This research advocates for the construction of Climate Change Haven Communities across the Appalachian Region. The proposed development plan can be extended to the northern tier states across the US and also to the n...This research advocates for the construction of Climate Change Haven Communities across the Appalachian Region. The proposed development plan can be extended to the northern tier states across the US and also to the northern and mountainous regions of Europe and Asia. We present an analogy to the earlier climate change period of the Last Glacial Maximum/“Ice Age” in which these same northern regions of the planet were covered in ice sheets making them uninhabitable for most humans and many plant and animal species. In some significant ways, the Ice Age scenario can be a reverse-model for our current climate crisis. We also advocate strongly for the prevention of upscale real estate development projects in these same regions of the globe, as these will foreclose the possibility of safely sheltering the millions of persons who will be displaced by climate change over the next 5 to 10 years.展开更多
Obesity and diabetes are major health problems in the United States. The primary aim of this study is to examine the association between obesity and diabetes and to estimate the cost of diabetes linked to obesity in t...Obesity and diabetes are major health problems in the United States. The primary aim of this study is to examine the association between obesity and diabetes and to estimate the cost of diabetes linked to obesity in the Appalachian region. A system of simultaneous equations approach, and a logit estimation are employed for the analyses. Behavioral Risk Factor Surveillance System (BRFSS) surveys for 2001 and 2009 are the main sources of data. Both county-level and individual-level data are used for the analyses. The simultaneous approach at county-level based on the changes of income, employment, obesity, and diabetes reveals that obesity increases diabetes, but diabetes does not have an effect on obesity. The counties with high initial levels of obesity had less obesity growth but more diabetes growth. Increasing income impacts negatively on diabetes growth. Logit analysis indicates that obesity significantly increases the risk of diabetes of adults’ in Appalachia. Besides, being employed, higher income, as well as engaging in exercise reduce the prevalence of diabetes, while age increases diabetes. The economic cost of obesity-related diabetes is $1.9 billion, and can be reduced through mitigating obesity.展开更多
This article inquires into how the maintenance of the residual practice of inspired preaching broadcast over the radio by Southern Appalachian Pentecostals, offers an accepted means by which women gain the power to ar...This article inquires into how the maintenance of the residual practice of inspired preaching broadcast over the radio by Southern Appalachian Pentecostals, offers an accepted means by which women gain the power to articulate the conflicts, desires and contradictions of their culture. The democratic ethos of Pentecostalism declares that all people who feel the call to preach must be given that opportunity which opens a space of women＇s voices within the traditionally male ＂preacher culture.＂ Because radio lacks the visual component, and inspired preaching is deemed valid by its effect of the body, women may preach over the radio without the potential for sexual display that could arouse men visually. By examining the content and delivery of women＇s sermons using studies in melodrama, the article explores the nature and articulation of dramatic conflicts, points of difference, and especially issues of the body as lived by the women of southern Appalachia. Thereby, the article locates sites of resistance and conflicts with power both within and without the region. Using Gramcian notions of hegemony, negotiation and consent, it explores how a particular culture successfully elaborates itself through language and how Appalachian women critique their culture without risk of dramatic change.展开更多
Streptococcus mutans is a well-known cause of dental caries,due to its acidogenicity,aciduricity,and ability to synthesize exopolysaccharides in dental plaques.Intriguingly,not all children who carry S.mutans manifest...Streptococcus mutans is a well-known cause of dental caries,due to its acidogenicity,aciduricity,and ability to synthesize exopolysaccharides in dental plaques.Intriguingly,not all children who carry S.mutans manifest caries,even with similar characteristics in oral hygiene,diet,and other environmental factors.This phenomenon suggests that host susceptibility potentially plays a role in the development of dental caries;however,the association between host genetics,S.mutans,and dental caries remains unclear.Therefore,this study examined the influence of host gene-by-S.mutans interaction on dental caries.Genome-wide association analyses were conducted in 709 US children (<13 years old),using the dbGap database acquired from the center for oral health research in appalachia (COHRA) and the Iowa Head Start programmes (GEIRS).A generalized estimating equation was used to examine the gene-by-S.mutans interaction effects on the outcomes (decayed and missing/filled primary teeth due to caries).Sequentially,the COHRA and GEIRS data were used to identify potential interactions and replicate the findings.Three loci at the genes interleukin 32 (IL32),galactokinase 2 (GALK2),and CUGBP,Elav-like family member 4 (CELF4) were linked to S.mutans carriage,and there was a severity of caries at a suggestive significance level among COHRA children (P < 9×10?5),and at a nominal significance level among GEIRS children (P = 0.047–0.001).The genetic risk score that combined the three loci also significantly interacted with S.mutans (P < 0.000 1).Functional analyses indicated that the identified genes are involved in the host immune response,galactose carbohydrate metabolism,and food-rewarding system,which could potentially be used to identify children at high risk for caries and to develop personalized caries prevention strategies.展开更多
Appalachia has been identified as the largest Climate Change Haven in the continental United States and could serve as a refuge for millions of persons. This research presents a marketing plan for promoting migration ...Appalachia has been identified as the largest Climate Change Haven in the continental United States and could serve as a refuge for millions of persons. This research presents a marketing plan for promoting migration to the Appalachian Region using advertising and a website that communicates the desirable qualities of the area. Communications will first be directed toward the current residents of Appalachia (the Internal Market) in order to create enthusiasm for welcoming new arrivals. Then, promotional messages will be sent to prospective migrants seeking to escape the negative effects of climate change in the Southeast and Southwest of the United States and globally (the External Market). The approach used here may be applicable to Climate Change Havens across the globe.展开更多
文摘This research advocates for the construction of Climate Change Haven Communities across the Appalachian Region. The proposed development plan can be extended to the northern tier states across the US and also to the northern and mountainous regions of Europe and Asia. We present an analogy to the earlier climate change period of the Last Glacial Maximum/“Ice Age” in which these same northern regions of the planet were covered in ice sheets making them uninhabitable for most humans and many plant and animal species. In some significant ways, the Ice Age scenario can be a reverse-model for our current climate crisis. We also advocate strongly for the prevention of upscale real estate development projects in these same regions of the globe, as these will foreclose the possibility of safely sheltering the millions of persons who will be displaced by climate change over the next 5 to 10 years.
文摘Obesity and diabetes are major health problems in the United States. The primary aim of this study is to examine the association between obesity and diabetes and to estimate the cost of diabetes linked to obesity in the Appalachian region. A system of simultaneous equations approach, and a logit estimation are employed for the analyses. Behavioral Risk Factor Surveillance System (BRFSS) surveys for 2001 and 2009 are the main sources of data. Both county-level and individual-level data are used for the analyses. The simultaneous approach at county-level based on the changes of income, employment, obesity, and diabetes reveals that obesity increases diabetes, but diabetes does not have an effect on obesity. The counties with high initial levels of obesity had less obesity growth but more diabetes growth. Increasing income impacts negatively on diabetes growth. Logit analysis indicates that obesity significantly increases the risk of diabetes of adults’ in Appalachia. Besides, being employed, higher income, as well as engaging in exercise reduce the prevalence of diabetes, while age increases diabetes. The economic cost of obesity-related diabetes is $1.9 billion, and can be reduced through mitigating obesity.
文摘This article inquires into how the maintenance of the residual practice of inspired preaching broadcast over the radio by Southern Appalachian Pentecostals, offers an accepted means by which women gain the power to articulate the conflicts, desires and contradictions of their culture. The democratic ethos of Pentecostalism declares that all people who feel the call to preach must be given that opportunity which opens a space of women＇s voices within the traditionally male ＂preacher culture.＂ Because radio lacks the visual component, and inspired preaching is deemed valid by its effect of the body, women may preach over the radio without the potential for sexual display that could arouse men visually. By examining the content and delivery of women＇s sermons using studies in melodrama, the article explores the nature and articulation of dramatic conflicts, points of difference, and especially issues of the body as lived by the women of southern Appalachia. Thereby, the article locates sites of resistance and conflicts with power both within and without the region. Using Gramcian notions of hegemony, negotiation and consent, it explores how a particular culture successfully elaborates itself through language and how Appalachian women critique their culture without risk of dramatic change.
基金supported by the National Institute of Dental and Craniofacial Research (NIDCR) grant K23DE027412
文摘Streptococcus mutans is a well-known cause of dental caries,due to its acidogenicity,aciduricity,and ability to synthesize exopolysaccharides in dental plaques.Intriguingly,not all children who carry S.mutans manifest caries,even with similar characteristics in oral hygiene,diet,and other environmental factors.This phenomenon suggests that host susceptibility potentially plays a role in the development of dental caries;however,the association between host genetics,S.mutans,and dental caries remains unclear.Therefore,this study examined the influence of host gene-by-S.mutans interaction on dental caries.Genome-wide association analyses were conducted in 709 US children (<13 years old),using the dbGap database acquired from the center for oral health research in appalachia (COHRA) and the Iowa Head Start programmes (GEIRS).A generalized estimating equation was used to examine the gene-by-S.mutans interaction effects on the outcomes (decayed and missing/filled primary teeth due to caries).Sequentially,the COHRA and GEIRS data were used to identify potential interactions and replicate the findings.Three loci at the genes interleukin 32 (IL32),galactokinase 2 (GALK2),and CUGBP,Elav-like family member 4 (CELF4) were linked to S.mutans carriage,and there was a severity of caries at a suggestive significance level among COHRA children (P < 9×10?5),and at a nominal significance level among GEIRS children (P = 0.047–0.001).The genetic risk score that combined the three loci also significantly interacted with S.mutans (P < 0.000 1).Functional analyses indicated that the identified genes are involved in the host immune response,galactose carbohydrate metabolism,and food-rewarding system,which could potentially be used to identify children at high risk for caries and to develop personalized caries prevention strategies.
文摘Appalachia has been identified as the largest Climate Change Haven in the continental United States and could serve as a refuge for millions of persons. This research presents a marketing plan for promoting migration to the Appalachian Region using advertising and a website that communicates the desirable qualities of the area. Communications will first be directed toward the current residents of Appalachia (the Internal Market) in order to create enthusiasm for welcoming new arrivals. Then, promotional messages will be sent to prospective migrants seeking to escape the negative effects of climate change in the Southeast and Southwest of the United States and globally (the External Market). The approach used here may be applicable to Climate Change Havens across the globe.
