In this work, we show the synthesis of ten (10) new derivatives of 3-imidazo [1,2-a]pyridinyl-1-arylpropenone (10a - d). These new compounds were obtained by condensation of Claisen-Schmidt between derivatives of 2-su...In this work, we show the synthesis of ten (10) new derivatives of 3-imidazo [1,2-a]pyridinyl-1-arylpropenone (10a - d). These new compounds were obtained by condensation of Claisen-Schmidt between derivatives of 2-substi- tuted-1H-imidazo[1,2-a]pyridine-3-carbaldehyde (3a - b and 7) and acetophenone derivatives (9a - e) in the presence of a base. The synthesized compounds were characterized by spectroscopic analyses <sup>1</sup>H and <sup>13</sup>C NMR. The antifungal activity of the ten (10) derivatives was determined on a resistant strain of Candida albicans by the microdilution method. The results showed that four (4) of them (10a, 10b, 10c and 10i) were active with minimum inhibitory concentrations (MICs) below 300 μmol/L. Of these four compounds, 10i was more potent than the others with a MIC of 41.98 μmol/L.展开更多
文摘In this work, we show the synthesis of ten (10) new derivatives of 3-imidazo [1,2-a]pyridinyl-1-arylpropenone (10a - d). These new compounds were obtained by condensation of Claisen-Schmidt between derivatives of 2-substi- tuted-1H-imidazo[1,2-a]pyridine-3-carbaldehyde (3a - b and 7) and acetophenone derivatives (9a - e) in the presence of a base. The synthesized compounds were characterized by spectroscopic analyses <sup>1</sup>H and <sup>13</sup>C NMR. The antifungal activity of the ten (10) derivatives was determined on a resistant strain of Candida albicans by the microdilution method. The results showed that four (4) of them (10a, 10b, 10c and 10i) were active with minimum inhibitory concentrations (MICs) below 300 μmol/L. Of these four compounds, 10i was more potent than the others with a MIC of 41.98 μmol/L.
