Research on the Preparation of an Anti-Acne Cream and Its Thermal Stability

In this paper, the preparation of tea tree oil and salicylic acid anti-acne cream was studied. The single emulsifier, compound emulsifier, thickener in the acidic system were screened, and the long-term thermal stability was investigated. The experimental results show that when the ether emulsifier, NIKKOL BC-150 and MONTANOV 68, is compounded in a mass ratio of 2:1 and the thickener is SEPIPLUS 400, the obtained product has good thermal stability, and its functional ingredients (tea tree oil and salicylic acid) did not change significantly at high temperatures.

祛痘新肤乳抗炎作用的实验研究

目的考察祛痘新肤乳的抗炎作用。方法采用二甲苯致小鼠耳肿胀、角叉菜胶致大鼠足肿胀及棉球肉芽肿模型观察祛痘新肤乳的抗炎作用。结果局部外用祛痘新肤乳显著抑制二甲苯引起的小鼠耳肿胀、角叉菜胶导致的大鼠足肿胀及大鼠棉球肉芽肿。结论祛痘新肤乳具有显著的抗炎作用,并呈现一定的量效关系。

祛痘新肤乳的皮肤毒性实验

目的考察祛痘新肤乳的安全性。方法对健康SD大鼠皮肤进行急性毒性实验;对健康新西兰兔进行皮肤刺激实验;用健康豚鼠进行皮肤变态反应实验。结果祛痘新肤乳对健康大鼠完整皮肤和破损皮肤均未引起急性毒性反应,对家兔完整皮肤无刺激性,对破损皮肤有轻微刺激性;且对豚鼠皮肤无致敏作用。结论祛痘新肤乳外用安全、无毒。