Actinomycetes are the main sources of antibiotics.The onset and level of production of each antibiotic is subject to complex control by multi-level regulators.These regulators exert their functions at hierarchical lev...Actinomycetes are the main sources of antibiotics.The onset and level of production of each antibiotic is subject to complex control by multi-level regulators.These regulators exert their functions at hierarchical levels.At the lower level,cluster-situated regulators(CSRs)directly control the transcription of neighboring genes within the gene cluster.Higher-level pleiotropic and global regulators exert their functions mainly through modulating the transcription of CSRs.Advances in understanding of the regulation of antibiotic biosynthesis in actinomycetes have inspired us to engineer these regulators for strain improvement and antibiotic discovery.展开更多
Antibiotic resistance presents a significant challenge to clinical,veterinary,and plant health and is now recognized by the World Health Organization(WHO)as a major emerging problem of global significance.As yet,there...Antibiotic resistance presents a significant challenge to clinical,veterinary,and plant health and is now recognized by the World Health Organization(WHO)as a major emerging problem of global significance.As yet,there have been no successful discoveries of classes of novel antibiotics since 1987.There is an antibiotic discovery void,and it is now widely acknowledged that there is an urgent need for the development of novel antimicrobial agents.For economic reasons,many of the largest pharmaceutical companies have abandoned the antibiotic field,and research conducted by academia was scaled back due to funding cuts following the economic crisis.A post-antibiotic era-in which common infections and minor injuries can kill-far from being an apocalyptic fantasy,is indeed a very real possibility for the 21st century.展开更多
基金the National Natural Science Foundation of China(31470206 and 31870061)a start-up grant from Southwest University(SWU117015)+1 种基金grants from Chongqing Science and Technology Commission(cstc2017jcyjAX0467 and cstc2018jcyjAX0066)the Fundamental Research Funds for the Central Universities(XDJK2018B029)to G.N.
文摘Actinomycetes are the main sources of antibiotics.The onset and level of production of each antibiotic is subject to complex control by multi-level regulators.These regulators exert their functions at hierarchical levels.At the lower level,cluster-situated regulators(CSRs)directly control the transcription of neighboring genes within the gene cluster.Higher-level pleiotropic and global regulators exert their functions mainly through modulating the transcription of CSRs.Advances in understanding of the regulation of antibiotic biosynthesis in actinomycetes have inspired us to engineer these regulators for strain improvement and antibiotic discovery.
基金DWN thanks Professors James Dooley and Ibrahim Banat at Ulster University for critical comments.The Department of Agriculture,Environment and Rural Affairs(DAERA)is gratefully acknowledged for facilitating this literature review process through an Evidence and Innovation project 16/3/11(activity 48125).
文摘Antibiotic resistance presents a significant challenge to clinical,veterinary,and plant health and is now recognized by the World Health Organization(WHO)as a major emerging problem of global significance.As yet,there have been no successful discoveries of classes of novel antibiotics since 1987.There is an antibiotic discovery void,and it is now widely acknowledged that there is an urgent need for the development of novel antimicrobial agents.For economic reasons,many of the largest pharmaceutical companies have abandoned the antibiotic field,and research conducted by academia was scaled back due to funding cuts following the economic crisis.A post-antibiotic era-in which common infections and minor injuries can kill-far from being an apocalyptic fantasy,is indeed a very real possibility for the 21st century.
