The efficacy and safety of ureteroscopic lithotripsy and flexible ureteroscopy with continuous anticoagulant or antiplatelet drugs:A multicenter retrospective real-world study

Objective The objective of this study is to assess the effectiveness and safety of ureteroscopic lithotripsy and flexible ureteroscopy(fURS)for treating patients on anticoagulant(AC)or antiplatelet(AP)medications.Patients and Methods The study included 213 patients with urinary stones who underwent ureteroscopic lithotripsy or fURS between January 2019 and October 2022 at the Shanghai Municipal Hospital Urology Specialist Alliance.Among these patients,15 received AC therapy,193 received AP therapy,and 5 received both AC and AP therapy.Patients were divided into 3 groups based on the real-world management of antithrombotic drugs:the continuation group(n=62),the discontinuation group(n=91),and the discontinuation and bridge heparin group(n=60).Intraoperative and postoperative outcomes were compared among the 3 groups.Results Age,sex,body mass index,stone location,stone size,stone side,and residual fragments were not different among the groups.None of the patients received blood transfusions or had thromboembolic events,emergencies for gross hematuria,significant bleeding-related complications,or unplanned secondary ureteroscopic surgery.The mean duration of hospital stay of the continuation group(3.97 days)was significantly lower than that of the discontinuation group(5.99 days)and the discontinuation and bridge heparin group(5.75 days)(p<0.001).Conclusions Ureteroscopic lithotripsy and fURS can be performed safely and effectively in patients on AC or AP drugs,resulting in reduced duration of hospital stay.

Intramuscular hematoma in rhabdomyolysis patients treated with low-molecular-weight heparin: Report of two cases

BACKGROUND Rhabdomyolysis is a serious complication of heat stroke.Unlike that in acute kidney injury,the risk of muscle bleeding in rhabdomyolysis is often ignored and can substantially increase via the widespread use of anticoagulants,leading to the formation of intramuscular hematoma.CASE SUMMARY During the summer,a middle-aged man and an elderly man were diagnosed with heat stroke,rhabdomyolysis,and acute renal impairment.Low-dose enoxaparin sodium was initiated for prophylaxis of deep vein thrombosis after the disease was stabilized with continuous renal replacement therapy.After that,the patients'hemoglobin decreased progressively,and no obvious intracranial,thoracic,digestive,or skin bleeding tendency was found.However,one of the patients had hip muscle pain,and computed tomography and color ultrasound confirmed that the patients separately had lumbar back and hip intermuscular hematoma.After discontinuation of anticoagulant drugs and monitoring of the steady increase in hemoglobin,the intermuscular hematomas were gradually absorbed.Following the use of prophylactic anticoagulation therapy,the patients'hemoglobin showed a progressive downward trend.Hematoma formation in the lumbosacral and buttock muscles was confirmed after excluding bleeding in typical regions(such as the digestive tract,thoracic cavity,and abdominal cavity).Anticoagulant drugs were discontinued immediately,and nutritional support was increased.Subsequently,the hemoglobin levels gradually increased,and the hematoma volumes gradually decreased.CONCLUSION Patients with rhabdomyolysis have a risk of muscle bleeding,and inappropriate use of anticoagulants may lead to an increased risk or even to the formation of an intermuscular hematoma. When continuous blood loss is found in the body, thepossibility of bleeding in the muscles and more typical sites should be considered.

Retroperitoneal and abdominal bleeding in anticoagulated COVID-19 hospitalized patients:Case series and brief literature review

BACKGROUND Hospitalized and severely ill coronavirus disease 2019(COVID-19)patients necessitate prophylactic or therapeutic anticoagulation to minimize the risk of thrombosis at different sites.Life-threatening bleeding complications include spontaneous iliopsoas hematoma,peritoneal bleeding,and extra-abdominal manifestations such as intracranial hemorrhage.CASE SUMMARY Bleeding in the abdominal wall results in less severe complications than seen with iliopsoas hematoma or peritoneal bleeding.In our case series of 9 patients,we present retroperitoneal and abdominal bleeding complications following anticoagulation in hospitalized COVID-19 patients with severe acute respiratory syndrome coronavirus 2 pneumonia.Contrast-enhanced computed tomography(CE-CT)is the best imaging modality for assessing hematoma secondary to anticoagulation and determines the therapeutic approach,whether interventional,surgical,or conservative management.CONCLUSION We present the role of CE-CT for rapid and precise localization of the bleeding site and prognostic counseling.Finally,we provide a brief review of the literature.