Effect of Aoshaen Injection (奥沙恩注射液) on Inflammatory Infiltration In Myocardlal Ischemla/Reperfuslon Injury

Objective: To study the effect and molecular mechanism of Aoshaen Injection(ASEI) on inflammatory infiltration in myocardial ischemia-reperfu-sion injury. Methods: Canine myocardial ischemia/ reperfusion model was made by left decending corornary artery ligation and reperfusion to observe the protective effect of ASEI in different phases. Results: ASEI restrained the augment of sinus cor-onaries blood leukocytes of different phases and decreased interlukin-1 (IL-1), interlukin-6 (IL-6 ) and tumor necrosis factor-a (TNF-a) evidently. However, no significant change of interlukin-8 was detected. ASEI obviously inhibited the inflammatory coefficient 30 min, 120 min, 180 min and 240 min after modeling, and reduced the infarcted area,

奥沙恩注射液Ⅰ期耐受性临床研究

目的：评价健康人体对奥沙恩注射液的耐受性和安全性。方法：将40例受试者随机分为单次给药组和连续给药组;单次给药组分别单次静脉滴注奥沙恩注射液30,60,100,150,200和250 mg;连续给药组以200 mg·d^-1剂量连续用药7 d;观察药物的不良反应、实验室检查、心电图以及生命体征。结果：在单次服药30-250 mg及200 mg·d^-1连续服药7 d的观察剂量范围内,奥沙恩注射液可引起一过性的血压下降,对其他生命体征和肝肾功能没有明显影响;主要不良反应有面色潮红、头晕、恶心、出汗等,个别有体温升高、心慌、腹痛等。结论：在观察剂量范围内,奥沙恩注射液的耐受性和安全性良好。