In order to discover novel compounds with high-activity to control aphid,a series of novel（E）-β-farnesene analogues containing 1,2,3-thiadiazole were designed and synthesized,and their structures were confirmed by ...In order to discover novel compounds with high-activity to control aphid,a series of novel（E）-β-farnesene analogues containing 1,2,3-thiadiazole were designed and synthesized,and their structures were confirmed by IR,^1H NMR,^13C NMR,and HRMS（ESI）.The stability of representative compounds was studied by HPLC and -1H NMR techniques.Repellent activity results indicated that compounds 8h and 8j displayed 60.3%and 62.0%repellent rates,respectively.The aphicidal bioassay results showed that most analogues exhibited considerable aphicidal activity against Myzus persicae.Especially,analogues 81,8s and 8t exhibited high activity with LC50 values of 33.4 μg/mL,50.2 μg/mL and 61.8 μg/mL,respectively,which were higher than the lead compound（E）-β-farnesene,but lower than commercial insecticide pymetrozine with a LC50 of 7.1 μg/mL展开更多
基金the financial support from the National Natural Science Foundation of China (No. 21132003)
文摘In order to discover novel compounds with high-activity to control aphid,a series of novel（E）-β-farnesene analogues containing 1,2,3-thiadiazole were designed and synthesized,and their structures were confirmed by IR,^1H NMR,^13C NMR,and HRMS（ESI）.The stability of representative compounds was studied by HPLC and -1H NMR techniques.Repellent activity results indicated that compounds 8h and 8j displayed 60.3%and 62.0%repellent rates,respectively.The aphicidal bioassay results showed that most analogues exhibited considerable aphicidal activity against Myzus persicae.Especially,analogues 81,8s and 8t exhibited high activity with LC50 values of 33.4 μg/mL,50.2 μg/mL and 61.8 μg/mL,respectively,which were higher than the lead compound（E）-β-farnesene,but lower than commercial insecticide pymetrozine with a LC50 of 7.1 μg/mL
