Hypoxia-inducible factor 1 alpha（HIF-1α） and its target genes vascular endothelial growth factor（VEGF） and transferrins（TF） play an important role in native endothermic animals＇ adaptation to the high altitude...Hypoxia-inducible factor 1 alpha（HIF-1α） and its target genes vascular endothelial growth factor（VEGF） and transferrins（TF） play an important role in native endothermic animals＇ adaptation to the high altitude environments. For ectothermic animals – especially frogs – it remains undetermined whether HIF-1α and its target genes（VEGF and TF） play an important role in high altitude adaptation, too. In this study, we compared the gene sequences and expression of HIF-1α and its target genes（VEGF and TF） between three Nanorana parkeri populations from different altitudes（3008 m a.s.l., 3440 m a.s.l. and 4312 m a.s.l.）. We observed that the c DNA sequences of HIF-1A exhibited high sequence similarity（99.38%） among the three altitudinally separated populations; but with increasing altitude, the expression of HIF-1A and its target genes（VEGF and TF） increased significantly. These results indicate that HIF-1α plays an important role in N. parkeri adaptation to the high altitude, similar to its role in endothermic animals.展开更多
An abrupt temperature change and a warming hiatus have strongly influenced the global climate.This study focused on these changes in Inner Mongolia, China. This study used the central clustering method, Mann-Kendall m...An abrupt temperature change and a warming hiatus have strongly influenced the global climate.This study focused on these changes in Inner Mongolia, China. This study used the central clustering method, Mann-Kendall mutation test and other methods to explore the abrupt temperature change and warming hiatus in three different temperature zones of the study region based on average annual data series.Among the temperature metrics investigated, average minimum temperature(Tnav) shifted the earliest,followed by average temperature(Tnv) and average maximum temperature(Txav). The latest change was observed in summer(1990 s), whereas the earliest was observed in winter(1970 s). Before and after the abrupt temperature change, Tnav fluctuated considerably, whereas there was only a slight change in Txav.Before and after the abrupt temperature change, the winter temperature changed more dramatically than the summer temperature. Before the abrupt temperature change, Tnav in the central region(0.322°C/10 a)and west region(0.48°C/10 a) contributed the most to the increasing temperatures. After the abrupt temperature change, Tnav in winter in the central region(0.519°C/10 a) and in autumn in the west region(0.729°C/10 a) contributed the most to the temperature increases. Overall, in the years in which temperature shifts occurred early, a warming hiatus also appeared early. The three temperature metrics in spring(1991)in the east region were the first to exhibit a warming hiatus. In the east region, Txav displayed the lowest rate of increase(0.412°C/a) in the period after the abrupt temperature change and before the warming hiatus,and the highest rate of increase after the warming hiatus.展开更多
基金supported by National Natural Science Foundation of China(No.31471994)
文摘Hypoxia-inducible factor 1 alpha（HIF-1α） and its target genes vascular endothelial growth factor（VEGF） and transferrins（TF） play an important role in native endothermic animals＇ adaptation to the high altitude environments. For ectothermic animals – especially frogs – it remains undetermined whether HIF-1α and its target genes（VEGF and TF） play an important role in high altitude adaptation, too. In this study, we compared the gene sequences and expression of HIF-1α and its target genes（VEGF and TF） between three Nanorana parkeri populations from different altitudes（3008 m a.s.l., 3440 m a.s.l. and 4312 m a.s.l.）. We observed that the c DNA sequences of HIF-1A exhibited high sequence similarity（99.38%） among the three altitudinally separated populations; but with increasing altitude, the expression of HIF-1A and its target genes（VEGF and TF） increased significantly. These results indicate that HIF-1α plays an important role in N. parkeri adaptation to the high altitude, similar to its role in endothermic animals.
基金supported by the Program for Young Talents of Science and Technology in Universities of the Inner Mongolia Autonomous Regionthe National Key Research and Development Plan (2017YFC0404305)the National Natural Science Foundation of China (51669016)
文摘An abrupt temperature change and a warming hiatus have strongly influenced the global climate.This study focused on these changes in Inner Mongolia, China. This study used the central clustering method, Mann-Kendall mutation test and other methods to explore the abrupt temperature change and warming hiatus in three different temperature zones of the study region based on average annual data series.Among the temperature metrics investigated, average minimum temperature(Tnav) shifted the earliest,followed by average temperature(Tnv) and average maximum temperature(Txav). The latest change was observed in summer(1990 s), whereas the earliest was observed in winter(1970 s). Before and after the abrupt temperature change, Tnav fluctuated considerably, whereas there was only a slight change in Txav.Before and after the abrupt temperature change, the winter temperature changed more dramatically than the summer temperature. Before the abrupt temperature change, Tnav in the central region(0.322°C/10 a)and west region(0.48°C/10 a) contributed the most to the increasing temperatures. After the abrupt temperature change, Tnav in winter in the central region(0.519°C/10 a) and in autumn in the west region(0.729°C/10 a) contributed the most to the temperature increases. Overall, in the years in which temperature shifts occurred early, a warming hiatus also appeared early. The three temperature metrics in spring(1991)in the east region were the first to exhibit a warming hiatus. In the east region, Txav displayed the lowest rate of increase(0.412°C/a) in the period after the abrupt temperature change and before the warming hiatus,and the highest rate of increase after the warming hiatus.
