as lipid metabolism index, platelet function index and inflammatory mediator contents were compared between the two groups, and correlation analysis was used to determine the inner link of serum HP-IgG and anti-HP-CagA-IgG contents with coronary artery lesions in patients with coronary heart disease. Results:Serum HP-IgG and anti-HP-CagA-IgG contents of CHD group were higher than those of control group;peripheral blood lipid metabolism index TC content was higher than that of control group whereas HDL-C and apoA1 contents were lower than those of control group;serum platelet function indexes P-selectin, PAF and PDGF contents were higher than those of control group;serum inflammatory mediators hs-CRP, IL-8, IL-17 and TNF-α contents were higher than those of control group. Pearson correlation analysis showed that serum HP-IgG and anti-HP-CagA-IgG contents in patients with coronary heart disease were closely related to the degree of coronary artery lesions. Conclusion: Serum HP-IgG and anti-HP-CagA-IgG contents were extremely high in patients with coronary heart disease, and the specific contents are closely related to coronary artery lesions.

冠心病患者血清中Hp特异性抗体、抗Hp-CagA抗体与冠脉病变的相关性

目的:探讨冠心病患者血清中Hp特异性抗体、抗Hp-CagA抗体与冠脉病变的相关性。方法:冠心病患者119例作为冠心病组、健康体检者100例作为正常对照组。对比两组血清中Hp-IgG、抗Hp-CagA-IgG含量及脂质代谢指标、血小板功能指标、炎症介质含量的差异,经相关性分析冠心病患者血清中Hp-IgG、抗Hp-CagA-IgG含量与冠脉病变的内在联系。结果:冠心病组血清中Hp-IgG、抗HpCagA-IgG的含量高于正常对照组;外周血中脂质代谢指标TC的含量高于正常对照组,HDL-C、apoA1的含量低于正常对照组;血清中血小板功能指标P-selectin、PAF、PDGF的含量高于正常对照组;血清中炎症介质hs-CRP、IL-8、IL-17、TNF-α的含量高于正常对照组。Pearson相关性分析发现,冠心病患者血清中Hp-IgG、抗Hp-CagA-IgG的含量与冠脉病变程度密切相关。结论:冠心病患者血清中HpIgG、抗Hp-CagA-IgG的含量异常增高,且具体含量与冠脉病变存在密切相关。

南京梅山地区消化病患者幽门螺杆菌抗体谱分析

目的研究南京梅山地区消化病患者幽门螺旋杆菌(Hp)抗体的阳性率及其在不同年龄组与性别之间的差异,引导临床了解本地区人群患病概况,从而为不同年龄、不同性别的人群提供预防与诊断依据。方法选取2019年10月至2022年6月期间该院2564例消化科患者血清,将年龄分为<18岁、18~<45岁、45~<60岁和≥60岁四组,根据性别分为男、女两组。采用免疫印迹法检测Hp抗体:抗CagA抗体、抗VacA抗体、抗UreA抗体和抗UreB抗体,并对数据进行χ^(2)检验。结果在2564例消化科就诊患者中,1529例为Hp阳性,感染率为59.6%,Hp感染主要以Hp-Ⅱ型为主,Hp-Ⅰ型和Hp-Ⅱ型感染比较差异有统计学意义(P<0.01);18~<45岁组、45~<60岁组和≥60岁组均以VacA抗体阳性率最低,比较差异均有统计学意义(P<0.01);VacA阳性、UreA阳性和UreB阳性组的年龄段差异均有统计学意义(P<0.01);感染Hp的男726例(53.9%)、女803例(65.9%),男性和女性均是Hp-Ⅱ型感染率高于Ⅰ型;UreB抗体阳性率最高、VacA抗体阳率最低,差异均有统计学意义(P<0.01)。结论消化道疾病的发生与感染Hp有关,对Hp进行分型检测对消化道疾病程度的判断、预后及诊疗有重要的指导意义,并可防止耐药性的产生。