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A Study of the People’s Nature in Woodcuts During the Anti-Japanese War in Shanxi
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作者 ZHANG Tong-yuan 《Journal of Literature and Art Studies》 2024年第11期1032-1040,共9页
The anti-Japanese woodcuts focus on the red revolutionary culture and describe the connotation of the Anti-Japanese War era,which is self-evident in the commemorative value of China’s revolutionary struggle history.F... The anti-Japanese woodcuts focus on the red revolutionary culture and describe the connotation of the Anti-Japanese War era,which is self-evident in the commemorative value of China’s revolutionary struggle history.For example,in Shanxi,China,woodcut art activities and social practice promotion activities organized around the theme of the Anti-Japanese War are also everywhere,which all show the people’s nature of the Chinese people during the revolutionary struggle from the two aspects of the red culture of the Anti-Japanese War and traditional art and culture,and its humanistic connotation is quite profound.In this paper,we first introduce the historical origin of woodcut during the Anti-Japanese War,and then show the people’s value connotation of woodcut art activities in Shanxi.This paper mainly discusses the image narration,language and picture narration and construction significance of woodcuts in Shanxi’s War of Resistance,fully reveals the narrative nature of image media,strives to arouse people’s recognition of this period of Shanxi’s War of Resistance culture and history,and reflects the realistic value and significance of Shanxi’s War of Resistance Woodcuts art activities. 展开更多
关键词 people’s nature Shanxi anti-japanese woodcarving image media narrative synergistic effect construction significance humanistic cultural identity
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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation
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作者 Hanki Kim Bum Jun Kim +4 位作者 Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young Choi 《Neural Regeneration Research》 SCIE CAS 2025年第1期107-115,共9页
High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the ex... High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain injury.Several drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system disorders.Although it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system disorders.In this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory role.Research targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1. 展开更多
关键词 central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 INFLAMMATION neural stem cells NEURODEVELOPMENT oligodendrocyte progenitor cells redox status REGENERATION
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An elasto-plastic constitutive model for soft rock considering mobilization of strength 被引量:6
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作者 李杭州 熊光东 赵桂平 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2016年第3期822-834,共13页
A new elasto-plastic constitutive model is presented in the framework of plasticity theory. The strength characteristics of a diatomaceous soft rock is investigated. The friction angle and cohesion of soft rock are mo... A new elasto-plastic constitutive model is presented in the framework of plasticity theory. The strength characteristics of a diatomaceous soft rock is investigated. The friction angle and cohesion of soft rock are mobilized as a function of plastic strain. A hyperbolic hardening function for the mobilized friction and a mixed parabolic and exponential equation for the mobilized cohesion are proposed. In view of the unified strength theory and the mobilizations of strength components, a yield function is given. A plastic potential function is determined by using the non-associated plastic flow rule. An elasto-plastic constitutive model is developed and verified. The results indicate that the proposed model can predict the behavior of soft rock accurately. The advantages of the proposed constitutive model are analyzed. The evidences support that the proposed constitutive model is a mixed hardening/softening model. A hump hardening/softening function for mobilized friction is extended to a more generalized condition. 展开更多
关键词 constitutive model mobilized strength component unified strength theory soft rock
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基于MobileNetV3Small-ECA的水稻病害轻量级识别研究 被引量:6
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作者 袁培森 欧阳柳江 +1 位作者 翟肇裕 田永超 《农业机械学报》 EI CAS CSCD 北大核心 2024年第1期253-262,共10页
为实现水稻病害的轻量化识别与检测,使用ECA注意力机制改进MobileNetV3Small模型,并使用共享参数迁移学习对水稻病害进行智能化轻量级识别和检测。在PlantVillage数据集上进行预训练,将预训练得到的共享参数迁移到对水稻病害识别模型上... 为实现水稻病害的轻量化识别与检测,使用ECA注意力机制改进MobileNetV3Small模型,并使用共享参数迁移学习对水稻病害进行智能化轻量级识别和检测。在PlantVillage数据集上进行预训练,将预训练得到的共享参数迁移到对水稻病害识别模型上微调优化。在开源水稻病害数据集上进行试验测试,试验结果表明,在非迁移学习下,识别准确率达到97.47%,在迁移学习下识别准确率达到99.92%,同时参数量减少26.69%。其次,通过Grad-CAM进行可视化,本文方法与其他注意力机制CBAM和SENET相比,ECA模块生成的结果与图像中病斑的位置和颜色更加一致,表明网络可以更好地聚焦水稻病害的特征,并且通过可视化和各水稻病害分析了误分类原因。本文方法实现了水稻病害识别模型的轻量化,使其能够在移动设备等资源受限的场景中部署,达到快速、高效、便携的目的。同时开发了基于Android的水稻病害识别系统,方便于在边缘端进行水稻病害识别分析。 展开更多
关键词 水稻病害识别 迁移学习 高效通道注意力机制 mobileNetV3Small 移动端部署
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Effectiveness of exercise in hepatic fat mobilization in nonalcoholic fatty liver disease: Systematic review 被引量:32
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作者 Pegah Golabi Cameron T Locklear +4 位作者 Patrick Austin Sophie Afdhal Melinda Byrns Lynn Gerber Zobair M Younossi 《World Journal of Gastroenterology》 SCIE CAS 2016年第27期6318-6327,共10页
AIM: To investigate the efficacy of exercise interventions on hepatic fat mobilization in non-alcoholic fatty liver disease(NAFLD) patients.METHODS: Ovid-Medline, Pub Med, EMBASE and Cochrane database were searched fo... AIM: To investigate the efficacy of exercise interventions on hepatic fat mobilization in non-alcoholic fatty liver disease(NAFLD) patients.METHODS: Ovid-Medline, Pub Med, EMBASE and Cochrane database were searched for randomized trials and prospective cohort studies in adults aged ≥ 18 which investigated the effects of at least 8 wk of exercise only or combination with diet on NAFLD from 2010 to 2016. The search terms used to identify articles, in which exercise was clearly described by type, duration, intensity and frequency were: "NASH", "NAFLD", "nonalcoholic steatohepatitis", "non-alcoholic fatty liver disease", "fat", "steatosis", "diet", "exercise", "MR spectroscopy" and "liver biopsy". NAFLD diagnosis, as well as the outcome measures, was confirmed by either hydrogen-magnetic resonance spectroscopy(H-MRS) or biopsy. Trials that included dietary interventions along with exercise were accepted if they met all criteria. RESULTS: Eight studies met selection criteria(6 with exercise only, 2 with diet and exercise with a total of 433 adult participants). Training interventions ranged between 8 and 48 wk in duration with a prescribed exercise frequency of 3 to 7 d per week, at intensities between 45% and 75% of VO2 peak. The most commonly used imaging modality was H-MRS and one study utilized biopsy. The effect of intervention on fat mobilization was 30.2% in the exercise only group and 49.8% in diet and exercise group. There was no difference between aerobic and resistance exercise intervention, although only one study compared thetwo interventions. The beneficial effects of exercise on intrahepatic triglyceride(IHTG) were seen even in the absence of significant weight loss. Although combining an exercise program with dietary interventions augmented the reduction in IHTG, as well as improved measures of glucose control and/or insulin sensitivity, exercise only significantly decreased hepatic lipid contents.CONCLUSION: Prescribed exercise in subjects with NAFLD reduces IHTG independent of dietary intervention. Diet and exercise was more effective than exercise alone in reducing IHTG. 展开更多
关键词 Non-alcoholic FATTY liver disease EXERCISE Diet FAT mobilization LIFESTYLE modification
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Autologous peripheral blood stem cell mobilization following dose-adjusted cyclophosphamide, doxorubicin, vincristine and prednisolone chemotherapy alone or in combination with rituximab in treating high-risk non-Hodgkin's lymphoma 被引量:4
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作者 Yuankai Shi Ping Zhou +11 位作者 Xiaohong Han Xiaohui He Shengyu Zhou Peng Liu Jianliang Yang Changgong Zhang Lin Gui Yan Qin Sheng Yang Liya Zhao Jiarui Yao Shuxiang Zhang 《Chinese Journal of Cancer》 SCIE CAS CSCD 2015年第11期522-530,共9页
Background: The regimen of cyclophosphamide, doxorubicin, vincristine, and prednisolone(CHOP) is an eicient treatment of non-Hodgkin's lymphoma(NHL). This study aimed to assess the eicacy and toxicity of dose-adju... Background: The regimen of cyclophosphamide, doxorubicin, vincristine, and prednisolone(CHOP) is an eicient treatment of non-Hodgkin's lymphoma(NHL). This study aimed to assess the eicacy and toxicity of dose-adjusted CHOP alone or in combination with rituximab(R-CHOP) by examining the stem cell mobilization in NHL patients. Factors afecting the collection of CD34+ cells were also explored.Methods: Our retrospective study included 39 patients eligible for autologous stem cell transplantation: 14 patients who expressed CD20 and were inancially eligible received R-CHOP for autologous peripheral blood stem cell(APBSC) mobilization; the remaining 25 patients received CHOP.Results: The median CD34+ cell yield was 7.01 × 106 cells/kg body weight(range 1.49–28.39 × 106 cells/kg body weight), with only two patients failing to meet the target CD34+ cell harvest of ber of apheresis procedures per patient was 1(range 1–3). The≥2.0 APBS× 106 cells/kg body weight. The median numC mobilization yield of the CHOP group appeared to be higher than that of the R-CHOP group(P response(CR) rate in = 0.005), whereas the success rate was similar between groups. R-CHOP elevated the completeB cell lymphoma patients as compared with CHOP(P = 0.01). No signiicant diferences in toxicity or engraftment were observed between the two groups.Conclusion: The present study demonstrated that dose-adjusted CHOP chemotherapy efectively mobilized APBSCs in NHL patients and that the addition of rituximab to dose-adjusted CHOP chemotherapy elevated the CR rate for patients with B-cell lymphoma. 展开更多
关键词 Stem cell transplantation mobilization CHOP regimen Rituximab Non-Hodgkin's lymphoma
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Chinese preparation Xuesaitong promotes the mobilization of bone marrow mesenchymal stem cells in rats with cerebral infarction 被引量:23
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作者 Jin-sheng Zhang Bao-xia Zhang +2 位作者 Mei-mei Du Xiao-ya Wang Wei Li 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第2期292-297,共6页
After cerebral ischemia, bone marrow mesenchymal stem cells are mobilized and travel from the bone marrow through peripheral circulation to the focal point of ischemia to initiate tissue regeneration. However, the num... After cerebral ischemia, bone marrow mesenchymal stem cells are mobilized and travel from the bone marrow through peripheral circulation to the focal point of ischemia to initiate tissue regeneration. However, the number of bone marrow mesenchymal stem cells mobilized into peripheral circulation is not enough to exert therapeutic effects, and the method by which blood circulation is promoted to remove blood stasis influences stem cell homing. The main ingredient of Xuesaitong capsules is Panax notoginseng saponins, and Xuesaitong is one of the main drugs used for promoting blood circulation and removing blood stasis. We established rat models of cerebral infarction by occlusion of the middle cerebral artery and then intragastrically administered Xuesaitong capsules(20, 40 and 60 mg/kg per day) for 28 successive days. Enzyme-linked immunosorbent assay showed that in rats with cerebral infarction, middle- and high-dose Xuesaitong significantly increased the level of stem cell factors and the number of CD117-positive cells in plasma and bone marrow and significantly decreased the number of CD54-and CD106-positive cells in plasma and bone marrow. The effect of low-dose Xuesaitong on these factors was not obvious. These findings demonstrate that middle- and high-dose Xuesaitong and hence Panax notoginseng saponins promote and increase the level and mobilization of bone marrow mesenchymal stem cells in peripheral blood. 展开更多
关键词 nerve regeneration Panax notoginseng saponin XUESAITONG bone marrow mesenchymal stem cell cerebral infarction mobilization peripheral circulation HOMING nerual regeneration
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Mobilization of Peripheral Blood Stem Cells Using Regimen Combining Docetaxel with Granulocyte Colony-stimulating Factor in Breast Cancer Patients 被引量:4
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作者 Jing Yu Jun Ren +8 位作者 Li-jun Di Guo-hong Song Yu-lin Zhu Jie Zhang Xu Liang Li Che Han-fang Jiang Jun Jia Chun-rong Zhang 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2011年第1期49-53,共5页
Objective:To evaluate the effectiveness and safety of the mobilization of peripheral blood hematopoietic stem cells by combining docetaxel with granulocyte colony-stimulating factor(G-CSF) in breast cancer patients... Objective:To evaluate the effectiveness and safety of the mobilization of peripheral blood hematopoietic stem cells by combining docetaxel with granulocyte colony-stimulating factor(G-CSF) in breast cancer patients.Methods:A total of 57 breast cancer patients were treated with docetaxel 120 mg/m2.When the white blood cell(WBC) count decreased to 1.0×109/L,patients were given G-CSF 5-g/kg daily by subcutaneous injection until the end of apheresis.Peripheral blood mononuclear cells(MNC) were isolated by Cobe Spectra Apheresis System.The percentage of CD34+ cell was assayed by flow cytometry.Results:At a median 6 of days(range 3-8) after the administration of docetaxel,the median WBC count decreased to 1.08×109/L(range 0.20-2.31).The median duration of G-CSF mobilization was 3 days(range 2-7).The MNC collection was conducted 8-12 days(median 10 days) after docetaxel treatment.The median MNC was 5.35×108/kg(range 0.59-14.07),the median CD34+ cell count was 2.43×106/kg(range 0.16-16.69).The CD34+ cell count was higher than 1.00×106/kg in 47 of 57 cases(82.46%) and higher than 2.00×106/kg in 36 cases(63.16%).The CD34+ cell count was higher than 2.00×106/kg in 27 collections(23.68%).The MNC count and the CD34+ cell count were correlated with the bottom of WBC after docetaxel chemotherapy(r=0.364,0.502,P=0.005,0.000).The CD34+ cell count was correlated with the MNC count(r=0.597,P=0.000).The mobilization and apheresis were well tolerated in all patients.Mild perioral numbness and numbness of hand or feet were observed in 3 cases.No serious adverse events were reported.Conclusion:Mobilization of peripheral blood hematopoietic stem cell by combining docetaxel with G-CSF was effective and safety in breast cancer patients. 展开更多
关键词 DOCETAXEL Granulocyte colony-stimulating factor(G-CSF) mobilization Stem cell
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Stem Reserve Mobilization and Sink Activity in Wheat under Drought Conditions 被引量:13
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作者 Anil K. Gupta Kamaljit Kaur Narinder Kaur 《American Journal of Plant Sciences》 2011年第1期70-77,共8页
The effect of water deficit on stem reserve mobilization and sink activity in wheat (Triticum aestivum L.) cultivars, viz., C306 (drought tolerant) and PBW343 (drought sensitive) was studied. Drought was maintained in... The effect of water deficit on stem reserve mobilization and sink activity in wheat (Triticum aestivum L.) cultivars, viz., C306 (drought tolerant) and PBW343 (drought sensitive) was studied. Drought was maintained in pot raised plants by withholding irrigation at 95 days after sowing (DAS), i.e. just five days before the initiation of anthesis. Drought induced a significant reduction in mean biomass of all the internodes of sensitive cultivar as compared to those of tolerant one. Mobilized dry matter and mobilization efficiency were observed to be higher in the internodes of tolerant cultivar, both under control and stress conditions, which resulted in enhanced translocation of stem reserves to the grains. Water soluble carbohydrates (WSC), which mainly occur as fructans, were observed to be higher in the internodes of tolerant cultivar than those of sensitive one. When drought was applied, fructans were mobilized more effectively from the internodes of tolerant cultivar. A significantly higher sucrose synthase activity in the grains of tolerant cultivar, under drought conditions, increased the sink strength by unloading the assimilates in the sink, thereby increasing further mobilization of assimilates to the grains. Grains of sensitive cultivar attained maturity much earlier as compared to the tolerant one, both under control and stress conditions. The longer duration of grain maturation in tolerant cultivar supported enhanced mobilization of stem reserves, thus restricting heavy decrease in grain yield, under stress conditions, as compared to the sensitive cultivar. It may, therefore, be concluded that certain characteristics viz., enhanced capability of fructan storage, higher mobilization efficiency, stronger sink activity and longer duration of grain maturation might help the drought tolerant cultivar in coping the stress 展开更多
关键词 Acid INVERTASE FRUCTANS Water Soluble Carbohydrate Sink Activity STEM Reserve mobilization Sucrose Synthase TRITICUM AESTIVUM
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Bio-Mobilization of Potassium from Clay Minerals: I. By Ectomycorrhizas 被引量:10
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作者 YUAN LING, FANG DEHUA, WANG ZHIHUI, SHUN HONG and HUANG JIANGUO (College of Resources and Environment, Southwest Agricultural University, Chongqing 400716 China) 《Pedosphere》 SCIE CAS CSCD 2000年第4期339-346,共8页
A pot experiment was carried out to investigate effect of ectomycorrhizal fungi on eucalyptus growth and K bio-mobilization from soils and clay minerals. In the experiment, sands mixed with soil, KCI-saturated vermicu... A pot experiment was carried out to investigate effect of ectomycorrhizal fungi on eucalyptus growth and K bio-mobilization from soils and clay minerals. In the experiment, sands mixed with soil, KCI-saturated vermiculate and mica, respectively, were used to nurse eucalyptus seedlings which were nonectomycorrhized or ectomycorrhized by an ectomycorrhizal fungus Pisolithus tinctorius strain XCI (Pt XC1) isolated from a forest soil from Xichang, Sichuan Province, China, and a worldwide well-known ectomycorrhizal fungus Pisolithus tinctorius strain 2144 (Pt 2144) obtained in Australia. More depletion of HCl-soluble K by mycorrhizas from the soil and minerals than nonmycorrhizas suggested that mycorrhizas had a great ability to mobilize K present in the interlayer and feldspar. Mycorrhizal seedlings depressed greatly K digested with HF-HCIO4 from substrates after consecutive extractions of soils and minerals by water, ammonium cetate and boiling HCl, while nonmycorrhizal seedlings reduced it little if any, showing that the mycorrhizal seedlings could mobilize and then utilize the structural K in mineral lattice. Ectomycorrhizal fungi played a very important role not only in promoting the growth of eucalyptus seedlings but also in mobilizing K in soils and minerals. The infection of Pt XC1 led to a better growth of eucalyptus seedlings and more K accumulation in the seedlings than that of Pt 2144. The large differences in K accumulation by the seedlings might be due to different abilities of the two ectomycorrhizal fungi to mobilize K in interlayer and lattice pools in the clay minerals. 展开更多
关键词 clay minerals ECTOMYCORRHIZAS EUCALYPTUS K mobilization
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Effectiveness of Maitland and Mulligan mobilization methods for adults with knee osteoarthritis:A systematic review and metaanalysis 被引量:6
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作者 Ling-Ling Li Xin-Jie Hu +1 位作者 Yong-Hui Di Wei Jiao 《World Journal of Clinical Cases》 SCIE 2022年第3期954-965,共12页
BACKGROUND As a serious global problem,knee osteoarthritis(KOA)often leads to pain and disability.Manual therapy is widely used as a kind of physical treatment for KOA.AIM To explore further the efficacy of Maitland a... BACKGROUND As a serious global problem,knee osteoarthritis(KOA)often leads to pain and disability.Manual therapy is widely used as a kind of physical treatment for KOA.AIM To explore further the efficacy of Maitland and Mulligan mobilization methods for adults with KOA.METHODS We searched PubMed,the Cochrane Library,EMbase,Web of Science and Google Scholar from inception to September 20,2020 to collect studies comparing Maitland and Mulligan mobilization methods in adults with KOA.The quality of the studies was assessed using the Physiotherapy Evidence Database Scale for randomized controlled trials.Data analyses were performed using Review Manager 5.0 software.RESULTS A total of 341 articles were screened from five electronic databases(PubMed,the Cochrane Library,EMbase,Web of Science and Google Scholar)after excluding duplicates.Ultimately,eight trials involving 471 subjects were included in present systematic review and meta-analysis.The mean PEDro scale score was 6.6.Mulligan mobilization was more effective in alleviating pain[standardized mean difference(SMD)=0.60;95%confidence interval(CI):0.17 to 1.03,P=0.007;I2=60%,P=0.020]and improving Western Ontario and McMaster Universities function score(SMD=7.41;95%CI:2.36 to 12.47,P=0.004;I2=92%,P=0.000).There was no difference in the effect of the two kinds of mobilization on improving the range of motion(SMD=9.63;95%CI:-1.23 to 20.48,P=0.080;I2=97%,P=0.000).CONCLUSION Mulligan mobilization technique is a promising intervention in alleviating pain and improving function score in KOA patients. 展开更多
关键词 Mulligan mobilization Maitland mobilization MANIPULATION Manual therapy Knee osteoarthritis META-ANALYSIS
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Mobilization of Phosphorus by Naturally Occurring Or-ganic Acids in Oxisols and Ultisols 被引量:8
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作者 HANXING-GUO C.F.JORDAN 《Pedosphere》 SCIE CAS CSCD 1995年第4期289-303,共15页
Citric and malic acids at concentrations of 0.1, 1.0, 10, and 100 mmol/L were added to three Ultisolsand one Oxisol. The amount of P in solution increased with increasing organic acid concentrations, while theaniount ... Citric and malic acids at concentrations of 0.1, 1.0, 10, and 100 mmol/L were added to three Ultisolsand one Oxisol. The amount of P in solution increased with increasing organic acid concentrations, while theaniount of Fe- and Al-bound P decreased. This result suggested that naturally occurring products of organicmatter decomposition could increase the P availability to plants in soils where there is a relatively large poolof Fe- and Al-bound P.The interactions between citric and malic acids at the above concentrations. and P added at rates of10, 20, 40, and 80 mg/kg were determined. At zero levels of organic acids, all added P became either labileor bound, and greater proportions remained soluble as the concentration of organic acids increased, whichsuggested that organic acids reduced fixation of dissolved P in Fe- and AI-rich soils.Agricultural practices which increase organic matter input on P-deficient acid soiIs could decrease Pdeficiency. This would be important in many tropical and subtropical regions where these soils are common,and where the costs of fertilizers and lime are relatively high. 展开更多
关键词 acid soils adsorption CHELATION phosphorous mobilization SOLUBILIZATION
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Brassinosteroid and gibberellin coordinate rice seed germination and embryo growth by regulating glutelin mobilization 被引量:6
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作者 Min Xiong Lingyi Chu +9 位作者 Qianfeng Li Jiawen Yu Yihao Yang Peng Zhou Yong Zhou Changquan Zhang Xiaolei Fan Dongsheng Zhao Changjie Yan Qiaoquan Liu 《The Crop Journal》 SCIE CSCD 2021年第5期1039-1048,共10页
Seed germination is the beginning of a new lifecycle,and involves many complex physiological and biochemical reactions including seed reserve mobilization in the endosperm and nutrient transport and reuse in the embry... Seed germination is the beginning of a new lifecycle,and involves many complex physiological and biochemical reactions including seed reserve mobilization in the endosperm and nutrient transport and reuse in the embryo.Although glutelin is a dominant storage protein in rice,its contribution to seed germination and its regulatory mechanisms are mostly unknown.Gibberellin (GA) and brassinosteroid (BR),two major growth-promoting phytohormones,also play positive roles in controlling seed germination.However,how GA and BR interact and coordinate seed germination and facilitate glutelin mobilization remains unclear.In the present study,biochemical and physiological analyses of seed germination indicated that both GA and BR promote seed germination and post-germination growth.Exogenous application of GA restored germination defects caused by BR deficiency or insensitivity.Proteomic and q RT-PCR results showed that the expression of several glutelin proteins and their encoding genes was induced by BR and GA in the embryo.Expression assays suggested that the increased accumulation of glutelin protein in the embryo was due to the accelerated degradation of glutelin by a cysteine proteinase (REP-1) in the endosperm.The breakdown of glutelin in the endosperm showed a strict positive correspondence with the length of the shoot.The GluA2 mutation led to reduced degradation rate of glutelin and defects in seed germination,and the promotion effect of GA on seed germination was weakened in the glua2mutant.In vitro culture assay of rice embryos showed that glutelin mobilization functioned downstream of the GA and BR pathways to promote shoot elongation.These findings suggest a mechanism that mediates crosstalk between BR and GA in co-regulating rice seed germination and embryo growth. 展开更多
关键词 Seed germination Glutelin mobilization BRASSINOSTEROID GIBBERELLIN Oryza sativa L.
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Nonlinear criterion for strength mobilization in brittle failure of rock and its extension to the tunnel scale 被引量:5
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作者 Rodolfo Cabezas Javier Vallejos 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2022年第4期685-705,共21页
As underground excavations are getting deeper and field stresses increase, the behavior of intact rock blocks plays an increasingly important role in understanding and estimating the overall rock mass strength. To mod... As underground excavations are getting deeper and field stresses increase, the behavior of intact rock blocks plays an increasingly important role in understanding and estimating the overall rock mass strength. To model the brittle behavior of intact rock blocks, the stress–strain curve is usually idealized considering a linear strength mobilization approach(cohesion-weakening-friction-strengthening, CWFS),however, it is well recognized that rock presents a nonlinear behavior in terms of the confining stress.This study extends the strength mobilization in brittle failure of rock using nonlinear criteria. To determine the model parameters, a standard statistical method that uses the complete laboratory stress–strain curves of the intact rock is employed. Several hypotheses of linear and nonlinear models are statistically compared for different types of rock and confining stress levels. Results demonstrate that the best approach to model the brittle failure of rock is to consider a nonlinear strength envelope, such as the Hoek-Brown criterion assuming a residual uniaxial compressive strength different from zero and a mi parameter that increases, both with simultaneous mobilization. This model helps to recreate highconfining conditions and a more realistic transition between peak and post-peak strength. The obtained parameters are discussed and compared with literature values to verify the validity and to develop guidelines for the estimation of parameters, providing an objective mobilization criterion. Finally, the nonlinear model was applied to a finite element code and extended to a tunnel scale in the brittle rock under high-stress conditions. A reasonable fit between the simulations and the in-situ overbreak measurements was found. 展开更多
关键词 Nonlinear strength Strength mobilization Brittle failure Intact rock Scaling
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Impact of parathyroid hormone on bone marrow-derived stem cell mobilization and migration 被引量:4
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作者 Bruno C Huber Ulrich Grabmaier Stefan Brunner 《World Journal of Stem Cells》 SCIE CAS 2014年第5期637-643,共7页
Parathyroid hormone(PTH) is well-known as the principal regulator of calcium homeostasis in the human body and controls bone metabolism via actions on the survival and activation of osteoblasts. The intermittent admin... Parathyroid hormone(PTH) is well-known as the principal regulator of calcium homeostasis in the human body and controls bone metabolism via actions on the survival and activation of osteoblasts. The intermittent administration of PTH has been shown to stimulate bone production in mice and men and therefore PTH administration has been recently approved for the treatment of osteoporosis. Besides to its physiological role in bone remodelling PTH has been demonstrated to influence and expand the bone marrow stem cell niche where hematopoietic stem cells, capable of both self-renewal and differentiation, reside. Moreover, intermittent PTH treatment is capable to induce mobilization of progenitor cells from the bone marrow into the bloodstream. This novel function of PTH on modulating the activity of the stem cell niche in the bone marrow as well as on mobilization and regeneration of bone marrow-derived stem cells offers new therapeutic options in bone marrow and stem cell transplantation as well as in the field of ischemic disorders. 展开更多
关键词 Parathyroid hormone Stem cells Bone marrow mobilization MIGRATION
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Evolution of deformation property and strength component mobilization for thermally treated Beishan granite under compression 被引量:5
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作者 CHEN Shi-wan LIANG Feng +1 位作者 ZUO Shuang-ying WU Dao-yong 《Journal of Central South University》 SCIE EI CAS CSCD 2021年第1期219-234,共16页
The cohesion weakening and friction strengthening(CWFS)model for rock reveals the strength components mobilization process during progressive brittle failure process of rock,which is very helpful in understanding mech... The cohesion weakening and friction strengthening(CWFS)model for rock reveals the strength components mobilization process during progressive brittle failure process of rock,which is very helpful in understanding mechanical properties of rock.However,the used incremental cyclic loading−unloading compression test for the determination of strength components is very complicated,which limits the application of CWFS model.In this paper,incremental cyclic loading−unloading compression test was firstly carried out to study the evolution of deformation and the strength properties of Beishan granite after various temperatures treated under different confining pressures.We found the axial and lateral unloading modulus are closely related to the applied stress and damage state of rock.Based on these findings,we can accurately determine the plastic strain during the entire failure process using conventional tri-axial compression test data.Furthermore,a strength component(cohesive and frictional strength)determination method was developed using conventional triaxial compression test.Using this method,we analyzed the variation of strength mobilization and deformation properties of Beishan granite after various temperatures treated.At last,a non-simultaneous strength mobilization model for thermally treated granite was obtained and verified by numerical simulation,which demonstrated the effectiveness of the proposed strength determination method. 展开更多
关键词 strength components mobilization secant unloading modulus Beishan granite thermally treated post-failure
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Radix Ilicis Pubescentis total flavonoids combined with mobilization of bone marrow stem cells to protect against cerebral ischemia/reperfusion injury 被引量:3
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作者 Ming-san Miao Lin Guo +1 位作者 Rui-qi Li Xiao Ma 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第2期278-284,共7页
Previous studies have shown that Radix Ilicis Pubescentis total flavonoids have a neuroprotective effect, but it remains unclear whether Radix Ilicis Pubescentis total flavonoids have a synergistic effect with the rec... Previous studies have shown that Radix Ilicis Pubescentis total flavonoids have a neuroprotective effect, but it remains unclear whether Radix Ilicis Pubescentis total flavonoids have a synergistic effect with the recombinant human granulocyte colony stimulating factor-mobilized bone marrow stem cell transplantation on cerebral ischemia/reperfusion injury. Rat ischemia models were administered 0.3, 0.15 and 0.075 g/kg Radix Ilicis Pubescentis total flavonoids from 3 days before modeling to 2 days after injury. Results showed that Radix Ilicis Pubescentis total flavonoids could reduce pathological injury in rats with cerebral ischemia/reperfusion injury. The number of Nissl bodies increased, Bax protein expression decreased, Bcl-2 protein expression increased and the number of CD34-positive cells increased. Therefore, Radix Ilicis Pubescentis total flavonoids can improve the bone marrow stem cell mobilization effect, enhance the anti-apoptotic ability of nerve cells, and have a neuroprotective effect on cerebral ischemia/reperfusion injury in rats. 展开更多
关键词 nerve regeneration Radix Ilicis Pubescentis total flavonoids bone marrow stem cells mobilization cerebral ischemia/reperfusion Nissl bodies Bax Bcl-2 CD34 neurons neural regeneration
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Early mobilization for mechanically ventilated patients in the intensive care unit:a systematic review and meta-analysis 被引量:1
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作者 Meng Yue Zhan-Ying Ma +2 位作者 Meng-Jie Lei Chu-Yun Cui Yi Jin 《Frontiers of Nursing》 CAS 2018年第4期301-310,共10页
Background: Early mobilization(EM) is a regimen that was carried out by physiotherapists in a relatively early stage. It has been investigated by an increasing number of researchers. However, there has not been a meta... Background: Early mobilization(EM) is a regimen that was carried out by physiotherapists in a relatively early stage. It has been investigated by an increasing number of researchers. However, there has not been a meta-analysis concerning whether EM could benefit the clinical outcomes of critically ill patients requiring mechanical ventilation(MV). The present systematic review aims to evaluate the effect of EM compared with immobilization for mechanically ventilated patients.Methods: A computerized literature search was performed in six databases for related articles from inception to June 2017. We included randomized controlled trials and controlled clinical trials and used the Physiotherapy Evidence Database scale to assess the quality of included studies. Primary outcomes were measures of muscle function, duration of MV, and incidence of mortality.Secondary outcomes were adverse effects and length of stay(LOS) in intensive care unit(ICU) and hospital.Results: Eight trials were included; of those, only one study without standard EM reported that the intervention was invalid to improve the outcomes. The result of meta-analysis indicated that EM shortened the duration of MV; however, it had no positive effect on mortality and LOS in ICU.Conclusions: This review suggests that EM improves the muscle function and ventilation duration. Further research highlighting standard intervention and specific groups is needed. 展开更多
关键词 early mobilization EXERCISE mechanical ventilation intensive care unit META-ANALYSIS REVIEW
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Peripheral blood stem cell mobilization in multiple myeloma: Growth factors or chemotherapy? 被引量:1
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作者 Whitney D Wallis Muzaffar H Qazilbash 《World Journal of Transplantation》 2017年第5期250-259,共10页
High-dose therapy followed by autologous hematopoietic stem cell(HSC) transplant is considered standard of care for eligible patients with multiple myeloma. The optimal colection strategy should be effective in procur... High-dose therapy followed by autologous hematopoietic stem cell(HSC) transplant is considered standard of care for eligible patients with multiple myeloma. The optimal colection strategy should be effective in procuring sufficient HSC while maintaining a low toxicity profile. Currently available mobilization strategies include growth factors alone,growth factors in combination with chemotherapy,or growth factors in combination with chemokine receptor antagonists; however,the optimal strategy has yet to be elucidated. Herein,we review the risks and benefits of each approach. 展开更多
关键词 Multiple MYELOMA Stem cell mobilization Growth FACTORS CHEMOTHERAPY
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Hydrogeochemical characteristics and its role in controlling arsenic mobilization in a shallow aquifer 被引量:1
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作者 Ayan Das Abhijit Mandal 《Acta Geochimica》 EI CAS CSCD 2021年第6期912-925,共14页
The relevance of groundwater hydrogeochemistry to explain the occurrence and distribution of arsenic in groundwater is of great interest.The insightful discussions on the control of shallow groundwater(<50 m)hydrog... The relevance of groundwater hydrogeochemistry to explain the occurrence and distribution of arsenic in groundwater is of great interest.The insightful discussions on the control of shallow groundwater(<50 m)hydrogeochemistry in arsenic mobilization are known to be a viable tool to explain the arsenic menace in shallow groundwater.The present investigation emphasizes the hydrogeochemical driver and/or control over the reductive dissolution of Fe-bearing host minerals and thereby releasing arsenic into the shallow groundwater of the study area.The study suggests that hydrogeochemical evolution is mainly governed by carbonate minerals dissolution,silicate weathering,and competitive ion-exchange processes in the shallow aquifers(<50 m).The present study also indicates the prevalence of carbonate minerals dissolution over silicate weathering.The emergence of Cl^(-)concentration in the shallow groundwater founds the possibilities of anthropogenic inputs into the shallow aquifers(<50 m).The reducing environment in shallow aquifers(<50 m)of the study area is evident in the reductive dissolution of Febearing shallow aquifer minerals which absorb arsenic in the solid phase and mobilize arsenic onto shallow groundwater.The study opted for many statistical approaches to delineate the correlation among major and minor ionic constituents of the groundwater which are very helpful to understand the comprehensive mechanism of arsenic mobilization into shallow groundwater. 展开更多
关键词 Arsenic mobilization Groundwater hydrogeochemistry Aquifer sediments Shallow aquifers Redox environment
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