合成制备了不同分子量的PLA-PEG-PLA嵌段共聚物,并应用1 H NMR对其进行测试表征.然后将共聚物作为亲水性添加剂,用自行研发的中空纤维膜纺丝机对应制备了不同的PLA共混中空纤维膜.对制成的中空纤维膜进行水通量、残留率、水接触角、抗...合成制备了不同分子量的PLA-PEG-PLA嵌段共聚物,并应用1 H NMR对其进行测试表征.然后将共聚物作为亲水性添加剂,用自行研发的中空纤维膜纺丝机对应制备了不同的PLA共混中空纤维膜.对制成的中空纤维膜进行水通量、残留率、水接触角、抗污染性能等测试以及SEM观察,研究了该添加剂对PLA中空纤维膜各种性能的影响.结果发现,制成的中空纤维膜超滤性能优异,添加PLA-PEG-PLA嵌段共聚物会提高PLA中空纤维膜的抗污染性能,并且共聚物分子量越大,中空纤维膜的亲水性越好,抗污染性能越好.展开更多
The accelerated blood clearance(ABC) phenomenon which is induced by repeated injection of poly(ethylene glycol)(PEG)-coated colloidal carriers gives clinical challenge to the promising drug delivery system. It is nece...The accelerated blood clearance(ABC) phenomenon which is induced by repeated injection of poly(ethylene glycol)(PEG)-coated colloidal carriers gives clinical challenge to the promising drug delivery system. It is necessary to decrease this unexpected immunological response.A novel 4-arm poly(ethylene glycol-5000)4-cholesteryl methyl amide(4-arm PEG5000-CHMA)has been synthesized. The structure of 4-arm PEG5000-CHMA was confirmed by IR and 1H-NMR spectrum. The pharmacokinetics of the tocopheryl nicotinate(TN)-loaded nanoemulsions modified with 4-arm PEG5000-CHMA or/and 1, 2-distearoyl-Sn-glycero-3-phosphoethanolamine-n-[methoxy(poly-ethyleneglycol)-2000](mPEG2000-DSPE) have been studied. Furthermore, the ABC phenomenon has been detailed investigated in rats by TN-loaded nanoemulsions modified with 4-arm PEG5000-CHMA and mPEG2000-DSPE(CPNE). The plasma levels of TN and anti-PEG IgM antibody were determined by HPLC and ELISA, respectively.The circulation time of the CPNEs were comparable to the mPEG2000-DSPE coated nanoemulsions. Moreover, the ABC phenomenon can be decreased by CPNEs. This study designs a method to decrease the ABC phenomenon and develops a clinical promising nanoemulsion for therapeutic or imaging purpose.展开更多
文摘合成制备了不同分子量的PLA-PEG-PLA嵌段共聚物,并应用1 H NMR对其进行测试表征.然后将共聚物作为亲水性添加剂,用自行研发的中空纤维膜纺丝机对应制备了不同的PLA共混中空纤维膜.对制成的中空纤维膜进行水通量、残留率、水接触角、抗污染性能等测试以及SEM观察,研究了该添加剂对PLA中空纤维膜各种性能的影响.结果发现,制成的中空纤维膜超滤性能优异,添加PLA-PEG-PLA嵌段共聚物会提高PLA中空纤维膜的抗污染性能,并且共聚物分子量越大,中空纤维膜的亲水性越好,抗污染性能越好.
基金supported by the National Natural Science Foundation of China (Grant No. 81072602, Grant No. 81373334)
文摘The accelerated blood clearance(ABC) phenomenon which is induced by repeated injection of poly(ethylene glycol)(PEG)-coated colloidal carriers gives clinical challenge to the promising drug delivery system. It is necessary to decrease this unexpected immunological response.A novel 4-arm poly(ethylene glycol-5000)4-cholesteryl methyl amide(4-arm PEG5000-CHMA)has been synthesized. The structure of 4-arm PEG5000-CHMA was confirmed by IR and 1H-NMR spectrum. The pharmacokinetics of the tocopheryl nicotinate(TN)-loaded nanoemulsions modified with 4-arm PEG5000-CHMA or/and 1, 2-distearoyl-Sn-glycero-3-phosphoethanolamine-n-[methoxy(poly-ethyleneglycol)-2000](mPEG2000-DSPE) have been studied. Furthermore, the ABC phenomenon has been detailed investigated in rats by TN-loaded nanoemulsions modified with 4-arm PEG5000-CHMA and mPEG2000-DSPE(CPNE). The plasma levels of TN and anti-PEG IgM antibody were determined by HPLC and ELISA, respectively.The circulation time of the CPNEs were comparable to the mPEG2000-DSPE coated nanoemulsions. Moreover, the ABC phenomenon can be decreased by CPNEs. This study designs a method to decrease the ABC phenomenon and develops a clinical promising nanoemulsion for therapeutic or imaging purpose.
