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Low side lobe pattern synthesis using projection method with genetic algorithm for truncated cone conformal phased arrays 被引量:7
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作者 Guoqi Zeng Siyin Li +1 位作者 Yan Zhang Shanwei L 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2014年第4期554-559,共6页
A hybrid method for synthesizing antenna's three dimensional (3D) pattern is proposed to obtain the low sidelobe feature of truncated cone conformal phased arrays. In this method, the elements of truncated cone con... A hybrid method for synthesizing antenna's three dimensional (3D) pattern is proposed to obtain the low sidelobe feature of truncated cone conformal phased arrays. In this method, the elements of truncated cone conformal phased arrays are projected to the tangent plane in one generatrix of the truncated cone. Then two dimensional (2D) Chebyshev amplitude distribution optimization is respectively used in two mutual vertical directions of the tangent plane. According to the location of the elements, the excitation current amplitude distribution of each element on the conformal structure is derived reversely, then the excitation current amplitude is further optimized by using the genetic algorithm (GA). A truncated cone problem with 8x8 elements on it, and a 3D pattern desired side lobe level (SLL) up to 35 dB, is studied. By using the hybrid method, the optimal goal is accomplished with acceptable CPU time, which indicates that this hybrid method for the low sidelobe synthesis is feasible. 展开更多
关键词 conformal phased array low side lobe pattern synthe-sis projection method genetic algorithm optimization.
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Hybrid alternate projection algorithm and its application for practical conformal array pattern synthesis
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作者 Fei Zhao Shunlian Chai +2 位作者 Huiying Qi Ke Xiao Junjie Mao 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2012年第5期625-632,共8页
Based on the fabricated 12-element cavity-backed microstrip sector cylinder array,a novel hybrid alternate projection algorithm(HAPA),which combines analytical method with numerical techniques effectively,is propose... Based on the fabricated 12-element cavity-backed microstrip sector cylinder array,a novel hybrid alternate projection algorithm(HAPA),which combines analytical method with numerical techniques effectively,is proposed for synthesizing the pattern of practical conformal array.The algorithm applies the variable direction aperture projection method with mutual coupling correction techniques to provide the good initial excitations of elements to the enhanced alternate projection algorithm(EAPA).In order to do further optimization,which improves the convergent speed of the algorithm significantly.Finally,the HAPA has been applied to the fabricated sector cylinder array with mutual coupling considered.The results of synthesized patterns,such as low sidelobe with null points formed pattern,beam scanning with low sidelobe pattern and the shaped beam pattern are presented.It demonstrates the validity of HAPA in practical conformal array synthesis. 展开更多
关键词 conformal array alternate projection algorithm aperture projection method pattern synthesis mutual coupling
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Array Antenna Pattern Synthesis Based on Selective Levy Flight Culture Wolf Pack Algorithm
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作者 Ting Wang Hailin Tang +2 位作者 Yuebao Yu Bin Zheng Huijuan Liu 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2020年第5期68-80,共13页
Due to the shortcomings such as the premature convergence and the bad local optimal searching capability in traditional intelligence methods for pattern synthesis,a new type of wolf pack algorithm named Levy⁃Cultural ... Due to the shortcomings such as the premature convergence and the bad local optimal searching capability in traditional intelligence methods for pattern synthesis,a new type of wolf pack algorithm named Levy⁃Cultural Wolf Pack Algorithm(LCWPA)was designed on the basis of the Cultural Wolf Pack Algorithm(CWPA),which obeys the selective Levy flight.Because of the good overall management ability provided by the cultural algorithm in optimization process and the characteristics of excellent population diversity brought by Levy flight,the search efficiency of the new algorithm was greatly improved.When the algorithm was applied in the pattern synthesis of array antenna,the simulation results showed its high performance with multi⁃null and low side⁃lobe restrictions.In addition,the algorithm was superior to the Quantum Particle Swarm Optimization(QPSO),Particle Swarm Optimization(PSO),and Genetic Algorithm(GA)in optimization accuracy and operation speed,and is of very good generalization. 展开更多
关键词 array antenna pattern synthesis Levy flight wolf pack algorithm
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Antenna Array Pattern Synthesis via Coordinate Descent Method
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作者 Yuanhao Wang Xiaoxi He +2 位作者 Jiangning Wang Sergey Berezin Wolfgang Mathis 《Journal of Electromagnetic Analysis and Applications》 2015年第5期168-177,共10页
This paper presents an array pattern synthesis algorithm for arbitrary arrays based on coordinate descent method (CDM). With this algorithm, the complex element weights are found to minimize a weighted L2 norm of the ... This paper presents an array pattern synthesis algorithm for arbitrary arrays based on coordinate descent method (CDM). With this algorithm, the complex element weights are found to minimize a weighted L2 norm of the difference between desired and achieved pattern. Compared with traditional optimization techniques, CDM is easy to implement and efficient to reach the optimum solutions. Main advantage is the flexibility. CDM is suitable for linear and planar array with arbitrary array elements on arbitrary positions. With this method, we can configure arbitrary beam pattern, which gives it the ability to solve variety of beam forming problem, e.g. focused beam, shaped beam, nulls at arbitrary direction and with arbitrary beam width. CDM is applicable for phase-only and amplitude-only arrays as well, and furthermore, it is a suitable method to treat the problem of array with element failures. 展开更多
关键词 ANTENNA Phased array Optimization pattern Synthesis COORDINATE DESCENT Method
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Achieving Directionality and Transmit Diversity via Integrating Beam Pattern Scanning (BPS) Antenna Arrays and OFDM
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作者 Peh Keong Teh Seyed Alireza Zekavat 《Wireless Sensor Network》 2010年第2期186-196,共11页
In this paper, we introduce a novel merger of antenna arrays with scanning beam patterns, and Orthogonal Frequency Division Multiplexing (OFDM) systems. Controlled time varying phase shifts are applied to the antenna ... In this paper, we introduce a novel merger of antenna arrays with scanning beam patterns, and Orthogonal Frequency Division Multiplexing (OFDM) systems. Controlled time varying phase shifts are applied to the antenna array elements mounted at the base station with beam patterns directed toward the desired user. This creates a small beam pattern movement called Beam Pattern Scanning (BPS). In rich scattering environments BPS creates a time varying environment leading to time diversity exploitable at the receiver enhances its probability-of-error performance. Here, we apply OFDM signals to BPS antenna arrays, and we achieve: (1) directionality, which supports Space Division Multiple Access (SDMA);and (2) a time diversity gain, which leads to high performance. We discuss the structure of the base station antenna array and the OFDM receiver that exploits time diversity. We also introduce the merger of BPS and multi-carrier OFDM (MC-OFDM) systems. In MC-OFDM each bit is transmitted over all sub-carriers after serial to parallel conversion. BPS/ MC-OFDM receiver exploits both time diversity inherent in BPS, and frequency diversity inherent in MC-OFDM transmission technique. Simulation results show high Probability-of-error performance is achie- vable via BPS/OFDM and BPS/MC-OFDM schemes comparing to the traditional OFDM and MC-OFDM, respectively. Simulations also reveal that MC-OFDM system as well as its merger with BPS is capable of mitigating large Peak-to-Average Ratio (PAPR) problem in traditional OFDM system. In addition, performance simulations with coded OFDM (COFDM) and coded MC-OFDM (MC-COFDM) and their merger with BPS are studied. 展开更多
关键词 OFDM MC-OFDM ANTENNA array BEAM pattern SCANNING Transmit Diversity.
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Design of Printed Dipole Array for Omnidirectional Radiation Pattern
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作者 Jean-Marie Floc’h 《Wireless Engineering and Technology》 2019年第2期19-33,共15页
In this paper, we describe 2 kinds of printed dipole arrays and compare the performances of these arrays in term of reflexion coefficient, radiation pattern and dimensions. It is interesting to design array in order t... In this paper, we describe 2 kinds of printed dipole arrays and compare the performances of these arrays in term of reflexion coefficient, radiation pattern and dimensions. It is interesting to design array in order to obtain better performances in term of omnidirectional radiation pattern in comparison with single element. We choose this elementary source in order to obtain compact array with good performances. These antenna arrays are designed to have omnidirectional radiation pattern with horizontal polarization. We present an application dedicated to compact base station in the last section. 展开更多
关键词 PRINTED DIPOLE DIPOLE array Omnidirectionel RADIATION pattern HORIZONTAL POLARIZATION
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Shaped beam pattern synthesis with desired nulling level and minimum sidelobe level
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作者 Li-Ming Xu Qiang-Jian Song +3 位作者 Shi-Wen Lei Bo Chen Jing Tian Hao-Quan Hu 《Journal of Electronic Science and Technology》 CAS CSCD 2023年第1期35-45,共11页
For the anti-interference/denoise purpose,it usually requires minimizing the sidelobe level(SLL)of a wide-beam pattern with a desired low nulling level(NL)in the nulling region.To realize such an objective,the shaped-... For the anti-interference/denoise purpose,it usually requires minimizing the sidelobe level(SLL)of a wide-beam pattern with a desired low nulling level(NL)in the nulling region.To realize such an objective,the shaped-beam pattern synthesis(SBPS)is the most commonly used approach.However,since the SBPS problem focuses on synthesizing a predetermined beam shape,the minimum SLL via this approach cannot ensure to obtain the maximum power gain.Conversely,it cannot obtain the lowest SLL with a certain power gain requirement.Based on such consideration,this paper tries to further minimize SLL of a wide-beam pattern with a desired low NL nulling region,by solving the power gain pattern synthesis(PGPS)problem.The PGPS problem selects the array excitation by directly optimizing the power gain.Hence,it has the potential to reduce SLL,when achieving the equal mainlobe power gain constraint via SBPS.An iterative algorithm which converts the primal optimization problem into convex sub-problems is proposed,resulting in an effective problem-solving scheme.Numerical simulations demonstrate the proposed algorithm can obtain about 10-dB lower SLL than the existing algorithms. 展开更多
关键词 array synthesis Minimum sidelobe level(SLL) Nulling level(NL) pattern synthesis Wide-beam
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A new class of spectrally arbitrary complex sign pattern
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作者 Yinzhen MEI Peng WANG 《Frontiers of Mathematics in China》 CSCD 2024年第1期13-24,共12页
t Assume that S is an nth-order complex sign pattern.If for every nth degree complex coefficient polynomial f(λ)with a leading coefficient of 1,there exists a complex matrix C∈Q(S)such that the characteristic polyno... t Assume that S is an nth-order complex sign pattern.If for every nth degree complex coefficient polynomial f(λ)with a leading coefficient of 1,there exists a complex matrix C∈Q(S)such that the characteristic polynomial of C is f(λ),then S is called a spectrally arbitrary complex sign pattern.That is,if the spectrum of nth-order complex sign pattern S is a set comprised of all spectra of nth-order complex matrices,then S is called a spectrally arbitrary complex sign pattern.This paper presents a class of spectrally arbitrary complex sign pattern with only 3n nonzero elements by adopting the method of Schur complement and row reduction. 展开更多
关键词 Complex sign pattern potentially nilpotent spectrally arbitrary
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Reconfigurable Pattern Patch Antenna for Mid-Band 5G:A Review 被引量:1
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作者 Siti Rahena Isa Muzammil Jusoh +7 位作者 Thennarasan Sabapathy Jamel Nebhen Muhammad Ramlee Kamarudin Mohamed Nasrun Osman Qammer Hussain Abbasi Hasliza A.Rahim Mohd Najib Mohd Yasin Ping Jack Soh 《Computers, Materials & Continua》 SCIE EI 2022年第2期2699-2725,共27页
New requirements in communication technologies make it imperative to rehash conventional features such as reconfigurable antennas to adapt with the future adaptability advancements.This paper presents a comprehensive ... New requirements in communication technologies make it imperative to rehash conventional features such as reconfigurable antennas to adapt with the future adaptability advancements.This paper presents a comprehensive review of reconfigurable antennas,specifically in terms of radiation patterns for adaptation in the upcoming Fifth Generation(5G)New Radio frequency bands.They represent the key of antenna technology for materializing a high rate transmission,increased spectral and energy efficiency,reduced interference,and improved the beam steering and beam shaping,thereby land a great promise for planar antennas to boost the mid-band 5G.This review begins with an overview of the underlying principals in reconfiguring radiation patterns,followed by the presentations of the implemented innovative antenna topologies to suit particular advanced features.The various adaptation techniques of radiation pattern reconfigurable planar antennas and the understanding of its antenna design approaches has been investigated for its radiation pattern enhancement.A variety of design configurations have also been critically studied for their compatibilities to be operated in the midband communication systems.The review provides new insights on pattern reconfigurable antenna where such antennas are categorized as beam steering antenna and beamshaping antennas where the operation modes and purposes are clearly investigated.The review also revealed that for mid-band 5G communication,the commonly used electronic switching such as PIN diodes have sufficient isolation loss to provide the required beam performance. 展开更多
关键词 5G mid-band pattern antenna reconfigurable antenna phased array antenna antenna and propagation
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Superhydrophilic–superhydrophobic patterned surfaces:From simplified fabrication to emerging applications
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作者 Hao Chen Xiaoping Li Dachao Li 《Nanotechnology and Precision Engineering》 CAS CSCD 2022年第3期55-79,共25页
Superhydrophilic–superhydrophobic patterned surfaces constitute a branch of surface chemistry involving the two extreme states of superhydrophilicity and superhydrophobicity combined on the same surface in precise pa... Superhydrophilic–superhydrophobic patterned surfaces constitute a branch of surface chemistry involving the two extreme states of superhydrophilicity and superhydrophobicity combined on the same surface in precise patterns.Such surfaces have many advantages,including controllable wettability,enrichment ability,accessibility,and the ability to manipulate and pattern water droplets,and they offer new functionalities and possibilities for a wide variety of emerging applications,such as microarrays,biomedical assays,microfluidics,and environmental protection.This review presents the basic theory,simplified fabrication,and emerging applications of superhydrophilic–superhydrophobic patterned surfaces.First,the fundamental theories of wettability that explain the spreading of a droplet on a solid surface are described.Then,the fabrication methods for preparing superhydrophilic–superhydrophobic patterned surfaces are introduced,and the emerging applications of such surfaces that are currently being explored are highlighted.Finally,the remaining challenges of constructing such surfaces and future applications that would benefit from their use are discussed. 展开更多
关键词 SUPERHYDROPHOBICITY SUPERHYDROPHILICITY Wettability patterns Droplet array Biosensor
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Beam Pattern Synthesis Based on Hybrid Optimization Algorithm
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作者 郁彦利 王英民 李磊 《Defence Technology(防务技术)》 SCIE EI CAS 2010年第3期171-176,共6页
As conventional methods for beam pattern synthesis can not always obtain the desired optimum pattern for the arbitrary underwater acoustic sensor arrays,a hybrid numerical synthesis method based on adaptive principle ... As conventional methods for beam pattern synthesis can not always obtain the desired optimum pattern for the arbitrary underwater acoustic sensor arrays,a hybrid numerical synthesis method based on adaptive principle and genetic algorithm was presented in this paper.First,based on the adaptive theory,a given array was supposed as an adaptive array and its sidelobes were reduced by assigning a number of interference signals in the sidelobe region.An initial beam pattern was obtained after several iterations and adjustments of the interference intensity,and based on its parameters,a desired pattern was created.Then,an objective function based on the difference between the designed and desired patterns can be constructed.The pattern can be optimized by using the genetic algorithm to minimize the objective function.A design example for a double-circular array demonstrates the effectiveness of this method.Compared with the approaches existing before,the proposed method can reduce the sidelobe effectively and achieve less synthesis magnitude error in the mainlobe.The method can search for optimum attainable pattern for the specific elements if the desired pattern can not be found. 展开更多
关键词 information processing array beam pattern synthesis genetic algorithm OPTIMIZATION
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Minimal Critical Sets of Refined Inertias for Irreducible Sign Patterns of Order 2 被引量:3
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作者 Ber-Lin Yu 《Advances in Linear Algebra & Matrix Theory》 2013年第2期7-10,共4页
Let S be a nonempty, proper subset of all refined inertias. Then, S is called a critical set of refined inertias for ireducible sign patterns of order n if is sufficient for any sign pattern A to be refined inertially... Let S be a nonempty, proper subset of all refined inertias. Then, S is called a critical set of refined inertias for ireducible sign patterns of order n if is sufficient for any sign pattern A to be refined inertially arbitrary. If no proper subset of Sis a critical set of refined inertias, then S is a minimal critical set of refined inertias for sign patterns of order n . In this paper, all minimal critical sets of refined inertias for irreducible sign patterns of order 2 are identified. As a by-product, a new approach is presented to identify all minimal critical sets of inertias for irreducible sign patterns of order 2. 展开更多
关键词 Associated DIGRAPH Inertially arbitrary SIGN pattern Refined INERTIA Critical Set of Refined Inertias
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Beam Pattern Scanning (BPS) versus Space-Time Block Coding (STBC) and Space-Time Trellis Coding (STTC)
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作者 Peh Keong TEH Seyed ZEKAVAT 《International Journal of Communications, Network and System Sciences》 2009年第6期469-479,共11页
In this paper, Beam Pattern Scanning (BPS), a transmit diversity technique, is compared with two well known transmit diversity techniques, space-time block coding (STBC) and space-time trellis coding (STTC). In BPS (a... In this paper, Beam Pattern Scanning (BPS), a transmit diversity technique, is compared with two well known transmit diversity techniques, space-time block coding (STBC) and space-time trellis coding (STTC). In BPS (also called beam pattern oscillation), controlled time varying weight vectors are applied to the antenna array elements mounted at the base station (BS). This creates a small movement in the antenna array pattern directed toward the desired user. In rich scattering environments, this small beam pattern movement creates an artificial fast fading channel. The receiver is designed to exploit time diversity benefits of the fast fading channel. Via the application of simple combining techniques, BPS improves the probability-of-error performance and network capacity with minimal cost and complexity. In this work, to highlight the potential of the BPS, we compare BPS and Space-Time Coding (i.e., STBC and STTC) schemes. The comparisons are in terms of their complexity, system physical dimension, network capacity, probability-of-error performance, and spectrum efficiency. It is shown that BPS leads to higher network capacity and performance with a smaller antenna dimension and complexity with minimal loss in spectrum efficiency. This identifies BPS as a promising scheme for future wireless communications with smart antennas. 展开更多
关键词 Antenna array Beam pattern SWEEPING Transmit Diversity SPACE-TIME Block CODES and SPACE-TIME TRELLIS Coding
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Parametric array differential Pattern time delay shift coding underwater acoustic communication in the under-ice environment 被引量:1
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作者 YIN Jingwei ZHANG Xiao +2 位作者 ZHU Guangping TANG Shengyu SUN Hui 《Chinese Journal of Acoustics》 CSCD 2016年第4期431-439,共9页
In order to meet the demands of underwater acoustic communication in under ice environment,a differential Pattern time delay shift coding underwater acoustic communication method based on parametric array is introduce... In order to meet the demands of underwater acoustic communication in under ice environment,a differential Pattern time delay shift coding underwater acoustic communication method based on parametric array is introduced in this paper.The under ice underwater acoustic channel is characterized by heavy multipath transmission.Under this model,a parametric array emission method of Pattern signal is derived and the system performance is analyzed.A broadband low frequency sound waves with narrow beam-pattern,which will reduce the interface reflections and suppress the effects of multipath transmission,can be obtained by the emission method.The Songhua River under ice trial results show that there is an anti-multipath property and a higher data rate in the under-ice acoustic channel in proposed approach. 展开更多
关键词 TIME LFM Parametric array differential pattern time delay shift coding underwater acoustic communication in the under-ice environment
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A CLASS OF SPECTRALLY ARBITRARY RAY PATTERNS
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作者 Jiangwu Deng 《Annals of Applied Mathematics》 2017年第3期254-265,共12页
An n × n ray pattern A is said to be spectrally arbitrary if for every monic nth degree polynomial f(x) with coefficients from C, there is a complex matrix in the ray pattern class of A such that its characteri... An n × n ray pattern A is said to be spectrally arbitrary if for every monic nth degree polynomial f(x) with coefficients from C, there is a complex matrix in the ray pattern class of A such that its characteristic polynomial is f(x). In this paper, a family ray patterns is proved to be spectrally arbitrary by using Nilpotent-Jacobian method. 展开更多
关键词 ray pattern Nilpotent-Jacobian method spectrally arbitrary
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Pattern Synthesis and Polarization Optimization of a Conical Array 被引量:1
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作者 Qing-Qiang He Yu-Hong Liang Bing-Zhong Wang 《Journal of Electronic Science and Technology》 CAS 2011年第1期71-77,共7页
A feasible method for synthesizing millimeter-wave conical array and optimizing low cross-polarization is proposed.Starting from the far-field superposition principle,an efficient approach including element mutual cou... A feasible method for synthesizing millimeter-wave conical array and optimizing low cross-polarization is proposed.Starting from the far-field superposition principle,an efficient approach including element mutual coupling and mounted platform effects is used to calculate the far-field patterns.A coordinate transform is applied to create polarization quantities,and a general process for the element polarized pattern transformation is performed.Corresponding numerical example is given and the desired sidelobe level and low cross-polarization are optimized.The numerical results indicate the proposed method is valid. 展开更多
关键词 Conical array coordinate transformation low cross-polarization genetic algorithm pattern synthesis.
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1D Acoustic Velocity-Independent DOA Estimation Method with Arbitrary Arrays 被引量:1
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作者 Gengxin Ning Liang Xie +1 位作者 Xiaopeng Li Jun Zhang 《Journal of Communications and Information Networks》 CSCD 2020年第2期121-129,共9页
The performance of conventional direction of arrival(DOA)method is greatly affected by the uncertainty of wave velocity in underwater environment.To solve this problem,an acoustic velocity-independent method is propos... The performance of conventional direction of arrival(DOA)method is greatly affected by the uncertainty of wave velocity in underwater environment.To solve this problem,an acoustic velocity-independent method is proposed to estimate the underwater DOA using two arbitrary intersecting uniform linear arrays in this study.By introducing the additional array compared to the conventional DOA methods,the proposed algorithm can make its performance independent of the acoustic velocity through the geometric relationship between those two arrays.The simulation results demonstrate that the proposed method is more accurate and robust than other methods in an unknown sound velocity. 展开更多
关键词 underwater DOA estimation arbitrary intersecting uniform linear array acoustic velocityindependent method
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A New Class of Minimally Spectrally Arbitrary Sign Patterns
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作者 LI Xi SHAO Yah Ling GAO Yu Bin 《Journal of Mathematical Research and Exposition》 CSCD 北大核心 2008年第2期389-395,共7页
If every monic real polynomial of degree n can be achieved as the characteristic polynomial of some matrix B∈Q(A),then sign pattern A of order n is a spectrally arbitrary pattern.A sign pattern A is minimally spectra... If every monic real polynomial of degree n can be achieved as the characteristic polynomial of some matrix B∈Q(A),then sign pattern A of order n is a spectrally arbitrary pattern.A sign pattern A is minimally spectrally arbitrary if it is spectrally arbitrary but is not spectrally arbitrary if any nonzero entry(or entries)of A is replaced by zero.In this article,we give some new sign patterns which are minimally spectrally arbitrary for order n≥9. 展开更多
关键词 图论 数学理论 计算方法 多项式
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Pattern synthesis optimization of 3-D ODAR based on improved GA using LSFE method 被引量:3
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作者 龙伟军 贲德 +1 位作者 BAKHSHI ASIM D 张弓 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2011年第1期96-100,共5页
Pattern synthesis in 3-D opportunistic digital array radar(ODAR) becomes complex when a multitude of antennas are considered to be randomly distributed in a three dimensional space.In order to obtain an optimal patter... Pattern synthesis in 3-D opportunistic digital array radar(ODAR) becomes complex when a multitude of antennas are considered to be randomly distributed in a three dimensional space.In order to obtain an optimal pattern,several freedoms must be constrained.A new pattern synthesis approach based on the improved genetic algorithm(GA) using the least square fitness estimation(LSFE) method is proposed.Parameters optimized by this method include antenna locations,stimulus states and phase weights.The new algorithm demonstrates that the fitness variation tendency of GA can be effectively predicted after several "eras" by the LSFE method.It is shown that by comparing the variation of LSFE curve slope,the GA operator can be adaptively modified to avoid premature convergence of the algorithm.The validity of the algorithm is verified using computer implementation. 展开更多
关键词 antenna radiation patterns genetic algorithm(GA) opportunistic digital array radar(ODAR) pattern synthesis the least square fitness estimation(LSFE)
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Discovery of laryngeal carcinoma by serum proteomic pattern analysis 被引量:22
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作者 XIAO Xueyuan1, ZHAO Xiaodong2, LIU Jiankai3, GUO Fuzheng1, LIU Danhui1 & HE Dacheng1 1. Key Laboratory for Cell Proliferation and Regulation Biology, Ministry of Education, Beijing Normal University, Universities?Confeder-ated Institute of Proteomics, Beijing 100875, China 2. Department of Otolaryngology-Head and Neck Surgery, Third Affiliated Hospital, Jilin University, Changchun 130031, China 3. Department of Biochemistry, Jilin University, Changchun 130021, China 《Science China(Life Sciences)》 SCIE CAS 2004年第3期219-223,共5页
Laryngeal carcinoma is the most common malignancy among head and neck tu-mors. The purpose of this study is to find biomarkers for laryngeal carcinoma in patient blood serum using the Surface Enhanced Laser Desorption... Laryngeal carcinoma is the most common malignancy among head and neck tu-mors. The purpose of this study is to find biomarkers for laryngeal carcinoma in patient blood serum using the Surface Enhanced Laser Desorption/Ionization (SELDI) technique. Serum samples from 33 laryngeal carcinoma (12 cases of glottis, 18 of supraglottis and 3 of subglottis) patients and 31 age- and sex-matched healthy people were analyzed by SELDI-TOF on a Pro-teinChip reader, PBSII-C. Protein profiles were generated using WCX2 protein chips. Protein peak clustering and classification analyses were performed utilizing the Biomarker Wizard and Biomarker Pattern software packages, respectively. The results showed that sixteen peaks had significant difference between laryngeal cancer patients and healthy group, eight of which were up-regulated in the patient samples, and the others were down-regulated. Two protein peaks 8153 Da and 2035 Da were automatically chosen for the system training and development of a classification tree. The analysis yielded a correct percentage of 96.9% for patients and 96.7% for control. The results suggest that serum is a useful resource for the detection of specific bio-markers for laryngeal carcinoma. Proteinchip Array System was a useful tool for a high throughput screening of large-sized serum samples to discover potential biomarkers for carci-noma. 展开更多
关键词 protein chip array system LARYNGEAL carcinoma BIOMARKER pattern.
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