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A New Potent Inhibitor of Thrombin from the Leech Haemendipsa Yanyuanensis 被引量:1
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作者 ZHAO Rong le College of Life Sciences, Beijing Normal University, Beijing 100875, China 《Journal of Shanghai University(English Edition)》 CAS 2001年第1期86-88,共3页
Two components of anticoagulant protein were isolated from the leech Haemendipsa yanyuanensis by heparin agarose affinity chromatography and ultracentrifugation. The determination of anticoagulant activity and cha... Two components of anticoagulant protein were isolated from the leech Haemendipsa yanyuanensis by heparin agarose affinity chromatography and ultracentrifugation. The determination of anticoagulant activity and characterization analysis of the protein using the method of chromogenic substrate indicates that the anticoagulant protein is thrombin specific but not factor Xa specific. The results lay a foundation for the research of the anticoagulant mechanism and application of anticoagulant protein from H. yanyuanensis. 展开更多
关键词 Heamendipsa yanyuanensis anticoagulant protein THROMBIN factor Xa
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