[Objectives]To study the antioxidant and hypoglycemic effects of different parts of Ardisia gigantifolia Stapf.[Methods]The hydroxyl radical scavenging activity,DPPH radical scavenging activity and total antioxidant c...[Objectives]To study the antioxidant and hypoglycemic effects of different parts of Ardisia gigantifolia Stapf.[Methods]The hydroxyl radical scavenging activity,DPPH radical scavenging activity and total antioxidant capacity of ABTS of 75%ethanol extract of A.gigantifolia Stapf and the petroleum ether,ethyl acetate,n-butanol,chloroform and aqueous extract were measured with Vc as positive control.At the same time,acarbose was used as reference substance to determine the inhibitory effect of each polar site onα-glucosidase.[Results]All parts of A.gigantifolia Stapf had antioxidant activity,among which ethyl acetate had the strongest antioxidant activity,and the scavenging rate of hydroxyl radical and DPPH radical was higher than that of positive control.The results showed that petroleum ether,ethyl acetate and chloroform had a good inhibitory effect onα-glucosidase(better than acarbose).[Conclusions]The ethyl acetate part of A.gigantifolia Stapf had the best antioxidant activity and inhibitory effect onα-glucosidase.It provides a basis for further research and development of A.gigantifolia Stapf.展开更多
One new triterpenoid sapoin with two known triterpenoid sapoins:3β-O-{α-L-rhamnopyranosyl-(1→3)-[β-D-xylopyranose-(1→2)]-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranosyl}-3β-hydroxy-13β,28-epoxy-oleanan-16-oxo-...One new triterpenoid sapoin with two known triterpenoid sapoins:3β-O-{α-L-rhamnopyranosyl-(1→3)-[β-D-xylopyranose-(1→2)]-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranosyl}-3β-hydroxy-13β,28-epoxy-oleanan-16-oxo-30-al(1),3β-O-{α-L-rhamnopyranosyl-(1→3)-[(β-D-xylopyranosyl-(1→2)]-β-D-galactopyranosyl-(1→4)-[(β-D-glucopyranosyl-(1→2)]-α-L-ara-binopyranoside}-16α-hydroxy-13,28-epoxy-oleanane(2) and cyclamiretin A 3β-O-α-L-rhamnopyranosyl-(l→3)-[P-D-xylopyranosyl-(1→2)]-β-D-glucopyranosyl-(1→4)-[β-D-glucopyranosyl-(...展开更多
This paper comprehensively reviews the research progress on the pharmacological effects of Ardisia gigantifolia Stapf in recent years,and finds that Ardisia gigantifolia Stapf has good pharmacological effects in many ...This paper comprehensively reviews the research progress on the pharmacological effects of Ardisia gigantifolia Stapf in recent years,and finds that Ardisia gigantifolia Stapf has good pharmacological effects in many aspects,including anti-inflammation,anti-oxidation,anti-thrombosis,anti-tumor and so on.In particular,more than ten saponins have been found to have good anti-tumor activity and have potential research value,which can provide reference for the full development and utilization of Ardisia gigantifolia Stapf resources.展开更多
[Objectives] To screen out the anti-inflammatory and analgesic parts of Ardisia gigantifolia stapf.and to explore the toxicological safety of each part.[Methods]The carrageenan-induced toe swelling experiment of mice,...[Objectives] To screen out the anti-inflammatory and analgesic parts of Ardisia gigantifolia stapf.and to explore the toxicological safety of each part.[Methods]The carrageenan-induced toe swelling experiment of mice,acetic acid-induced peritoneal capillary permeability experiment,pain writhing test,and mouse maximum tolerated dose experiment were carried out.Taking mouse toe swelling,capillary permeability,pain writhing reaction times,and animal death number as indicators,anti-inflammatory and analgesic effects were screened and toxicological safety was evaluated for petroleum ether,ethyl acetate,n-butanol and water parts of A.gigantifolia.[Results] The petroleum ether part of A.gigantifolia can significantly reduce the degree of carrageenan-induced toe swelling of(P < 0.05),significantly inhibit the glacial acetic acid induced capillary permeability of mice(P < 0.05) and the times of pain writhing of mice(P < 0.01),no death was observed in each group after 150-fold of clinical equivalent dose administration,and no abnormality was observed in body weight and tissues of mice.[Conclusions]The petroleum ether part of A.gigantifolia is active part of anti-inflammatory and analgesic effect,and each part is low in toxicological safety.展开更多
[Objectives]The research aimed to study the characteristics of Ardisia gigantifolia and its adulterants Embelia scandens and Mappianthus iodoides for identification. [Methods] Through the trait identification method,p...[Objectives]The research aimed to study the characteristics of Ardisia gigantifolia and its adulterants Embelia scandens and Mappianthus iodoides for identification. [Methods] Through the trait identification method,powder microscopic identification method,TLC,inclusions detection and content determination,A. gigantifolia and its adulterants were contrasted. [Results]The morphological and histological characteristics of A. gigantifolia,E. scandens and M. iodoides were different from each other. Containing water,total ash,acid insoluble ash and other inclusions also had difference; the total triterpenoid saponins were respectively 122. 90 mg/g of A. gigantifolia,147. 052 mg/g of E. scandens,and 63. 06 mg/g of M. iodoides. [Conclusions] These methods are accurate and reliable,which could be used for the identification of A. gigantifolia and its adulterants.展开更多
【目的】对近几年来走马胎化学成分的研究进展进行梳理、归纳,以期为走马胎的进一步研究、开发、利用提供参考。【方法】主要对2006-2016年中国知网、万方、重庆维普等中文数据库与Web of science,Pub Med等英文数据库,以题名或关键词为...【目的】对近几年来走马胎化学成分的研究进展进行梳理、归纳,以期为走马胎的进一步研究、开发、利用提供参考。【方法】主要对2006-2016年中国知网、万方、重庆维普等中文数据库与Web of science,Pub Med等英文数据库,以题名或关键词为"走马胎"和/或"化学成分"进行检索,整理、总结近10年来有关走马胎化学成分及其药理的研究文献。【结果】走马胎主要成分是三萜皂苷类,此外还有香豆素类、甾醇类、酚类等成分;走马胎根茎中齐墩果烷型三萜皂苷类化合物具有抗肿瘤作用,岩白菜素类化合物具有抗氧化作用。此外,走马胎提取液还具有抗血栓的作用。【结论】目前走马胎的活性成分研究部位主要集中在根茎,果实与叶子的活性成分研究尚少;对走马胎化学成分的研究主要集中在三萜皂苷类的分离与鉴定以及抗癌活性筛选,对其他类化合物和生物活性比如抗炎镇痛等方面研究尚少。【建议】加强走马胎叶子与果实的活性成分研究,以便阐明其传统利用的合理性;进一步加强研究走马胎的化学成分及其药效机理,为从现代药理学角度阐明民族传统医药知识的合理性奠定基础。展开更多
基金Supported by Guilin Scientific Research and Technology Development Plan Project(2020011203-2)Guangxi Science and Technology Major Project(GuiKe AA22096020)+2 种基金Guilin Scientific Research and Technology Development Plan Project(20220104-4,20210202-1,2020011203-1)Open Project of Guangxi Key Laboratory of Cancer Immunology and Microenvironment Regulation(2022KF005)Central Fund for Guiding Local Science and Technology Development(ZY20230102).
文摘[Objectives]To study the antioxidant and hypoglycemic effects of different parts of Ardisia gigantifolia Stapf.[Methods]The hydroxyl radical scavenging activity,DPPH radical scavenging activity and total antioxidant capacity of ABTS of 75%ethanol extract of A.gigantifolia Stapf and the petroleum ether,ethyl acetate,n-butanol,chloroform and aqueous extract were measured with Vc as positive control.At the same time,acarbose was used as reference substance to determine the inhibitory effect of each polar site onα-glucosidase.[Results]All parts of A.gigantifolia Stapf had antioxidant activity,among which ethyl acetate had the strongest antioxidant activity,and the scavenging rate of hydroxyl radical and DPPH radical was higher than that of positive control.The results showed that petroleum ether,ethyl acetate and chloroform had a good inhibitory effect onα-glucosidase(better than acarbose).[Conclusions]The ethyl acetate part of A.gigantifolia Stapf had the best antioxidant activity and inhibitory effect onα-glucosidase.It provides a basis for further research and development of A.gigantifolia Stapf.
基金supported by National Natural Science Foundation of China(No.30701079)
文摘One new triterpenoid sapoin with two known triterpenoid sapoins:3β-O-{α-L-rhamnopyranosyl-(1→3)-[β-D-xylopyranose-(1→2)]-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranosyl}-3β-hydroxy-13β,28-epoxy-oleanan-16-oxo-30-al(1),3β-O-{α-L-rhamnopyranosyl-(1→3)-[(β-D-xylopyranosyl-(1→2)]-β-D-galactopyranosyl-(1→4)-[(β-D-glucopyranosyl-(1→2)]-α-L-ara-binopyranoside}-16α-hydroxy-13,28-epoxy-oleanane(2) and cyclamiretin A 3β-O-α-L-rhamnopyranosyl-(l→3)-[P-D-xylopyranosyl-(1→2)]-β-D-glucopyranosyl-(1→4)-[β-D-glucopyranosyl-(...
基金Project of Guangdong Provincial Bureau of Chinese Medicine(20201371)Guangdong Medical Research Foundation(A2020170)Science and Technology Plan of Zhongshan City,Guangdong Province(2019B1014).
文摘This paper comprehensively reviews the research progress on the pharmacological effects of Ardisia gigantifolia Stapf in recent years,and finds that Ardisia gigantifolia Stapf has good pharmacological effects in many aspects,including anti-inflammation,anti-oxidation,anti-thrombosis,anti-tumor and so on.In particular,more than ten saponins have been found to have good anti-tumor activity and have potential research value,which can provide reference for the full development and utilization of Ardisia gigantifolia Stapf resources.
基金Supported by the Project of Traditional Chinese Medicine Bureau of Guangdong Province(20171282)
文摘[Objectives] To screen out the anti-inflammatory and analgesic parts of Ardisia gigantifolia stapf.and to explore the toxicological safety of each part.[Methods]The carrageenan-induced toe swelling experiment of mice,acetic acid-induced peritoneal capillary permeability experiment,pain writhing test,and mouse maximum tolerated dose experiment were carried out.Taking mouse toe swelling,capillary permeability,pain writhing reaction times,and animal death number as indicators,anti-inflammatory and analgesic effects were screened and toxicological safety was evaluated for petroleum ether,ethyl acetate,n-butanol and water parts of A.gigantifolia.[Results] The petroleum ether part of A.gigantifolia can significantly reduce the degree of carrageenan-induced toe swelling of(P < 0.05),significantly inhibit the glacial acetic acid induced capillary permeability of mice(P < 0.05) and the times of pain writhing of mice(P < 0.01),no death was observed in each group after 150-fold of clinical equivalent dose administration,and no abnormality was observed in body weight and tissues of mice.[Conclusions]The petroleum ether part of A.gigantifolia is active part of anti-inflammatory and analgesic effect,and each part is low in toxicological safety.
基金Supported by Scientific Research Program of Guangdong Provincial Administration of Traditional Chinese Medicine(20171282)Zhongshan Science and Technology Plan Project(2017B1094)
文摘[Objectives]The research aimed to study the characteristics of Ardisia gigantifolia and its adulterants Embelia scandens and Mappianthus iodoides for identification. [Methods] Through the trait identification method,powder microscopic identification method,TLC,inclusions detection and content determination,A. gigantifolia and its adulterants were contrasted. [Results]The morphological and histological characteristics of A. gigantifolia,E. scandens and M. iodoides were different from each other. Containing water,total ash,acid insoluble ash and other inclusions also had difference; the total triterpenoid saponins were respectively 122. 90 mg/g of A. gigantifolia,147. 052 mg/g of E. scandens,and 63. 06 mg/g of M. iodoides. [Conclusions] These methods are accurate and reliable,which could be used for the identification of A. gigantifolia and its adulterants.
文摘【目的】对近几年来走马胎化学成分的研究进展进行梳理、归纳,以期为走马胎的进一步研究、开发、利用提供参考。【方法】主要对2006-2016年中国知网、万方、重庆维普等中文数据库与Web of science,Pub Med等英文数据库,以题名或关键词为"走马胎"和/或"化学成分"进行检索,整理、总结近10年来有关走马胎化学成分及其药理的研究文献。【结果】走马胎主要成分是三萜皂苷类,此外还有香豆素类、甾醇类、酚类等成分;走马胎根茎中齐墩果烷型三萜皂苷类化合物具有抗肿瘤作用,岩白菜素类化合物具有抗氧化作用。此外,走马胎提取液还具有抗血栓的作用。【结论】目前走马胎的活性成分研究部位主要集中在根茎,果实与叶子的活性成分研究尚少;对走马胎化学成分的研究主要集中在三萜皂苷类的分离与鉴定以及抗癌活性筛选,对其他类化合物和生物活性比如抗炎镇痛等方面研究尚少。【建议】加强走马胎叶子与果实的活性成分研究,以便阐明其传统利用的合理性;进一步加强研究走马胎的化学成分及其药效机理,为从现代药理学角度阐明民族传统医药知识的合理性奠定基础。
