Spherical roller bearings in railway car wheels are critical components whose failure may have catastrophic consequences. The present study aims to analyse the mechanical stability of greases and temperature of bearin...Spherical roller bearings in railway car wheels are critical components whose failure may have catastrophic consequences. The present study aims to analyse the mechanical stability of greases and temperature of bearings as indicators for condition-based bearing maintenance. The performed case study includes nine fully-formulated commercial greases examined in the wheel bearings of five ore cars operated in northern Scandinavia. The studied ore cars travelled a distance of about 300 000 km during a period of three years. Small samples of the greases were taken on eight occasions to test their mechanical stability. In addition, the temperatures of the bearings were continuously recorded. After the test period, the wear, electrical damage, and corrosion of the bearings were examined. One of the findings is that the shear stress of the grease at a certain shear velocity （the certain yieldstress （CEY） value） is a good maintenance indicator and is highly dependent on the grease type. The bearing＇s wear, electrical damage and corrosion also depend on the grease type. However, no oxidation of the greases was identified. The paper also outlines a systematic methodology to determine an overall maintenance indicator for railway roller bearings which is based on the field measurements.展开更多
Nanocrystals(NCs),a colloidal dispersion system formulated with stabilizers,have attracted widespread interest due to their ability to effectively improve the oral bioavailability of poorly water-soluble drugs.The sta...Nanocrystals(NCs),a colloidal dispersion system formulated with stabilizers,have attracted widespread interest due to their ability to effectively improve the oral bioavailability of poorly water-soluble drugs.The stabilizer plays a key role because it can affect the physical stability and even the oral bioavailability of NCs.However,how stabilizers affect the bioavailability of NCs remains unknown.In this study,F68,F127,HPMC,and PVP were each used as a stabilizer to formulate naringenin NCs.The NCs formulated with PVP exhibited excellent release behaviors,cellular uptake,permeability,oral bioavailability,and anti-inflammatory effects.The underlying mechanism is that PVP effectively inhibits the formation of naringenin dimer,which in turn improves the physical stability of the supersaturated solution generated when NC is dissolved.This finding provides insights into the effects of stabilizers on the in vivo performances of NCs and supplies valuable knowledge for the development of poorly water-soluble drugs.展开更多
现有安全稳定控制系统(简称稳控系统)的可靠性评估方法本质上属于静态建模,由于未能体现系统内各装置老化和检修等动态过程,在一定程度上影响了评估结果的准确性。为此,文中提出一种基于马尔可夫链蒙特卡洛(Markov chain Monte Carlo,MC...现有安全稳定控制系统(简称稳控系统)的可靠性评估方法本质上属于静态建模,由于未能体现系统内各装置老化和检修等动态过程,在一定程度上影响了评估结果的准确性。为此,文中提出一种基于马尔可夫链蒙特卡洛(Markov chain Monte Carlo,MCMC)的稳控系统动态可靠性评估方法。首先针对失效过程,构建四状态非齐次马尔可夫模型来模拟装置老化过程,并给出各状态评判方法;其次针对修复过程,分析不同检修策略对装置状态转移的影响以体现状态检修的差异性;最后考虑稳控装置状态转移过程的时序或条件相关性,对稳控系统可靠性进行动态建模。以实际稳控系统为例,仿真对比不同检修策略下的可靠性,并对模型参数进行灵敏度分析。评估结果表明,该方法可以求解稳控系统的时变可用度,用于指导稳控装置现场合理检修。展开更多
文摘Spherical roller bearings in railway car wheels are critical components whose failure may have catastrophic consequences. The present study aims to analyse the mechanical stability of greases and temperature of bearings as indicators for condition-based bearing maintenance. The performed case study includes nine fully-formulated commercial greases examined in the wheel bearings of five ore cars operated in northern Scandinavia. The studied ore cars travelled a distance of about 300 000 km during a period of three years. Small samples of the greases were taken on eight occasions to test their mechanical stability. In addition, the temperatures of the bearings were continuously recorded. After the test period, the wear, electrical damage, and corrosion of the bearings were examined. One of the findings is that the shear stress of the grease at a certain shear velocity （the certain yieldstress （CEY） value） is a good maintenance indicator and is highly dependent on the grease type. The bearing＇s wear, electrical damage and corrosion also depend on the grease type. However, no oxidation of the greases was identified. The paper also outlines a systematic methodology to determine an overall maintenance indicator for railway roller bearings which is based on the field measurements.
基金by the National Natural Science Foundation of China(No.82173765)the Science Foundation for Outstanding Youth of Liaoning Province(2021-YQ-08)+5 种基金Ningxia Key Research and Invention Program(No.2021BEG02039)Basic Research Projects of Liaoning Provincial Department of Education(2020LFW01)the Career Development Program for Young Teachers in Shenyang Pharmaceutical University(ZQN2019003)the Outstanding Youth Lifting Program in Shenyang Pharmaceutical University(YQ202115)the Natural Science Foundation of Liaoning Province(2020-MS-074)Open Fund of Key Laboratory of Biotechnology and Bioresources Utilization(Dalian Minzu University),Ministry of Education(KF2022005),China.
文摘Nanocrystals(NCs),a colloidal dispersion system formulated with stabilizers,have attracted widespread interest due to their ability to effectively improve the oral bioavailability of poorly water-soluble drugs.The stabilizer plays a key role because it can affect the physical stability and even the oral bioavailability of NCs.However,how stabilizers affect the bioavailability of NCs remains unknown.In this study,F68,F127,HPMC,and PVP were each used as a stabilizer to formulate naringenin NCs.The NCs formulated with PVP exhibited excellent release behaviors,cellular uptake,permeability,oral bioavailability,and anti-inflammatory effects.The underlying mechanism is that PVP effectively inhibits the formation of naringenin dimer,which in turn improves the physical stability of the supersaturated solution generated when NC is dissolved.This finding provides insights into the effects of stabilizers on the in vivo performances of NCs and supplies valuable knowledge for the development of poorly water-soluble drugs.
文摘现有安全稳定控制系统(简称稳控系统)的可靠性评估方法本质上属于静态建模,由于未能体现系统内各装置老化和检修等动态过程,在一定程度上影响了评估结果的准确性。为此,文中提出一种基于马尔可夫链蒙特卡洛(Markov chain Monte Carlo,MCMC)的稳控系统动态可靠性评估方法。首先针对失效过程,构建四状态非齐次马尔可夫模型来模拟装置老化过程,并给出各状态评判方法;其次针对修复过程,分析不同检修策略对装置状态转移的影响以体现状态检修的差异性;最后考虑稳控装置状态转移过程的时序或条件相关性,对稳控系统可靠性进行动态建模。以实际稳控系统为例,仿真对比不同检修策略下的可靠性,并对模型参数进行灵敏度分析。评估结果表明,该方法可以求解稳控系统的时变可用度,用于指导稳控装置现场合理检修。
