Fish have limited ability in endogenous biosynthesis of arginine.Arginine is an indispensable amino acid for fish,and the arginine requirement varies with fish species and fish size.Recent studies on fish have demonst...Fish have limited ability in endogenous biosynthesis of arginine.Arginine is an indispensable amino acid for fish,and the arginine requirement varies with fish species and fish size.Recent studies on fish have demonstrated that arginine influences nutrient metabolism,stimulates insulin release,is involved in nonspecific immune responses and antioxidant responses,and elevates disease resistance.Specifically,arginine can regulate energy homeostasis via modulating the adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)pathway,and also regulate protein synthesis via activating the target of rapamycin(TOR)signaling pathway.The present article reviews pertinent knowledge of arginine in fish,including dietary quantitative requirements,endogenous anabolism and catabolism,regulation of the endocrine and metabolic systems,and immune-regulatory functions under pathogenic challenge.Our findings showed that further data about the distribution of arginine after intake into specific cells,its sub-cellular sensor to initiate downstream signaling pathways,and its effects on fish mucosal immunity,especially the adaptive immune response against pathogenic infection in different species,are urgently needed.展开更多
＂Why do arginine and pyrimidines have to be considered together？＂ This was the question I asked when I was invited by Barbara Zimmermann to attend the 23rd Intemational Conference on Arginine and Pyrimidines （ICAP...＂Why do arginine and pyrimidines have to be considered together？＂ This was the question I asked when I was invited by Barbara Zimmermann to attend the 23rd Intemational Conference on Arginine and Pyrimidines （ICAP） three years ago. The meeting was held in the summer of 2012 at Bogota, Columbia, known as the ＂the Athens of South America＂. I am not alone in wanting to know more about the relationship between arginine and pyrimidines. Last summer, when ! was organising the next ICAP meeting at Oxford （Aughey et al., 2014）, one of my colleagues asked me, ＂Why such a weird name for a conference？＂ I am not sure if I had given her a satisfying answer and I was enthused to find out what the reasons may be.展开更多
基金funded by National Natural Science Foundation of China(Grant No.31802317)
文摘Fish have limited ability in endogenous biosynthesis of arginine.Arginine is an indispensable amino acid for fish,and the arginine requirement varies with fish species and fish size.Recent studies on fish have demonstrated that arginine influences nutrient metabolism,stimulates insulin release,is involved in nonspecific immune responses and antioxidant responses,and elevates disease resistance.Specifically,arginine can regulate energy homeostasis via modulating the adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)pathway,and also regulate protein synthesis via activating the target of rapamycin(TOR)signaling pathway.The present article reviews pertinent knowledge of arginine in fish,including dietary quantitative requirements,endogenous anabolism and catabolism,regulation of the endocrine and metabolic systems,and immune-regulatory functions under pathogenic challenge.Our findings showed that further data about the distribution of arginine after intake into specific cells,its sub-cellular sensor to initiate downstream signaling pathways,and its effects on fish mucosal immunity,especially the adaptive immune response against pathogenic infection in different species,are urgently needed.
文摘＂Why do arginine and pyrimidines have to be considered together？＂ This was the question I asked when I was invited by Barbara Zimmermann to attend the 23rd Intemational Conference on Arginine and Pyrimidines （ICAP） three years ago. The meeting was held in the summer of 2012 at Bogota, Columbia, known as the ＂the Athens of South America＂. I am not alone in wanting to know more about the relationship between arginine and pyrimidines. Last summer, when ! was organising the next ICAP meeting at Oxford （Aughey et al., 2014）, one of my colleagues asked me, ＂Why such a weird name for a conference？＂ I am not sure if I had given her a satisfying answer and I was enthused to find out what the reasons may be.
