Risk assessment is critical in preventing aortic dissection(AD).This study aims to evaluate the wall stress(WS)distribution,especially at the locations of proximal tears in patient-specific type-B aortic dissection(TB...Risk assessment is critical in preventing aortic dissection(AD).This study aims to evaluate the wall stress(WS)distribution,especially at the locations of proximal tears in patient-specific type-B aortic dissection(TBAD)to explore the pathogenesis of dissection.In addition,the shape of the aortas were assessed and associated with TBAD risk.In this paper,30 three-dimensional models were reconstructed based on patient-specific CT angiography images,and finite element analysis(FEA)was used to analyze the admission blood pressure.In addition,the anatomic variables including the head vessel angles,the aorta diameters,curvatures and torturosity ware measured.Tears occurred at either local high WS or low WS region,and these acute TBAD patients can be classified into three groups based on the location of initial intimal tears.In addition,the WS values at tear sites of each group showed significant difference(P<0.001).Moreover,the angles of the left subclavian and brachiocephalic arteries were statistical different among three groups.Increased wall stress or decreased wall strength both contribute to the pathogenesis of aortic dissections.In addition,abnormal head vessel angles may be monitored as an important risk factor for aortic dissection,and its specific features may further help to determine the potential tear location.展开更多
Warm ischemia is one of the most important causes of valvular damage from death of donor to its valve harvesting. This study aimed at using qualitative and quantitative methods to characterize warm ischemic injury thr...Warm ischemia is one of the most important causes of valvular damage from death of donor to its valve harvesting. This study aimed at using qualitative and quantitative methods to characterize warm ischemic injury through models of SD rat's aortic valves and design to show the relationship among ultrastructural, biological and biochemical changes concerning with the length of warm ischemia time (WIT). 102 harvested SD rat's aortic valves were divided into 6 groups of different ischemic time for this study. 432 photomicrographs of transmission electron microscopy (TEM) were put into computer for analysis. The volume ratio of nucleus to plasma in cells (Vnp) and the ratio of extramembrane area to volume of mitochondria (S / V) were used to characterize the degree of valvular cell injuries. Valvular cells culture and biochemical metabolism including glucose degredation and H-3-TdR absorption rate were adopted. The valvular cells depicted a significant decrease and H-3-TdR taking-up also being inhibited under the influence of prolonged WIT.展开更多
基金This work was supported by grants from National Natural Science Foundation of China(81770471,12072214,1802253)Sichuan Provincial Department of Science and Technology Application Basic Project(2018YYJC,2019YJ0026).
文摘Risk assessment is critical in preventing aortic dissection(AD).This study aims to evaluate the wall stress(WS)distribution,especially at the locations of proximal tears in patient-specific type-B aortic dissection(TBAD)to explore the pathogenesis of dissection.In addition,the shape of the aortas were assessed and associated with TBAD risk.In this paper,30 three-dimensional models were reconstructed based on patient-specific CT angiography images,and finite element analysis(FEA)was used to analyze the admission blood pressure.In addition,the anatomic variables including the head vessel angles,the aorta diameters,curvatures and torturosity ware measured.Tears occurred at either local high WS or low WS region,and these acute TBAD patients can be classified into three groups based on the location of initial intimal tears.In addition,the WS values at tear sites of each group showed significant difference(P<0.001).Moreover,the angles of the left subclavian and brachiocephalic arteries were statistical different among three groups.Increased wall stress or decreased wall strength both contribute to the pathogenesis of aortic dissections.In addition,abnormal head vessel angles may be monitored as an important risk factor for aortic dissection,and its specific features may further help to determine the potential tear location.
文摘Warm ischemia is one of the most important causes of valvular damage from death of donor to its valve harvesting. This study aimed at using qualitative and quantitative methods to characterize warm ischemic injury through models of SD rat's aortic valves and design to show the relationship among ultrastructural, biological and biochemical changes concerning with the length of warm ischemia time (WIT). 102 harvested SD rat's aortic valves were divided into 6 groups of different ischemic time for this study. 432 photomicrographs of transmission electron microscopy (TEM) were put into computer for analysis. The volume ratio of nucleus to plasma in cells (Vnp) and the ratio of extramembrane area to volume of mitochondria (S / V) were used to characterize the degree of valvular cell injuries. Valvular cells culture and biochemical metabolism including glucose degredation and H-3-TdR absorption rate were adopted. The valvular cells depicted a significant decrease and H-3-TdR taking-up also being inhibited under the influence of prolonged WIT.
