Artocarpus heterophyllus Lam.(Moraceae)has been traditionally used in treating various diseases such as diabetes,diarrhea,malarial fever,inflammation,wound healing and other diseases.Since various bioactive compounds ...Artocarpus heterophyllus Lam.(Moraceae)has been traditionally used in treating various diseases such as diabetes,diarrhea,malarial fever,inflammation,wound healing and other diseases.Since various bioactive compounds have been found in this plant,this review focuses on the phytochemical and pharmacological properties of a potent bioactive compound artocarpin.Despite its various functions,a mechanistic review on this compound has not been reviewed specifically.Here,pharmacological studies in vitro and in vivo on artocarpin are discussed thoroughly stressing on anticancer,antimicrobial,anti-tyrosinase,antioxidant and antiinflammatory aspects of artocarpin.This review would be beneficial for future study to show the competency of natural products for their therapeutic characteristics.展开更多
Objective: One appealing strategy to overcome and prevent resistant problem is the use of combined two or more antibacterial substances. Lawsone methyl ether(LME) is the naphthoquinone found in the leaves of Impatiens...Objective: One appealing strategy to overcome and prevent resistant problem is the use of combined two or more antibacterial substances. Lawsone methyl ether(LME) is the naphthoquinone found in the leaves of Impatiens balsamina. The objective of this study is to determine the interaction of LME with some antibiotics(ampicillin, tetracycline, norfloxacin, and clotrimazole) and a natural compound, artocarpin against methicillin-resistant Staphylococcus aureus(MRSA), Candida albicans, and Trychophyton rubrum.Methods: A broth microdilution method was used to determine the minimum inhibition concentration(MIC). Synergistic effects were evaluated at their own MIC using the checkerboard method and time-kill assay.Results: LME showed moderate antibacterial activity against MRSA with MIC value of 15.6 μg/mL, and exhibited strong antifungal activities against T. rubrum and C. albicans with MIC values of 7.8 and 3.9 μg/m L,respectively. The interaction of LME with the natural compound artocarpin against MRSA produced a synergy with fractional inhibitory concentration index(FICI) value of 0.31, while the combination of LME and clotrimazole exhibited synergy against C. albicans and T. rubrum with FICI values of 0.38 and 0.24, respectively. The time-kill assays confirmed that the compounds in combination enhanced their antimicrobial activities against the resistant microorganisms with different degrees.Conclusion: LME in combination with clotrimazole exhibited synergy effect against C. albicans and T.rubrum. In combination with artocarpin, it showed synergy effect against MRSA.展开更多
基金supported by the Ministry of Higher Education(MOHE)under FRGS grant with vote number RR 237.
文摘Artocarpus heterophyllus Lam.(Moraceae)has been traditionally used in treating various diseases such as diabetes,diarrhea,malarial fever,inflammation,wound healing and other diseases.Since various bioactive compounds have been found in this plant,this review focuses on the phytochemical and pharmacological properties of a potent bioactive compound artocarpin.Despite its various functions,a mechanistic review on this compound has not been reviewed specifically.Here,pharmacological studies in vitro and in vivo on artocarpin are discussed thoroughly stressing on anticancer,antimicrobial,anti-tyrosinase,antioxidant and antiinflammatory aspects of artocarpin.This review would be beneficial for future study to show the competency of natural products for their therapeutic characteristics.
基金supported by The Thailand Research Fund (Grant No. DBG6180031)
文摘Objective: One appealing strategy to overcome and prevent resistant problem is the use of combined two or more antibacterial substances. Lawsone methyl ether(LME) is the naphthoquinone found in the leaves of Impatiens balsamina. The objective of this study is to determine the interaction of LME with some antibiotics(ampicillin, tetracycline, norfloxacin, and clotrimazole) and a natural compound, artocarpin against methicillin-resistant Staphylococcus aureus(MRSA), Candida albicans, and Trychophyton rubrum.Methods: A broth microdilution method was used to determine the minimum inhibition concentration(MIC). Synergistic effects were evaluated at their own MIC using the checkerboard method and time-kill assay.Results: LME showed moderate antibacterial activity against MRSA with MIC value of 15.6 μg/mL, and exhibited strong antifungal activities against T. rubrum and C. albicans with MIC values of 7.8 and 3.9 μg/m L,respectively. The interaction of LME with the natural compound artocarpin against MRSA produced a synergy with fractional inhibitory concentration index(FICI) value of 0.31, while the combination of LME and clotrimazole exhibited synergy against C. albicans and T. rubrum with FICI values of 0.38 and 0.24, respectively. The time-kill assays confirmed that the compounds in combination enhanced their antimicrobial activities against the resistant microorganisms with different degrees.Conclusion: LME in combination with clotrimazole exhibited synergy effect against C. albicans and T.rubrum. In combination with artocarpin, it showed synergy effect against MRSA.
