Individuals with Glucose-6-phosphate dehydrogenase (G6PD) deficiency are susceptible to hemolytic anemia when exposed to pro-oxidant substances. This study investigates the hemolytic impact of Artemisia annua (A. annu...Individuals with Glucose-6-phosphate dehydrogenase (G6PD) deficiency are susceptible to hemolytic anemia when exposed to pro-oxidant substances. This study investigates the hemolytic impact of Artemisia annua (A. annua) extracts in G6PD-deficient subjects through a mixed experimental approach. In the in vitro phase, red blood cells from G6PD-deficient individuals and rats induced with Dehydroepiandrosterone (DHEA) were exposed to various concentrations of A. annua infusion, with distilled water and physiological saline as positive and negative controls respectively. The in vivo study involved G6PD-deficient Wistar rats divided into three groups receiving A. annua infusion, quinine (positive control), and distilled water (negative control) via gavage. Blood samples were collected for biochemical and hematological analyses. Notably, at a 40% concentration of A. annua infusion, there was a significant increase in the hemolysis rate of G6PD-deficient red blood cells compared to controls (p A. annua exhibited elevated aspartate aminotransferase (129.25 ± 4.55 U/L vs. 80.09 ± 4.03 U/L;p A. annua infusion tested positive for saponins. These findings underscore the risk of hemolysis in G6PD-deficient individuals upon ingesting A. annua.展开更多
All nuclei in mesophyll cells of Artemisia marschalliana are located in vacuoles and occupy up to 90% of their volume. The ultrastructural organization of chromatin in nuclei shows different degrees of its decondensat...All nuclei in mesophyll cells of Artemisia marschalliana are located in vacuoles and occupy up to 90% of their volume. The ultrastructural organization of chromatin in nuclei shows different degrees of its decondensation, up to complete separation of DNA from histones. It is possible that the separation of DNA from histones enables Artemisia to grow in soils with high salinity.展开更多
Malaria causes many deaths around the world, particularly in Africa, which ultimately affects the socio-economic development of African countries. The resistance of Plasmodium falciparum to quinine-based drugs led to ...Malaria causes many deaths around the world, particularly in Africa, which ultimately affects the socio-economic development of African countries. The resistance of Plasmodium falciparum to quinine-based drugs led to new studies showing the efficiency of new artemisin-based drugs. The molecule artemisin is extracted from Artemisia annua a plant from China that has been used for decades in traditional Chinese medicine. The purpose of this study is to improve the production of sweet wormwood (Artemisia annua) using organic fertilizers in the north of Cote d’Ivoire. To do so, a morpho-pedological characterization of the study site was firstly performed to determine the soil type and their fertility level. Then, a randomized complete block system including two factors (the quantity of compost and the plant density) was implemented to test the effect of organic amendment and plant arrangement on the growth of Artemisia annua. Six treatments were set up: a control plot (no compost) where the plants are arranged in square (T0D1) and the plants are arranged in staggered (T0D2). Then, a treatment with compost addition of 25 t/ha where the plants are arranged in square (T1D1) and in staggered (T1D2). A treatment with compost addition of 50 t/ha where plants are arranged in square (T2D1) and in staggered (T2D2). Our results showed that the soils hosting our experimentation are Arenithic Plinthic Ferrasols with a very low level of fertility, prone to leaching and erosion. T1D2 and T2D2 treatments obtained the highest yields of 2.82 t/ha and 3.91 t/ha, respectively. Our findings indicate that a high dose of organic amendment combined with a staggered plant arrangement strongly improves the biomass production of sweet wormwood. This is in agreement with previous studies showing that the addition of organic matter can restore the level of soil fertility by increasing soil porosity and the activity of micro and macroorganisms.展开更多
文摘Individuals with Glucose-6-phosphate dehydrogenase (G6PD) deficiency are susceptible to hemolytic anemia when exposed to pro-oxidant substances. This study investigates the hemolytic impact of Artemisia annua (A. annua) extracts in G6PD-deficient subjects through a mixed experimental approach. In the in vitro phase, red blood cells from G6PD-deficient individuals and rats induced with Dehydroepiandrosterone (DHEA) were exposed to various concentrations of A. annua infusion, with distilled water and physiological saline as positive and negative controls respectively. The in vivo study involved G6PD-deficient Wistar rats divided into three groups receiving A. annua infusion, quinine (positive control), and distilled water (negative control) via gavage. Blood samples were collected for biochemical and hematological analyses. Notably, at a 40% concentration of A. annua infusion, there was a significant increase in the hemolysis rate of G6PD-deficient red blood cells compared to controls (p A. annua exhibited elevated aspartate aminotransferase (129.25 ± 4.55 U/L vs. 80.09 ± 4.03 U/L;p A. annua infusion tested positive for saponins. These findings underscore the risk of hemolysis in G6PD-deficient individuals upon ingesting A. annua.
文摘All nuclei in mesophyll cells of Artemisia marschalliana are located in vacuoles and occupy up to 90% of their volume. The ultrastructural organization of chromatin in nuclei shows different degrees of its decondensation, up to complete separation of DNA from histones. It is possible that the separation of DNA from histones enables Artemisia to grow in soils with high salinity.
文摘Malaria causes many deaths around the world, particularly in Africa, which ultimately affects the socio-economic development of African countries. The resistance of Plasmodium falciparum to quinine-based drugs led to new studies showing the efficiency of new artemisin-based drugs. The molecule artemisin is extracted from Artemisia annua a plant from China that has been used for decades in traditional Chinese medicine. The purpose of this study is to improve the production of sweet wormwood (Artemisia annua) using organic fertilizers in the north of Cote d’Ivoire. To do so, a morpho-pedological characterization of the study site was firstly performed to determine the soil type and their fertility level. Then, a randomized complete block system including two factors (the quantity of compost and the plant density) was implemented to test the effect of organic amendment and plant arrangement on the growth of Artemisia annua. Six treatments were set up: a control plot (no compost) where the plants are arranged in square (T0D1) and the plants are arranged in staggered (T0D2). Then, a treatment with compost addition of 25 t/ha where the plants are arranged in square (T1D1) and in staggered (T1D2). A treatment with compost addition of 50 t/ha where plants are arranged in square (T2D1) and in staggered (T2D2). Our results showed that the soils hosting our experimentation are Arenithic Plinthic Ferrasols with a very low level of fertility, prone to leaching and erosion. T1D2 and T2D2 treatments obtained the highest yields of 2.82 t/ha and 3.91 t/ha, respectively. Our findings indicate that a high dose of organic amendment combined with a staggered plant arrangement strongly improves the biomass production of sweet wormwood. This is in agreement with previous studies showing that the addition of organic matter can restore the level of soil fertility by increasing soil porosity and the activity of micro and macroorganisms.
