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Meta-analysis of anti-ribosomal P antibodies in lupus psychosis
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作者 Kim Linz Brian J Miller 《World Journal of Meta-Analysis》 2013年第3期121-129,共9页
AIM: To perform a meta-analysis of the prevalence of anti-ribosomal P (aRP) antibodies in lupus psychosis, and the odds of psychosis in aRP-positive subjects.METHODS: We identifed articles by searching PubMed, Psy... AIM: To perform a meta-analysis of the prevalence of anti-ribosomal P (aRP) antibodies in lupus psychosis, and the odds of psychosis in aRP-positive subjects.METHODS: We identifed articles by searching PubMed, PsychInfo, and ISI, and the reference lists of identifed studies.RESULTS: Twenty-four studies met the inclusion criteria. Positive aRP antibodies were found in 51% (91 of 179 total cases) of cases of lupus psychosis. There was an almost 3.5-fold increased odds of psychosis in aRP-positive patients (OR = 3.46, 95%CI: 1.97-6.09, P 〈 0.001). The population attributable risk percentage was 36% for aRP antibodies.CONCLUSION: aRP antibodies are common in lupus psychosis, although the potential mechanism(s) underlying this association remain unclear. Given the overlap between the clinical presentation and risk factors for lupus psychosis and schizophrenia, further investigation of aRP antibodies in schizophrenia is warranted. 展开更多
关键词 Systemic lupus erythematosus PSYCHOSIS AUTOANTIBODIES anti-ribosomal P antibodies Metaanalysis
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Pathogenesis of Neuropsychiatric Syndromes of Systemic Lupus Erythematosus
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作者 Taku Yoshio Hiroshi Okamoto 《Open Journal of Rheumatology and Autoimmune Diseases》 2015年第2期46-56,共11页
The pathogenesis of neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE) is multifactorial and can involve various inflammatory cytokines, autoantibodies such as anti-neuronal antibodies, anti-ribosomal ... The pathogenesis of neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE) is multifactorial and can involve various inflammatory cytokines, autoantibodies such as anti-neuronal antibodies, anti-ribosomal P antibodies, anti-NR2 glutamate receptor binding antibodies, anti-Sm antibodies, anti-U1-RNP antibodies and anti-phospholipid antibodies, and immune complexes (IC). Disruption of the blood-brain barrier (BBB) is integral to the neuropathology of SLE. Recently the possibility has been reported that aforementioned autoantibodies in the circulation may be strongly associated with disruption of the BBB. Each of these mechanisms might contribute to the pathogenesis of focal NPSLE (for example, cerebrovascular disease, movement disorders, myelopathy, seizures and cranial neuropathy) or diffuse NPSLE (for example, acute confusional state, psychosis and cognitive dysfunction) to varying degrees. In this review we focus on how the aforementioned autoantibodies, the BBB, IC and cytokines as well as chemokines are associated with the appearance of NPSLE. 展开更多
关键词 NEUROPSYCHIATRIC Systemic Lupus Erythematosus anti-ribosomal P ANTIBODIES Anti-NR2 Glutamate Receptor Binding ANTIBODIES INTERLEUKIN-6 Granulocyte-Colony Stimulating Factor The Blood-Brain Barrier
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