Rudyard Kipling＇s Jungle Boobs depict empathy in the animal and animal-human world, and the illustrations of Rudyard＇s father, John Lockwood Kipling, and the American artist and prolific illustrator, Aldren Watson, ...Rudyard Kipling＇s Jungle Boobs depict empathy in the animal and animal-human world, and the illustrations of Rudyard＇s father, John Lockwood Kipling, and the American artist and prolific illustrator, Aldren Watson, help depict that empathy. Lockwood Kipling was both influence on and interpreter of the Jungle Books, as shown above all in the development from his Beast andMan in lndia of 1891 through his illustrations for the 1894 Jungle Book, and 1895 Second Jungle Book, to his illustrations that appear in the rearranged stories of The Jungle Book, and Second Jungle Book in the 1897 Scribners Outward Bound （O/B） editions. A variation on Lockwood＇s O/B mode of Jungle Books illustrations is found in Watson＇s illustrations for the 1948 Doubleday edition, Jungle Boobs, which is the title I will use throughout.1 Part One details the influence of two animal empathy writers, Lockwood Kipling and Ernest Thompson Seton, on the Jungle Books. Part Two uses recent philosophical studies of empathy in the animal and human relationship. Part Three applies a German philosophy of art history to the new look of the O/B and Doubleday Jungle Books. Part Four interprets selected Jungle Books stories in the light of Parts one, two and three.展开更多
Acute retinal necrosis(ARN)is a devastating syndrome characterized by panuveitis,retinal necrosis,and a high rate of retinal detachment that may result in poor visual outcomes if not promptly diagnosed and treated.ARN...Acute retinal necrosis(ARN)is a devastating syndrome characterized by panuveitis,retinal necrosis,and a high rate of retinal detachment that may result in poor visual outcomes if not promptly diagnosed and treated.ARN is most commonly caused by viruses within the herpesvirus family.Etiologies include varicella-zoster virus,herpes simplex virus,and cytomegalovirus,and may be promptly diagnosed by polymerase chain reaction testing of aqueous or vitreous fluid.The true incidence of ARN is not known due to its rarity;as a result,clinical treatment is often guided by retrospective case series,case reports,and expert opinion.Standard of care has evolved over time but currently includes a combination of systemic and intravitreal antiviral in conjunction with topical or oral steroids and surgical therapy as needed.Combination therapy may reduce the rate of severe vision loss and increase the rate of visual acuity gain,although further studies are needed in this area.In particular for patients with mild to moderate disease,combination therapy may reduce the rate of retinal detachment.Adjunctive therapies including oral corticosteroid and prophylactic laser barricade are incompletely studied,but corticosteroid in particular,may reduce inflammation,which also is involved in the severe disease pathogenesis observed in ARN.This review discusses the advances in diagnosis and treatment of ARN,including management with combination antiviral medication and surgical interventions.展开更多
Based on a model of network encoding and dynamics called the artificial genome, we propose a segmental duplication and divergence model for evolving artificial regulatory networks. We find that this class of networks ...Based on a model of network encoding and dynamics called the artificial genome, we propose a segmental duplication and divergence model for evolving artificial regulatory networks. We find that this class of networks share structural properties with natural transcriptional regulatory networks. Specifically, these networks can display scale-free and small-world structures. We also find that these networks have a higher probability to operate in the ordered regimen, and a lower probability to operate in the chaotic regimen. That is, the dynamics of these networks is similar to that of natural networks. The results show that the structure and dynamics inherent in natural networks may be in part due to their method of generation rather than being exclusively shaped by subsequent evolution under natural selection.展开更多
文摘Rudyard Kipling＇s Jungle Boobs depict empathy in the animal and animal-human world, and the illustrations of Rudyard＇s father, John Lockwood Kipling, and the American artist and prolific illustrator, Aldren Watson, help depict that empathy. Lockwood Kipling was both influence on and interpreter of the Jungle Books, as shown above all in the development from his Beast andMan in lndia of 1891 through his illustrations for the 1894 Jungle Book, and 1895 Second Jungle Book, to his illustrations that appear in the rearranged stories of The Jungle Book, and Second Jungle Book in the 1897 Scribners Outward Bound （O/B） editions. A variation on Lockwood＇s O/B mode of Jungle Books illustrations is found in Watson＇s illustrations for the 1948 Doubleday edition, Jungle Boobs, which is the title I will use throughout.1 Part One details the influence of two animal empathy writers, Lockwood Kipling and Ernest Thompson Seton, on the Jungle Books. Part Two uses recent philosophical studies of empathy in the animal and human relationship. Part Three applies a German philosophy of art history to the new look of the O/B and Doubleday Jungle Books. Part Four interprets selected Jungle Books stories in the light of Parts one, two and three.
基金This project was supported by the National Eye Institute/National Institutes of Health core grant P30-EY06360(Department of Ophthalmology,Emory University School of Medicine)National Eye Institute of the National Institutes of Health under award RO1 EY029594(SY)+1 种基金The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the views or policies of the Department of Health and Human Services,nor does mention of trade names,commercial products,or organizations imply endorsement by the U.S.GovernmentThis research was also supported an unrestricted departmental grant from Research to Prevent Blindness,Inc.to the Emory Eye Center,Emory University School of Medicine and Association for Research in Vision and Ophthalmology Mallinckrodt Young Investigator Award(SY).
文摘Acute retinal necrosis(ARN)is a devastating syndrome characterized by panuveitis,retinal necrosis,and a high rate of retinal detachment that may result in poor visual outcomes if not promptly diagnosed and treated.ARN is most commonly caused by viruses within the herpesvirus family.Etiologies include varicella-zoster virus,herpes simplex virus,and cytomegalovirus,and may be promptly diagnosed by polymerase chain reaction testing of aqueous or vitreous fluid.The true incidence of ARN is not known due to its rarity;as a result,clinical treatment is often guided by retrospective case series,case reports,and expert opinion.Standard of care has evolved over time but currently includes a combination of systemic and intravitreal antiviral in conjunction with topical or oral steroids and surgical therapy as needed.Combination therapy may reduce the rate of severe vision loss and increase the rate of visual acuity gain,although further studies are needed in this area.In particular for patients with mild to moderate disease,combination therapy may reduce the rate of retinal detachment.Adjunctive therapies including oral corticosteroid and prophylactic laser barricade are incompletely studied,but corticosteroid in particular,may reduce inflammation,which also is involved in the severe disease pathogenesis observed in ARN.This review discusses the advances in diagnosis and treatment of ARN,including management with combination antiviral medication and surgical interventions.
文摘Based on a model of network encoding and dynamics called the artificial genome, we propose a segmental duplication and divergence model for evolving artificial regulatory networks. We find that this class of networks share structural properties with natural transcriptional regulatory networks. Specifically, these networks can display scale-free and small-world structures. We also find that these networks have a higher probability to operate in the ordered regimen, and a lower probability to operate in the chaotic regimen. That is, the dynamics of these networks is similar to that of natural networks. The results show that the structure and dynamics inherent in natural networks may be in part due to their method of generation rather than being exclusively shaped by subsequent evolution under natural selection.
