Neoplasms is one of the main diseases for harming health. It is difficult to prevent the neoplasms because the factors of bringing out them are complex. To raise survival rate the early diagnosis of tumors is very imp...Neoplasms is one of the main diseases for harming health. It is difficult to prevent the neoplasms because the factors of bringing out them are complex. To raise survival rate the early diagnosis of tumors is very important. Radionuclide imaging is useful to detect recurrent or residual disease and to identify benign or malignant tumor. Several tumor imaging agents as following have clinical significance in diagnosing tumors.展开更多
Antibody drug conjugates(ADCs)normally compose of a humanized antibody and small molecular drug via a chemical linker.After decades of preclinical and clinical studies,a series of ADCs have been widely used for treati...Antibody drug conjugates(ADCs)normally compose of a humanized antibody and small molecular drug via a chemical linker.After decades of preclinical and clinical studies,a series of ADCs have been widely used for treating specific tumor types in the clinic such as brentuximab vedotin(Adcetris?)for relapsed Hodgkin’s lymphoma and systemic anaplastic large cell lymphoma,gemtuzumab ozogamicin(Mylotarg?)for acute myeloid leukemia,ado-trastuzumab emtansine(Kadcyla?)for HER2-positive metastatic breast cancer,inotuzumab ozogamicin(Besponsa?)and most recently polatuzumab vedotin-piiq(Polivy?)for B cell malignancies.More than eighty ADCs have been investigated in different clinical stages from approximately six hundred clinical trials to date.This review summarizes the key elements of ADCs and highlights recent advances of ADCs,as well as important lessons learned from clinical data,and future directions.展开更多
文摘Neoplasms is one of the main diseases for harming health. It is difficult to prevent the neoplasms because the factors of bringing out them are complex. To raise survival rate the early diagnosis of tumors is very important. Radionuclide imaging is useful to detect recurrent or residual disease and to identify benign or malignant tumor. Several tumor imaging agents as following have clinical significance in diagnosing tumors.
基金supported by the start-up fund from the College of Pharmacy at The Ohio State University
文摘Antibody drug conjugates(ADCs)normally compose of a humanized antibody and small molecular drug via a chemical linker.After decades of preclinical and clinical studies,a series of ADCs have been widely used for treating specific tumor types in the clinic such as brentuximab vedotin(Adcetris?)for relapsed Hodgkin’s lymphoma and systemic anaplastic large cell lymphoma,gemtuzumab ozogamicin(Mylotarg?)for acute myeloid leukemia,ado-trastuzumab emtansine(Kadcyla?)for HER2-positive metastatic breast cancer,inotuzumab ozogamicin(Besponsa?)and most recently polatuzumab vedotin-piiq(Polivy?)for B cell malignancies.More than eighty ADCs have been investigated in different clinical stages from approximately six hundred clinical trials to date.This review summarizes the key elements of ADCs and highlights recent advances of ADCs,as well as important lessons learned from clinical data,and future directions.
